Modulation of longevity and tissue homeostasis by the drosophila PGC-1 homolog

Cell Metabolism

Volumn 14, Issue 5, 2011, Pages 623-634

  Rera, Michael ^a   Bahadorani, Sepehr ^a   Cho, Jaehyoung ^a   Koehler, Christopher L ^c,d   Ulgherait, Matthew ^a,b   Hur, Jae H ^a   Ansari, William S ^d   Lo Jr , Thomas ^a   Jones, D Leanne ^c,d   Walker, David W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS DNA; CITRATE SYNTHASE; DROSOPHILA PCG 1 HOMOLOG; DROSOPHILA PROTEIN; HEAT SHOCK PROTEIN 60; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TRANSCRIPTION FACTOR GAL4; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT ANIMAL; AEROBIC METABOLISM; AGING; AMPLICON; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELL CYCLE; CELL DENSITY; CELL DIFFERENTIATION; CELL PROLIFERATION; CITRIC ACID CYCLE; CONTROLLED STUDY; DAUGHTER CELL; DIGESTIVE SYSTEM; DROSOPHILA; DRUG ACTIVITY; ENZYME ACTIVITY; FEMALE; FERTILITY; GENE ACTIVITY; GENE OVEREXPRESSION; HOMEOSTASIS; INTESTINE EPITHELIUM; LARVA; LIFE EXTENSION; LIFESPAN; LONGEVITY; MALE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PREDICTIVE VALUE; PRIORITY JOURNAL; STARVATION; STEM CELL; SURVIVAL TIME; TISSUE SURVIVAL; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CELL RESPIRATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENERGY METABOLISM; FEMALE; GENE EXPRESSION; GLUCOSE; HOMEOSTASIS; INTESTINES; LONGEVITY; MALE; MAMMALS; MICE; MITOCHONDRIA; ORGAN SPECIFICITY; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; SEQUENCE HOMOLOGY, AMINO ACID; STEM CELLS; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 80455143200     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2011.09.013     Document Type: Article

References (51)

1. B. Al-Anzi, and K. Zinn Colorimetric measurement of triglycerides cannot provide an accurate measure of stored fat content in Drosophila PLoS ONE 5 2010 e12353
2. S. Bahadorani, J.H. Hur, T. Lo Jr., K. Vu, and D.W. Walker Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila Aging Cell 9 2010 100 103
3. N.A. Bishop, and L. Guarente Two neurons mediate diet-restriction-induced longevity in C. elegans Nature 447 2007 545 549 (Pubitemid 46868049)
4. B. Biteau, C.E. Hochmuth, and H. Jasper JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut Cell Stem Cell 3 2008 442 455
5. B. Biteau, J. Karpac, S. Supoyo, M. Degennaro, R. Lehmann, and H. Jasper Lifespan extension by preserving proliferative homeostasis in Drosophila PLoS Genet. 6 2010 e1001159
6. N.D. Bonawitz, M. Chatenay-Lapointe, Y. Pan, and G.S. Shadel Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression Cell Metab. 5 2007 265 277 (Pubitemid 46477854)
7. M. Boyle, C. Wong, M. Rocha, and D.L. Jones Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis Cell Stem Cell 1 2007 470 478 (Pubitemid 47506538)
8. A.H. Brand, and N. Perrimon Targeted gene expression as a means of altering cell fates and generating dominant phenotypes Development 118 1993 401 415 (Pubitemid 23214028)
9. J. Cho, J.H. Hur, and D.W. Walker The role of mitochondria in Drosophila aging Exp. Gerontol. 46 2011 331 334
10. N.H. Choi, J.G. Kim, D.J. Yang, Y.S. Kim, and M.A. Yoo Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor Aging Cell 7 2008 318 334
11. A.E. Civitarese, S. Carling, L.K. Heilbronn, M.H. Hulver, B. Ukropcova, W.A. Deutsch, S.R. Smith, E. Ravussin CALERIE Pennington Team Calorie restriction increases muscle mitochondrial biogenesis in healthy humans PLoS Med. 4 2007 e76
12. L. Cui, H. Jeong, F. Borovecki, C.N. Parkhurst, N. Tanese, and D. Krainc Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration Cell 127 2006 59 69 (Pubitemid 44466642)
13. B. Gershman, O. Puig, L. Hang, R.M. Peitzsch, M. Tatar, and R.S. Garofalo High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO Physiol. Genomics 29 2007 24 34 (Pubitemid 46708759)
14. L. Guarente Mitochondria - a nexus for aging, calorie restriction, and sirtuins? Cell 132 2008 171 176 (Pubitemid 351172441)
15. C. Handschin, Y.M. Kobayashi, S. Chin, P. Seale, K.P. Campbell, and B.M. Spiegelman PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy Genes Dev. 21 2007 770 783 (Pubitemid 46572357)
16. S. Herzig, F. Long, U.S. Jhala, S. Hedrick, R. Quinn, A. Bauer, D. Rudolph, G. Schutz, C. Yoon, and P. Puigserver CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 Nature 413 2001 179 183 (Pubitemid 32867880)
17. C.E. Hochmuth, B. Biteau, D. Bohmann, and H. Jasper Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila Cell Stem Cell 8 2011 188 199
18. K. Ito, A. Hirao, F. Arai, S. Matsuoka, K. Takubo, I. Hamaguchi, K. Nomiyama, K. Hosokawa, K. Sakurada, and N. Nakagata Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells Nature 431 2004 997 1002 (Pubitemid 39434422)
19. M. Katic, A.R. Kennedy, I. Leykin, A. Norris, A. McGettrick, S. Gesta, S.J. Russell, M. Bluher, E. Maratos-Flier, and C.R. Kahn Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice Aging Cell 6 2007 827 839 (Pubitemid 350131051)
20. S.J. Lin, M. Kaeberlein, A.A. Andalis, L.A. Sturtz, P.A. Defossez, V.C. Culotta, G.R. Fink, and L. Guarente Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration Nature 418 2002 344 348 (Pubitemid 34790687)
21. J. Lin, C. Handschin, and B.M. Spiegelman Metabolic control through the PGC-1 family of transcription coactivators Cell Metab. 1 2005 361 370 (Pubitemid 43960626)
22. G.J. Lithgow, and G.A. Walker Stress resistance as a determinate of C. elegans lifespan Mech. Ageing Dev. 123 2002 765 771 (Pubitemid 34178489)
23. G. López-Lluch, N. Hunt, B. Jones, M. Zhu, H. Jamieson, S. Hilmer, M.V. Cascajo, J. Allard, D.K. Ingram, P. Navas, and R. de Cabo Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency Proc. Natl. Acad. Sci. USA 103 2006 1768 1773 (Pubitemid 43228768)
24. D. Mathur, A. Bost, I. Driver, and B. Ohlstein A transient niche regulates the specification of Drosophila intestinal stem cells Science 327 2010 210 213
25. S.A. McCarroll, C.T. Murphy, S. Zou, S.D. Pletcher, C.S. Chin, Y.N. Jan, C. Kenyon, C.I. Bargmann, and H. Li Comparing genomic expression patterns across species identifies shared transcriptional profile in aging Nat. Genet. 36 2004 197 204 (Pubitemid 38174381)
26. C.A. Micchelli, and N. Perrimon Evidence that stem cells reside in the adult Drosophila midgut epithelium Nature 439 2006 475 479 (Pubitemid 43152838)
27. E. Nisoli, C. Tonello, A. Cardile, V. Cozzi, R. Bracale, L. Tedesco, S. Falcone, A. Valerio, O. Cantoni, and E. Clementi Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS Science 310 2005 314 317 (Pubitemid 41457197)
28. B. Ohlstein, and A. Spradling The adult Drosophila posterior midgut is maintained by pluripotent stem cells Nature 439 2006 470 474 (Pubitemid 43152837)
29. E. Owusu-Ansah, and U. Banerjee Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation Nature 461 2009 537 541
30. E. Owusu-Ansah, A. Yavari, S. Mandal, and U. Banerjee Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint Nat. Genet. 40 2008 356 361 (Pubitemid 351311760)
31. J.S. Park, Y.S. Kim, and M.A. Yoo The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila Aging (Albany NY) 1 2009 637 651
32. L. Partridge, D. Gems, and D.J. Withers Sex and death: what is the connection? Cell 120 2005 461 472 (Pubitemid 40269761)
33. L. Poirier, A. Shane, J. Zheng, and L. Seroude Characterization of the Drosophila gene-switch system in aging studies: a cautionary tale Aging Cell 7 2008 758 770
34. P. Puigserver, and B.M. Spiegelman Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator Endocr. Rev. 24 2003 78 90 (Pubitemid 36223280)
35. T.A. Rando Stem cells, ageing and the quest for immortality Nature 441 2006 1080 1086 (Pubitemid 43990720)
36. E. Sahin, S. Colla, M. Liesa, J. Moslehi, F.L. Müller, M. Guo, M. Cooper, D. Kotton, A.J. Fabian, and C. Walkey Telomere dysfunction induces metabolic and mitochondrial compromise Nature 470 2011 359 365
37. R.C. Scarpulla Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator Ann. N Y Acad. Sci. 1147 2008 321 334
38. R.C. Scarpulla Transcriptional paradigms in mammalian mitochondrial biogenesis and function Physiol. Rev. 88 2008 611 638 (Pubitemid 351520089)
39. J. Smith, E. Ladi, M. Mayer-Proschel, and M. Noble Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell Proc. Natl. Acad. Sci. USA 97 2000 10032 10037
40. J. St-Pierre, S. Drori, M. Uldry, J.M. Silvaggi, J. Rhee, S. Jäger, C. Handschin, K. Zheng, J. Lin, and W. Yang Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators Cell 127 2006 397 408 (Pubitemid 44572377)
41. S.K. Tiefenböck, C. Baltzer, N.A. Egli, and C. Frei The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling EMBO J. 29 2010 171 183
42. Z. Tothova, and D.G. Gilliland FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system Cell Stem Cell 1 2007 140 152 (Pubitemid 47215597)
43. D.C. Wallace A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine Annu. Rev. Genet. 39 2005 359 407 (Pubitemid 43011120)
44. L. Wang, and D.L. Jones The effects of aging on stem cell behavior in Drosophila Exp. Gerontol. 46 2011 340 344
45. T. Wenz, F. Diaz, B.M. Spiegelman, and C.T. Moraes Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype Cell Metab. 8 2008 249 256
46. T. Wenz, S.G. Rossi, R.L. Rotundo, B.M. Spiegelman, and C.T. Moraes Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging Proc. Natl. Acad. Sci. USA 106 2009 20405 20410
47. J.C. Yoon, P. Puigserver, G. Chen, J. Donovan, Z. Wu, J. Rhee, G. Adelmant, J. Stafford, C.R. Kahn, and D.K. Granner Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 Nature 413 2001 131 138 (Pubitemid 32867868)
48. J.M. Zahn, R. Sonu, H. Vogel, E. Crane, K. Mazan-Mamczarz, R. Rabkin, R.W. Davis, K.G. Becker, A.B. Owen, and S.K. Kim Transcriptional profiling of aging in human muscle reveals a common aging signature PLoS Genet. 2 2006 e115
49. Y. Zhang, L.W. Castellani, C.J. Sinal, F.J. Gonzalez, and P.A. Edwards Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR Genes Dev. 18 2004 157 169 (Pubitemid 38141784)
50. B. Zheng, Z. Liao, J.J. Locascio, K.A. Lesniak, S.S. Roderick, M.L. Watt, A.C. Eklund, Y. Zhang-James, P.D. Kim, M.A. Hauser Global PD Gene Expression (GPEX) Consortium PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease Sci. Transl. Med. 2 2010 ra73
51. B.M. Zid, A.N. Rogers, S.D. Katewa, M.A. Vargas, M.C. Kolipinski, T.A. Lu, S. Benzer, and P. Kapahi 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila Cell 139 2009 149 160