Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3

Journal of Biological Chemistry

Volumn 282, Issue 4, 2007, Pages 2529-2537

  Gao, Ling ^a   Wang, Jiakun ^b,c   Sekhar, Konjeti R ^b,c   Yin, Huiyong ^a   Yared, Nicholas F ^b,c   Schneider, Scott N ^d   Sasi, Soumya ^b,c   Dalton, Timothy P ^d   Anderson, Mark E ^e   Chan, Jefferson Y ^f   Morrow, Jason D ^a   Freeman, Michael L ^a,b,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c VANDERBILT INGRAM CANCER CENTER   (United States)

^d UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^e UNIVERSITY OF IOWA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID (DHA); EICOSAPENTAENOIC ACID (EPA); FREE RADICAL OXIDATION; REACTIVE OXYGEN;

DETOXIFICATION; GENE EXPRESSION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; OXIDATION; OXIDATIVE STRESS;

FATTY ACIDS;

CYCLOPENTENONE; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; ISOPROSTANE DERIVATIVE; OMEGA 3 FATTY ACID; PROTEIN CULLIN3; PROTEIN KEAP1; REACTIVE OXYGEN METABOLITE; REGULATOR PROTEIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CUL3 PROTEIN, HUMAN; CULLIN; KEAP1 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DETOXIFICATION; FATTY ACID OXIDATION; HUMAN; HUMAN CELL; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN STABILITY; REGULATORY MECHANISM; TANDEM MASS SPECTROMETRY; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; OXIDATION REDUCTION REACTION; REPORTER GENE; TRANSACTIVATION;

ANIMALS; CELL CYCLE PROTEINS; CELL LINE; CULLIN PROTEINS; FATTY ACIDS, OMEGA-3; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MOLECULAR STRUCTURE; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXIDATIVE STRESS; TRANS-ACTIVATION (GENETICS);

EID: 34047273206     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M607622200     Document Type: Article

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