Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells

Blood

Volumn 118, Issue 11, 2011, Pages 2941-2950

  Yahata, Takashi ^a   Takanashi, Tomomi ^a   Muguruma, Yukari ^a   Ibrahim, Abd Aziz ^a   Matsuzawa, Hideyuki ^a   Uno, Tomoko ^a   Sheng, Yin ^a   Onizuka, Makoto ^a   Ito, Mamoru ^b   Kato, Shunichi ^a   Ando, Kiyoshi ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; DNA; ENZYME INHIBITOR; GLUTATHIONE SYNTHASE; REACTIVE OXYGEN METABOLITE;

ADULT; AGED; ARTICLE; BONE MARROW CELL; CELL AGING; CELL FRACTIONATION; CELL FUNCTION; CELL PROLIFERATION; CELL RENEWAL; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VIVO STUDY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SENESCENCE;

EID: 80052930073     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-01-330050     Document Type: Article

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