Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

Nature Neuroscience

Volumn 5, Issue 8, 2002, Pages 731-736

  Panov, Alexander V ^a   Gutekunst, Claire Anne ^a   Leavitt, Blair R ^b   Hayden, Michael R ^b   Burke, James R ^c   Strittmatter, Warren J ^c   Greenamyre, J Timothy ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; HUNTINGTIN; MUTANT PROTEIN; POLYGLUTAMINE;

ADULT; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BEHAVIOR DISORDER; BRAIN MITOCHONDRION; CALCIUM CELL LEVEL; CELL MEMBRANE POTENTIAL; CELL ORGANELLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; LYMPHOBLAST; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; MOUSE; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; BRAIN; BRAIN CHEMISTRY; CALCIUM; CELL LINE; DISEASE MODELS, ANIMAL; HUMANS; HUNTINGTON DISEASE; INTRACELLULAR MEMBRANES; LYMPHOCYTES; MEMBRANE POTENTIALS; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; MITOCHONDRIA; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; RECOMBINANT FUSION PROTEINS; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 0036327065     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn884     Document Type: Article

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