The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease

Science

Volumn 313, Issue 5795, 2006, Pages 1929-1935

  Lamb, Justin ^a   Crawford, Emily D ^a,h   Peck, David ^a   Modell, Joshua W ^a   Blat, Irene C ^a   Wrobel, Matthew J ^a   Lerner, Jim ^a   Brunet, Jean Philippe ^a   Subramanian, Aravind ^a   Ross, Kenneth N ^a   Reich, Michael ^a   Hieronymus, Haley ^a,b   Wei, Guo ^a,b   Armstrong, Scott A ^b,c   Haggarty, Stephen J ^a,d   Clemons, Paul A ^a   Wei, Ru ^a   Carr, Steven A ^a   Lander, Eric S ^c,e,f   Golub, Todd R ^a,b,c,e,g  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^g HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; DRUG PRODUCTS; GENES; MOLECULES; PERTURBATION TECHNIQUES; PHARMACOKINETICS;

CONNECTIVITY MAP; DRUG ACTION; GENE EXPRESSION;

GENETIC ENGINEERING;

DISEASE; DRUG; GENE; GENE EXPRESSION; MAP; SOFTWARE;

ARTICLE; COMPUTER PROGRAM; DOWN REGULATION; FEASIBILITY STUDY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MAMMAL CELL; PRIORITY JOURNAL;

ALZHEIMER DISEASE; CELL LINE; CELL LINE, TUMOR; DATABASES, FACTUAL; DEXAMETHASONE; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; ESTROGENS; GENE EXPRESSION; GENE EXPRESSION PROFILING; HISTONE DEACETYLASES; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; LIMONINS; OBESITY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTHIAZINES; SIROLIMUS; SOFTWARE;

EID: 33749335282     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1132939     Document Type: Article

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