MTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis

Cell Stem Cell

Volumn 11, Issue 3, 2012, Pages 401-414

  Iglesias Bartolome, Ramiro ^a   Patel, Vyomesh ^a   Cotrim, Ana ^a   Leelahavanichkul, Kantima ^a   Molinolo, Alfredo A ^a   Mitchell, James B ^b   Gutkind, J Silvio ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL PROLIFERATION; CELL RENEWAL; CONTROLLED STUDY; ENZYME INHIBITION; EPITHELIAL STEM CELL; EPITHELIUM BASAL CELL; EPITHELIUM CELL; FEMALE; IONIZING RADIATION; KERATINOCYTE; MITOCHONDRION; MOUSE; MOUTH MUCOSA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION INDUCED MUCOSITIS; RADIATION INJURY; STOMATITIS;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL AGING; CELL COMPARTMENTATION; CELL DEATH; CELL PROLIFERATION; CELLS, CULTURED; CLONE CELLS; CYTOPROTECTION; EPITHELIAL CELLS; HEAD AND NECK NEOPLASMS; HUMANS; KERATINOCYTES; MICE; MOUTH MUCOSA; MUCOSITIS; OXIDATIVE STRESS; RADIATION INJURIES; RADIATION, IONIZING; SIROLIMUS; STEM CELLS; SUPEROXIDE DISMUTASE; TOR SERINE-THREONINE KINASES;

MAMMALIA;

EID: 84866054806     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2012.06.007     Document Type: Article

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