-
1
-
-
0030744876
-
Mutation in the α-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos M.H., et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276 (1997) 2045-2047
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
-
2
-
-
22244442489
-
The biochemistry of Parkinson's disease
-
Cookson M.R. The biochemistry of Parkinson's disease. Annu. Rev. Biochem. 74 (2005) 29-52
-
(2005)
Annu. Rev. Biochem.
, vol.74
, pp. 29-52
-
-
Cookson, M.R.1
-
3
-
-
10744227740
-
Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications
-
Farrer M., et al. Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications. Ann. Neurol. 55 (2004) 174-179
-
(2004)
Ann. Neurol.
, vol.55
, pp. 174-179
-
-
Farrer, M.1
-
4
-
-
32044453611
-
Clinical heterogeneity of α-synuclein gene duplication in Parkinson's disease
-
Nishioka K., et al. Clinical heterogeneity of α-synuclein gene duplication in Parkinson's disease. Ann. Neurol. 59 (2006) 298-309
-
(2006)
Ann. Neurol.
, vol.59
, pp. 298-309
-
-
Nishioka, K.1
-
5
-
-
0242300619
-
α-Synuclein locus triplication causes Parkinson's disease
-
Singleton A.B., et al. α-Synuclein locus triplication causes Parkinson's disease. Science 302 (2003) 841
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
-
6
-
-
33746869343
-
Collaborative analysis of α-synuclein gene promoter variability and Parkinson disease
-
Maraganore D.M., et al. Collaborative analysis of α-synuclein gene promoter variability and Parkinson disease. JAMA 296 (2006) 661-670
-
(2006)
JAMA
, vol.296
, pp. 661-670
-
-
Maraganore, D.M.1
-
7
-
-
0028985267
-
The precursor protein of non-A β component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
-
Iwai A., et al. The precursor protein of non-A β component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 14 (1995) 467-475
-
(1995)
Neuron
, vol.14
, pp. 467-475
-
-
Iwai, A.1
-
8
-
-
0028277520
-
Identification of two distinct synucleins from human brain
-
Jakes R., et al. Identification of two distinct synucleins from human brain. FEBS Lett. 345 (1994) 27-32
-
(1994)
FEBS Lett.
, vol.345
, pp. 27-32
-
-
Jakes, R.1
-
9
-
-
0036315240
-
Demonstration of α-synuclein immunoreactivity in neuronal and glial cytoplasm in normal human brain tissue using proteinase K and formic acid pretreatment
-
Mori F., et al. Demonstration of α-synuclein immunoreactivity in neuronal and glial cytoplasm in normal human brain tissue using proteinase K and formic acid pretreatment. Exp. Neurol. 176 (2002) 98-104
-
(2002)
Exp. Neurol.
, vol.176
, pp. 98-104
-
-
Mori, F.1
-
10
-
-
0036884733
-
Pathogenesis of Parkinson's disease: dopamine, vesicles and α-synuclein
-
Lotharius J., and Brundin P. Pathogenesis of Parkinson's disease: dopamine, vesicles and α-synuclein. Nat. Rev. Neurosci. 3 (2002) 932-942
-
(2002)
Nat. Rev. Neurosci.
, vol.3
, pp. 932-942
-
-
Lotharius, J.1
Brundin, P.2
-
11
-
-
14944348552
-
The role of (-synuclein in both neuroprotection and neurodegeneration
-
Sidhu A., et al. The role of (-synuclein in both neuroprotection and neurodegeneration. Ann. N. Y. Acad. Sci. 1035 (2004) 250-270
-
(2004)
Ann. N. Y. Acad. Sci.
, vol.1035
, pp. 250-270
-
-
Sidhu, A.1
-
12
-
-
0034077041
-
Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system
-
Abeliovich A., et al. Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25 (2000) 239-252
-
(2000)
Neuron
, vol.25
, pp. 239-252
-
-
Abeliovich, A.1
-
13
-
-
0037109727
-
Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking α-synuclein
-
Cabin D.E., et al. Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking α-synuclein. J. Neurosci. 22 (2002) 8797-8807
-
(2002)
J. Neurosci.
, vol.22
, pp. 8797-8807
-
-
Cabin, D.E.1
-
14
-
-
6944227811
-
Double-knockout mice for α- and β-synucleins: effect on synaptic functions
-
Chandra S., et al. Double-knockout mice for α- and β-synucleins: effect on synaptic functions. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 14966-14971
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 14966-14971
-
-
Chandra, S.1
-
15
-
-
5144234034
-
Alpha-synuclein and transgenic mouse models
-
Fernagut P.O., and Chesselet M.F. Alpha-synuclein and transgenic mouse models. Neurobiol. Dis. 17 (2004) 123-130
-
(2004)
Neurobiol. Dis.
, vol.17
, pp. 123-130
-
-
Fernagut, P.O.1
Chesselet, M.F.2
-
16
-
-
0037155197
-
Lipid droplet binding and oligomerization properties of the Parkinson's disease protein α-synuclein
-
Cole N.B., et al. Lipid droplet binding and oligomerization properties of the Parkinson's disease protein α-synuclein. J. Biol. Chem. 277 (2002) 6344-6352
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 6344-6352
-
-
Cole, N.B.1
-
17
-
-
0345189364
-
Yeast cells provide insight into α-synuclein biology and pathobiology
-
Outeiro T.F., and Lindquist S. Yeast cells provide insight into α-synuclein biology and pathobiology. Science 302 (2003) 1772-1775
-
(2003)
Science
, vol.302
, pp. 1772-1775
-
-
Outeiro, T.F.1
Lindquist, S.2
-
18
-
-
15244347219
-
Helix periodicity, topology, and dynamics of membrane-associated α-synuclein
-
Bussell Jr. R., et al. Helix periodicity, topology, and dynamics of membrane-associated α-synuclein. Protein Sci. 14 (2005) 862-872
-
(2005)
Protein Sci.
, vol.14
, pp. 862-872
-
-
Bussell Jr., R.1
-
19
-
-
24744432079
-
A combinatorial code for the interaction of α-synuclein with membranes
-
Kubo S., et al. A combinatorial code for the interaction of α-synuclein with membranes. J. Biol. Chem. 280 (2005) 31664-31672
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31664-31672
-
-
Kubo, S.1
-
20
-
-
12144267004
-
Fluorescence studies suggest a role for α-synuclein in the phosphatidylinositol lipid signaling pathway
-
Narayanan V., et al. Fluorescence studies suggest a role for α-synuclein in the phosphatidylinositol lipid signaling pathway. Biochemistry 44 (2005) 462-470
-
(2005)
Biochemistry
, vol.44
, pp. 462-470
-
-
Narayanan, V.1
-
21
-
-
1642264194
-
Structural determinants of PLD2 inhibition by α-synuclein
-
Payton J.E., et al. Structural determinants of PLD2 inhibition by α-synuclein. J. Mol. Biol. 337 (2004) 1001-1009
-
(2004)
J. Mol. Biol.
, vol.337
, pp. 1001-1009
-
-
Payton, J.E.1
-
22
-
-
20444362984
-
Fatty acid incorporation is decreased in astrocytes cultured from α-synuclein gene-ablated mice
-
Castagnet P.I., et al. Fatty acid incorporation is decreased in astrocytes cultured from α-synuclein gene-ablated mice. J. Neurochem. 94 (2005) 839-849
-
(2005)
J. Neurochem.
, vol.94
, pp. 839-849
-
-
Castagnet, P.I.1
-
23
-
-
20444400627
-
Alpha-synuclein gene deletion decreases brain palmitate uptake and alters the palmitate metabolism in the absence of α-synuclein palmitate binding
-
Golovko M.Y., et al. Alpha-synuclein gene deletion decreases brain palmitate uptake and alters the palmitate metabolism in the absence of α-synuclein palmitate binding. Biochemistry 44 (2005) 8251-8259
-
(2005)
Biochemistry
, vol.44
, pp. 8251-8259
-
-
Golovko, M.Y.1
-
24
-
-
27644578107
-
Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking α-synuclein
-
Ellis C.E., et al. Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking α-synuclein. Mol. Cell. Biol. 25 (2005) 10190-10201
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 10190-10201
-
-
Ellis, C.E.1
-
25
-
-
27544507306
-
Alpha-synuclein cooperates with CSPα in preventing neurodegeneration
-
Chandra S., et al. Alpha-synuclein cooperates with CSPα in preventing neurodegeneration. Cell 123 (2005) 383-396
-
(2005)
Cell
, vol.123
, pp. 383-396
-
-
Chandra, S.1
-
26
-
-
0030882856
-
Alpha-synuclein in Lewy bodies
-
Spillantini M.G., et al. Alpha-synuclein in Lewy bodies. Nature 388 (1997) 839-840
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
-
27
-
-
0034646391
-
Fibrils formed in vitro from α-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid
-
Conway K.A., et al. Fibrils formed in vitro from α-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid. Biochemistry 39 (2000) 2552-2563
-
(2000)
Biochemistry
, vol.39
, pp. 2552-2563
-
-
Conway, K.A.1
-
28
-
-
0034712918
-
Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation
-
Serpell L.C., et al. Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 4897-4902
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 4897-4902
-
-
Serpell, L.C.1
-
29
-
-
2442700253
-
Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication
-
Miller D.W., et al. Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication. Neurology 62 (2004) 1835-1838
-
(2004)
Neurology
, vol.62
, pp. 1835-1838
-
-
Miller, D.W.1
-
30
-
-
26844527655
-
Genetic mouse models of parkinsonism: strengths and limitations
-
Fleming S.M., et al. Genetic mouse models of parkinsonism: strengths and limitations. NeuroRx. 2 (2005) 495-503
-
(2005)
NeuroRx.
, vol.2
, pp. 495-503
-
-
Fleming, S.M.1
-
31
-
-
0034704752
-
A Drosophila model of Parkinson's disease
-
Feany M.B., and Bender W.W. A Drosophila model of Parkinson's disease. Nature 404 (2000) 394-398
-
(2000)
Nature
, vol.404
, pp. 394-398
-
-
Feany, M.B.1
Bender, W.W.2
-
32
-
-
17844406856
-
Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
-
Chen L., and Feany M.B. Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat. Neurosci. 8 (2005) 657-663
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 657-663
-
-
Chen, L.1
Feany, M.B.2
-
33
-
-
0036174010
-
α-Synuclein is phosphorylated in synucleinopathy lesions
-
Fujiwara H., et al. α-Synuclein is phosphorylated in synucleinopathy lesions. Nat. Cell Biol. 4 (2002) 160-164
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
-
34
-
-
14844335694
-
The E46K mutation in α-synuclein increases amyloid fibril formation
-
Greenbaum E.A., et al. The E46K mutation in α-synuclein increases amyloid fibril formation. J. Biol. Chem. 280 (2005) 7800-7807
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 7800-7807
-
-
Greenbaum, E.A.1
-
35
-
-
0035800097
-
Vesicle permeabilization by protofibrillar α-synuclein: implications for the pathogenesis and treatment of Parkinson's disease
-
Volles M.J., et al. Vesicle permeabilization by protofibrillar α-synuclein: implications for the pathogenesis and treatment of Parkinson's disease. Biochemistry 40 (2001) 7812-7819
-
(2001)
Biochemistry
, vol.40
, pp. 7812-7819
-
-
Volles, M.J.1
-
36
-
-
33750284754
-
Interaction of α-synuclein and dopamine metabolites in the pathogenesis of Parkinson's disease: a case for the selective vulnerability of the substantia nigra
-
Galvin J.E. Interaction of α-synuclein and dopamine metabolites in the pathogenesis of Parkinson's disease: a case for the selective vulnerability of the substantia nigra. Acta Neuropathol. (Berl.) 112 (2006) 115-126
-
(2006)
Acta Neuropathol. (Berl.)
, vol.112
, pp. 115-126
-
-
Galvin, J.E.1
-
37
-
-
0036278335
-
Dopamine-dependent neurotoxicity of α-synuclein: a mechanism for selective neurodegeneration in Parkinson disease
-
Xu J., et al. Dopamine-dependent neurotoxicity of α-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat. Med. 8 (2002) 600-606
-
(2002)
Nat. Med.
, vol.8
, pp. 600-606
-
-
Xu, J.1
-
38
-
-
0035834360
-
Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct
-
Conway K.A., et al. Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct. Science 294 (2001) 1346-1349
-
(2001)
Science
, vol.294
, pp. 1346-1349
-
-
Conway, K.A.1
-
39
-
-
8844266996
-
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
-
Paisan-Ruiz C., et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 44 (2004) 595-600
-
(2004)
Neuron
, vol.44
, pp. 595-600
-
-
Paisan-Ruiz, C.1
-
40
-
-
8844233579
-
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
-
Zimprich A., et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44 (2004) 601-607
-
(2004)
Neuron
, vol.44
, pp. 601-607
-
-
Zimprich, A.1
-
41
-
-
28544441181
-
Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data
-
Khan N.L., et al. Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data. Brain 128 (2005) 2786-2796
-
(2005)
Brain
, vol.128
, pp. 2786-2796
-
-
Khan, N.L.1
-
42
-
-
16444380313
-
LRRK2 mutations and Parkinsonism
-
Albrecht M. LRRK2 mutations and Parkinsonism. Lancet 365 (2005) 1230
-
(2005)
Lancet
, vol.365
, pp. 1230
-
-
Albrecht, M.1
-
43
-
-
19944432921
-
A common LRRK2 mutation in idiopathic Parkinson's disease
-
Gilks W.P., et al. A common LRRK2 mutation in idiopathic Parkinson's disease. Lancet 365 (2005) 415-416
-
(2005)
Lancet
, vol.365
, pp. 415-416
-
-
Gilks, W.P.1
-
44
-
-
31344432937
-
LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs
-
Lesage S., et al. LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs. N. Engl. J. Med. 354 (2006) 422-423
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 422-423
-
-
Lesage, S.1
-
45
-
-
31344439221
-
LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews
-
Ozelius L.J., et al. LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews. N. Engl. J. Med. 354 (2006) 424-425
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 424-425
-
-
Ozelius, L.J.1
-
46
-
-
33645790701
-
LRRK2 expression linked to dopamine-innervated areas
-
Galter D., et al. LRRK2 expression linked to dopamine-innervated areas. Ann. Neurol. 59 (2006) 714-719
-
(2006)
Ann. Neurol.
, vol.59
, pp. 714-719
-
-
Galter, D.1
-
47
-
-
33646146878
-
Anatomical localization of leucine-rich repeat kinase 2 in mouse brain
-
Melrose H., et al. Anatomical localization of leucine-rich repeat kinase 2 in mouse brain. Neuroscience (2006)
-
(2006)
Neuroscience
-
-
Melrose, H.1
-
48
-
-
33644934224
-
LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain
-
Simon-Sanchez J., et al. LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain. Eur. J. Neurosci. 23 (2006) 659-666
-
(2006)
Eur. J. Neurosci.
, vol.23
, pp. 659-666
-
-
Simon-Sanchez, J.1
-
49
-
-
31144443248
-
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
-
Gloeckner C.J., et al. The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. Hum. Mol. Genet. 15 (2006) 223-232
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 223-232
-
-
Gloeckner, C.J.1
-
50
-
-
28044460070
-
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
-
West A.B., et al. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 16842-16847
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 16842-16847
-
-
West, A.B.1
-
51
-
-
32044432395
-
Biochemical and pathological characterization of Lrrk2
-
Giasson B.I., et al. Biochemical and pathological characterization of Lrrk2. Ann. Neurol. 59 (2006) 315-322
-
(2006)
Ann. Neurol.
, vol.59
, pp. 315-322
-
-
Giasson, B.I.1
-
52
-
-
33750317653
-
LRRK2 protein is a component of lewy bodies
-
Zhu X., et al. LRRK2 protein is a component of lewy bodies. Ann. Neurol. (2006)
-
(2006)
Ann. Neurol.
-
-
Zhu, X.1
-
53
-
-
0032499264
-
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
-
Kitada T., et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392 (1998) 605-608
-
(1998)
Nature
, vol.392
, pp. 605-608
-
-
Kitada, T.1
-
54
-
-
0342368772
-
Association between early-onset Parkinson's disease and mutations in the parkin gene
-
Lucking C.B., et al. Association between early-onset Parkinson's disease and mutations in the parkin gene. N. Engl. J. Med. 342 (2000) 1560-1567
-
(2000)
N. Engl. J. Med.
, vol.342
, pp. 1560-1567
-
-
Lucking, C.B.1
-
55
-
-
1542285483
-
Genetics of parkin-linked disease
-
West A.B., and Maidment N.T. Genetics of parkin-linked disease. Hum. Genet. 114 (2004) 327-336
-
(2004)
Hum. Genet.
, vol.114
, pp. 327-336
-
-
West, A.B.1
Maidment, N.T.2
-
56
-
-
24644462201
-
Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers
-
Pramstaller P.P., et al. Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers. Ann. Neurol. 58 (2005) 411-422
-
(2005)
Ann. Neurol.
, vol.58
, pp. 411-422
-
-
Pramstaller, P.P.1
-
57
-
-
5444236802
-
Parkin-associated Parkinson's disease
-
von Coelln R., et al. Parkin-associated Parkinson's disease. Cell Tissue Res. 318 (2004) 175-184
-
(2004)
Cell Tissue Res.
, vol.318
, pp. 175-184
-
-
von Coelln, R.1
-
58
-
-
0033933048
-
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
-
Shimura H., et al. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat. Genet. 25 (2000) 302-305
-
(2000)
Nat. Genet.
, vol.25
, pp. 302-305
-
-
Shimura, H.1
-
59
-
-
10444241856
-
BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
-
Kalia S.K., et al. BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Neuron 44 (2004) 931-945
-
(2004)
Neuron
, vol.44
, pp. 931-945
-
-
Kalia, S.K.1
-
60
-
-
0037016687
-
Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain
-
Fallon L., et al. Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. J. Biol. Chem. 277 (2002) 486-491
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 486-491
-
-
Fallon, L.1
-
61
-
-
24144470504
-
Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin
-
Sriram S.R., et al. Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin. Hum. Mol. Genet. 14 (2005) 2571-2586
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 2571-2586
-
-
Sriram, S.R.1
-
62
-
-
0141891953
-
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
-
Goldberg M.S., et al. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J. Biol. Chem. 278 (2003) 43628-43635
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 43628-43635
-
-
Goldberg, M.S.1
-
63
-
-
10744221310
-
Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse
-
Itier J.M., et al. Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse. Hum. Mol. Genet. 12 (2003) 2277-2291
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 2277-2291
-
-
Itier, J.M.1
-
64
-
-
24144497601
-
Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death
-
Ko H.S., et al. Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. J. Neurosci. 25 (2005) 7968-7978
-
(2005)
J. Neurosci.
, vol.25
, pp. 7968-7978
-
-
Ko, H.S.1
-
65
-
-
2442481789
-
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
-
Palacino J.J., et al. Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J. Biol. Chem. 279 (2004) 18614-18622
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 18614-18622
-
-
Palacino, J.J.1
-
66
-
-
0037386532
-
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
-
Greene J.C., et al. Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 4078-4083
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 4078-4083
-
-
Greene, J.C.1
-
67
-
-
2542560342
-
Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress
-
Pesah Y., et al. Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development 131 (2004) 2183-2194
-
(2004)
Development
, vol.131
, pp. 2183-2194
-
-
Pesah, Y.1
-
68
-
-
33644778845
-
Parkin enhances mitochondrial biogenesis in proliferating cells
-
Kuroda Y., et al. Parkin enhances mitochondrial biogenesis in proliferating cells. Hum. Mol. Genet. 15 (2006) 883-895
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 883-895
-
-
Kuroda, Y.1
-
69
-
-
2542534741
-
S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function
-
Chung K.K., et al. S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science 304 (2004) 1328-1331
-
(2004)
Science
, vol.304
, pp. 1328-1331
-
-
Chung, K.K.1
-
70
-
-
0344875488
-
Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones
-
Winklhofer K.F., et al. Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones. J. Biol. Chem. 278 (2003) 47199-47208
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 47199-47208
-
-
Winklhofer, K.F.1
-
71
-
-
3242733689
-
Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity
-
101, 10810-10814
-
Yao D., et al. Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proc. Natl. Acad. Sci. U. S. A. 20 (2004) 101, 10810-10814
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.20
-
-
Yao, D.1
-
72
-
-
30744443484
-
Dopamine covalently modifies and functionally inactivates parkin
-
LaVoie M.J., et al. Dopamine covalently modifies and functionally inactivates parkin. Nat. Med. 11 (2005) 1214-1221
-
(2005)
Nat. Med.
, vol.11
, pp. 1214-1221
-
-
LaVoie, M.J.1
-
73
-
-
4444237208
-
Novel PINK1 mutations in early-onset parkinsonism
-
Hatano Y., et al. Novel PINK1 mutations in early-onset parkinsonism. Ann. Neurol. 56 (2004) 424-427
-
(2004)
Ann. Neurol.
, vol.56
, pp. 424-427
-
-
Hatano, Y.1
-
74
-
-
2442668926
-
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
-
Valente E.M., et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304 (2004) 1158-1160
-
(2004)
Science
, vol.304
, pp. 1158-1160
-
-
Valente, E.M.1
-
75
-
-
33644610520
-
The genetics of Parkinson disease: implications for neurological care
-
Klein C., and Schlossmacher M.G. The genetics of Parkinson disease: implications for neurological care. Nat. Clin. Pract. Neurol. 2 (2006) 136-146
-
(2006)
Nat. Clin. Pract. Neurol.
, vol.2
, pp. 136-146
-
-
Klein, C.1
Schlossmacher, M.G.2
-
76
-
-
27944444154
-
Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism
-
Silvestri L., et al. Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism. Hum. Mol. Genet. 14 (2005) 3477-3492
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 3477-3492
-
-
Silvestri, L.1
-
77
-
-
33750598457
-
-
Abou-Sleiman, P. M. et al. (2006) A heterozygous effect for PINK1 mutations in Parkinson's disease? Ann. Neurol. (in press)
-
-
-
-
78
-
-
17644365438
-
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability
-
Beilina A., et al. Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 5703-5708
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 5703-5708
-
-
Beilina, A.1
-
79
-
-
33745087689
-
PINK1 protein in normal human brain and Parkinson's disease
-
Gandhi S., et al. PINK1 protein in normal human brain and Parkinson's disease. Brain 129 (2006) 1720-1731
-
(2006)
Brain
, vol.129
, pp. 1720-1731
-
-
Gandhi, S.1
-
80
-
-
26644440926
-
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations
-
Petit A., et al. Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. J. Biol. Chem. 280 (2005) 34025-34032
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 34025-34032
-
-
Petit, A.1
-
81
-
-
33745589773
-
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
-
Clark I.E., et al. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441 (2006) 1162-1166
-
(2006)
Nature
, vol.441
, pp. 1162-1166
-
-
Clark, I.E.1
-
82
-
-
33745602748
-
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
-
Park J., et al. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441 (2006) 1157-1161
-
(2006)
Nature
, vol.441
, pp. 1157-1161
-
-
Park, J.1
-
83
-
-
1642379155
-
Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease
-
Bonifati V., et al. Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease. J. Mol. Med. 82 (2004) 163-174
-
(2004)
J. Mol. Med.
, vol.82
, pp. 163-174
-
-
Bonifati, V.1
-
84
-
-
24944534660
-
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis
-
Zhang L., et al. Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Hum. Mol. Genet. 14 (2005) 2063-2073
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 2063-2073
-
-
Zhang, L.1
-
85
-
-
31344464179
-
The oxidation state of DJ-1 regulates its chaperone activity toward α-synuclein
-
Zhou W., et al. The oxidation state of DJ-1 regulates its chaperone activity toward α-synuclein. J. Mol. Biol. 356 (2006) 1036-1048
-
(2006)
J. Mol. Biol.
, vol.356
, pp. 1036-1048
-
-
Zhou, W.1
-
86
-
-
33646826619
-
Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases
-
Choi J., et al. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J. Biol. Chem. 281 (2006) 10816-10824
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 10816-10824
-
-
Choi, J.1
-
87
-
-
13844253723
-
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
-
Goldberg M.S., et al. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45 (2005) 489-496
-
(2005)
Neuron
, vol.45
, pp. 489-496
-
-
Goldberg, M.S.1
-
88
-
-
26444489693
-
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signalling
-
102, 13670-13675
-
Yang Y., et al. Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signalling. Proc. Natl. Acad. Sci. U. S. A. 20 (2005) 102, 13670-13675
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.20
-
-
Yang, Y.1
-
89
-
-
25144433763
-
Dopaminergic function in a family with the PARK6 form of autosomal recessive Parkinson's syndrome
-
Kessler K.R., et al. Dopaminergic function in a family with the PARK6 form of autosomal recessive Parkinson's syndrome. J. Neural. Transm. 112 (2005) 1345-1353
-
(2005)
J. Neural. Transm.
, vol.112
, pp. 1345-1353
-
-
Kessler, K.R.1
-
90
-
-
11444265305
-
Dopaminergic dysfunction in unrelated, asymptomatic carriers of a single parkin mutation
-
Khan N.L., et al. Dopaminergic dysfunction in unrelated, asymptomatic carriers of a single parkin mutation. Neurology 64 (2005) 134-136
-
(2005)
Neurology
, vol.64
, pp. 134-136
-
-
Khan, N.L.1
|