-
1
-
-
67649866121
-
Mitochondria and reactive oxygen species
-
Kowaltowski AJ, et al: Mitochondria and reactive oxygen species. Free Radic Biol Med 2009; 47: 333-343.
-
(2009)
Free Radic Biol Med
, vol.47
, pp. 333-343
-
-
Kowaltowski, A.J.1
-
2
-
-
0035782650
-
Reactive oxygen species and mitochondrial diseases
-
Kirkinezos IG, Moraes CT: Reactive oxygen species and mitochondrial diseases. Semin Cell Dev Biol 2001; 12: 449-457.
-
(2001)
Semin Cell Dev Biol
, vol.12
, pp. 449-457
-
-
Kirkinezos, I.G.1
Moraes, C.T.2
-
3
-
-
2642565930
-
Hydroxyl-radical production in physiological reactions. A novel function of peroxidase
-
Chen SX, Schopfer P: Hydroxyl-radical production in physiological reactions. A novel function of peroxidase. Eur J Biochem 1999; 260: 726-735.
-
(1999)
Eur J Biochem
, vol.260
, pp. 726-735
-
-
Chen, S.X.1
Schopfer, P.2
-
4
-
-
70449715463
-
Reactive oxygen species and peroxisomes: Struggling for balance
-
Bonekamp NA, et al: Reactive oxygen species and peroxisomes: struggling for balance. Biofactors 2009; 35: 346-355.
-
(2009)
Biofactors
, vol.35
, pp. 346-355
-
-
Bonekamp, N.A.1
-
5
-
-
33846794822
-
The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
-
Bedard K, Krause KH: The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007; 87: 245-313.
-
(2007)
Physiol Rev
, vol.87
, pp. 245-313
-
-
Bedard, K.1
Krause, K.H.2
-
7
-
-
0035750172
-
Toxic metals and oxidative stress. I. Mechanisms involved in metal-induced oxidative damage
-
Ercal N, Gurer-Orhan H, Aykin-Burns N: Toxic metals and oxidative stress. I. Mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem 2001; 1: 529-539.
-
(2001)
Curr Top Med Chem
, vol.1
, pp. 529-539
-
-
Ercal, N.1
Gurer-Orhan, H.2
Aykin-Burns, N.3
-
9
-
-
0034096271
-
Mechanisms of anti-cancer agents: Emphasis on oxidative stress and electron transfer
-
Kovacic P, Osuna JA Jr: Mechanisms of anti-cancer agents: emphasis on oxidative stress and electron transfer. Curr Pharm Des 2000; 6: 277-309.
-
(2000)
Curr Pharm des
, vol.6
, pp. 277-309
-
-
Kovacic, P.1
Osuna Jr., J.A.2
-
10
-
-
67649641505
-
Role of oxidative stress in cadmium toxicity and carcinogenesis
-
Liu J, Qu W, Kadiiska MB: Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol 2009; 238: 209-214.
-
(2009)
Toxicol Appl Pharmacol
, vol.238
, pp. 209-214
-
-
Liu, J.1
Qu, W.2
Kadiiska, M.B.3
-
11
-
-
47949103112
-
Cellular effects of long wavelength UV light (UVA) in mammalian cells
-
McMillan TJ, et al: Cellular effects of long wavelength UV light (UVA) in mammalian cells. J Pharm Pharmacol 2008; 60: 969-976.
-
(2008)
J Pharm Pharmacol
, vol.60
, pp. 969-976
-
-
McMillan, T.J.1
-
13
-
-
60749131956
-
Radiation chemistry comes before radiation biology
-
O'Neill P, Wardman P: Radiation chemistry comes before radiation biology. Int J Radiat Biol 2009; 85: 9-25.
-
(2009)
Int J Radiat Biol
, vol.85
, pp. 9-25
-
-
O'neill, P.1
Wardman, P.2
-
14
-
-
34347379422
-
Hypoxia-induced reactive oxygen species formation in skeletal muscle
-
Clanton TL: Hypoxia-induced reactive oxygen species formation in skeletal muscle. J Appl Physiol (1985) 2007; 102: 2379-2388.
-
(2007)
J Appl Physiol (1985)
, vol.102
, pp. 2379-2388
-
-
Clanton, T.L.1
-
15
-
-
64149087422
-
Therapeutic strategies by modulating oxygen stress in cancer and inflammation
-
Fang J, Seki T, Maeda H: Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv Drug Deliv Rev 2009; 61: 290-302.
-
(2009)
Adv Drug Deliv Rev
, vol.61
, pp. 290-302
-
-
Fang, J.1
Seki, T.2
Maeda, H.3
-
16
-
-
28544448737
-
Reactive oxygen species amplify glucose signalling in renal cells cultured under high glucose and in diabetic kidney
-
Ha H, Lee HB: Reactive oxygen species amplify glucose signalling in renal cells cultured under high glucose and in diabetic kidney. Nephrology (Carlton) 2005; 10(suppl):S7-S10.
-
(2005)
Nephrology (Carlton)
, vol.10
, Issue.SUPPL.
-
-
Ha, H.1
Lee, H.B.2
-
17
-
-
8544224992
-
Metal-induced oxidative stress and signal transduction
-
Leonard SS, Harris GK, Shi X: Metal-induced oxidative stress and signal transduction. Free Radic Biol Med 2004; 37: 1921-1942.
-
(2004)
Free Radic Biol Med
, vol.37
, pp. 1921-1942
-
-
Leonard, S.S.1
Harris, G.K.2
Shi, X.3
-
18
-
-
78649906789
-
Environmentally induced oxidative stress in aquatic animals
-
Lushchak VI: Environmentally induced oxidative stress in aquatic animals. Aquat Toxicol 2011; 101: 13-30.
-
(2011)
Aquat Toxicol
, vol.101
, pp. 13-30
-
-
Lushchak, V.I.1
-
19
-
-
77955035878
-
Reactive oxygen species in TNFalpha-induced signaling and cell death
-
Morgan MJ, Liu ZG: Reactive oxygen species in TNFalpha-induced signaling and cell death. Mol Cells 2010; 30: 1-12.
-
(2010)
Mol Cells
, vol.30
, pp. 1-12
-
-
Morgan, M.J.1
Liu, Z.G.2
-
20
-
-
0031987938
-
Anthracyclinederived chemotherapeutics in apoptosis and free radical cytotoxicity
-
Muller I, Niethammer D, Bruchelt G: Anthracyclinederived chemotherapeutics in apoptosis and free radical cytotoxicity. Int J Mol Med 1998; 1: 491-494.
-
(1998)
Int J Mol Med
, vol.1
, pp. 491-494
-
-
Muller, I.1
Niethammer, D.2
Bruchelt, G.3
-
21
-
-
33749986298
-
Free radicals and antioxidants in normal physiological functions and human disease
-
Valko M, et al: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007; 39: 44-84.
-
(2007)
Int J Biochem Cell Biol
, vol.39
, pp. 44-84
-
-
Valko, M.1
-
23
-
-
79960286223
-
Signal transduction by reactive oxygen species
-
Finkel T: Signal transduction by reactive oxygen species. J Cell Biol 2011; 194: 7-15.
-
(2011)
J Cell Biol
, vol.194
, pp. 7-15
-
-
Finkel, T.1
-
24
-
-
33847620225
-
Aging: A revisited theory based on free radicals generated by NOX family NADPH oxidases
-
Krause KH: Aging: a revisited theory based on free radicals generated by NOX family NADPH oxidases. Exp Gerontol 2007; 42: 256-262.
-
(2007)
Exp Gerontol
, vol.42
, pp. 256-262
-
-
Krause, K.H.1
-
25
-
-
84866432422
-
Reactive oxygen species: From health to disease
-
Brieger K, et al: Reactive oxygen species: from health to disease. Swiss Med Wkly 2012; 142:w13659.
-
(2012)
Swiss Med Wkly
, vol.142
-
-
Brieger, K.1
-
26
-
-
80053337585
-
Clinical review: Oxygen as a signaling molecule
-
Bartz RR, Piantadosi CA: Clinical review: oxygen as a signaling molecule. Crit Care 2010; 14: 234.
-
(2010)
Crit Care
, vol.14
, pp. 234
-
-
Bartz, R.R.1
Piantadosi, C.A.2
-
27
-
-
0034011261
-
Oxyradicals and DNA damage
-
Marnett LJ: Oxyradicals and DNA damage. Carcinogenesis 2000; 21: 361-370.
-
(2000)
Carcinogenesis
, vol.21
, pp. 361-370
-
-
Marnett, L.J.1
-
28
-
-
84875185107
-
DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation
-
Cadet J, Wagner JR: DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation. Cold Spring Harb Perspect Biol 2013; 5:a012559.
-
(2013)
Cold Spring Harb Perspect Biol
, vol.5
-
-
Cadet, J.1
Wagner, J.R.2
-
29
-
-
0036591855
-
Free radical-induced damage to DNA: Mechanisms and measurement
-
Dizdaroglu M, et al: Free radical-induced damage to DNA: mechanisms and measurement. Free Radic Biol Med 2002; 32: 1102-1115.
-
(2002)
Free Radic Biol Med
, vol.32
, pp. 1102-1115
-
-
Dizdaroglu, M.1
-
30
-
-
34248541922
-
Life and death: Metabolic rate, membrane composition, and life span of animals
-
Hulbert AJ, et al: Life and death: metabolic rate, membrane composition, and life span of animals. Physiol Rev 2007; 87: 1175-1213.
-
(2007)
Physiol Rev
, vol.87
, pp. 1175-1213
-
-
Hulbert, A.J.1
-
31
-
-
80053629048
-
Molecular and structural antioxidant defenses against oxidative stress in animals
-
Pamplona R, Costantini D: Molecular and structural antioxidant defenses against oxidative stress in animals. Am J Physiol Regul Integr Comp Physiol 2011; 301:R843-R863.
-
(2011)
Am J Physiol Regul Integr Comp Physiol
, vol.301
-
-
Pamplona, R.1
Costantini, D.2
-
32
-
-
84860716543
-
Repair of persistent strand breaks in the mitochondrial genome
-
Sykora P, Wilson DM 3rd, Bohr VA: Repair of persistent strand breaks in the mitochondrial genome. Mech Ageing Dev 2012; 133: 169-175.
-
(2012)
Mech Ageing Dev
, vol.133
, pp. 169-175
-
-
Sykora, P.1
Wilson III, D.M.2
Bohr, V.A.3
-
33
-
-
58149350129
-
The proteasome and its role in the degradation of oxidized proteins
-
Jung T, Grune T: The proteasome and its role in the degradation of oxidized proteins. IUBMB Life 2008; 60: 743-752.
-
(2008)
IUBMB Life
, vol.60
, pp. 743-752
-
-
Jung, T.1
Grune, T.2
-
34
-
-
42649129672
-
MtDNA mutations, functional decline and turnover of mitochondria in aging
-
Pang CY, Ma YS, Wei YU: MtDNA mutations, functional decline and turnover of mitochondria in aging. Front Biosci 2008; 13: 3661-3675.
-
(2008)
Front Biosci
, vol.13
, pp. 3661-3675
-
-
Pang, C.Y.1
Ma, Y.S.2
Wei, Y.U.3
-
35
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
Harman D: Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956; 11: 298-300.
-
(1956)
J Gerontol
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
36
-
-
0031916984
-
The free radical theory of aging matures
-
Beckman KB, Ames BN: The free radical theory of aging matures. Physiol Rev 1998; 78: 547-581.
-
(1998)
Physiol Rev
, vol.78
, pp. 547-581
-
-
Beckman, K.B.1
Ames, B.N.2
-
37
-
-
0036628724
-
Role of oxidative stress and protein oxidation in the aging process
-
Sohal RS: Role of oxidative stress and protein oxidation in the aging process. Free Radic Biol Med 2002; 33: 37-44.
-
(2002)
Free Radic Biol Med
, vol.33
, pp. 37-44
-
-
Sohal, R.S.1
-
38
-
-
0024541837
-
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
-
Linnane AW, et al: Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1989; 1: 642-645.
-
(1989)
Lancet
, vol.1
, pp. 642-645
-
-
Linnane, A.W.1
-
39
-
-
0019160038
-
Mitochondrial role in cell aging
-
Miquel J, et al: Mitochondrial role in cell aging. Exp Gerontol 1980; 15: 575-591.
-
(1980)
Exp Gerontol
, vol.15
, pp. 575-591
-
-
Miquel, J.1
-
40
-
-
0034193996
-
The biosynthesis and functional role of cardiolipin
-
Schlame M, Rua D, Greenberg ML: The biosynthesis and functional role of cardiolipin. Prog Lipid Res 2000; 39: 257-288.
-
(2000)
Prog Lipid Res
, vol.39
, pp. 257-288
-
-
Schlame, M.1
Rua, D.2
Greenberg, M.L.3
-
41
-
-
84896778365
-
Age-related changes in mitochondrial membrane composition of Nothobranchius rachovii
-
Lucas-Sanchez A, et al: Age-related changes in mitochondrial membrane composition of Nothobranchius rachovii . J Gerontol A Biol Sci Med Sci 2014; 69: 142-151.
-
(2014)
J Gerontol A Biol Sci Med Sci
, vol.69
, pp. 142-151
-
-
Lucas-Sanchez, A.1
-
42
-
-
84862980210
-
Age-related changes in mitochondrial membrane composition of rainbow trout (Oncorhynchus mykiss) heart and brain
-
Almaida-Pagan PF, et al: Age-related changes in mitochondrial membrane composition of rainbow trout (Oncorhynchus mykiss) heart and brain. Comp Biochem Physiol B Biochem Mol Biol 2012; 163: 129-137.
-
(2012)
Comp Biochem Physiol B Biochem Mol Biol
, vol.163
, pp. 129-137
-
-
Almaida-Pagan, P.F.1
-
43
-
-
0026707798
-
Effect of age-related lipid peroxidation on membrane fluidity and phospholipase A2: Modulation by dietary restriction
-
Yu BP, Suescun EA, Yang SY: Effect of age-related lipid peroxidation on membrane fluidity and phospholipase A2: modulation by dietary restriction. Mech Ageing Dev 1992; 65: 17-33.
-
(1992)
Mech Ageing Dev
, vol.65
, pp. 17-33
-
-
Yu, B.P.1
Suescun, E.A.2
Yang, S.Y.3
-
44
-
-
0030915483
-
Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase
-
Hagen TM, et al: Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc Natl Acad Sci USA 1997; 94: 3064-3069.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3064-3069
-
-
Hagen, T.M.1
-
45
-
-
52949106861
-
Membrane phospholipids, lipoxidative damage and molecular integrity: A causal role in aging and longevity
-
Pamplona R: Membrane phospholipids, lipoxidative damage and molecular integrity: a causal role in aging and longevity. Biochim Biophys Acta 2008; 1777: 1249-1262.
-
(2008)
Biochim Biophys Acta
, vol.1777
, pp. 1249-1262
-
-
Pamplona, R.1
-
46
-
-
0034891121
-
Lipid peroxidation in aging and age-dependent diseases
-
Spiteller G: Lipid peroxidation in aging and age-dependent diseases. Exp Gerontol 2001; 36: 1425-1457.
-
(2001)
Exp Gerontol
, vol.36
, pp. 1425-1457
-
-
Spiteller, G.1
-
47
-
-
2342577555
-
Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain
-
Pamplona R, et al: Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain. Exp Gerontol 2004; 39: 725-733.
-
(2004)
Exp Gerontol
, vol.39
, pp. 725-733
-
-
Pamplona, R.1
-
48
-
-
0346731073
-
Maillard reaction products in tissue proteins: New products and new perspectives
-
Thorpe SR, Baynes JW: Maillard reaction products in tissue proteins: new products and new perspectives. Amino Acids 2003; 25: 275-281.
-
(2003)
Amino Acids
, vol.25
, pp. 275-281
-
-
Thorpe, S.R.1
Baynes, J.W.2
-
49
-
-
69949091187
-
Response to the increase of oxidative stress and mutation of mitochondrial DNA in aging
-
Ma YS, et al: Response to the increase of oxidative stress and mutation of mitochondrial DNA in aging. Biochim Biophys Acta 2009; 1790: 1021-1029.
-
(2009)
Biochim Biophys Acta
, vol.1790
, pp. 1021-1029
-
-
Ma, Y.S.1
-
50
-
-
33744972513
-
Mitochondrial protein oxidation and degradation in response to oxidative stress and aging
-
Bulteau AL, Szweda LI, Friguet B: Mitochondrial protein oxidation and degradation in response to oxidative stress and aging. Exp Gerontol 2006; 41: 653-657.
-
(2006)
Exp Gerontol
, vol.41
, pp. 653-657
-
-
Bulteau, A.L.1
Szweda, L.I.2
Friguet, B.3
-
51
-
-
0030841350
-
Protein oxidation in aging, disease, and oxidative stress
-
Berlett BS, Stadtman ER: Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 1997; 272: 20313-20316.
-
(1997)
J Biol Chem
, vol.272
, pp. 20313-20316
-
-
Berlett, B.S.1
Stadtman, E.R.2
-
52
-
-
0033120863
-
Fe-S proteins in sensing and regulatory functions
-
Beinert H, Kiley PJ: Fe-S proteins in sensing and regulatory functions. Curr Opin Chem Biol 1999; 3: 152-157.
-
(1999)
Curr Opin Chem Biol
, vol.3
, pp. 152-157
-
-
Beinert, H.1
Kiley, P.J.2
-
53
-
-
67549136242
-
Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect
-
Veatch JR, et al: Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell 2009; 137: 1247-1258.
-
(2009)
Cell
, vol.137
, pp. 1247-1258
-
-
Veatch, J.R.1
-
54
-
-
0036790385
-
Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging
-
Wei YH, Lee HC: Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging. Exp Biol Med (Maywood) 2002; 227: 671-682.
-
(2002)
Exp Biol Med (Maywood)
, vol.227
, pp. 671-682
-
-
Wei, Y.H.1
Lee, H.C.2
-
55
-
-
79959450877
-
Mitochondrial DNA mutations in disease and aging
-
Park CB, Larsson NG: Mitochondrial DNA mutations in disease and aging. J Cell Biol 2011; 193: 809-818.
-
(2011)
J Cell Biol
, vol.193
, pp. 809-818
-
-
Park, C.B.1
Larsson, N.G.2
-
56
-
-
0003097634
-
Protein degradation in mitochondria: Implications for oxidative stress, aging and disease: A novel etiological classification of mitochondrial proteolytic disorders
-
Bota DA, Davies KJ: Protein degradation in mitochondria: implications for oxidative stress, aging and disease: a novel etiological classification of mitochondrial proteolytic disorders. Mitochondrion 2001; 1: 33-49.
-
(2001)
Mitochondrion
, vol.1
, pp. 33-49
-
-
Bota, D.A.1
Davies, K.J.2
-
57
-
-
77954490419
-
Oxidized mitochondrial protein degradation and repair in aging and oxidative stress
-
Ugarte N, Petropoulos I, Friguet B: Oxidized mitochondrial protein degradation and repair in aging and oxidative stress. Antioxid Redox Signal 2010; 13: 539-549.
-
(2010)
Antioxid Redox Signal
, vol.13
, pp. 539-549
-
-
Ugarte, N.1
Petropoulos, I.2
Friguet, B.3
-
58
-
-
58949084649
-
Base excision repair of oxidative DNA damage and association with cancer and aging
-
Maynard S, et al: Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis 2009; 30: 2-10.
-
(2009)
Carcinogenesis
, vol.30
, pp. 2-10
-
-
Maynard, S.1
-
59
-
-
84860704002
-
Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases
-
Hegde ML, et al: Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases. Mech Ageing Dev 2012; 133: 157-168.
-
(2012)
Mech Ageing Dev
, vol.133
, pp. 157-168
-
-
Hegde, M.L.1
-
60
-
-
33644992894
-
Mitochondrial DNA maintenance and bioenergetics
-
Stuart JA, Brown MF: Mitochondrial DNA maintenance and bioenergetics. Biochim Biophys Acta 2006; 1757: 79-89.
-
(2006)
Biochim Biophys Acta
, vol.1757
, pp. 79-89
-
-
Stuart, J.A.1
Brown, M.F.2
-
62
-
-
16844366524
-
Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging
-
Lemasters JJ: Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res 2005; 8: 3-5.
-
(2005)
Rejuvenation Res
, vol.8
, pp. 3-5
-
-
Lemasters, J.J.1
-
63
-
-
79959354999
-
Mitochondria and the autophagy-inflammation-cell death axis in organismal aging
-
Green DR, Galluzzi L, Kroemer G: Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 2011; 333: 1109-1112.
-
(2011)
Science
, vol.333
, pp. 1109-1112
-
-
Green, D.R.1
Galluzzi, L.2
Kroemer, G.3
-
65
-
-
79955945927
-
Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging
-
Batlevi Y, La Spada AR: Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging. Neurobiol Dis 2011; 43: 46-51.
-
(2011)
Neurobiol Dis
, vol.43
, pp. 46-51
-
-
Batlevi, Y.1
La Spada, A.R.2
-
66
-
-
34548655310
-
Highly resistant macromolecular components and low rate of generation of endogenous damage: Two key traits of longevity
-
Pamplona R, Barja G: Highly resistant macromolecular components and low rate of generation of endogenous damage: two key traits of longevity. Ageing Res Rev 2007; 6: 189-210.
-
(2007)
Ageing Res Rev
, vol.6
, pp. 189-210
-
-
Pamplona, R.1
Barja, G.2
-
67
-
-
0036236733
-
Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: A homeoviscous-longevity adaptation?
-
Pamplona R, Barja G, Portero-Otin M: Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation? Ann NY Acad Sci 2002; 959: 475-490.
-
(2002)
Ann NY Acad Sci
, vol.959
, pp. 475-490
-
-
Pamplona, R.1
Barja, G.2
Portero-Otin, M.3
-
68
-
-
33646704229
-
Is the mitochondrial free radical theory of aging intact?
-
Sanz A, Pamplona R, Barja G: Is the mitochondrial free radical theory of aging intact? Antioxid Redox Signal 2006; 8: 582-599.
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 582-599
-
-
Sanz, A.1
Pamplona, R.2
Barja, G.3
-
70
-
-
0032947552
-
Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae
-
Kirchman PA, et al: Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae . Genetics 1999; 152: 179-190.
-
(1999)
Genetics
, vol.152
, pp. 179-190
-
-
Kirchman, P.A.1
-
71
-
-
0035515923
-
Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
-
Feng J, Bussiere F, Hekimi S: Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans . Dev Cell 2001; 1: 633-644.
-
(2001)
Dev Cell
, vol.1
, pp. 633-644
-
-
Feng, J.1
Bussiere, F.2
Hekimi, S.3
-
72
-
-
0037228016
-
A systematic RNAi screen identifies a critical role for mitochondria in C. Elegans longevity
-
Lee SS, et al: A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 2003; 33: 40-48.
-
(2003)
Nat Genet
, vol.33
, pp. 40-48
-
-
Lee, S.S.1
-
73
-
-
26944501617
-
Evolutionary conservation of the clk- 1-dependent mechanism of longevity: Loss of mclk1 increases cellular fitness and lifespan in mice
-
Liu X, et al: Evolutionary conservation of the clk- 1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev 2005; 19: 2424-2434.
-
(2005)
Genes Dev
, vol.19
, pp. 2424-2434
-
-
Liu, X.1
-
74
-
-
33847304164
-
Increased longevity and refractoriness to Ca 2+ -dependent neurodegeneration in Surf1 knockout mice
-
Dell'agnello C, et al: Increased longevity and refractoriness to Ca 2+ -dependent neurodegeneration in Surf1 knockout mice. Hum Mol Genet 2007; 16: 431-444.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 431-444
-
-
Dell'agnello, C.1
-
75
-
-
70349782312
-
Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain
-
Copeland JM, et al: Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain. Curr Biol 2009; 19: 1591-1598.
-
(2009)
Curr Biol
, vol.19
, pp. 1591-1598
-
-
Copeland, J.M.1
-
76
-
-
77956241785
-
Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans
-
Yang W, Hekimi S: Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans . Aging Cell 2010; 9: 433-447.
-
(2010)
Aging Cell
, vol.9
, pp. 433-447
-
-
Yang, W.1
Hekimi, S.2
-
77
-
-
0037147103
-
Rates of behavior and aging specified by mitochondrial function during development
-
Dillin A, et al: Rates of behavior and aging specified by mitochondrial function during development. Science 2002; 298: 2398-2401.
-
(2002)
Science
, vol.298
, pp. 2398-2401
-
-
Dillin, A.1
-
78
-
-
0033529032
-
Apparent uncoupling of energy production and consumption in long-lived Clk mutants of Caenorhabditis elegans
-
Braeckman BP, et al: Apparent uncoupling of energy production and consumption in long-lived Clk mutants of Caenorhabditis elegans . Curr Biol 1999; 9: 493-496.
-
(1999)
Curr Biol
, vol.9
, pp. 493-496
-
-
Braeckman, B.P.1
-
79
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
Trifunovic A, et al: Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004; 429: 417-423.
-
(2004)
Nature
, vol.429
, pp. 417-423
-
-
Trifunovic, A.1
-
80
-
-
22344456832
-
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
-
Kujoth GC, et al: Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005; 309: 481-484.
-
(2005)
Science
, vol.309
, pp. 481-484
-
-
Kujoth, G.C.1
-
81
-
-
41349087783
-
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice
-
Vermulst M, et al: DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet 2008; 40: 392-394.
-
(2008)
Nat Genet
, vol.40
, pp. 392-394
-
-
Vermulst, M.1
-
82
-
-
2342520175
-
Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon12 of the K-ras oncogene in lung tumors
-
Xie Y, et al: Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon12 of the K-ras oncogene in lung tumors. Cancer Res 2004; 64: 3096-3102.
-
(2004)
Cancer Res
, vol.64
, pp. 3096-3102
-
-
Xie, Y.1
-
83
-
-
13244277942
-
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life
-
Elchuri S, et al: CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene 2005; 24: 367-380.
-
(2005)
Oncogene
, vol.24
, pp. 367-380
-
-
Elchuri, S.1
-
84
-
-
0024547664
-
Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity
-
Phillips JP, et al: Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity. Proc Natl Acad Sci USA 1989; 86: 2761-2765.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 2761-2765
-
-
Phillips, J.P.1
-
85
-
-
84859483420
-
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
-
Velarde MC, et al: Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY) 2012; 4: 3-12.
-
(2012)
Aging (Albany NY)
, vol.4
, pp. 3-12
-
-
Velarde, M.C.1
-
86
-
-
0034284973
-
Extension of life-span with superoxide dismutase/catalase mimetics
-
Melov S, et al: Extension of life-span with superoxide dismutase/catalase mimetics. Science 2000; 289: 1567-1569.
-
(2000)
Science
, vol.289
, pp. 1567-1569
-
-
Melov, S.1
-
87
-
-
84879409744
-
Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing
-
Gruber J, et al: Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing. Biotechnol Adv 2013; 31: 563-592.
-
(2013)
Biotechnol Adv
, vol.31
, pp. 563-592
-
-
Gruber, J.1
-
88
-
-
0028220114
-
Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
-
Orr WC, Sohal RS: Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster . Science 1994; 263: 1128-1130.
-
(1994)
Science
, vol.263
, pp. 1128-1130
-
-
Orr, W.C.1
Sohal, R.S.2
-
89
-
-
21144434217
-
Extension of murine life span by overexpression of catalase targeted to mitochondria
-
Schriner SE, et al: Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 2005; 308: 1909-1911.
-
(2005)
Science
, vol.308
, pp. 1909-1911
-
-
Schriner, S.E.1
-
90
-
-
78649497300
-
Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance
-
Lee HY, et al: Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metab 2010; 12: 668-674.
-
(2010)
Cell Metab
, vol.12
, pp. 668-674
-
-
Lee, H.Y.1
-
91
-
-
78049434938
-
Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria
-
Dai DF, et al: Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria. Aging Cell 2010; 9: 536-544.
-
(2010)
Aging Cell
, vol.9
, pp. 536-544
-
-
Dai, D.F.1
-
92
-
-
1842544684
-
Effects of short-and mediumterm calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production
-
Bevilacqua L, et al: Effects of short-and mediumterm calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production. Am J Physiol Endocrinol Metab 2004; 286: E852-E861.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.286
-
-
Bevilacqua, L.1
-
93
-
-
0035403165
-
Caloric restriction decreases mitochondrial free radical generation at complex i and lowers oxidative damage to mitochondrial DNA in the rat heart
-
Gredilla R, et al: Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart. FASEB J 2001; 15: 1589-1591.
-
(2001)
FASEB J
, vol.15
, pp. 1589-1591
-
-
Gredilla, R.1
-
94
-
-
13844256455
-
Protein restriction without strong caloric restriction decreases mitochondrial oxygen radical production and oxidative DNA damage in rat liver
-
Sanz A, Caro P, Barja G: Protein restriction without strong caloric restriction decreases mitochondrial oxygen radical production and oxidative DNA damage in rat liver. J Bioenerg Biomembr 2004; 36: 545-552.
-
(2004)
J Bioenerg Biomembr
, vol.36
, pp. 545-552
-
-
Sanz, A.1
Caro, P.2
Barja, G.3
-
95
-
-
0033581704
-
The p66shc adaptor protein controls oxidative stress response and life span in mammals
-
Migliaccio E, et al: The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 1999; 402: 309-313.
-
(1999)
Nature
, vol.402
, pp. 309-313
-
-
Migliaccio, E.1
-
96
-
-
22744447211
-
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
-
Giorgio M, et al: Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 2005; 122: 221-233.
-
(2005)
Cell
, vol.122
, pp. 221-233
-
-
Giorgio, M.1
-
97
-
-
0037192473
-
Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
-
Nemoto S, Finkel T: Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 2002; 295: 2450-2452.
-
(2002)
Science
, vol.295
, pp. 2450-2452
-
-
Nemoto, S.1
Finkel, T.2
-
98
-
-
0041885207
-
Linking oxidative stress and genetics of aging with p66Shc signaling and forkhead transcription factors
-
Purdom S, Chen QM: Linking oxidative stress and genetics of aging with p66Shc signaling and forkhead transcription factors. Biogerontology 2003; 4: 181-191.
-
(2003)
Biogerontology
, vol.4
, pp. 181-191
-
-
Purdom, S.1
Chen, Q.M.2
-
99
-
-
77953806512
-
Oxidative stress-dependent p66Shc phosphorylation in skin fibroblasts of children with mitochondrial disorders
-
Lebiedzinska M, et al: Oxidative stress-dependent p66Shc phosphorylation in skin fibroblasts of children with mitochondrial disorders. Biochim Biophys Acta 2010; 1797: 952-960.
-
(2010)
Biochim Biophys Acta
, vol.1797
, pp. 952-960
-
-
Lebiedzinska, M.1
-
100
-
-
37549002891
-
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
-
Lombard DB, et al: Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol 2007; 27: 8807-8814.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 8807-8814
-
-
Lombard, D.B.1
-
101
-
-
78649521247
-
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
-
Qiu X, et al: Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 2010; 12: 662-667.
-
(2010)
Cell Metab
, vol.12
, pp. 662-667
-
-
Qiu, X.1
-
102
-
-
78650248160
-
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
-
Tao R, et al: Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell 2010; 40: 893-904.
-
(2010)
Mol Cell
, vol.40
, pp. 893-904
-
-
Tao, R.1
-
103
-
-
80052291180
-
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
-
Jing E, et al: Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci USA 2011; 108: 14608-14613.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 14608-14613
-
-
Jing, E.1
-
104
-
-
78651468722
-
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
-
Someya S, et al: Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 2010; 143: 802-812.
-
(2010)
Cell
, vol.143
, pp. 802-812
-
-
Someya, S.1
-
105
-
-
79953210362
-
Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis
-
Fernandez-Marcos PJ, Auwerx J: Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr 2011; 93: 884S-890S.
-
(2011)
Am J Clin Nutr
, vol.93
-
-
Fernandez-Marcos, P.J.1
Auwerx, J.2
-
106
-
-
80455143200
-
Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog
-
Rera M, et al: Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metab 2011; 14: 623-634.
-
(2011)
Cell Metab
, vol.14
, pp. 623-634
-
-
Rera, M.1
-
107
-
-
39149086121
-
Stems cells and the pathways to aging and cancer
-
Rossi DJ, Jamieson CH, Weissman IL: Stems cells and the pathways to aging and cancer. Cell 2008; 132: 681-696.
-
(2008)
Cell
, vol.132
, pp. 681-696
-
-
Rossi, D.J.1
Jamieson, C.H.2
Weissman, I.L.3
-
108
-
-
33745614062
-
Stem cells, ageing and the quest for immortality
-
Rando TA: Stem cells, ageing and the quest for immortality. Nature 2006; 441: 1080-1086.
-
(2006)
Nature
, vol.441
, pp. 1080-1086
-
-
Rando, T.A.1
-
109
-
-
84870290830
-
Redox regulation of stem/ progenitor cells and bone marrow iche
-
Urao N, Ushio-Fukai M: Redox regulation of stem/ progenitor cells and bone marrow iche. Free Radic Biol Med 2013; 54: 26-39.
-
(2013)
Free Radic Biol Med
, vol.54
, pp. 26-39
-
-
Urao, N.1
Ushio-Fukai, M.2
-
110
-
-
80052930073
-
Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells
-
Yahata T, et al: Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells. Blood 2011; 118: 2941-2950.
-
(2011)
Blood
, vol.118
, pp. 2941-2950
-
-
Yahata, T.1
-
111
-
-
69049087814
-
Mitochondrial functionality in reproduction: From gonads and gametes to embryos and embryonic stem cells
-
Ramalho-Santos J, et al: Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells. Hum Reprod Update 2009; 15: 553-572.
-
(2009)
Hum Reprod Update
, vol.15
, pp. 553-572
-
-
Ramalho-Santos, J.1
-
112
-
-
84867905197
-
Mitochondrial superoxide production negatively regulates neural progenitor proliferation and cerebral cortical development
-
Hou Y, et al: Mitochondrial superoxide production negatively regulates neural progenitor proliferation and cerebral cortical development. Stem Cells 2012; 30: 2535-2547.
-
(2012)
Stem Cells
, vol.30
, pp. 2535-2547
-
-
Hou, Y.1
-
113
-
-
84873243518
-
Selective impairment on the proliferation of neural progenitor cells by oxidative phosphorylation disruption
-
Lee Y, et al: Selective impairment on the proliferation of neural progenitor cells by oxidative phosphorylation disruption. Neurosci Lett 2013; 535: 134-139.
-
(2013)
Neurosci Lett
, vol.535
, pp. 134-139
-
-
Lee, Y.1
-
114
-
-
49249086654
-
Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells
-
Chen CT, et al: Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells. Stem Cells 2008; 26: 960-968.
-
(2008)
Stem Cells
, vol.26
, pp. 960-968
-
-
Chen, C.T.1
-
115
-
-
84876694073
-
Ketamine enhances human neural stem cell proliferation and induces neuronal apoptosis via reactive oxygen species-mediated mitochondrial pathway
-
Bai X, et al: Ketamine enhances human neural stem cell proliferation and induces neuronal apoptosis via reactive oxygen species-mediated mitochondrial pathway. Anesth Analg 2013; 116: 869-880.
-
(2013)
Anesth Analg
, vol.116
, pp. 869-880
-
-
Bai, X.1
-
116
-
-
84869830820
-
N-acetylcysteine protects induced pluripotent stem cells from in vitro stress: Impact on differentiation outcome
-
Berniakovich I, Laricchia-Robbio L, Izpisua Belmonte JC: N-acetylcysteine protects induced pluripotent stem cells from in vitro stress: impact on differentiation outcome. Int J Dev Biol 2012; 56: 729-735.
-
(2012)
Int J Dev Biol
, vol.56
, pp. 729-735
-
-
Berniakovich, I.1
Laricchia-Robbio, L.2
Izpisua Belmonte, J.C.3
-
117
-
-
33749187336
-
Increased 'vigilance' of antioxidant mechanisms in neural stem cells potentiates their capability to resist oxidative stress
-
Madhavan L, Ourednik V, Ourednik J: Increased 'vigilance' of antioxidant mechanisms in neural stem cells potentiates their capability to resist oxidative stress. Stem Cells 2006; 24: 2110-2119.
-
(2006)
Stem Cells
, vol.24
, pp. 2110-2119
-
-
Madhavan, L.1
Ourednik, V.2
Ourednik, J.3
-
118
-
-
35548936968
-
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
-
Jang YY, Sharkis SJ: A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood 2007; 110: 3056-3063.
-
(2007)
Blood
, vol.110
, pp. 3056-3063
-
-
Jang, Y.Y.1
Sharkis, S.J.2
-
119
-
-
84879559313
-
Cord blood-derived CD34+ hematopoietic cells with low mitochondrial mass are enriched in hematopoietic repopulating stem cell function
-
Romero-Moya D, et al: Cord blood-derived CD34+ hematopoietic cells with low mitochondrial mass are enriched in hematopoietic repopulating stem cell function. Haematologica 2013; 98: 1022-1029.
-
(2013)
Haematologica
, vol.98
, pp. 1022-1029
-
-
Romero-Moya, D.1
-
120
-
-
55049083950
-
Stem cells, phenotypic inversion, and differentiation
-
Siggins RW, et al: Stem cells, phenotypic inversion, and differentiation. Int J Clin Exp Med 2008; 1: 2-21.
-
(2008)
Int J Clin Exp Med
, vol.1
, pp. 2-21
-
-
Siggins, R.W.1
-
121
-
-
33747875396
-
Dynamic changes in mitochondrial biogenesis and antioxidant enzymes during the spontaneous differentiation of human embryonic stem cells
-
Cho YM, et al: Dynamic changes in mitochondrial biogenesis and antioxidant enzymes during the spontaneous differentiation of human embryonic stem cells. Biochem Biophys Res Commun 2006; 348: 1472-1478.
-
(2006)
Biochem Biophys Res Commun
, vol.348
, pp. 1472-1478
-
-
Cho, Y.M.1
-
122
-
-
13744262804
-
Derivation and characterization of new human embryonic stem cell lines: SNUhES1, SNUhES2, and SNUhES3
-
Oh SK, et al: Derivation and characterization of new human embryonic stem cell lines: SNUhES1, SNUhES2, and SNUhES3. Stem Cells 2005; 23: 211-219.
-
(2005)
Stem Cells
, vol.23
, pp. 211-219
-
-
Oh, S.K.1
-
123
-
-
16244366793
-
The impact of mitochondrial genetics on male infertility
-
St John JC, Jokhi RP, Barratt CL: The impact of mitochondrial genetics on male infertility. Int J Androl 2005; 28: 65-73.
-
(2005)
Int J Androl
, vol.28
, pp. 65-73
-
-
St John, J.C.1
Jokhi, R.P.2
Barratt, C.L.3
-
124
-
-
27744563079
-
The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells
-
St John JC, et al: The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells. Cloning Stem Cells 2005; 7: 141-153.
-
(2005)
Cloning Stem Cells
, vol.7
, pp. 141-153
-
-
St John, J.C.1
-
125
-
-
33846501510
-
Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells
-
Chung S, et al: Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells. Nat Clin Pract Cardiovasc Med 2007; 4(suppl 1):S60-S67.
-
(2007)
Nat Clin Pract Cardiovasc Med
, vol.4
, Issue.SUPPL. 1
-
-
Chung, S.1
-
126
-
-
40949088547
-
Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells
-
Saretzki G, et al: Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells. Stem Cells 2008; 26: 455-464.
-
(2008)
Stem Cells
, vol.26
, pp. 455-464
-
-
Saretzki, G.1
-
127
-
-
22544446192
-
Characterization of mitochondrial and extra-mitochondrial oxygen consuming reactions in human hematopoietic stem cells. Novel evidence of the occurrence of NAD(P)H oxidase activity
-
Piccoli C, et al: Characterization of mitochondrial and extra-mitochondrial oxygen consuming reactions in human hematopoietic stem cells. Novel evidence of the occurrence of NAD(P)H oxidase activity. J Biol Chem 2005; 280: 26467-26476.
-
(2005)
J Biol Chem
, vol.280
, pp. 26467-26476
-
-
Piccoli, C.1
-
128
-
-
7244250309
-
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
-
Ito K, et al: Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 2004; 431: 997-1002.
-
(2004)
Nature
, vol.431
, pp. 997-1002
-
-
Ito, K.1
-
129
-
-
79955778862
-
Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism
-
Nitta E, et al: Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism. Blood 2011; 117: 4169-4180.
-
(2011)
Blood
, vol.117
, pp. 4169-4180
-
-
Nitta, E.1
-
130
-
-
78650302424
-
ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3 -/- mice
-
Yalcin S, et al: ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3 -/- mice. EMBO J 2010; 29: 4118-4131.
-
(2010)
EMBO J
, vol.29
, pp. 4118-4131
-
-
Yalcin, S.1
-
131
-
-
33846419112
-
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
-
Tothova Z, et al: FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007; 128: 325-339.
-
(2007)
Cell
, vol.128
, pp. 325-339
-
-
Tothova, Z.1
-
132
-
-
84866876832
-
Mouse hematopoietic cell-targeted STAT3 deletion: Stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype
-
Mantel C, et al: Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype. Blood 2012; 120: 2589-2599.
-
(2012)
Blood
, vol.120
, pp. 2589-2599
-
-
Mantel, C.1
-
133
-
-
79551515518
-
FIP200, an essential component of mammalian autophagy is indispensible for fetal hematopoiesis
-
Liu F, Guan JL: FIP200, an essential component of mammalian autophagy is indispensible for fetal hematopoiesis. Autophagy 2011; 7: 229-230.
-
(2011)
Autophagy
, vol.7
, pp. 229-230
-
-
Liu, F.1
Guan, J.L.2
-
134
-
-
84876893671
-
FIP200 is required for maintenance and differentiation of postnatal neural stem cells
-
Wang C, et al: FIP200 is required for maintenance and differentiation of postnatal neural stem cells. Nat Neurosci 2013; 16: 532-542.
-
(2013)
Nat Neurosci
, vol.16
, pp. 532-542
-
-
Wang, C.1
-
135
-
-
79960327664
-
Mitochondrial peptidase IMMP2L mutation causes early onset of age-associated disorders and impairs adult stem cell self-renewal
-
George SK, et al: Mitochondrial peptidase IMMP2L mutation causes early onset of age-associated disorders and impairs adult stem cell self-renewal. Aging Cell 2011; 10: 584-594.
-
(2011)
Aging Cell
, vol.10
, pp. 584-594
-
-
George, S.K.1
-
136
-
-
53349091768
-
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
-
Chen C, et al: TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med 2008; 205: 2397-2408.
-
(2008)
J Exp Med
, vol.205
, pp. 2397-2408
-
-
Chen, C.1
-
137
-
-
65949113818
-
The axis of mTOR-mitochondria- ROS and stemness of the hematopoietic stem cells
-
Chen C, et al: The axis of mTOR-mitochondria- ROS and stemness of the hematopoietic stem cells. Cell Cycle 2009; 8: 1158-1160.
-
(2009)
Cell Cycle
, vol.8
, pp. 1158-1160
-
-
Chen, C.1
-
138
-
-
84866054806
-
MTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis
-
Iglesias-Bartolome R, et al: mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. Cell Stem Cell 2012; 11: 401-414.
-
(2012)
Cell Stem Cell
, vol.11
, pp. 401-414
-
-
Iglesias-Bartolome, R.1
-
139
-
-
84883395307
-
Lamin A deregulation in human mesenchymal stem cells promotes an impairment in their chondrogenic potential and imbalance in their response to oxidative stress
-
Mateos J, et al: Lamin A deregulation in human mesenchymal stem cells promotes an impairment in their chondrogenic potential and imbalance in their response to oxidative stress. Stem Cell Res 2013; 11: 1137-1148.
-
(2013)
Stem Cell Res
, vol.11
, pp. 1137-1148
-
-
Mateos, J.1
-
140
-
-
84878516294
-
PGC-1alpha prevents apoptosis in adipose-derived stem cells by reducing reactive oxygen species production in a diabetic microenvironment
-
Jiang XY, et al: PGC-1alpha prevents apoptosis in adipose-derived stem cells by reducing reactive oxygen species production in a diabetic microenvironment. Diabetes Res Clin Pract 2013; 100: 368-375.
-
(2013)
Diabetes Res Clin Pract
, vol.100
, pp. 368-375
-
-
Jiang, X.Y.1
-
141
-
-
84860539151
-
NADPH oxidase2 regulates bone marrow microenvironment following hindlimb ischemia: Role in reparative mobilization of progenitor cells
-
Urao N, et al: NADPH oxidase2 regulates bone marrow microenvironment following hindlimb ischemia: role in reparative mobilization of progenitor cells. Stem Cells 2012; 30: 923-934.
-
(2012)
Stem Cells
, vol.30
, pp. 923-934
-
-
Urao, N.1
-
142
-
-
77956217067
-
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells
-
Takubo K, et al: Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell 2010; 7: 391-402.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 391-402
-
-
Takubo, K.1
-
143
-
-
35848943667
-
Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging
-
Rossi DJ, et al: Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging. Cell Cycle 2007; 6: 2371-2376.
-
(2007)
Cell Cycle
, vol.6
, pp. 2371-2376
-
-
Rossi, D.J.1
-
144
-
-
34250007142
-
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
-
Rossi DJ, et al: Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007; 447: 725-729.
-
(2007)
Nature
, vol.447
, pp. 725-729
-
-
Rossi, D.J.1
-
145
-
-
84855417557
-
Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice
-
Ahlqvist KJ, et al: Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice. Cell Metab 2012; 15: 100-109.
-
(2012)
Cell Metab
, vol.15
, pp. 100-109
-
-
Ahlqvist, K.J.1
-
146
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick L, Moorhead PS: The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25: 585-621.
-
(1961)
Exp Cell Res
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
147
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
-
Campisi J: Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005; 120: 513-522.
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
148
-
-
0017054251
-
The cell biology of human aging
-
Hayflick L: The cell biology of human aging. N Engl J Med 1976; 295: 1302-1308.
-
(1976)
N Engl J Med
, vol.295
, pp. 1302-1308
-
-
Hayflick, L.1
-
149
-
-
85047689866
-
Telomeres, stem cells, senescence, and cancer
-
Sharpless NE, DePinho RA: Telomeres, stem cells, senescence, and cancer. J Clin Invest 2004; 113: 160-168.
-
(2004)
J Clin Invest
, vol.113
, pp. 160-168
-
-
Sharpless, N.E.1
Depinho, R.A.2
-
150
-
-
38049057905
-
DNA damage in telomeres and mitochondria during cellular senescence: Is there a connection?
-
Passos JF, Saretzki G, von Zglinicki T: DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res 2007; 35: 7505-7513.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 7505-7513
-
-
Passos, J.F.1
Saretzki, G.2
Von Zglinicki, T.3
-
151
-
-
84878771657
-
Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging
-
Ngo JK, Pomatto LC, Davies KJ: Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging. Redox Biol 2013; 1: 258-264.
-
(2013)
Redox Biol
, vol.1
, pp. 258-264
-
-
Ngo, J.K.1
Pomatto, L.C.2
Davies, K.J.3
-
152
-
-
14944345009
-
Ectopic mTERT expression in mouse embryonic stem cells does not affect differentiation but confers resistance to differentiation- and stress-induced p53-dependent apoptosis
-
Lee MK, Hande MP, Sabapathy K: Ectopic mTERT expression in mouse embryonic stem cells does not affect differentiation but confers resistance to differentiation- and stress-induced p53-dependent apoptosis. J Cell Sci 2005; 118: 819-829.
-
(2005)
J Cell Sci
, vol.118
, pp. 819-829
-
-
Lee, M.K.1
Hande, M.P.2
Sabapathy, K.3
-
153
-
-
11244347171
-
Glycolytic enzymes can modulate cellular life span
-
Kondoh H, et al: Glycolytic enzymes can modulate cellular life span. Cancer Res 2005; 65: 177-185.
-
(2005)
Cancer Res
, vol.65
, pp. 177-185
-
-
Kondoh, H.1
-
154
-
-
0029051426
-
Oxidative DNA damage and senescence of human diploid fibroblast cells
-
Chen Q, et al: Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci USA 1995; 92: 4337-4341.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 4337-4341
-
-
Chen, Q.1
-
155
-
-
0037470062
-
Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening
-
Serra V, et al: Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening. J Biol Chem 2003; 278: 6824-6830.
-
(2003)
J Biol Chem
, vol.278
, pp. 6824-6830
-
-
Serra, V.1
-
156
-
-
43049163718
-
Free radicals and senescence
-
Lu T, Finkel T: Free radicals and senescence. Exp Cell Res 2008; 314: 1918-1922.
-
(2008)
Exp Cell Res
, vol.314
, pp. 1918-1922
-
-
Lu, T.1
Finkel, T.2
-
157
-
-
0042195820
-
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
-
Parrinello S, et al: Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 2003; 5: 741-747.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 741-747
-
-
Parrinello, S.1
-
158
-
-
0029127226
-
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
-
von Zglinicki T, et al: Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 1995; 220: 186-193.
-
(1995)
Exp Cell Res
, vol.220
, pp. 186-193
-
-
Von Zglinicki, T.1
-
159
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, et al: Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349-352.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
-
160
-
-
35448962513
-
A continuous correlation between oxidative stress and telomere shortening in fibroblasts
-
Richter T, von Zglinicki T: A continuous correlation between oxidative stress and telomere shortening in fibroblasts. Exp Gerontol 2007; 42: 1039-1042.
-
(2007)
Exp Gerontol
, vol.42
, pp. 1039-1042
-
-
Richter, T.1
Von Zglinicki, T.2
-
161
-
-
0038331337
-
Mitochondrial dysfunction leads to telomere attrition and genomic instability
-
Liu L, et al: Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell 2002; 1: 40-46.
-
(2002)
Aging Cell
, vol.1
, pp. 40-46
-
-
Liu, L.1
-
162
-
-
0041419866
-
MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress
-
Saretzki G, Murphy MP, von Zglinicki T: MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress. Aging Cell 2003; 2: 141-143.
-
(2003)
Aging Cell
, vol.2
, pp. 141-143
-
-
Saretzki, G.1
Murphy, M.P.2
Von Zglinicki, T.3
-
163
-
-
0037181064
-
Site-specific probing of oxidative reactivity and telomerase function using 7,8-dihydro-8-oxoguanine in telomeric DNA
-
Szalai VA, Singer MJ, Thorp HH: Site-specific probing of oxidative reactivity and telomerase function using 7,8-dihydro-8-oxoguanine in telomeric DNA. J Am Chem Soc 2002; 124: 1625-1631.
-
(2002)
J Am Chem Soc
, vol.124
, pp. 1625-1631
-
-
Szalai, V.A.1
Singer, M.J.2
Thorp, H.H.3
-
164
-
-
14844354067
-
Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2
-
Opresko PL, et al: Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Res 2005; 33: 1230-1239.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 1230-1239
-
-
Opresko, P.L.1
-
165
-
-
46249125488
-
How shelterin protects mammalian telomeres
-
Palm W, de Lange: How shelterin protects mammalian telomeres. Annu Rev Genet 2008; 42: 301-334.
-
(2008)
Annu Rev Genet
, vol.42
, pp. 301-334
-
-
Palm, W.1
De Lange2
-
166
-
-
1842611977
-
Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells
-
Haendeler J, et al: Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ Res 2004; 94: 768-775.
-
(2004)
Circ Res
, vol.94
, pp. 768-775
-
-
Haendeler, J.1
-
167
-
-
4344577088
-
Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents
-
Achanta G, Huang P: Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents. Cancer Res 2004; 64: 6233-6239.
-
(2004)
Cancer Res
, vol.64
, pp. 6233-6239
-
-
Achanta, G.1
Huang, P.2
-
168
-
-
78649819167
-
Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence
-
Fujita K, et al: Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence. Nat Cell Biol 2010; 12: 1205-1212.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 1205-1212
-
-
Fujita, K.1
-
169
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M, et al: Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997; 88: 593-601412.
-
(1997)
Cell
, vol.88
, pp. 593-601412
-
-
Serrano, M.1
-
170
-
-
68949096538
-
Mitochondrial dysfunction contributes to oncogene-induced senescence
-
Moiseeva O, et al: Mitochondrial dysfunction contributes to oncogene-induced senescence. Mol Cell Biol 2009; 29: 4495-4507.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 4495-4507
-
-
Moiseeva, O.1
-
172
-
-
84862818143
-
Mitochondria-ROS crosstalk in the control of cell death and aging
-
Marchi S, et al: Mitochondria-ROS crosstalk in the control of cell death and aging. J Signal Transduct 2012; 2012: 329635.
-
(2012)
J Signal Transduct
, vol.2012
, pp. 329635
-
-
Marchi, S.1
-
173
-
-
0034537290
-
Autophagy as a regulated pathway of cellular degradation
-
Klionsky DJ, Emr SD: Autophagy as a regulated pathway of cellular degradation. Science 2000; 290: 1717-1721.
-
(2000)
Science
, vol.290
, pp. 1717-1721
-
-
Klionsky, D.J.1
Emr, S.D.2
-
174
-
-
84862779963
-
IP Receptors, mitochondria, and Ca signaling: Implications for aging
-
Decuypere JP, et al: IP Receptors, mitochondria, and Ca signaling: implications for aging. J Aging Res 2011; 2011: 920178.
-
(2011)
J Aging Res
, vol.2011
, pp. 920178
-
-
Decuypere, J.P.1
-
175
-
-
72649091698
-
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
-
Bjedov I, et al: Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster . Cell Metab 2010; 11: 35-46.
-
(2010)
Cell Metab
, vol.11
, pp. 35-46
-
-
Bjedov, I.1
-
176
-
-
84055190702
-
Rapamycin-induced glucose intolerance: Hunger or starvation diabetes
-
Blagosklonny MV: Rapamycin-induced glucose intolerance: hunger or starvation diabetes. Cell Cycle 2011; 10: 4217-4224.
-
(2011)
Cell Cycle
, vol.10
, pp. 4217-4224
-
-
Blagosklonny, M.V.1
-
177
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison DE, et al: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009; 460: 392-395.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
-
179
-
-
51349095898
-
Restoration of chaperonemediated autophagy in aging liver improves cellular maintenance and hepatic function
-
Zhang C, Cuervo AM: Restoration of chaperonemediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med 2008; 14: 959-965.
-
(2008)
Nat Med
, vol.14
, pp. 959-965
-
-
Zhang, C.1
Cuervo, A.M.2
-
180
-
-
0042508791
-
Neuropathologic changes in Alzheimer's disease
-
Wenk GL: Neuropathologic changes in Alzheimer's disease. J Clin Psychiatry 2003; 64(suppl 9):7-10.
-
(2003)
J Clin Psychiatry
, vol.64
, Issue.SUPPL. 9
, pp. 7-10
-
-
Wenk, G.L.1
-
181
-
-
0025734299
-
The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease
-
Blass JP, Gibson GE: The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease. Rev Neurol (Paris) 1991; 147: 513-525.
-
(1991)
Rev Neurol (Paris)
, vol.147
, pp. 513-525
-
-
Blass, J.P.1
Gibson, G.E.2
-
182
-
-
0025183062
-
Induction of Alzheimer antigens by an uncoupler of oxidative phosphorylation
-
Blass JP, et al: Induction of Alzheimer antigens by an uncoupler of oxidative phosphorylation. Arch Neurol 1990; 47: 864-869.
-
(1990)
Arch Neurol
, vol.47
, pp. 864-869
-
-
Blass, J.P.1
-
183
-
-
0035341254
-
Mitochondrial abnormalities in Alzheimer's disease
-
Hirai K, et al: Mitochondrial abnormalities in Alzheimer's disease. J Neurosci 2001; 21: 3017-3023.
-
(2001)
J Neurosci
, vol.21
, pp. 3017-3023
-
-
Hirai, K.1
-
184
-
-
0026718966
-
Brain cytochrome oxidase in Alzheimer's disease
-
Kish SJ, et al: Brain cytochrome oxidase in Alzheimer's disease. J Neurochem 1992; 59: 776-779.
-
(1992)
J Neurochem
, vol.59
, pp. 776-779
-
-
Kish, S.J.1
-
185
-
-
34648859471
-
Oxidative damage in mild cognitive impairment and early Alzheimer's disease
-
Lovell MA, Markesbery WR: Oxidative damage in mild cognitive impairment and early Alzheimer's disease. J Neurosci Res 2007; 85: 3036-3040.
-
(2007)
J Neurosci Res
, vol.85
, pp. 3036-3040
-
-
Lovell, M.A.1
Markesbery, W.R.2
-
186
-
-
1842504323
-
Redox-active metals, oxidative stress, and Alzheimer's disease pathology
-
Huang X, et al: Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Ann NY Acad Sci 2004; 1012: 153-163.
-
(2004)
Ann NY Acad Sci
, vol.1012
, pp. 153-163
-
-
Huang, X.1
-
187
-
-
84860198618
-
Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation
-
Leuner K, et al: Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. Antioxid Redox Signal 2012; 16: 1421-1433.
-
(2012)
Antioxid Redox Signal
, vol.16
, pp. 1421-1433
-
-
Leuner, K.1
-
188
-
-
77955283395
-
Animal and human studies with the mitochondria-targeted antioxidant MitoQ
-
Smith RA, Murphy MP: Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Ann NY Acad Sci 2010; 1201: 96-103.
-
(2010)
Ann NY Acad Sci
, vol.1201
, pp. 96-103
-
-
Smith, R.A.1
Murphy, M.P.2
-
189
-
-
47849101646
-
Evaluation of coenzyme Q as an antioxidant strategy for Alzheimer's disease
-
Wadsworth TL, et al: Evaluation of coenzyme Q as an antioxidant strategy for Alzheimer's disease. J Alzheimers Dis 2008; 14: 225-234.
-
(2008)
J Alzheimers Dis
, vol.14
, pp. 225-234
-
-
Wadsworth, T.L.1
-
190
-
-
0037437192
-
Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells
-
Anandatheerthavarada HK, et al: Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. J Cell Biol 2003; 161: 41-54.
-
(2003)
J Cell Biol
, vol.161
, pp. 41-54
-
-
Anandatheerthavarada, H.K.1
-
191
-
-
43849096294
-
Brain oxidative stress in a tripletransgenic mouse model of Alzheimer disease
-
Resende R, et al: Brain oxidative stress in a tripletransgenic mouse model of Alzheimer disease. Free Radic Biol Med 2008; 44: 2051-2057.
-
(2008)
Free Radic Biol Med
, vol.44
, pp. 2051-2057
-
-
Resende, R.1
-
192
-
-
46449119069
-
Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models
-
Sonnen JA, et al: Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models. Free Radic Biol Med 2008; 45: 219-230.
-
(2008)
Free Radic Biol Med
, vol.45
, pp. 219-230
-
-
Sonnen, J.A.1
-
193
-
-
80051665640
-
Neuroprotective strategies involving ROS in Alzheimer disease
-
Dumont M, Beal MF: Neuroprotective strategies involving ROS in Alzheimer disease. Free Radic Biol Med 2011; 51: 1014-1026.
-
(2011)
Free Radic Biol Med
, vol.51
, pp. 1014-1026
-
-
Dumont, M.1
Beal, M.F.2
-
194
-
-
0348111546
-
Cytochrome c oxidase is decreased in Alzheimer's disease platelets
-
Cardoso SM, et al: Cytochrome c oxidase is decreased in Alzheimer's disease platelets. Neurobiol Aging 2004; 25: 105-110.
-
(2004)
Neurobiol Aging
, vol.25
, pp. 105-110
-
-
Cardoso, S.M.1
-
195
-
-
0036272650
-
Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities
-
Casley CS, et al: Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J Neurochem 2002; 80: 91-100.
-
(2002)
J Neurochem
, vol.80
, pp. 91-100
-
-
Casley, C.S.1
-
196
-
-
35348923542
-
Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease
-
Fukui, H, et al: Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 2007; 104: 14163- 14168.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 14163-14168
-
-
Fukui, H.1
-
197
-
-
0028110234
-
Cortical cytochrome oxidase activity is reduced in Alzheimer's disease
-
Mutisya EM, Bowling AC, Beal MF: Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. J Neurochem 1994; 63: 2179-2184.
-
(1994)
J Neurochem
, vol.63
, pp. 2179-2184
-
-
Mutisya, E.M.1
Bowling, A.C.2
Beal, M.F.3
-
198
-
-
38849150935
-
Mitochondrial oxidative stress causes hyperphosphorylation of tau
-
Melov S, et al: Mitochondrial oxidative stress causes hyperphosphorylation of tau. PLoS One 2007; 2:e536.
-
(2007)
PLoS One
, vol.2
, pp. 536
-
-
Melov, S.1
-
199
-
-
79958721260
-
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: Implications for neuronal damage
-
Manczak M, Calkins MJ, Reddy PH: Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. Human molecular genetics 2011; 20: 2495-2509.
-
(2011)
Human Molecular Genetics
, vol.20
, pp. 2495-2509
-
-
Manczak, M.1
Calkins, M.J.2
Reddy, P.H.3
-
200
-
-
58049218922
-
Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
-
Wang X, et al: Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci USA 2008; 105: 19318- 19323.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19318-19323
-
-
Wang, X.1
-
201
-
-
34249881080
-
Autophagocytosis of mitochondria is prominent in Alzheimer disease
-
Moreira PI, et al: Autophagocytosis of mitochondria is prominent in Alzheimer disease. J Neuropathol Exp Neurol 2007; 66: 525-532.
-
(2007)
J Neuropathol Exp Neurol
, vol.66
, pp. 525-532
-
-
Moreira, P.I.1
-
202
-
-
33750370804
-
Understanding the molecular causes of Parkinson's disease
-
Wood-Kaczmar A, Gandhi S, Wood NW: Understanding the molecular causes of Parkinson's disease. Trends Mol Med 2006; 12: 521-528.
-
(2006)
Trends Mol Med
, vol.12
, pp. 521-528
-
-
Wood-Kaczmar, A.1
Gandhi, S.2
Wood, N.W.3
-
203
-
-
0020680904
-
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
-
Langston J, et al: Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983; 219: 979-980.
-
(1983)
Science
, vol.219
, pp. 979-980
-
-
Langston, J.1
-
204
-
-
0027995435
-
Complex I, iron, and ferritin in Parkinson's disease substantia nigra
-
Mann VM, et al: Complex I, iron, and ferritin in Parkinson's disease substantia nigra. Ann Neurol 1994; 36: 876-881.
-
(1994)
Ann Neurol
, vol.36
, pp. 876-881
-
-
Mann, V.M.1
-
205
-
-
0032829070
-
Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
-
Langston JW, et al: Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine exposure. Ann Neurol 1999; 46: 598-605.
-
(1999)
Ann Neurol
, vol.46
, pp. 598-605
-
-
Langston, J.W.1
-
206
-
-
0141741347
-
Parkinson's disease: Mechanisms and models
-
Dauer W, Przedborski S: Parkinson's disease: mechanisms and models. Neuron 2003; 39: 889- 909.
-
(2003)
Neuron
, vol.39
, pp. 889-909
-
-
Dauer, W.1
Przedborski, S.2
-
207
-
-
37049004489
-
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
-
Schapira AH: Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol 2008; 7: 97-109.
-
(2008)
Lancet Neurol
, vol.7
, pp. 97-109
-
-
Schapira, A.H.1
-
208
-
-
1542617769
-
Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP
-
Song DD, et al: Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP. Exp Neurol 2004; 186: 158-172.
-
(2004)
Exp Neurol
, vol.186
, pp. 158-172
-
-
Song, D.D.1
-
209
-
-
30644471051
-
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
-
Martin LJ, et al: Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci 2006; 26: 41-50.
-
(2006)
J Neurosci
, vol.26
, pp. 41-50
-
-
Martin, L.J.1
-
210
-
-
78049383132
-
Mitochondrial alpha-synuclein accumulation impairs complex i function in dopaminergic neurons and results in increased mitophagy in vivo
-
Chinta SJ, et al: Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo. Neurosci Lett 2010; 486: 235-239.
-
(2010)
Neurosci Lett
, vol.486
, pp. 235-239
-
-
Chinta, S.J.1
-
211
-
-
23644442282
-
Heat shock prevents alpha-synuclein- induced apoptosis in a yeast model of Parkinson's disease
-
Flower TR, et al: Heat shock prevents alpha-synuclein- induced apoptosis in a yeast model of Parkinson's disease. J Mol Biol 2005; 351: 1081-1100.
-
(2005)
J Mol Biol
, vol.351
, pp. 1081-1100
-
-
Flower, T.R.1
-
212
-
-
39049097607
-
Oxidative-stress-induced apoptosis in PBLs of two patients with Parkinson disease secondary to alpha-synuclein mutation
-
Battisti C, et al: Oxidative-stress-induced apoptosis in PBLs of two patients with Parkinson disease secondary to alpha-synuclein mutation. J Neurol Sci 2008; 267: 120-124.
-
(2008)
J Neurol Sci
, vol.267
, pp. 120-124
-
-
Battisti, C.1
-
213
-
-
77958450202
-
Inhibition of mitochondrial fusion by alpha-synuclein is rescued by PINK1, Parkin and DJ-1
-
Kamp F, et al: Inhibition of mitochondrial fusion by alpha-synuclein is rescued by PINK1, Parkin and DJ-1. EMBO J 2010; 29: 3571-3589.
-
(2010)
EMBO J
, vol.29
, pp. 3571-3589
-
-
Kamp, F.1
-
214
-
-
84863325404
-
Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson's disease
-
Xie W, Chung KK: Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson's disease. J Neurochem 2012; 122: 404-414.
-
(2012)
J Neurochem
, vol.122
, pp. 404-414
-
-
Xie, W.1
Chung, K.K.2
-
215
-
-
0032499264
-
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
-
Kitada T, et al: Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 1998; 392: 605-608.
-
(1998)
Nature
, vol.392
, pp. 605-608
-
-
Kitada, T.1
-
216
-
-
10044275502
-
Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease
-
Rogaeva E, et al: Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease. Arch Neurol 2004; 61: 1898-1904.
-
(2004)
Arch Neurol
, vol.61
, pp. 1898-1904
-
-
Rogaeva, E.1
-
217
-
-
2442668926
-
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
-
Valente EM, et al: Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 2004; 304: 1158-1160.
-
(2004)
Science
, vol.304
, pp. 1158-1160
-
-
Valente, E.M.1
-
218
-
-
33746080412
-
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
-
Yang Y, et al: Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci USA 2006; 103: 10793-10798.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 10793-10798
-
-
Yang, Y.1
-
219
-
-
33745602748
-
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
-
Park J, et al: Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 2006; 441: 1157-1161.
-
(2006)
Nature
, vol.441
, pp. 1157-1161
-
-
Park, J.1
-
220
-
-
33745589773
-
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
-
Clark IE, et al: Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 2006; 441: 1162-1166.
-
(2006)
Nature
, vol.441
, pp. 1162-1166
-
-
Clark, I.E.1
-
221
-
-
36049038504
-
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
-
Exner N, et al: Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci 2007; 27: 12413-12418.
-
(2007)
J Neurosci
, vol.27
, pp. 12413-12418
-
-
Exner, N.1
-
222
-
-
55749090654
-
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
-
Deng H, et al: The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila . Proc Natl Acad Sci USA 2008; 105: 14503-14508.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 14503-14508
-
-
Deng, H.1
-
223
-
-
79960826207
-
The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons
-
Yu W, et al: The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Hum Mol Genet 2011; 20: 3227-3240.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 3227-3240
-
-
Yu, W.1
-
224
-
-
84863888014
-
Mao-B elevation decreases parkin's ability to efficiently clear damaged mitochondria: Protective effects of rapamycin
-
Siddiqui A, Hanson I, Andersen JK: Mao-B elevation decreases parkin's ability to efficiently clear damaged mitochondria: protective effects of rapamycin. Free Radic Res 2012; 46: 1011-1018.
-
(2012)
Free Radic Res
, vol.46
, pp. 1011-1018
-
-
Siddiqui, A.1
Hanson, I.2
Andersen, J.K.3
-
225
-
-
33644778845
-
Parkin enhances mitochondrial biogenesis in proliferating cells
-
Kuroda Y, et al: Parkin enhances mitochondrial biogenesis in proliferating cells. Hum Mol Genet 2006; 15: 883-895.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 883-895
-
-
Kuroda, Y.1
-
226
-
-
0142217556
-
DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism
-
Bonifati V, et al: DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism. Neurol Sci 2003; 24: 159-160.
-
(2003)
Neurol Sci
, vol.24
, pp. 159-160
-
-
Bonifati, V.1
-
227
-
-
1642527499
-
DJ-1 has a role in antioxidative stress to prevent cell death
-
Taira T, et al: DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep 2004; 5: 213-218.
-
(2004)
EMBO Rep
, vol.5
, pp. 213-218
-
-
Taira, T.1
-
228
-
-
33750052885
-
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
-
Clements CM, et al: DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci USA 2006; 103: 15091-15096.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 15091-15096
-
-
Clements, C.M.1
-
229
-
-
77956522541
-
Loss of the Parkinson's diseaselinked gene DJ-1 perturbs mitochondrial dynamics
-
Irrcher I, et al: Loss of the Parkinson's diseaselinked gene DJ-1 perturbs mitochondrial dynamics. Hum Mol Genet 2010; 19: 3734-3746.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 3734-3746
-
-
Irrcher, I.1
-
230
-
-
13844253723
-
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
-
Goldberg MS, et al: Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 2005; 45: 489-496.
-
(2005)
Neuron
, vol.45
, pp. 489-496
-
-
Goldberg, M.S.1
-
231
-
-
20144389422
-
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6- tetrahydropyrindine (MPTP) and oxidative stress
-
Kim RH, et al: Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci USA 2005; 102: 5215-5220.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 5215-5220
-
-
Kim, R.H.1
-
232
-
-
33947282153
-
DJ-1 and Parkin modulate dopamine- dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice
-
Paterna JC, et al: DJ-1 and Parkin modulate dopamine- dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice. Mol Ther 2007; 15: 698-704.
-
(2007)
Mol Ther
, vol.15
, pp. 698-704
-
-
Paterna, J.C.1
-
233
-
-
77949623516
-
Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1
-
Krebiehl G, et al: Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One 2010; 5:e9367.
-
(2010)
PLoS One
, vol.5
, pp. 9367
-
-
Krebiehl, G.1
-
234
-
-
84860539187
-
Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction
-
Wang X, et al: Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction. J Neurochem 2012; 121: 830-839.
-
(2012)
J Neurochem
, vol.121
, pp. 830-839
-
-
Wang, X.1
-
235
-
-
33646538477
-
Leucine-rich repeat kinase 2: Relevance to Parkinson's disease
-
Guo L, Wang W, Chen SG: Leucine-rich repeat kinase 2: relevance to Parkinson's disease. Int J Biochem Cell Biol 2006; 38: 1469-1475.
-
(2006)
Int J Biochem Cell Biol
, vol.38
, pp. 1469-1475
-
-
Guo, L.1
Wang, W.2
Chen, S.G.3
-
236
-
-
84863728713
-
Leucine-rich repeat kinase2 disturbs mitochondrial dynamics via Dynamin-like protein
-
Niu J, et al: Leucine-rich repeat kinase2 disturbs mitochondrial dynamics via Dynamin-like protein. J Neurochem 2012; 122: 650-658.
-
(2012)
J Neurochem
, vol.122
, pp. 650-658
-
-
Niu, J.1
-
237
-
-
84859259002
-
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1
-
Wang X, et al: LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1. Hum Mol Genet 2012; 21: 1931-1944.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 1931-1944
-
-
Wang, X.1
-
238
-
-
0027480960
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
-
MacDonald ME, et al: A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993; 72: 971-983.
-
(1993)
Cell
, vol.72
, pp. 971-983
-
-
Macdonald, M.E.1
-
240
-
-
40849147435
-
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking
-
Orr AL, et al: N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking. J Neurosci 2008; 28: 2783-2792.
-
(2008)
J Neurosci
, vol.28
, pp. 2783-2792
-
-
Orr, A.L.1
-
241
-
-
31544446034
-
Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation
-
Squitieri F, et al: Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation. Mech Ageing Dev 2006; 127: 217-220.
-
(2006)
Mech Ageing Dev
, vol.127
, pp. 217-220
-
-
Squitieri, F.1
-
242
-
-
0036327065
-
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
-
Panov AV, et al: Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines. Nat Neurosci 2002; 5: 731-736.
-
(2002)
Nat Neurosci
, vol.5
, pp. 731-736
-
-
Panov, A.V.1
-
243
-
-
3543141113
-
Mutant huntingtin directly increases susceptibility of mitochondria to the calciuminduced permeability transition and cytochrome c release
-
Choo YS, et al: Mutant huntingtin directly increases susceptibility of mitochondria to the calciuminduced permeability transition and cytochrome c release. Human molecular genetics 2004; 13: 1407- 1420.
-
(2004)
Human Molecular Genetics
, vol.13
, pp. 1407-1420
-
-
Choo, Y.S.1
-
244
-
-
32044473546
-
Low stability of Huntington muscle mitochondria against Ca 2+ in R6/2 mice
-
Gizatullina ZZ, et al: Low stability of Huntington muscle mitochondria against Ca 2+ in R6/2 mice. Ann Neurol 2006; 59: 407-411.
-
(2006)
Ann Neurol
, vol.59
, pp. 407-411
-
-
Gizatullina, Z.Z.1
-
245
-
-
12944263711
-
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
-
Steffan JS, et al: The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. Proc Natl Acad Sci USA 2000; 97: 6763-6768.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 6763-6768
-
-
Steffan, J.S.1
-
246
-
-
5344252327
-
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
-
Lin J, et al: Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 2004; 119: 121-135.
-
(2004)
Cell
, vol.119
, pp. 121-135
-
-
Lin, J.1
-
247
-
-
84860650335
-
Mitochondrial dysfunction in ALS
-
Cozzolino M, Carri MT: Mitochondrial dysfunction in ALS. Prog Neurobiol 2012; 97: 54-66.
-
(2012)
Prog Neurobiol
, vol.97
, pp. 54-66
-
-
Cozzolino, M.1
Carri, M.T.2
-
248
-
-
20444497908
-
Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia
-
Calabrese V, et al: Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia. J Neurol Sci 2005; 233: 145-162.
-
(2005)
J Neurol Sci
, vol.233
, pp. 145-162
-
-
Calabrese, V.1
-
249
-
-
0344736798
-
Loss of m-AAA protease in mitochondria causes complex i deficiency and increased sensitivity to oxidative stress in hereditary spastic paraplegia
-
Atorino L, et al: Loss of m-AAA protease in mitochondria causes complex I deficiency and increased sensitivity to oxidative stress in hereditary spastic paraplegia. J Cell Biol 2003; 163: 777-787.
-
(2003)
J Cell Biol
, vol.163
, pp. 777-787
-
-
Atorino, L.1
-
250
-
-
33746454624
-
Mitochondria and cancer: Warburg addressed
-
Wallace DC: Mitochondria and cancer: Warburg addressed. Cold Spring Harb Symp Quant Biol 2005; 70: 363-374.
-
(2005)
Cold Spring Harb Symp Quant Biol
, vol.70
, pp. 363-374
-
-
Wallace, D.C.1
-
251
-
-
18044383110
-
Mitochondrial dysfunction in cardiovascular disease
-
Ballinger SW: Mitochondrial dysfunction in cardiovascular disease. Free Radic Biol Med 2005; 38: 1278-1295.
-
(2005)
Free Radic Biol Med
, vol.38
, pp. 1278-1295
-
-
Ballinger, S.W.1
-
252
-
-
84865418540
-
Mitochondrial dysfunction in pancreatic beta cells
-
Supale S, et al: Mitochondrial dysfunction in pancreatic beta cells. Trends Endocrinol Metab 2012; 23: 477-487.
-
(2012)
Trends Endocrinol Metab
, vol.23
, pp. 477-487
-
-
Supale, S.1
-
254
-
-
37049016418
-
The role of mitochondrial DNA mutations in aging and sarcopenia: Implications for the mitochondrial vicious cycle theory of aging
-
Hiona A, Leeuwenburgh C: The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging. Exp Gerontol 2008; 43: 24-33.
-
(2008)
Exp Gerontol
, vol.43
, pp. 24-33
-
-
Hiona, A.1
Leeuwenburgh, C.2
-
255
-
-
33751242066
-
High oxidative damage levels in the longest-living rodent, the naked mole-rat
-
Andziak B, et al: High oxidative damage levels in the longest-living rodent, the naked mole-rat. Aging Cell 2006; 5: 463-471.
-
(2006)
Aging Cell
, vol.5
, pp. 463-471
-
-
Andziak, B.1
-
256
-
-
34748850786
-
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
-
Schulz TJ, et al: Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab 2007; 6: 280-293.
-
(2007)
Cell Metab
, vol.6
, pp. 280-293
-
-
Schulz, T.J.1
-
257
-
-
79959547070
-
Mitochondria-mediated hormetic response in life span extension of calorie-restricted Saccharomyces cerevisiae
-
Sharma PK, Agrawal V, Roy N: Mitochondria-mediated hormetic response in life span extension of calorie-restricted Saccharomyces cerevisiae . Age (Dordr) 2010; 33: 143-154.
-
(2010)
Age (Dordr)
, vol.33
, pp. 143-154
-
-
Sharma, P.K.1
Agrawal, V.2
Roy, N.3
-
258
-
-
77649341027
-
Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway
-
Zuin A, et al: Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway. EMBO J 2010; 29: 981-991.
-
(2010)
EMBO J
, vol.29
, pp. 981-991
-
-
Zuin, A.1
-
259
-
-
0037130175
-
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
-
Lin SJ, et al: Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 2002; 418: 344-348.
-
(2002)
Nature
, vol.418
, pp. 344-348
-
-
Lin, S.J.1
-
260
-
-
59049086591
-
The overexpression of major antioxidant enzymes does not extend the lifespan of mice
-
Perez VI, et al: The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell 2009; 8: 73-75.
-
(2009)
Aging Cell
, vol.8
, pp. 73-75
-
-
Perez, V.I.1
-
261
-
-
29144486726
-
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice
-
Tyynismaa H, et al: Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice. Proc Natl Acad Sci USA 2005; 102: 17687-17692.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17687-17692
-
-
Tyynismaa, H.1
-
262
-
-
84868007565
-
Physiological roles of mitochondrial reactive oxygen species
-
Sena LA, Chandel NS: Physiological roles of mitochondrial reactive oxygen species. Mol Cell 2012; 48: 158-167.
-
(2012)
Mol Cell
, vol.48
, pp. 158-167
-
-
Sena, L.A.1
Chandel, N.S.2
-
263
-
-
80053124673
-
Taking a 'good' look at free radicals in the aging process
-
Hekimi S, Lapointe J, Wen Y: Taking a 'good' look at free radicals in the aging process. Trends Cell Biol 2011; 21: 569-576.
-
(2011)
Trends Cell Biol
, vol.21
, pp. 569-576
-
-
Hekimi, S.1
Lapointe, J.2
Wen, Y.3
-
264
-
-
0031030678
-
Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1
-
Ewbank JJ, et al: Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. Science 1997; 275: 980-983.
-
(1997)
Science
, vol.275
, pp. 980-983
-
-
Ewbank, J.J.1
-
265
-
-
66149135335
-
Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice
-
Lapointe J, et al: Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice. J Biol Chem 2009; 284: 20364-20374.
-
(2009)
J Biol Chem
, vol.284
, pp. 20364-20374
-
-
Lapointe, J.1
-
266
-
-
78650455712
-
A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans
-
Yang W, Hekimi S: A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans . PLoS Biol 2010; 8:e1000556.
-
(2010)
PLoS Biol
, vol.8
-
-
Yang, W.1
Hekimi, S.2
|