Evolutionary conservation of the clk-1-dependent mechanism of longevity: Loss of mclk1 increases cellular fitness and lifespan in mice

Genes and Development

Volumn 19, Issue 20, 2005, Pages 2424-2434

  Liu, Xingxing ^a   Jiang, Ning ^a   Hughes, Bryan ^a   Bigras, Eve ^a   Shoubridge, Eric ^b   Hekimi, Siegfried ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Aging; clk 1; Loss of heterozygosity; mclk1; Reactive oxygen species; Ubiquinone

Indexed keywords

DNA; GENE PRODUCT; INSULIN; PROTEIN CLK1; UBIQUINONE; UNCLASSIFIED DRUG;

ANATOMY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CAENORHABDITIS ELEGANS; CELL DAMAGE; CELL FUNCTION; CELL PROTECTION; CLONE; EMBRYONIC STEM CELL; FERTILITY; GENE EXPRESSION; GENE INACTIVATION; GENE LOSS; GENETIC CONSERVATION; GROWTH; HOMOZYGOSITY; LIFESPAN; LIVER; LIVER CELL; LONGEVITY; MAMMAL; MOLECULAR MECHANICS; MOUSE; NEMATODE; NONHUMAN; OXIDATIVE STRESS; PHYSIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRESS;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CROSSES, GENETIC; DNA DAMAGE; EMBRYO; EVOLUTION, MOLECULAR; HEPATOCYTES; LONGEVITY; LOSS OF HETEROZYGOSITY; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; STEM CELLS; UBIQUINONE;

CAENORHABDITIS ELEGANS; MAMMALIA; NEMATODA;

EID: 26944501617     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1352905     Document Type: Article

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