-
1
-
-
0019305531
-
Dr. Carrel's immortal cells
-
Witkowski,J.A. (1980) Dr. Carrel's immortal cells. Med. History, 24, 129-142.
-
(1980)
Med. History
, vol.24
, pp. 129-142
-
-
Witkowski, J.A.1
-
2
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick,L. and Moorhead,P.S. (1961) The serial cultivation of human diploid cell strains. Exp. Cell Res., 25, 585-621.
-
(1961)
Exp. Cell Res
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
3
-
-
0004114076
-
-
Cambridge University Press, Cambridge
-
Holliday,R. (1995) Understanding Ageing Cambridge University Press, Cambridge.
-
(1995)
Understanding Ageing
-
-
Holliday, R.1
-
4
-
-
0015184804
-
Principle of marginotomy in template synthesis of polynucleotides]
-
Olovnikov,A.M. (1971) [Principle of marginotomy in template synthesis of polynucleotides]. Dokl Akad Nauk SSSR, 201, 1496-1499.
-
(1971)
Dokl Akad Nauk SSSR
, vol.201
, pp. 1496-1499
-
-
Olovnikov, A.M.1
-
5
-
-
0015515155
-
Origin of concatemeric T7 DNA
-
Watson,J.D. (1972) Origin of concatemeric T7 DNA. Nat. New Biol., 239, 197-201.
-
(1972)
Nat. New Biol
, vol.239
, pp. 197-201
-
-
Watson, J.D.1
-
6
-
-
0030177489
-
Telomeres, telomerase, and aging: Origin of the theory
-
Olovnikov,A.M. (1996) Telomeres, telomerase, and aging: Origin of the theory. Exp. Gerontol., 31, 443-448.
-
(1996)
Exp. Gerontol
, vol.31
, pp. 443-448
-
-
Olovnikov, A.M.1
-
7
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley,C.B., Futcher,A.B. and Greider,C.W. (1990) Telomeres shorten during ageing of human fibroblasts. Nature, 345, 458-460.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
8
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar,A.G., Ouellette,M., Frolkis,M., Holt,S.E., Chiu,C.P., Morin,G.B., Harley,C.B., Shay,J.W., Lichtsteiner,S. et al. (1998) Extension of life-span by introduction of telomerase into normal human cells. Science, 279, 349-352.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
Morin, G.B.6
Harley, C.B.7
Shay, J.W.8
Lichtsteiner, S.9
-
9
-
-
0033834612
-
The illusion of cell immortality
-
Hayflick,L. (2000) The illusion of cell immortality. Br. J. Cancer 83, 841-846.
-
(2000)
Br. J. Cancer
, vol.83
, pp. 841-846
-
-
Hayflick, L.1
-
10
-
-
13944262937
-
Understanding the odd science of aging
-
Kirkwood,T.B.L. (2005) Understanding the odd science of aging. Cell 120, 437-447.
-
(2005)
Cell
, vol.120
, pp. 437-447
-
-
Kirkwood, T.B.L.1
-
11
-
-
0018890645
-
Intraclonal variation in proliferative potential of human diploid fibroblasts: Stochastic mechanism for cellular aging
-
Smith,J.R. and Whitney,R.G. (1980) Intraclonal variation in proliferative potential of human diploid fibroblasts: Stochastic mechanism for cellular aging. Science, 207, 82-84.
-
(1980)
Science
, vol.207
, pp. 82-84
-
-
Smith, J.R.1
Whitney, R.G.2
-
12
-
-
0037313185
-
Extensive allelic variation and ultrashort telomeres in senescent human cells
-
Baird,D.M., Rowson,J., Wynford-Thomas,D. and Kipling,D. (2003) Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat. Genet., 33, 203-207.
-
(2003)
Nat. Genet
, vol.33
, pp. 203-207
-
-
Baird, D.M.1
Rowson, J.2
Wynford-Thomas, D.3
Kipling, D.4
-
13
-
-
0029939848
-
Heterogeneity in telomere length of human chromosomes
-
Lansdorp,P.M., Verwoerd,N.P., van de Rijke,F.M., Dragowska,V., Little,M.T., Dirks,R.W., Raap,A.K. and Tanke,H.J. (1996) Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet., 5 685-691.
-
(1996)
Hum. Mol. Genet
, vol.5
, pp. 685-691
-
-
Lansdorp, P.M.1
Verwoerd, N.P.2
van de Rijke, F.M.3
Dragowska, V.4
Little, M.T.5
Dirks, R.W.6
Raap, A.K.7
Tanke, H.J.8
-
14
-
-
3342972121
-
Does a sentinel or a subset of short telomeres determine replicative senescence?
-
Zou,Y., Sfeir,A., Gryaznov,S.M., Shay,J.W. and Wright,W.E. (2004) Does a sentinel or a subset of short telomeres determine replicative senescence? Mol. Biol. Cell, 15, 3709-3718.
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 3709-3718
-
-
Zou, Y.1
Sfeir, A.2
Gryaznov, S.M.3
Shay, J.W.4
Wright, W.E.5
-
15
-
-
0028295472
-
The expression of proliferation-dependent antigens during the lifespan of normal and progeroid human fibroblasts in culture
-
Kill,I.R., Faragher,R.G., Lawrence,K. and Shall,S. (1994) The expression of proliferation-dependent antigens during the lifespan of normal and progeroid human fibroblasts in culture. J. Cell Sci., 107, 571-579.
-
(1994)
J. Cell Sci
, vol.107
, pp. 571-579
-
-
Kill, I.R.1
Faragher, R.G.2
Lawrence, K.3
Shall, S.4
-
16
-
-
0031563829
-
Different kinetics of senescence in human fibroblasts and peritoneal mesothelial cells
-
Thomas,E., Al-Baker,E., Dropcova,S., Denyer,S., Ostad,N., Lloyd,A., Kill,I.R. and Faragher,R.G.A. (1997) Different kinetics of senescence in human fibroblasts and peritoneal mesothelial cells. Exp. Cell Res. 236, 355-358.
-
(1997)
Exp. Cell Res
, vol.236
, pp. 355-358
-
-
Thomas, E.1
Al-Baker, E.2
Dropcova, S.3
Denyer, S.4
Ostad, N.5
Lloyd, A.6
Kill, I.R.7
Faragher, R.G.A.8
-
17
-
-
0028261160
-
Escape from senescence in human diploid fibroblasts induced directly by mutant p53
-
Bond,J.A., Wyllie,F.S. and Wynford-Thomas,D. (1994) Escape from senescence in human diploid fibroblasts induced directly by mutant p53. Oncogene, 9, 1885-1889.
-
(1994)
Oncogene
, vol.9
, pp. 1885-1889
-
-
Bond, J.A.1
Wyllie, F.S.2
Wynford-Thomas, D.3
-
18
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
Fagagna,F.d.A.d., Reaper,P.M., Clay-Farrace,L., Fiegler,H., Carr,P., von Zglinicki,T., Saretzki,G., Carter,N.P. and Jackson,S.P. (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426, 194-198.
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
Fagagna, F.D.A.D.1
Reaper, P.M.2
Clay-Farrace, L.3
Fiegler, H.4
Carr, P.5
von Zglinicki, T.6
Saretzki, G.7
Carter, N.P.8
Jackson, S.P.9
-
19
-
-
2342435511
-
Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative fife span
-
Martin-Ruiz,C., Saretzki,G., Petrie,J., Ladhoff,J., Jeyapalan,J., Wei,W., Sedivy,J. and von Zglinicki,T. (2004) Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative fife span. J. Biol. Chem., 279, 17826-17833.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 17826-17833
-
-
Martin-Ruiz, C.1
Saretzki, G.2
Petrie, J.3
Ladhoff, J.4
Jeyapalan, J.5
Wei, W.6
Sedivy, J.7
von Zglinicki, T.8
-
20
-
-
34249028642
-
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
-
Passos,J.F., Saretzki,G., Ahmed,S., Nelson,G., Richter,T., Peters,H., Wappler,I., Birkett,M., Harold,G. et al. (2007) Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol., 5, e110.
-
(2007)
PLoS Biol
, vol.5
-
-
Passos, J.F.1
Saretzki, G.2
Ahmed, S.3
Nelson, G.4
Richter, T.5
Peters, H.6
Wappler, I.7
Birkett, M.8
Harold, G.9
-
21
-
-
0037335554
-
Telomere-driven replicative senescence is a stress response
-
von Zglinicki,T., Petrie,J. and Kirkwood,T.B. (2003) Telomere-driven replicative senescence is a stress response. Nat. Biotechnol., 21, 229-230.
-
(2003)
Nat. Biotechnol
, vol.21
, pp. 229-230
-
-
von Zglinicki, T.1
Petrie, J.2
Kirkwood, T.B.3
-
22
-
-
33846652598
-
-
de Lange,T, Lundblad,V. and Blackburn,E. H, eds, Cold Spring Harbour Laboratory Press, New York, pp
-
de Lange,T. (2006) In de Lange,T., Lundblad,V. and Blackburn,E. H. (eds), Telomeres, Cold Spring Harbour Laboratory Press, New York, pp. 387-431.
-
(2006)
Telomeres
, pp. 387-431
-
-
de Lange, T.1
-
23
-
-
0031000884
-
Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
-
Makarov,V.L., Hirose,Y. and Langmore,J.P. (1997) Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell, 88, 657-666.
-
(1997)
Cell
, vol.88
, pp. 657-666
-
-
Makarov, V.L.1
Hirose, Y.2
Langmore, J.P.3
-
24
-
-
0036682516
-
EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants
-
Maringele,L. and Lydall,D. (2002) EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants. Genes Dev., 16 1919-1933.
-
(2002)
Genes Dev
, vol.16
, pp. 1919-1933
-
-
Maringele, L.1
Lydall, D.2
-
25
-
-
15944368044
-
Telomere-end processing: The terminal nucleotidesof human chromosomes
-
Sfeir,A.J., Chai,W., Shay,J.W. and Wright,W.E. (2005) Telomere-end processing: The terminal nucleotidesof human chromosomes. Mol. Cell 18, 131-138.
-
(2005)
Mol. Cell
, vol.18
, pp. 131-138
-
-
Sfeir, A.J.1
Chai, W.2
Shay, J.W.3
Wright, W.E.4
-
26
-
-
5144219712
-
Exol and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants
-
Zubko,M.K., Guillard,S. and Lydall,D. (2004) Exol and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants. Genetics, 168, 103-115.
-
(2004)
Genetics
, vol.168
, pp. 103-115
-
-
Zubko, M.K.1
Guillard, S.2
Lydall, D.3
-
27
-
-
10944250780
-
Telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3′-overhang
-
Keys,B., Serra,V., Saretzki,G. and von Zglinicki,T. (2004) Telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3′-overhang. Aging Cell, 3, 103-109.
-
(2004)
Aging Cell
, vol.3
, pp. 103-109
-
-
Keys, B.1
Serra, V.2
Saretzki, G.3
von Zglinicki, T.4
-
28
-
-
0036629255
-
Oxidative stress shortens telomeres
-
von Zglinicki,T. (2002) Oxidative stress shortens telomeres. Trends Biochem. Sci., 27, 339-344.
-
(2002)
Trends Biochem. Sci
, vol.27
, pp. 339-344
-
-
von Zglinicki, T.1
-
29
-
-
0017405185
-
Low oxygen concentration extends the lifespan of cultured human diploid cells
-
Packer,L. and Fuehr,K. (1977) Low oxygen concentration extends the lifespan of cultured human diploid cells. Nature, 267, 423-425.
-
(1977)
Nature
, vol.267
, pp. 423-425
-
-
Packer, L.1
Fuehr, K.2
-
30
-
-
0042195820
-
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
-
Parrinello,S., Samper,E., Krtolica,A., Goldstein,J., Melov,S. and Campisi,J. (2003) Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat. Cell. Biol., 5, 741-747.
-
(2003)
Nat. Cell. Biol
, vol.5
, pp. 741-747
-
-
Parrinello, S.1
Samper, E.2
Krtolica, A.3
Goldstein, J.4
Melov, S.5
Campisi, J.6
-
31
-
-
1642602686
-
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable doublestrand breaks
-
Sedelnikova,O.A., Horikawa,J., Zimonjic,D.B., Popescu,N.C., Bonner,W.M. and Barrett,J.C. (2004) Senescing human cells and ageing mice accumulate DNA lesions with unrepairable doublestrand breaks. Nat. Cell. Biol. 6, 168-170.
-
(2004)
Nat. Cell. Biol
, vol.6
, pp. 168-170
-
-
Sedelnikova, O.A.1
Horikawa, J.2
Zimonjic, D.B.3
Popescu, N.C.4
Bonner, W.M.5
Barrett, J.C.6
-
32
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh,Y. (2003) ATM and related protein kinases: Safeguarding genome integrity. Nat. Rev. Cancer, 3, 155-168.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
33
-
-
0033963144
-
Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast
-
Dumont,P., Burton,M., Chen,Q.M., Gonos,E.S., Frippiat,C., Mazarati,J.-B., Eliaers,F., Remacle,J. and Toussaint,O. (2000) Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast. Free Rad. Biol. Med., 28, 361-373.
-
(2000)
Free Rad. Biol. Med
, vol.28
, pp. 361-373
-
-
Dumont, P.1
Burton, M.2
Chen, Q.M.3
Gonos, E.S.4
Frippiat, C.5
Mazarati, J.-B.6
Eliaers, F.7
Remacle, J.8
Toussaint, O.9
-
34
-
-
0033789360
-
Spontaneous and radiation-induced differentiation of fibroblasts
-
Herskind,C. and Rodemann,H.P. (2000) Spontaneous and radiation-induced differentiation of fibroblasts. Exp. Gerontol., 35, 747-755.
-
(2000)
Exp. Gerontol
, vol.35
, pp. 747-755
-
-
Herskind, C.1
Rodemann, H.P.2
-
35
-
-
0032485213
-
Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
-
Robles,S. and Adami,G. (1998) Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene, 16, 1113-1123.
-
(1998)
Oncogene
, vol.16
, pp. 1113-1123
-
-
Robles, S.1
Adami, G.2
-
36
-
-
0034437351
-
Molecular manifestations and molecular determinants of telomere capping
-
Blackburn,E.H., Chan,S., Chang,J., Fulton,T.B., Krauskopf,A., McEachern,M., Prescott,J., Roy,J., Smith,C. et al. (2000) Molecular manifestations and molecular determinants of telomere capping. Cold Spring Harb Symp Quant Biol., 65, 253-263.
-
(2000)
Cold Spring Harb Symp Quant Biol
, vol.65
, pp. 253-263
-
-
Blackburn, E.H.1
Chan, S.2
Chang, J.3
Fulton, T.B.4
Krauskopf, A.5
McEachern, M.6
Prescott, J.7
Roy, J.8
Smith, C.9
-
37
-
-
24944460598
-
Shelterin: The protein complex that shapes and safeguards human telomeres
-
de Lange,T. (2005) Shelterin: The protein complex that shapes and safeguards human telomeres. Genes Dev., 19, 2100-2110.
-
(2005)
Genes Dev
, vol.19
, pp. 2100-2110
-
-
de Lange, T.1
-
38
-
-
0033553536
-
Mammalian telomeres end in a large duplex loop
-
Griffith,J.D., Comeau,L., Rosenfield,S., Stansel,R.M., Bianchi,A., Moss,H. and de Lange,T. (1999) Mammalian telomeres end in a large duplex loop. Cell, 97, 503-514.
-
(1999)
Cell
, vol.97
, pp. 503-514
-
-
Griffith, J.D.1
Comeau, L.2
Rosenfield, S.3
Stansel, R.M.4
Bianchi, A.5
Moss, H.6
de Lange, T.7
-
39
-
-
0042420304
-
DNA damage foci at dysfunctional telomeres
-
Takai,H., Smogorzewska,A. and de Lange,T. (2003) DNA damage foci at dysfunctional telomeres. Curr. Biol., 13, 1549-1556.
-
(2003)
Curr. Biol
, vol.13
, pp. 1549-1556
-
-
Takai, H.1
Smogorzewska, A.2
de Lange, T.3
-
40
-
-
0035901505
-
Site-specific DNA damage at the GGG sequence by UVA involves acceleration of telomere shortening
-
Oikawa,S., Tada-Oikawa,S. and Kawanishi,S. (2001) Site-specific DNA damage at the GGG sequence by UVA involves acceleration of telomere shortening. Biochemistry, 40, 4763-4768.
-
(2001)
Biochemistry
, vol.40
, pp. 4763-4768
-
-
Oikawa, S.1
Tada-Oikawa, S.2
Kawanishi, S.3
-
41
-
-
0000726641
-
2+ -mediated fenton reactions has possible biological implications
-
2+ -mediated fenton reactions has possible biological implications. J. Biol. Chem., 274, 962-971.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 962-971
-
-
Henle, E.1
Han, Z.2
Tang, N.3
Rai, P.4
Luo, Y.5
Linn, S.6
-
42
-
-
0031821009
-
Preferential accumulation of single-stranded regions in telomeres of human fibroblasts
-
Petersen,S., Saretzki,G. and von Zglinicki,T. (1998) Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Exp. Cell Res., 239, 152-160.
-
(1998)
Exp. Cell Res
, vol.239
, pp. 152-160
-
-
Petersen, S.1
Saretzki, G.2
von Zglinicki, T.3
-
43
-
-
0028909019
-
DNA damage and repair in telomeres: Relation to aging
-
Kruk,P.A., Rampino,N.J. and Bohr,V.A. (1995) DNA damage and repair in telomeres: Relation to aging. PNAS, 92, 258-262.
-
(1995)
PNAS
, vol.92
, pp. 258-262
-
-
Kruk, P.A.1
Rampino, N.J.2
Bohr, V.A.3
-
44
-
-
0037192462
-
Senescence induced by altered telomere state, not telomere loss
-
Karlseder,J., Smogorzewska,A. and de Lange,T. (2002) Senescence induced by altered telomere state, not telomere loss. Science, 295, 2446-2449.
-
(2002)
Science
, vol.295
, pp. 2446-2449
-
-
Karlseder, J.1
Smogorzewska, A.2
de Lange, T.3
-
45
-
-
34247122749
-
TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts
-
Richter,T., Saretzki,G., Nelson,G., Melcher,M., Olijslagers,S. and von Zglinicki,T. (2007) TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts. Mech. Ageing Dev., 128, 340-345.
-
(2007)
Mech. Ageing Dev
, vol.128
, pp. 340-345
-
-
Richter, T.1
Saretzki, G.2
Nelson, G.3
Melcher, M.4
Olijslagers, S.5
von Zglinicki, T.6
-
46
-
-
2942569579
-
Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats
-
Ohki,R. and Ishikawa,F. (2004) Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats. Nucleic Acids Res., 32 1627-1637.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 1627-1637
-
-
Ohki, R.1
Ishikawa, F.2
-
47
-
-
19344374569
-
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response
-
Karlseder,J., Hoke,K., Mirzoeva,O.K., Bakkenist,C., Kastan,M.B., Petrini,J.H.J. and Lange,T.D. (2004) The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol., 2, e240.
-
(2004)
PLoS Biol
, vol.2
-
-
Karlseder, J.1
Hoke, K.2
Mirzoeva, O.K.3
Bakkenist, C.4
Kastan, M.B.5
Petrini, J.H.J.6
Lange, T.D.7
-
48
-
-
2542600695
-
DNA polymerase {beta} interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line
-
Fotiadou,P., Henegariu,O. and Sweasy,J.B. (2004) DNA polymerase {beta} interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line. Cancer Res., 64, 3830-3837.
-
(2004)
Cancer Res
, vol.64
, pp. 3830-3837
-
-
Fotiadou, P.1
Henegariu, O.2
Sweasy, J.B.3
-
49
-
-
14844354067
-
Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2
-
Opresko,P.L., Fan,J., Danzy,S., Wilson,D.M.III and Bohr,V.A. (2005) Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Res., 33, 1230-1239.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 1230-1239
-
-
Opresko, P.L.1
Fan, J.2
Danzy, S.3
Wilson III, D.M.4
Bohr, V.A.5
-
50
-
-
0029127226
-
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
-
von Zglinicki,T., Saretzki,G., Docke,W. and Lotze,C. (1995) Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp. Cell Res., 220, 186-193.
-
(1995)
Exp. Cell Res
, vol.220
, pp. 186-193
-
-
von Zglinicki, T.1
Saretzki, G.2
Docke, W.3
Lotze, C.4
-
51
-
-
0032054781
-
Accelerated telomere shortening in fibroblasts after extended periods of confluency
-
Sitte,N., Saretzki,G. and von Zglinicki,T. (1998) Accelerated telomere shortening in fibroblasts after extended periods of confluency. Free Rad. Biol. Med., 24, 885-893.
-
(1998)
Free Rad. Biol. Med
, vol.24
, pp. 885-893
-
-
Sitte, N.1
Saretzki, G.2
von Zglinicki, T.3
-
52
-
-
38049085754
-
-
Evans,M.D. and Cooke,M.S, eds, Landes Bioscience, Austin, TX, pp
-
Richter,T. and von Zglinicki,T. (2006) In Evans,M.D. and Cooke,M.S. (eds), Oxidative DNA Damage and Telomere Shortening, Landes Bioscience, Austin, TX, pp. 100-108.
-
(2006)
Oxidative DNA Damage and Telomere Shortening
, pp. 100-108
-
-
Richter, T.1
von Zglinicki, T.2
-
53
-
-
20444371017
-
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
-
Masutomi,K., Possemato,R., Wong,J.M.Y., Currier,J.L., Tothova,Z., Manola,J.B., Ganesan,S., Lansdorp,P.M., Collins,K. et al. (2005) The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. PNAS, 102, 8222-8227.
-
(2005)
PNAS
, vol.102
, pp. 8222-8227
-
-
Masutomi, K.1
Possemato, R.2
Wong, J.M.Y.3
Currier, J.L.4
Tothova, Z.5
Manola, J.B.6
Ganesan, S.7
Lansdorp, P.M.8
Collins, K.9
-
54
-
-
0032493742
-
Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress
-
Furumoto,K., Inoue,E., Nagao,N., Hiyama,E. and Miwa,N. (1998) Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci., 63, 935-948.
-
(1998)
Life Sci
, vol.63
, pp. 935-948
-
-
Furumoto, K.1
Inoue, E.2
Nagao, N.3
Hiyama, E.4
Miwa, N.5
-
55
-
-
1842611977
-
Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells
-
Haendeler,J., Hoffmann,J., Diehl,J.F., Vasa,M., Spyridopoulos,I., Zeiher,A.M. and Dimmeler,S. (2004) Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ. Res., 94, 768-775.
-
(2004)
Circ. Res
, vol.94
, pp. 768-775
-
-
Haendeler, J.1
Hoffmann, J.2
Diehl, J.F.3
Vasa, M.4
Spyridopoulos, I.5
Zeiher, A.M.6
Dimmeler, S.7
-
56
-
-
3042591085
-
Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells
-
Kurz,D.J., Decary,S., Hong,Y., Trivier,E., Akhmedov,A. and Erusalimsky,J.D. (2004) Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J. Cell Sci., 117, 2417-2426.
-
(2004)
J. Cell Sci
, vol.117
, pp. 2417-2426
-
-
Kurz, D.J.1
Decary, S.2
Hong, Y.3
Trivier, E.4
Akhmedov, A.5
Erusalimsky, J.D.6
-
57
-
-
33747625689
-
Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: Effects of telomerase and oxidative stress
-
Matthews,C., Gorenne,I., Scott,S., Figg,N., Kirkpatrick,P., Ritchie,A., Goddard,M. and Bennett,M. (2006) Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: Effects of telomerase and oxidative stress. Circ. Res., 99, 156-164.
-
(2006)
Circ. Res
, vol.99
, pp. 156-164
-
-
Matthews, C.1
Gorenne, I.2
Scott, S.3
Figg, N.4
Kirkpatrick, P.5
Ritchie, A.6
Goddard, M.7
Bennett, M.8
-
58
-
-
33646040063
-
4-Hydroxynonenal inhibits telomerase activity and hTERT expression in human leukemic cell lines
-
Pizzimenti,S., Briatore,F., Laurora,S., Toaldo,C., Maggio,M., De Grandi,M., Meaglia,L., Menegatti,E., Giglioni,B. et al. (2006) 4-Hydroxynonenal inhibits telomerase activity and hTERT expression in human leukemic cell lines. Free Rad. Biol. Med., 40, 1578-1591.
-
(2006)
Free Rad. Biol. Med
, vol.40
, pp. 1578-1591
-
-
Pizzimenti, S.1
Briatore, F.2
Laurora, S.3
Toaldo, C.4
Maggio, M.5
De Grandi, M.6
Meaglia, L.7
Menegatti, E.8
Giglioni, B.9
-
59
-
-
0033954684
-
Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
-
von Zglinicki,T., Pilger,R. and Sitte,N. (2000) Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. Free Rad. Biol. Med., 28, 64-74.
-
(2000)
Free Rad. Biol. Med
, vol.28
, pp. 64-74
-
-
von Zglinicki, T.1
Pilger, R.2
Sitte, N.3
-
60
-
-
0037470062
-
Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening
-
Serra,V., von Zglinicki,T., Lorenz,M. and Saretzki,G. (2003) Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening. J. Biol. Chem., 278 6824-6830.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 6824-6830
-
-
Serra, V.1
von Zglinicki, T.2
Lorenz, M.3
Saretzki, G.4
-
61
-
-
0041419866
-
MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress
-
Saretzki,G., Murphy,M.P. and von Zglinicki,T. (2003) MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress. Aging Cell, 2, 141-143.
-
(2003)
Aging Cell
, vol.2
, pp. 141-143
-
-
Saretzki, G.1
Murphy, M.P.2
von Zglinicki, T.3
-
62
-
-
2142666372
-
Developmental differences in the immortalization of lung fibroblasts by telomerase
-
Forsyth,N.R., Evans,A.P., Shay,J.W. and Wright,W.E. (2003) Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell, 2, 235-243.
-
(2003)
Aging Cell
, vol.2
, pp. 235-243
-
-
Forsyth, N.R.1
Evans, A.P.2
Shay, J.W.3
Wright, W.E.4
-
63
-
-
35448962513
-
A continuous correlation between oxidative stress and telomere shortening in fibroblasts
-
DOI: 10.1016/j.expger.2007.08.005
-
Richter,T. and von Zglinicki,T. (2007) A continuous correlation between oxidative stress and telomere shortening in fibroblasts. Exp. Gerontol., DOI: 10.1016/j.expger.2007.08.005.
-
(2007)
Exp. Gerontol
-
-
Richter, T.1
von Zglinicki, T.2
-
64
-
-
10344229954
-
From the cover: Accelerated telomere shortening in response to life stress
-
Epel,E.S., Blackburn,E.H., Lin,J., Dhabhar,F.S., Adler,N.E., Morrow,J.D. and Cawthon,R.M. (2004) From the cover: Accelerated telomere shortening in response to life stress. PNAS, 101, 17312-17315.
-
(2004)
PNAS
, vol.101
, pp. 17312-17315
-
-
Epel, E.S.1
Blackburn, E.H.2
Lin, J.3
Dhabhar, F.S.4
Adler, N.E.5
Morrow, J.D.6
Cawthon, R.M.7
-
65
-
-
23844517498
-
Obesity, cigarette smoking, and telomere length in women
-
Valdes,A.M., Andrew,T., Gardner,J.P., Kimura,M., Oeisner,E., Cherkas,L.F., Aviv,A. and Spector,T.D. (2005) Obesity, cigarette smoking, and telomere length in women. The Lancet, 366, 662-664.
-
(2005)
The Lancet
, vol.366
, pp. 662-664
-
-
Valdes, A.M.1
Andrew, T.2
Gardner, J.P.3
Kimura, M.4
Oeisner, E.5
Cherkas, L.F.6
Aviv, A.7
Spector, T.D.8
-
66
-
-
18044398540
-
Telomeres as biomarkers for ageing and age-related diseases
-
von Zglinicki,T. and Martin-Ruiz,C.M. (2005) Telomeres as biomarkers for ageing and age-related diseases. Curr. Mol. Med., 5, 197-203.
-
(2005)
Curr. Mol. Med
, vol.5
, pp. 197-203
-
-
von Zglinicki, T.1
Martin-Ruiz, C.M.2
-
67
-
-
33644692330
-
Cellular senescence in aging primates
-
Herbig,U., Ferreira,M., Condel,L., Carey,D. and Sedivy,J.M. (2006) Cellular senescence in aging primates. Science, 311, 1257-1258.
-
(2006)
Science
, vol.311
, pp. 1257-1258
-
-
Herbig, U.1
Ferreira, M.2
Condel, L.3
Carey, D.4
Sedivy, J.M.5
-
68
-
-
33846090789
-
Accumulation of senescent cells in mitotic tissue of aging primates
-
Jeyapalan,J.C., Ferreira,M., Sedivy,J.M. and Herbig,U. (2007) Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev., 128, 36-4.
-
(2007)
Mech. Ageing Dev
, vol.128
, pp. 36-34
-
-
Jeyapalan, J.C.1
Ferreira, M.2
Sedivy, J.M.3
Herbig, U.4
-
69
-
-
0033004248
-
Differences in electron transport potential, antioxidant defenses, and oxidant generation in young and senescent fetal lung fibroblasts (WI-38)
-
Allen,R.G., Tresini,M., Keogh,B.P., Doggett,D.L. and Cristofalo,V.J. (1999) Differences in electron transport potential, antioxidant defenses, and oxidant generation in young and senescent fetal lung fibroblasts (WI-38). J. Cell Physiol., 180, 114-122.
-
(1999)
J. Cell Physiol
, vol.180
, pp. 114-122
-
-
Allen, R.G.1
Tresini, M.2
Keogh, B.P.3
Doggett, D.L.4
Cristofalo, V.J.5
-
70
-
-
3042781117
-
Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts
-
Hutter,E., Renner,K., Pfister,G., Stockl,P., Jansen-Durr,P. and Gnaiger,E. (2004) Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem. J. 380, 919-928.
-
(2004)
Biochem. J
, vol.380
, pp. 919-928
-
-
Hutter, E.1
Renner, K.2
Pfister, G.3
Stockl, P.4
Jansen-Durr, P.5
Gnaiger, E.6
-
71
-
-
0036814967
-
Replicative senescence of human fibroblasts: The role of Ras-dependent signaling and oxidative stress
-
Hutter,E., Unterluggauer,H., Uberall,F., Schramek,H. and Jansen-Durr,P. (2002) Replicative senescence of human fibroblasts: The role of Ras-dependent signaling and oxidative stress. Exp. Gerontol., 37, 1165-1174.
-
(2002)
Exp. Gerontol
, vol.37
, pp. 1165-1174
-
-
Hutter, E.1
Unterluggauer, H.2
Uberall, F.3
Schramek, H.4
Jansen-Durr, P.5
-
72
-
-
0346256784
-
Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
-
Zwerschke,W., Mazurek,S., Stockl,P., Hutter,E., Eigenbrodt,E. and Jansen-Durr,P. (2003) Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence. Biochem. J., 376 403-411.
-
(2003)
Biochem. J
, vol.376
, pp. 403-411
-
-
Zwerschke, W.1
Mazurek, S.2
Stockl, P.3
Hutter, E.4
Eigenbrodt, E.5
Jansen-Durr, P.6
-
73
-
-
0034117954
-
Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts
-
Sitte,N., Merker,K., von Zglinicki,T. and Grune,T. (2000) Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts. Free Rad. Biol. Med., 28, 701-708.
-
(2000)
Free Rad. Biol. Med
, vol.28
, pp. 701-708
-
-
Sitte, N.1
Merker, K.2
von Zglinicki, T.3
Grune, T.4
-
74
-
-
0035092972
-
Lipofuscin accumulation in proliferating fibroblasts in vitro: An indicator of oxidative stress
-
Sitte,N., Merker,K., Grune,T. and von Zglinicki,T. (2001) Lipofuscin accumulation in proliferating fibroblasts in vitro: An indicator of oxidative stress. Exp. Gerontol., 36, 475-486.
-
(2001)
Exp. Gerontol
, vol.36
, pp. 475-486
-
-
Sitte, N.1
Merker, K.2
Grune, T.3
von Zglinicki, T.4
-
75
-
-
33748306003
-
Nicotinamide extends replicative lifespan of human cells
-
Kang,H.T., Lee,H.I. and Hwang,E.S. (2006) Nicotinamide extends replicative lifespan of human cells. Aging Cell, 5, 423-436.
-
(2006)
Aging Cell
, vol.5
, pp. 423-436
-
-
Kang, H.T.1
Lee, H.I.2
Hwang, E.S.3
-
76
-
-
0038331337
-
Mitochondrial dysfunction leads to telomere attrition and genomic instability
-
Liu,L., Trimarchi,J.R., Smith,P.J. and Keefe,D.L. (2002) Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell, 1, 40-46.
-
(2002)
Aging Cell
, vol.1
, pp. 40-46
-
-
Liu, L.1
Trimarchi, J.R.2
Smith, P.J.3
Keefe, D.L.4
-
77
-
-
0030916581
-
Advanced telomere shortening in respiratory chain disorders
-
Oexle,K. and Zwirner,A. (1997) Advanced telomere shortening in respiratory chain disorders. Hum. Mol. Genet., 6, 905-908.
-
(1997)
Hum. Mol. Genet
, vol.6
, pp. 905-908
-
-
Oexle, K.1
Zwirner, A.2
-
78
-
-
21244431867
-
Mitochondria, telomeres and cell senescence
-
Passos,J.F. and von Zglinicki,T. (2005) Mitochondria, telomeres and cell senescence. Exp. Gerontol., 40, 466-472.
-
(2005)
Exp. Gerontol
, vol.40
, pp. 466-472
-
-
Passos, J.F.1
von Zglinicki, T.2
-
79
-
-
0035930836
-
A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA
-
Sozou,P.D. and Kirkwood,T. (2001) A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA. J. Theor. Biol., 213, 573-586.
-
(2001)
J. Theor. Biol
, vol.213
, pp. 573-586
-
-
Sozou, P.D.1
Kirkwood, T.2
-
80
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
Harman,D. (1956) Aging: A theory based on free radical and radiation chemistry. J. Gerontol., 11, 298-300.
-
(1956)
J. Gerontol
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
81
-
-
0015319592
-
The biologic clock: The mitochondria?
-
Harman,D. (1972) The biologic clock: The mitochondria? J. Am. Geriatr. Soc., 20, 145-147.
-
(1972)
J. Am. Geriatr. Soc
, vol.20
, pp. 145-147
-
-
Harman, D.1
-
82
-
-
33750706163
-
Mitochondrial DNA damage and the aging process; facts and imaginations
-
Wiesner,R.J., Zsurka,G. and Kunz,W.S. (2006) Mitochondrial DNA damage and the aging process; facts and imaginations. Free Radical Res., 40, 1284-1294.
-
(2006)
Free Radical Res
, vol.40
, pp. 1284-1294
-
-
Wiesner, R.J.1
Zsurka, G.2
Kunz, W.S.3
-
83
-
-
33750627938
-
To repair or not to repair - no longer a question': Repair of mitochondrial DNA shielding against age and cancer
-
Berneburg,M., Kamenisch,Y., Krutmann,J. and Rocken,M. (2006) To repair or not to repair - no longer a question': Repair of mitochondrial DNA shielding against age and cancer. Exp. Dermatol., 15, 1005-1015.
-
(2006)
Exp. Dermatol
, vol.15
, pp. 1005-1015
-
-
Berneburg, M.1
Kamenisch, Y.2
Krutmann, J.3
Rocken, M.4
-
84
-
-
0031032817
-
Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
-
Yakes,F.M. and Van Houten,B. (1997) Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. PNAS, 94, 514-519.
-
(1997)
PNAS
, vol.94
, pp. 514-519
-
-
Yakes, F.M.1
Van Houten, B.2
-
85
-
-
0037449724
-
Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death
-
Santos,J.H., Hunakova,L., Chen,Y., Bortner,C. and Van Houten,B. (2003) Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death. J. Biol. Chem., 278, 1728-1734.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 1728-1734
-
-
Santos, J.H.1
Hunakova, L.2
Chen, Y.3
Bortner, C.4
Van Houten, B.5
-
86
-
-
0031885843
-
Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle
-
Brierley,E.J., Johnson,M.A., Lightowlers,R.N., James,O.F. and Turnbull,D.M. (1998) Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle. Ann. Neurol. 43, 217-223.
-
(1998)
Ann. Neurol
, vol.43
, pp. 217-223
-
-
Brierley, E.J.1
Johnson, M.A.2
Lightowlers, R.N.3
James, O.F.4
Turnbull, D.M.5
-
88
-
-
0024366601
-
Cytochrome-c-oxidase deficient cardiomyocytes in the human heart-an age-related phenomenon. A histochemical ultracytochemical study
-
Muller-Hocker,J. (1989) Cytochrome-c-oxidase deficient cardiomyocytes in the human heart-an age-related phenomenon. A histochemical ultracytochemical study. Am. J. Pathol., 134, 1167-1173.
-
(1989)
Am. J. Pathol
, vol.134
, pp. 1167-1173
-
-
Muller-Hocker, J.1
-
89
-
-
0027525966
-
Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly
-
Muller,Hocker,J., Seibel,P., Schneiderbanger,K. and Kadenbach,B. (1993) Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly. Virchows Arch. A Pathol. Anat. Histopathol., 422, 7-15.
-
(1993)
Virchows Arch. A Pathol. Anat. Histopathol
, vol.422
, pp. 7-15
-
-
Muller1
Hocker, J.2
Seibel, P.3
Schneiderbanger, K.4
Kadenbach, B.5
-
90
-
-
0347600946
-
Mitochondrial DNA mutations in human colonic crypt stem cells
-
Taylor,R.W., Barron,M.J., Borthwick,G.M., Gospel,A., Chinnery,P.F., Samuels,D.C., Taylor,G.A., Plusa,S.M., Needham,S.J. et al. (2003) Mitochondrial DNA mutations in human colonic crypt stem cells. J. Clin. Inv., 112, 1351-1360.
-
(2003)
J. Clin. Inv
, vol.112
, pp. 1351-1360
-
-
Taylor, R.W.1
Barron, M.J.2
Borthwick, G.M.3
Gospel, A.4
Chinnery, P.F.5
Samuels, D.C.6
Taylor, G.A.7
Plusa, S.M.8
Needham, S.J.9
-
91
-
-
0032533691
-
Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy
-
Lee,C.M., Lopez,M.E., Weindruch,R. and Aiken,J.M. (1998) Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy. Free Rad. Biol. Med., 25, 964-972.
-
(1998)
Free Rad. Biol. Med
, vol.25
, pp. 964-972
-
-
Lee, C.M.1
Lopez, M.E.2
Weindruch, R.3
Aiken, J.M.4
-
92
-
-
0035504933
-
Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: Analysis by laser-capture microdissection
-
Cao,Z., Wanagat,J., McKiernan,S.H. and Aiken,J.M. (2001) Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: Analysis by laser-capture microdissection. Nucleic Acids Res., 29, 4502-4508.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 4502-4508
-
-
Cao, Z.1
Wanagat, J.2
McKiernan, S.H.3
Aiken, J.M.4
-
93
-
-
0035127889
-
Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia
-
Wanagat,J., Cao,Z., Pathare,P. and Aiken,J.M. (2001) Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia. FASEB J., 15, 322-332.
-
(2001)
FASEB J
, vol.15
, pp. 322-332
-
-
Wanagat, J.1
Cao, Z.2
Pathare, P.3
Aiken, J.M.4
-
94
-
-
33646375711
-
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
-
Bender,A., Krishnan,K.J., Morris,C.M., Taylor,G.A., Reeve,A.K., Perry,R.H., Jaros,E., Hersheson,J.S., Betts,J. et al. (2006) High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat. Genet., 38, 515-517.
-
(2006)
Nat. Genet
, vol.38
, pp. 515-517
-
-
Bender, A.1
Krishnan, K.J.2
Morris, C.M.3
Taylor, G.A.4
Reeve, A.K.5
Perry, R.H.6
Jaros, E.7
Hersheson, J.S.8
Betts, J.9
-
95
-
-
33646351299
-
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
-
Kraytsberg,Y., Kudryavtseva,E., McKee,A.C., Geula,C., Kowall,N.W. and Khrapko,K. (2006) Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat. Genet., 38, 518-520.
-
(2006)
Nat. Genet
, vol.38
, pp. 518-520
-
-
Kraytsberg, Y.1
Kudryavtseva, E.2
McKee, A.C.3
Geula, C.4
Kowall, N.W.5
Khrapko, K.6
-
96
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
Trifunovic,A., Wredenberg,A., Falkenberg,M., Spelbrink,J.N., Rovio,A.T., Bruder,C.E., Bohlooly,Y.M., Gidlof,S., Oldfors,A. et al. (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature, 429, 417-423.
-
(2004)
Nature
, vol.429
, pp. 417-423
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
Spelbrink, J.N.4
Rovio, A.T.5
Bruder, C.E.6
Bohlooly, Y.M.7
Gidlof, S.8
Oldfors, A.9
-
97
-
-
22344456832
-
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
-
Kujoth,G.C., Hiona,A., Pugh,T.D., Someya,S., Panzer,K., Wohlgemuth,S.E., Hofer,T., Seo,A.Y., Sullivan,R. et al. (2005) Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science, 309, 481-484.
-
(2005)
Science
, vol.309
, pp. 481-484
-
-
Kujoth, G.C.1
Hiona, A.2
Pugh, T.D.3
Someya, S.4
Panzer, K.5
Wohlgemuth, S.E.6
Hofer, T.7
Seo, A.Y.8
Sullivan, R.9
-
98
-
-
29144458899
-
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
-
Trifunovic,A., Hansson,A., Wredenberg,A., Rovio,A.T., Dufour,E., Khvorostov,I., Spelbrink,J.N., Wibom,R., Jacobs,H.T. et al. (2005) Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. PNAS, 101, 17993-17998.
-
(2005)
PNAS
, vol.101
, pp. 17993-17998
-
-
Trifunovic, A.1
Hansson, A.2
Wredenberg, A.3
Rovio, A.T.4
Dufour, E.5
Khvorostov, I.6
Spelbrink, J.N.7
Wibom, R.8
Jacobs, H.T.9
-
99
-
-
34047116291
-
Mitochondrial point mutations do not limit the natural fifespan of mice
-
Vermulst,M., Bielas,J.H., Kujoth,G.C., Ladiges,W.C., Rabinovitch,P.S., Prolla,T.A. and Loeb,L.A. (2007) Mitochondrial point mutations do not limit the natural fifespan of mice. Nat. Genet., 39, 540-543.
-
(2007)
Nat. Genet
, vol.39
, pp. 540-543
-
-
Vermulst, M.1
Bielas, J.H.2
Kujoth, G.C.3
Ladiges, W.C.4
Rabinovitch, P.S.5
Prolla, T.A.6
Loeb, L.A.7
-
100
-
-
0033595684
-
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
-
Michikawa,Y., Mazzucchelli,F., Bresolin,N., Scarlato,G. and Attardi,G. (1999) Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science, 286, 774-779.
-
(1999)
Science
, vol.286
, pp. 774-779
-
-
Michikawa, Y.1
Mazzucchelli, F.2
Bresolin, N.3
Scarlato, G.4
Attardi, G.5
-
101
-
-
0033232317
-
Role of nuclear background and in vivo environment in variable segregation behavior of the aging-dependent T414G mutation at critical control site for human fibroblast mtDNA replication
-
Michikawa,Y., Laderman,K., Richter,K. and Attardi,G. (1999) Role of nuclear background and in vivo environment in variable segregation behavior of the aging-dependent T414G mutation at critical control site for human fibroblast mtDNA replication. Somat. Cell Mol. Genet., 25, 333-342.
-
(1999)
Somat. Cell Mol. Genet
, vol.25
, pp. 333-342
-
-
Michikawa, Y.1
Laderman, K.2
Richter, K.3
Attardi, G.4
-
102
-
-
0036355070
-
Measuring oxidative mtDNA damage and repair using quantitative PCR
-
Santos,J.H., Mandavilli,B.S. and Van Houten,B. (2002) Measuring oxidative mtDNA damage and repair using quantitative PCR. Methods Mol. Biol., 197, 159-176.
-
(2002)
Methods Mol. Biol
, vol.197
, pp. 159-176
-
-
Santos, J.H.1
Mandavilli, B.S.2
Van Houten, B.3
-
103
-
-
34547958816
-
Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence
-
Lee,S., Jeong,S.-Y., Lim,W.-C., Kim,S., Park,Y.-Y., Sun,X., Youle,R.J. and Cho,H. (2007) Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J. Biol. Chem., 282, 22977-22983.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 22977-22983
-
-
Lee, S.1
Jeong, S.-Y.2
Lim, W.-C.3
Kim, S.4
Park, Y.-Y.5
Sun, X.6
Youle, R.J.7
Cho, H.8
-
104
-
-
34548790754
-
Mitochondria and ageing: Winning and losing in the numbers game
-
Passos,J.F., Von Zglinicki,T. and Kirkwood,T.B. (2007) Mitochondria and ageing: Winning and losing in the numbers game. BioEssays, 29 908-917.
-
(2007)
BioEssays
, vol.29
, pp. 908-917
-
-
Passos, J.F.1
Von Zglinicki, T.2
Kirkwood, T.B.3
-
105
-
-
0036294999
-
A role for mitochondria as potential regulators of cellular life span
-
Xu,D. and Finkel,T. (2002) A role for mitochondria as potential regulators of cellular life span. Bioch. Biophy. Res. Com., 294 245-248.
-
(2002)
Bioch. Biophy. Res. Com
, vol.294
, pp. 245-248
-
-
Xu, D.1
Finkel, T.2
-
106
-
-
33746591648
-
Genes and pathways downstream of telomerase in melanoma metastasis
-
Bagheri,S., Nosrati,M., Li,S., Fong,S., Torabian,S., Rangel,J., Moore,D.H., Federman,S., LaPosa,R.R. et al. (2006) Genes and pathways downstream of telomerase in melanoma metastasis. PNAS, 103, 11306-11311.
-
(2006)
PNAS
, vol.103
, pp. 11306-11311
-
-
Bagheri, S.1
Nosrati, M.2
Li, S.3
Fong, S.4
Torabian, S.5
Rangel, J.6
Moore, D.H.7
Federman, S.8
LaPosa, R.R.9
-
107
-
-
0032580369
-
Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis
-
Kondo,Y., Kondo,S., Tanaka,Y., Haqqi,T., Barna,B.P. and Cowell,J.K. (1998) Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis. Oncogene 16, 2243-2248.
-
(1998)
Oncogene
, vol.16
, pp. 2243-2248
-
-
Kondo, Y.1
Kondo, S.2
Tanaka, Y.3
Haqqi, T.4
Barna, B.P.5
Cowell, J.K.6
-
108
-
-
21244502260
-
Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA
-
Li,S., Crothers,J., Haqq,C.M. and Blackburn,F.H. (2005) Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA. J. Biol. Chem., 280, 23709-23717.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 23709-23717
-
-
Li, S.1
Crothers, J.2
Haqq, C.M.3
Blackburn, F.H.4
-
109
-
-
33746851957
-
hTERT: A novel endogenous inhibitor of the mitochondrial cell death pathway
-
Massard,C., Zermati,Y., Pauleau,A.L., Larochette,N., Métivier,D., Sabatier,L., Kroemer,G. and Soria,J.C. (2006) hTERT: A novel endogenous inhibitor of the mitochondrial cell death pathway. Oncogene, 25 4505-4514.
-
(2006)
Oncogene
, vol.25
, pp. 4505-4514
-
-
Massard, C.1
Zermati, Y.2
Pauleau, A.L.3
Larochette, N.4
Métivier, D.5
Sabatier, L.6
Kroemer, G.7
Soria, J.C.8
-
110
-
-
0034775290
-
Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells
-
Saretzki,G., Ludwig,A., von Zglinicki,T. and Runnebaum,I.B. (2001) Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells. Cancer Gene Ther, 8, 827-834.
-
(2001)
Cancer Gene Ther
, vol.8
, pp. 827-834
-
-
Saretzki, G.1
Ludwig, A.2
von Zglinicki, T.3
Runnebaum, I.B.4
-
111
-
-
0033548430
-
Anti-apoptotic role of telomerase in pheochromocytoma cells
-
Fu,W., Begley,J.G., Killen,M.W. and Mattson,M.P. (1999) Anti-apoptotic role of telomerase in pheochromocytoma cells. J. Biol. Chem., 274, 7264-7271.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 7264-7271
-
-
Fu, W.1
Begley, J.G.2
Killen, M.W.3
Mattson, M.P.4
-
112
-
-
0037390962
-
TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein binding ability
-
Zhang,P., Chan,S.L., Fu,W., Mendoza,M. and Mattson,M.P. (2003) TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein binding ability. FASEB J., 17, 767-769.
-
(2003)
FASEB J
, vol.17
, pp. 767-769
-
-
Zhang, P.1
Chan, S.L.2
Fu, W.3
Mendoza, M.4
Mattson, M.P.5
-
113
-
-
0037427086
-
hTERT associates with human telomeres and enhances genomic stability and DNA repair
-
Sharma,G.G., Gupta,A., Wang,H., Scherthan,H., Dhar,S., Gandhi,V., Iliakis,G., Shay,J.W., Young,C.S. et al. (2003) hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene, 22, 131-146.
-
(2003)
Oncogene
, vol.22
, pp. 131-146
-
-
Sharma, G.G.1
Gupta, A.2
Wang, H.3
Scherthan, H.4
Dhar, S.5
Gandhi, V.6
Iliakis, G.7
Shay, J.W.8
Young, C.S.9
-
114
-
-
0036357711
-
Telomerase activation causes vascular smooth muscle cell proliferation in genetic hypertension
-
Cao,Y., Li,H.E., Mu,F.-T., Ebisui,O., Funder,J.W. and Liu,J.-P. (2002) Telomerase activation causes vascular smooth muscle cell proliferation in genetic hypertension. FASEB J., 16, 96-98.
-
(2002)
FASEB J
, vol.16
, pp. 96-98
-
-
Cao, Y.1
Li, H.E.2
Mu, F.-T.3
Ebisui, O.4
Funder, J.W.5
Liu, J.-P.6
-
115
-
-
0035853058
-
Telomere dysfunction alters the chemotherapeutic profile of transformed cells
-
Lee,K.-H., Rudolph,K.L., Ju,Y.J., Greenberg,R.A., Cannizzaro,L., Chin,L., Weiler,S.R. and DePinho,R.A. (2001) Telomere dysfunction alters the chemotherapeutic profile of transformed cells. PNAS, 98, 3381-3386.
-
(2001)
PNAS
, vol.98
, pp. 3381-3386
-
-
Lee, K.-H.1
Rudolph, K.L.2
Ju, Y.J.3
Greenberg, R.A.4
Cannizzaro, L.5
Chin, L.6
Weiler, S.R.7
DePinho, R.A.8
-
116
-
-
0035300424
-
Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase
-
Ludwig,A., Saretzki,G., Holm,P.S., Tiemann,F., Lorenz,M., Emrich,T., Harley,C.B. and von Zglinicki,T. (2001) Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase. Cancer Res., 61, 3053-3061.
-
(2001)
Cancer Res
, vol.61
, pp. 3053-3061
-
-
Ludwig, A.1
Saretzki, G.2
Holm, P.S.3
Tiemann, F.4
Lorenz, M.5
Emrich, T.6
Harley, C.B.7
von Zglinicki, T.8
-
117
-
-
0037220314
-
Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly(ADP-Ribose) polymerase inhibitor
-
Tentori,L., Portarena,I., Barbarino,M., Balduzzi,A., Levati,L., Vergati,M., Biroccio,A., Gold,B., Lombardi,M.L. et al. (2003) Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly(ADP-Ribose) polymerase inhibitor. Mol. Pharmacol., 63, 192-202.
-
(2003)
Mol. Pharmacol
, vol.63
, pp. 192-202
-
-
Tentori, L.1
Portarena, I.2
Barbarino, M.3
Balduzzi, A.4
Levati, L.5
Vergati, M.6
Biroccio, A.7
Gold, B.8
Lombardi, M.L.9
-
118
-
-
16444384725
-
Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage
-
Armstrong,L., Saretzki,G., Peters,H., Wappler,I., Evans,J., Hole,N., von Zglinicki,T. and Lako,M. (2005) Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage. Stem Cells, 23, 516-529.
-
(2005)
Stem Cells
, vol.23
, pp. 516-529
-
-
Armstrong, L.1
Saretzki, G.2
Peters, H.3
Wappler, I.4
Evans, J.5
Hole, N.6
von Zglinicki, T.7
Lako, M.8
-
119
-
-
0037047068
-
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
-
Nautiyal,S., DeRisi,J.L. and Blackburn,E.H. (2002) The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae. PNAS, 99, 9316-9321.
-
(2002)
PNAS
, vol.99
, pp. 9316-9321
-
-
Nautiyal, S.1
DeRisi, J.L.2
Blackburn, E.H.3
-
120
-
-
0038056347
-
Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
-
Smith,L.L., Coller,H.A. and Robetts,J.M. (2003) Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat. Cell Biol., 5, 474-479.
-
(2003)
Nat. Cell Biol
, vol.5
, pp. 474-479
-
-
Smith, L.L.1
Coller, H.A.2
Robetts, J.M.3
-
121
-
-
0038721199
-
Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of Tyrosine 707
-
Haendeler,J., Hoffmann,J., Brandes,R.P., Zeiher,A.M. and Dimmeler,S. (2003) Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of Tyrosine 707. Mol. Cell. Biol., 23, 4598-4610.
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 4598-4610
-
-
Haendeler, J.1
Hoffmann, J.2
Brandes, R.P.3
Zeiher, A.M.4
Dimmeler, S.5
-
122
-
-
13844272923
-
Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage
-
Santos,J.H., Meyer,J.N., Skorvaga,M., Annab,L.A. and Van Houten,B. (2004) Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. Aging Cell, 3, 399-411.
-
(2004)
Aging Cell
, vol.3
, pp. 399-411
-
-
Santos, J.H.1
Meyer, J.N.2
Skorvaga, M.3
Annab, L.A.4
Van Houten, B.5
-
123
-
-
33744745014
-
Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis
-
Santos,J.H., Meyer,J.N. and Van Houten,B. (2006) Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. Hum. Mol. Genet., 15, 1757-1768.
-
(2006)
Hum. Mol. Genet
, vol.15
, pp. 1757-1768
-
-
Santos, J.H.1
Meyer, J.N.2
Van Houten, B.3
-
124
-
-
0034725652
-
Reactive oxygen species as mediators of angiotensin II signaling
-
Griendling,K.K. and Ushio-Fukai,M. (2000) Reactive oxygen species as mediators of angiotensin II signaling. Regulatory Peptides, 91 21-27.
-
(2000)
Regulatory Peptides
, vol.91
, pp. 21-27
-
-
Griendling, K.K.1
Ushio-Fukai, M.2
-
125
-
-
0033609046
-
Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes
-
Liu,K., Schoonmaker,M.M., Levine,B.L., June,C.H., Hodes,R.J. and Weng,N.-P. (1999) Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes. PNAS, 96 5147-5152.
-
(1999)
PNAS
, vol.96
, pp. 5147-5152
-
-
Liu, K.1
Schoonmaker, M.M.2
Levine, B.L.3
June, C.H.4
Hodes, R.J.5
Weng, N.-P.6
-
126
-
-
0034086553
-
The catalytic subunit of telomerase protects neurons against amyloid (β)-peptide-induced apoptosis
-
Zhu,H., Fu,W. and Mattson,M.P. (2000) The catalytic subunit of telomerase protects neurons against amyloid (β)-peptide-induced apoptosis. J. Neurochem., 75, 117-124.
-
(2000)
J. Neurochem
, vol.75
, pp. 117-124
-
-
Zhu, H.1
Fu, W.2
Mattson, M.P.3
-
127
-
-
10744219690
-
Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity
-
Kang,H.J., Choi,Y.S., Hong,S.-B., Kim,K.-W., Woo,R.-S., Won,S.J., Kim,E.J., Jeon,H.K., Jo,S.-Y. et al. (2004) Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity. J. Neurosci. 24, 1280-1287.
-
(2004)
J. Neurosci
, vol.24
, pp. 1280-1287
-
-
Kang, H.J.1
Choi, Y.S.2
Hong, S.-B.3
Kim, K.-W.4
Woo, R.-S.5
Won, S.J.6
Kim, E.J.7
Jeon, H.K.8
Jo, S.-Y.9
|