메뉴 건너뛰기




Volumn 6, Issue 19, 2007, Pages 2371-2376

Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging

Author keywords

Aging; Genomic instability; Genomic maintenance; Hematopoietic; Quiescent

Indexed keywords

ACUTE STRESS; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; CELL COUNT; CELL CYCLE; CELL DAMAGE; CELL PROTECTION; CELL STRESS; CONTROLLED STUDY; DEPLETION; DNA DAMAGE; DNA REPAIR; GENOME; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; MOUSE; NONHUMAN; REVIEW; STEADY STATE; TISSUE REGENERATION;

EID: 35848943667     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.6.19.4759     Document Type: Review
Times cited : (140)

References (59)
  • 1
    • 0032980506 scopus 로고    scopus 로고
    • In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells
    • Cheshier SH, Morrison SJ, Liao X, Weissman IL. In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proc Natl Acad Sci USA 1999; 96:3120-5.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3120-3125
    • Cheshier, S.H.1    Morrison, S.J.2    Liao, X.3    Weissman, I.L.4
  • 2
    • 0030914867 scopus 로고    scopus 로고
    • Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment
    • Bradford GB, Williams B, Rossi R, Bertoncello I. Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment. Exp Hematol 1997; 25:445-53.
    • (1997) Exp Hematol , vol.25 , pp. 445-453
    • Bradford, G.B.1    Williams, B.2    Rossi, R.3    Bertoncello, I.4
  • 3
    • 28544436371 scopus 로고    scopus 로고
    • Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
    • Passegue E, Wagers AJ, Giuriato S, Anderson WC, Weissman IL. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med 2005; 202:1599-611.
    • (2005) J Exp Med , vol.202 , pp. 1599-1611
    • Passegue, E.1    Wagers, A.J.2    Giuriato, S.3    Anderson, W.C.4    Weissman, I.L.5
  • 4
    • 0029796633 scopus 로고    scopus 로고
    • Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell
    • Osawa M, Hanada K, Hamada H, Nakauchi H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 1996; 273:242-5.
    • (1996) Science , vol.273 , pp. 242-245
    • Osawa, M.1    Hanada, K.2    Hamada, H.3    Nakauchi, H.4
  • 5
    • 0023922373 scopus 로고
    • Purification and characterization of mouse hematopoietic stem cells
    • Spangrude GJ, Heimfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science 1988; 241:58-62.
    • (1988) Science , vol.241 , pp. 58-62
    • Spangrude, G.J.1    Heimfeld, S.2    Weissman, I.L.3
  • 6
    • 21244463426 scopus 로고    scopus 로고
    • SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    • Kiel MJ, Yilmaz OH, Iwashita T, Terhorst C, Morrison SJ. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 2005; 121:1109-21.
    • (2005) Cell , vol.121 , pp. 1109-1121
    • Kiel, M.J.1    Yilmaz, O.H.2    Iwashita, T.3    Terhorst, C.4    Morrison, S.J.5
  • 9
    • 33746617272 scopus 로고    scopus 로고
    • Hematopoietic stem cells: The paradigmatic tissue-specific stem cell
    • Bryder D, Rossi DJ, Weissman IL. Hematopoietic stem cells: The paradigmatic tissue-specific stem cell. Am J Pathol 2006; 169:338-46.
    • (2006) Am J Pathol , vol.169 , pp. 338-346
    • Bryder, D.1    Rossi, D.J.2    Weissman, I.L.3
  • 11
    • 0034613690 scopus 로고    scopus 로고
    • Age-associated characteristics of murine hematopoietic stem cells
    • Sudo K, Ema H, Morita Y, Nakauchi H. Age-associated characteristics of murine hematopoietic stem cells. J Exp Med 2000; 192:1273-80.
    • (2000) J Exp Med , vol.192 , pp. 1273-1280
    • Sudo, K.1    Ema, H.2    Morita, Y.3    Nakauchi, H.4
  • 12
    • 0038806560 scopus 로고    scopus 로고
    • Major age-related changes of mouse hematopoietic stem/progenitor cells
    • Kim M, Moon HB, Spangrude GJ. Major age-related changes of mouse hematopoietic stem/progenitor cells. Ann NY Acad Sci 2003; 996:195-208.
    • (2003) Ann NY Acad Sci , vol.996 , pp. 195-208
    • Kim, M.1    Moon, H.B.2    Spangrude, G.J.3
  • 13
    • 35848952347 scopus 로고    scopus 로고
    • Age dependent increase in SP distribution within Hematopoiesis: Implications for our understanding of the mechanism of aging
    • Pearce DJ, Anjos-Afonso F, Ridler CM, Eddaoudi A, Bonnet D. Age dependent increase in SP distribution within Hematopoiesis: Implications for our understanding of the mechanism of aging. Stem Cells 2006.
    • (2006) Stem Cells
    • Pearce, D.J.1    Anjos-Afonso, F.2    Ridler, C.M.3    Eddaoudi, A.4    Bonnet, D.5
  • 14
    • 0033562357 scopus 로고    scopus 로고
    • Dynamic changes in mouse hematopoietic stem cell numbers during aging
    • de Haan G, Van Zant G. Dynamic changes in mouse hematopoietic stem cell numbers during aging. Blood 1999; 93:3294-301.
    • (1999) Blood , vol.93 , pp. 3294-3301
    • de Haan, G.1    Van Zant, G.2
  • 15
    • 23744439044 scopus 로고    scopus 로고
    • Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells
    • Liang Y, Van Zant G, Szilvassy SJ. Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood 2005; 106:1479-87.
    • (2005) Blood , vol.106 , pp. 1479-1487
    • Liang, Y.1    Van Zant, G.2    Szilvassy, S.J.3
  • 16
    • 0017782437 scopus 로고
    • Evolution of ageing
    • Kirkwood TB. Evolution of ageing. Nature 1977; 270:301-4.
    • (1977) Nature , vol.270 , pp. 301-304
    • Kirkwood, T.B.1
  • 17
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • Kirkwood TB. Understanding the odd science of aging. Cell 2005; 120:437-47.
    • (2005) Cell , vol.120 , pp. 437-447
    • Kirkwood, T.B.1
  • 19
  • 21
    • 0041440074 scopus 로고    scopus 로고
    • Repopulating defect of mismatch repair-deficient hematopoietic stem cells
    • Reese JS, Liu L, Gerson SL. Repopulating defect of mismatch repair-deficient hematopoietic stem cells. Blood 2003; 102:1626-33.
    • (2003) Blood , vol.102 , pp. 1626-1633
    • Reese, J.S.1    Liu, L.2    Gerson, S.L.3
  • 23
    • 0032742894 scopus 로고    scopus 로고
    • Hematopoietic compartment of Fanconi anemia group C null mice contains fewer lineage-negative CD34+ primitive hematopoietic cells and shows reduced reconstruction ability
    • Carreau M, Gan OI, Liu L, Doedens M, Dick JE, Buchwald M. Hematopoietic compartment of Fanconi anemia group C null mice contains fewer lineage-negative CD34+ primitive hematopoietic cells and shows reduced reconstruction ability. Exp Hematol 1999; 27:1667-74.
    • (1999) Exp Hematol , vol.27 , pp. 1667-1674
    • Carreau, M.1    Gan, O.I.2    Liu, L.3    Doedens, M.4    Dick, J.E.5    Buchwald, M.6
  • 25
    • 0037480961 scopus 로고    scopus 로고
    • Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
    • Allsopp RC, Morin GB, DePinho R, Harley CB, Weissman IL. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood 2003; 102:517-20.
    • (2003) Blood , vol.102 , pp. 517-520
    • Allsopp, R.C.1    Morin, G.B.2    DePinho, R.3    Harley, C.B.4    Weissman, I.L.5
  • 28
    • 0345636016 scopus 로고    scopus 로고
    • Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells
    • Allsopp RC, Morin GB, Horner JW, DePinho R, Harley CB, Weissman IL. Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells. Nat Med 2003; 9:369-71.
    • (2003) Nat Med , vol.9 , pp. 369-371
    • Allsopp, R.C.1    Morin, G.B.2    Horner, J.W.3    DePinho, R.4    Harley, C.B.5    Weissman, I.L.6
  • 31
    • 33749452454 scopus 로고    scopus 로고
    • Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect
    • Bowie MB, McKnight KD, Kent DG, McCaffrey L, Hoodless PA, Eaves CJ. Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect. J Clin Invest 2006; 116:2808-16.
    • (2006) J Clin Invest , vol.116 , pp. 2808-2816
    • Bowie, M.B.1    McKnight, K.D.2    Kent, D.G.3    McCaffrey, L.4    Hoodless, P.A.5    Eaves, C.J.6
  • 32
    • 33745322046 scopus 로고    scopus 로고
    • Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property
    • Nygren JM, Bryder D, Jacobsen SE. Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property. J Immunol 2006; 177:201-8.
    • (2006) J Immunol , vol.177 , pp. 201-208
    • Nygren, J.M.1    Bryder, D.2    Jacobsen, S.E.3
  • 34
    • 0031471226 scopus 로고    scopus 로고
    • Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival, and development
    • Nussenzweig A, Sokol K, Burgman P, Li L, Li GC. Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival, and development. Proc Natl Acad Sci USA 1997; 94:13588-93.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13588-13593
    • Nussenzweig, A.1    Sokol, K.2    Burgman, P.3    Li, L.4    Li, G.C.5
  • 40
    • 34250007142 scopus 로고    scopus 로고
    • Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
    • Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007; 447:725-9.
    • (2007) Nature , vol.447 , pp. 725-729
    • Rossi, D.J.1    Bryder, D.2    Seita, J.3    Nussenzweig, A.4    Hoeijmakers, J.5    Weissman, I.L.6
  • 42
    • 0034624828 scopus 로고    scopus 로고
    • A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    • Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 2000; 404:193-7.
    • (2000) Nature , vol.404 , pp. 193-197
    • Akashi, K.1    Traver, D.2    Miyamoto, T.3    Weissman, I.L.4
  • 46
    • 33646948760 scopus 로고    scopus 로고
    • Advances in understanding the genetic basis for bone-marrow failure
    • Lieberman L, Dror Y. Advances in understanding the genetic basis for bone-marrow failure. Curr Opin Pediatr 2006; 18:15-21.
    • (2006) Curr Opin Pediatr , vol.18 , pp. 15-21
    • Lieberman, L.1    Dror, Y.2
  • 48
    • 29144450333 scopus 로고    scopus 로고
    • The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: Implications for the Mre11 complex as a DNA damage sensor
    • Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH. The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: Implications for the Mre11 complex as a DNA damage sensor. Genes Dev 2005; 19:3043-54.
    • (2005) Genes Dev , vol.19 , pp. 3043-3054
    • Morales, M.1    Theunissen, J.W.2    Kim, C.F.3    Kitagawa, R.4    Kastan, M.B.5    Petrini, J.H.6
  • 50
    • 0016692602 scopus 로고
    • Mutation selection and the natural history of cancer
    • Cairns J. Mutation selection and the natural history of cancer. Nature 1975; 255:197-200.
    • (1975) Nature , vol.255 , pp. 197-200
    • Cairns, J.1
  • 51
    • 0036591968 scopus 로고    scopus 로고
    • Intestinal stem cells protect their genome by selective segregation of template DNA strands
    • Potten CS, Owen G, Booth D. Intestinal stem cells protect their genome by selective segregation of template DNA strands. J Cell Sci 2002; 115:2381-8.
    • (2002) J Cell Sci , vol.115 , pp. 2381-2388
    • Potten, C.S.1    Owen, G.2    Booth, D.3
  • 52
    • 24144490682 scopus 로고    scopus 로고
    • Support for the immortal strand hypothesis: Neural stem cells partition DNA asymmetrically in vitro
    • Karpowicz P, Morshead C, Kam A, Jervis E, Ramunas J, Cheng V, van der Kooy D. Support for the immortal strand hypothesis: Neural stem cells partition DNA asymmetrically in vitro. J Cell Biol 2005; 170:721-32.
    • (2005) J Cell Biol , vol.170 , pp. 721-732
    • Karpowicz, P.1    Morshead, C.2    Kam, A.3    Jervis, E.4    Ramunas, J.5    Cheng, V.6    van der Kooy, D.7
  • 53
    • 33745762804 scopus 로고    scopus 로고
    • Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells
    • Shinin V, Gayraud-Morel B, Gomes D, Tajbakhsh S. Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells. Nat Cell Biol 2006; 8:677-87.
    • (2006) Nat Cell Biol , vol.8 , pp. 677-687
    • Shinin, V.1    Gayraud-Morel, B.2    Gomes, D.3    Tajbakhsh, S.4
  • 54
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou BB, Elledge SJ. The DNA damage response: Putting checkpoints in perspective. Nature 2000; 408:433-9.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 56
    • 0032694069 scopus 로고    scopus 로고
    • Comparison of hematopoietic activities of human bone marrow and umbilical cord blood CD34 positive and negative cells
    • Kim DK, Fujiki Y, Fukushima T, Ema H, Shibuya A, Nakauchi H. Comparison of hematopoietic activities of human bone marrow and umbilical cord blood CD34 positive and negative cells. Stem Cells 1999; 17:286-94.
    • (1999) Stem Cells , vol.17 , pp. 286-294
    • Kim, D.K.1    Fujiki, Y.2    Fukushima, T.3    Ema, H.4    Shibuya, A.5    Nakauchi, H.6
  • 57
  • 58
    • 0035871894 scopus 로고    scopus 로고
    • Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle
    • Wright DE, Cheshier SH, Wagers AJ, Randall TD, Christensen JL, Weissman IL. Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle. Blood 2001; 97:2278-85.
    • (2001) Blood , vol.97 , pp. 2278-2285
    • Wright, D.E.1    Cheshier, S.H.2    Wagers, A.J.3    Randall, T.D.4    Christensen, J.L.5    Weissman, I.L.6
  • 59
    • 31344461821 scopus 로고    scopus 로고
    • Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning
    • Bhattacharya D, Rossi DJ, Bryder D, Weissman IL. Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning. J Exp Med 2006; 203:73-85.
    • (2006) J Exp Med , vol.203 , pp. 73-85
    • Bhattacharya, D.1    Rossi, D.J.2    Bryder, D.3    Weissman, I.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.