-
1
-
-
34548186667
-
Cellular senescence: when bad things happen to good cells
-
Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nature Rev Mol Cell Biol. 2007; 8: 729-740.
-
(2007)
Nature Rev Mol Cell Biol
, vol.8
, pp. 729-740
-
-
Campisi, J.1
d'Adda di Fagagna, F.2
-
2
-
-
70349773104
-
2009. Healing and hurting: molecular mechanisms, functions and pathologies of cellular senescence
-
Adams PD. 2009. Healing and hurting: molecular mechanisms, functions and pathologies of cellular senescence. Mol Cell. 2009; 36: 2-14.
-
(2009)
Mol Cell
, vol.36
, pp. 2-14
-
-
Adams, P.D.1
-
3
-
-
60849127227
-
Cellular senescence, ageing and disease
-
Burton DG. Cellular senescence, ageing and disease. Age. 2009; 31: 1-9.
-
(2009)
Age
, vol.31
, pp. 1-9
-
-
Burton, D.G.1
-
4
-
-
13944270339
-
Senescent cells, tumor suppression and organismal aging: Good citizens, bad neighbors
-
Campisi J. Senescent cells, tumor suppression and organismal aging: Good citizens, bad neighbors. Cell. 2005; 120: 513-522.
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
5
-
-
34447543913
-
Cellular senescence in cancer and aging
-
Collado M, Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell. 2007; 130: 223-233.
-
(2007)
Cell
, vol.130
, pp. 223-233
-
-
Collado, M.1
Blasco, M.A.2
Serrano, M.3
-
6
-
-
0029047362
-
A novel biomarker identifies senescent human cells in culture and in aging skin in vivo
-
Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith OM, Peacocke M, Campisi J. A novel biomarker identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA. 1995; 92: 9363-9367.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
Medrano, E.E.7
Linskens, M.8
Rubelj, I.9
Pereira-Smith, O.M.10
Peacocke, M.11
Campisi, J.12
-
7
-
-
33644692330
-
Cellular senescence in aging primates
-
Herbig U, Ferreira M, Condel L, Carey D, Sedivy JM. Cellular senescence in aging primates. Science. 2006; 311: 1257.
-
(2006)
Science
, vol.311
, pp. 1257
-
-
Herbig, U.1
Ferreira, M.2
Condel, L.3
Carey, D.4
Sedivy, J.M.5
-
8
-
-
33748327046
-
p16 is a robust in vivo biomarker of cellular aging in human skin
-
Ressler S, Bartkova J, Niederegger H, Bartek J, Scharffetter- Kochanek K, Jansen-Durr P, Wlaschek M. p16 is a robust in vivo biomarker of cellular aging in human skin. Aging Cell. 2006; 5: 379-389.
-
(2006)
Aging Cell
, vol.5
, pp. 379-389
-
-
Ressler, S.1
Bartkova, J.2
Niederegger, H.3
Bartek, J.4
Scharffetter-Kochanek, K.5
Jansen-Durr, P.6
Wlaschek, M.7
-
9
-
-
66149167336
-
DNA damage response and cellular senescence in tissues of aging mice
-
Wang C, Jurk D, Maddick M, Nelson G, Martin-Ruiz C, von Zglinicki T. DNA damage response and cellular senescence in tissues of aging mice. Aging Cell. 2009; 8: 311-323.
-
(2009)
Aging Cell
, vol.8
, pp. 311-323
-
-
Wang, C.1
Jurk, D.2
Maddick, M.3
Nelson, G.4
Martin-Ruiz, C.5
von Zglinicki, T.6
-
10
-
-
3042781117
-
Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts
-
Hutter E, Renner K, Pfister G, Stockl P, Jansen-Durr P, Gnaiger E. Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem J. 2004; 380: 919-928.
-
(2004)
Biochem J
, vol.380
, pp. 919-928
-
-
Hutter, E.1
Renner, K.2
Pfister, G.3
Stockl, P.4
Jansen-Durr, P.5
Gnaiger, E.6
-
11
-
-
34547958816
-
Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence
-
Lee S, Jeong SY, Lim WC, Kim S, Park YY, Sun X, Youle RJ, Cho H. Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J Biol Chem. 2007; 282: 22977-22983.
-
(2007)
J Biol Chem
, vol.282
, pp. 22977-22983
-
-
Lee, S.1
Jeong, S.Y.2
Lim, W.C.3
Kim, S.4
Park, Y.Y.5
Sun, X.6
Youle, R.J.7
Cho, H.8
-
12
-
-
0242552555
-
Influence of induced reactive oxygen species in p53-mediated cell fate decisions
-
Macip S, Igarashi M, Berggren P, Yu J, Lee SW, Aaronson SA. Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol Cell Biol. 2003; 23: 8576-8585.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8576-8585
-
-
Macip, S.1
Igarashi, M.2
Berggren, P.3
Yu, J.4
Lee, S.W.5
Aaronson, S.A.6
-
13
-
-
68949096538
-
Mitochondrial dysfunction contributes to oncogeneinduced senescence
-
Moiseeva O, Bourdeau V, Roux A, Deschênes-Simard X, Ferbeyre G. Mitochondrial dysfunction contributes to oncogeneinduced senescence. Mol Cell Biol. 2009; 29: 4495-4507.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 4495-4507
-
-
Moiseeva, O.1
Bourdeau, V.2
Roux, A.3
Deschênes-Simard, X.4
Ferbeyre, G.5
-
14
-
-
76649142385
-
Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1
-
Park YY, Lee S, Karbowski M, Neutzner A, Youle RJ, Cho H. Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1. J Cell Sci. 2010; 123: 619-626.
-
(2010)
J Cell Sci
, vol.123
, pp. 619-626
-
-
Park, Y.Y.1
Lee, S.2
Karbowski, M.3
Neutzner, A.4
Youle, R.J.5
Cho, H.6
-
15
-
-
34249028642
-
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
-
Passos JF, Saretzki G, Ahmed S, Nelson G, Richter T, Peters H, Wappler I, Birket MJ, Harold G, Schaeuble K, Birch-Machin MA, Kirkwood TB, von Zglinicki T. Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol. 2007; 5: e110.
-
(2007)
PLoS Biol
, vol.5
-
-
Passos, J.F.1
Saretzki, G.2
Ahmed, S.3
Nelson, G.4
Richter, T.5
Peters, H.6
Wappler, I.7
Birket, M.J.8
Harold, G.9
Schaeuble, K.10
Birch-Machin, M.A.11
Kirkwood, T.B.12
von Zglinicki, T.13
-
16
-
-
33744988093
-
Sustained inhibition of oxidative phosphorylation impairs cell proliferation and induces premature senescence in human fibroblasts
-
Stockl P, Hutter E, Zwerschke W, Jansen-Durr P. Sustained inhibition of oxidative phosphorylation impairs cell proliferation and induces premature senescence in human fibroblasts. Exp Gerontol. 2006; 41: 674-682.
-
(2006)
Exp Gerontol
, vol.41
, pp. 674-682
-
-
Stockl, P.1
Hutter, E.2
Zwerschke, W.3
Jansen-Durr, P.4
-
17
-
-
0141763944
-
Senescence-enhanced oxidative stress is associated with deficiency of mitochondrial cytochrome c oxidase in vascular endothelial cells
-
Xin MG, Zhang J, Block ER, Patel JM. Senescence-enhanced oxidative stress is associated with deficiency of mitochondrial cytochrome c oxidase in vascular endothelial cells. Mech Ageing Dev. 2003; 124: 911-919.
-
(2003)
Mech Ageing Dev
, vol.124
, pp. 911-919
-
-
Xin, M.G.1
Zhang, J.2
Block, E.R.3
Patel, J.M.4
-
18
-
-
0027082270
-
Role of free radicals in aging and disease
-
Harman D. Role of free radicals in aging and disease. Ann N Y Acad Sci. 1992; 673: 126-141.
-
(1992)
Ann N Y Acad Sci
, vol.673
, pp. 126-141
-
-
Harman, D.1
-
19
-
-
13944278132
-
Mitochondria, oxidants, and aging
-
Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell. 2005; 120: 483-495.
-
(2005)
Cell
, vol.120
, pp. 483-495
-
-
Balaban, R.S.1
Nemoto, S.2
Finkel, T.3
-
20
-
-
43049163718
-
Free radicals and senescence
-
Lu T, Finkel T. Free radicals and senescence. Exp Cell Res. 2008; 314: 1918-1922.
-
(2008)
Exp Cell Res
, vol.314
, pp. 1918-1922
-
-
Lu, T.1
Finkel, T.2
-
21
-
-
67649840689
-
Regulation of superoxide dismutase genes: implications in disease
-
Miao L, St Clair DK. Regulation of superoxide dismutase genes: implications in disease. Free Radic Biol Med. 2009; 47: 344-356.
-
(2009)
Free Radic Biol Med
, vol.47
, pp. 344-356
-
-
Miao, L.1
St Clair, D.K.2
-
22
-
-
0942298545
-
Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice
-
Hinerfeld D, Traini MD, Weinberger RP, Cochran B, Doctrow SR, Harry J, Melov S. Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice. J Neurochem. 2004; 88:657-667.
-
(2004)
J Neurochem
, vol.88
, pp. 657-667
-
-
Hinerfeld, D.1
Traini, M.D.2
Weinberger, R.P.3
Cochran, B.4
Doctrow, S.R.5
Harry, J.6
Melov, S.7
-
23
-
-
0028827252
-
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
-
Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nature Genet. 1995; 11:376-381.
-
(1995)
Nature Genet
, vol.11
, pp. 376-381
-
-
Li, Y.1
Huang, T.T.2
Carlson, E.J.3
Melov, S.4
Ursell, P.C.5
Olson, J.L.6
Noble, L.J.7
Yoshimura, M.P.8
Berger, C.9
Chan, P.H.10
Wallace, D.C.11
Epstein, C.J.12
-
24
-
-
13044285432
-
Mitochondrial disease in superoxide dismutase 2 mutant mice
-
Melov S, Coskun P, Patel M, Tuinstra R, Cottrell B, Jun AS, Zastawny TH, Dizdaroglu M, Goodman SI, Huang TT, Miziorko H, Epstein CJ, Wallace DC. Mitochondrial disease in superoxide dismutase 2 mutant mice. Proc Natl Acad Sci USA. 1999; 96: 846- 851.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 846-851
-
-
Melov, S.1
Coskun, P.2
Patel, M.3
Tuinstra, R.4
Cottrell, B.5
Jun, A.S.6
Zastawny, T.H.7
Dizdaroglu, M.8
Goodman, S.I.9
Huang, T.T.10
Miziorko, H.11
Epstein, C.J.12
Wallace, D.C.13
-
25
-
-
0035503501
-
Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics
-
Melov S, Doctrow SR, Schneider JA, Haberson J, Patel M, Coskun PE, Huffman K, Wallace DC, Malfroy B. Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J. Neurosci. 2001; 21: 8348-8353.
-
(2001)
J. Neurosci.
, vol.21
, pp. 8348-8353
-
-
Melov, S.1
Doctrow, S.R.2
Schneider, J.A.3
Haberson, J.4
Patel, M.5
Coskun, P.E.6
Huffman, K.7
Wallace, D.C.8
Malfroy, B.9
-
26
-
-
1842612108
-
Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts
-
Erratum in: Aging Cell. 2003; 2(6): 343
-
Samper E, Nicholls DG, Melov S. Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts. Aging Cell. 2003; 2:277-285. Erratum in: Aging Cell. 2003; 2(6): 343.
-
(2003)
Aging Cell
, vol.2
, pp. 277-285
-
-
Samper, E.1
Nicholls, D.G.2
Melov, S.3
-
27
-
-
0042195820
-
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
-
Erratum in: Nat Cell Biol. 2003, 5: 839
-
Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol. 2003; 5:741-747. Erratum in: Nat Cell Biol. 2003, 5: 839.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 741-747
-
-
Parrinello, S.1
Samper, E.2
Krtolica, A.3
Goldstein, J.4
Melov, S.5
Campisi, J.6
-
28
-
-
58549087616
-
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence
-
Rai P, Onder TT, Young JJ, McFaline JL, Pang B, Dedon PC, Weinberg RA. Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc Natl Acad Sci U S A. 2009; 106: 169-174.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 169-174
-
-
Rai, P.1
Onder, T.T.2
Young, J.J.3
McFaline, J.L.4
Pang, B.5
Dedon, P.C.6
Weinberg, R.A.7
-
29
-
-
77952243245
-
Role of antioxidants in the skin: anti-aging effects
-
Masaki H. Role of antioxidants in the skin: anti-aging effects. J Dermatol Sci. 2010; 58: 85-90.
-
(2010)
J Dermatol Sci
, vol.58
, pp. 85-90
-
-
Masaki, H.1
-
30
-
-
78649964383
-
Clinical aspects and molecular diagnostics of skin aging
-
Zouboulis CC and Makrantonaki E. Clinical aspects and molecular diagnostics of skin aging. Clin Dermatol. 2011; 29: 3-14.
-
(2011)
Clin Dermatol
, vol.29
, pp. 3-14
-
-
Zouboulis, C.C.1
Makrantonaki, E.2
-
31
-
-
33646946746
-
Senescence-associated betagalactosidase is lysosomal beta-galactosidase
-
Lee BY, Han JA, Im JS, Morrone A, Johung K, Goodwin EC, Kleijer WJ, DiMaio D, Hwang ES. Senescence-associated betagalactosidase is lysosomal beta-galactosidase. Aging Cell. 2006; 5: 187-195.
-
(2006)
Aging Cell
, vol.5
, pp. 187-195
-
-
Lee, B.Y.1
Han, J.A.2
Im, J.S.3
Morrone, A.4
Johung, K.5
Goodwin, E.C.6
Kleijer, W.J.7
DiMaio, D.8
Hwang, E.S.9
-
32
-
-
77149164811
-
Feedback between p21 and reactive oxygen production is necessary for cell senescence
-
Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TB, von Zglinicki T. Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol. 2010; 6: 347
-
(2010)
Mol Syst Biol
, vol.6
, pp. 347
-
-
Passos, J.F.1
Nelson, G.2
Wang, C.3
Richter, T.4
Simillion, C.5
Proctor, C.J.6
Miwa, S.7
Olijslagers, S.8
Hallinan, J.9
Wipat, A.10
Saretzki, G.11
Rudolph, K.L.12
Kirkwood, T.B.13
von Zglinicki, T.14
-
33
-
-
33750510904
-
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence
-
Takahashi A, Ohtani N, Yamakoshi K, Iida S, Tahara H, Nakayama K, Nakayama KI, Ide T, Saya H, Hara E. Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol. 2006; 8: 1291- 1297.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1291-1297
-
-
Takahashi, A.1
Ohtani, N.2
Yamakoshi, K.3
Iida, S.4
Tahara, H.5
Nakayama, K.6
Nakayama, K.I.7
Ide, T.8
Saya, H.9
Hara, E.10
-
34
-
-
0032815110
-
Mouse models of mitochondrial disease, oxidative stress, and senescence
-
Melov S, Coskun PE, Wallace DC. Mouse models of mitochondrial disease, oxidative stress, and senescence. Mutat Res. 1999; 434: 233-242.
-
(1999)
Mutat Res
, vol.434
, pp. 233-242
-
-
Melov, S.1
Coskun, P.E.2
Wallace, D.C.3
-
35
-
-
58949084649
-
Base excision repair of oxidative DNA damage and association with cancer and aging
-
Maynard S, Schurman SH, Harboe C, de Souza-Pinto1 NC, Bohr VA. Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis. 2009; 30: 2- 10.
-
(2009)
Carcinogenesis
, vol.30
, pp. 2-10
-
-
Maynard, S.1
Schurman, S.H.2
Harboe, C.3
de Souza-Pinto1, N.C.4
Bohr, V.A.5
-
36
-
-
45849099050
-
Living on a break: cellular senescence as a DNA-damage response
-
d'Adda di Fagagna F. Living on a break: cellular senescence as a DNA-damage response. Nature Rev Cancer. 2008; 8: 512-522.
-
(2008)
Nature Rev Cancer
, vol.8
, pp. 512-522
-
-
d'Adda di Fagagna, F.1
-
37
-
-
2442511752
-
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
-
Herbig U, Jobling WA, Chen BP, Chen DJ, Sedivy J. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell. 2004; 14: 501-513.
-
(2004)
Mol Cell
, vol.14
, pp. 501-513
-
-
Herbig, U.1
Jobling, W.A.2
Chen, B.P.3
Chen, D.J.4
Sedivy, J.5
-
38
-
-
33846128155
-
The DNA damage signaling pathway is a critical mediator of oncogeneinduced senescence
-
Mallette FA, Gaumont-Leclerc MF, Ferbeyre G. The DNA damage signaling pathway is a critical mediator of oncogeneinduced senescence. Genes Dev. 2007; 21: 43-48.
-
(2007)
Genes Dev
, vol.21
, pp. 43-48
-
-
Mallette, F.A.1
Gaumont-Leclerc, M.F.2
Ferbeyre, G.3
-
39
-
-
69949125332
-
Both telomeric and nontelomeric DNA damage are determinants of mammalian cellular senescence
-
Nakamura AJ, Chiang YJ, Hathcock KS, Horikawa I, Sedelnikova OA, Hodes RJ, Bonner WM. Both telomeric and nontelomeric DNA damage are determinants of mammalian cellular senescence. Epigenetics Chromatin. 2008; 1: 6.
-
(2008)
Epigenetics Chromatin
, vol.1
, pp. 6
-
-
Nakamura, A.J.1
Chiang, Y.J.2
Hathcock, K.S.3
Horikawa, I.4
Sedelnikova, O.A.5
Hodes, R.J.6
Bonner, W.M.7
-
40
-
-
74849091341
-
Pseudo-DNA damage response in senescent cells
-
Pospelova TV, Demidenko ZN, Bukreeva EI, Pospelov VA, Gudkov AV, Blagosklonny MV. Pseudo-DNA damage response in senescent cells. Cell Cycle. 2009; 8: 4112-4118.
-
(2009)
Cell Cycle
, vol.8
, pp. 4112-4118
-
-
Pospelova, T.V.1
Demidenko, Z.N.2
Bukreeva, E.I.3
Pospelov, V.A.4
Gudkov, A.V.5
Blagosklonny, M.V.6
-
41
-
-
68249096784
-
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
-
Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nature Cell Biol. 2009; 11: 973-979.
-
(2009)
Nature Cell Biol
, vol.11
, pp. 973-979
-
-
Rodier, F.1
Coppé, J.P.2
Patil, C.K.3
Hoeijmakers, W.A.4
Muñoz, D.P.5
Raza, S.R.6
Freund, A.7
Campeau, E.8
Davalos, A.R.9
Campisi, J.10
-
42
-
-
1642602686
-
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks
-
Sedelnikova OA, Horikawa I, Zimonjic DB, Popescu NC, Bonner WM, Barrett JC. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nature Cell Biol. 2004; 6: 168-170.
-
(2004)
Nature Cell Biol
, vol.6
, pp. 168-170
-
-
Sedelnikova, O.A.1
Horikawa, I.2
Zimonjic, D.B.3
Popescu, N.C.4
Bonner, W.M.5
Barrett, J.C.6
-
43
-
-
10944257464
-
Human cell senescence as a DNA damage response
-
Von Zglinicki T, Saretzki G, Ladhoff J, d'Adda di Fagagna F, Jackson SP. Human cell senescence as a DNA damage response. Mech Ageing Dev. 2005; 126: 111-117.
-
(2005)
Mech Ageing Dev
, vol.126
, pp. 111-117
-
-
Von Zglinicki, T.1
Saretzki, G.2
Ladhoff, J.3
d'Adda di Fagagna, F.4
Jackson, S.P.5
-
44
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem. 1998; 273: 5858-5868.
-
(1998)
J Biol Chem
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
45
-
-
77953166592
-
GammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization
-
Löbrich M, Shibata A, Beucher A, Fisher A, Ensminger M, Goodarzi AA, Barton O, Jeggo PA. GammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle. 2010; 9: 662-669.
-
(2010)
Cell Cycle
, vol.9
, pp. 662-669
-
-
Löbrich, M.1
Shibata, A.2
Beucher, A.3
Fisher, A.4
Ensminger, M.5
Goodarzi, A.A.6
Barton, O.7
Jeggo, P.A.8
-
46
-
-
33750030758
-
The regulation of INK4/ARF in cancer and aging
-
Kim WY, Sharpless NE. The regulation of INK4/ARF in cancer and aging. Cell. 2006; 127: 265-275.
-
(2006)
Cell
, vol.127
, pp. 265-275
-
-
Kim, W.Y.1
Sharpless, N.E.2
-
47
-
-
84900969225
-
Ink4a/Arf expression is a biomarker of aging
-
Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, Sharpless NE. Ink4a/Arf expression is a biomarker of aging. J Clin Invest. 2004; 114: 1299-1307.
-
(2004)
J Clin Invest
, vol.114
, pp. 1299-1307
-
-
Krishnamurthy, J.1
Torrice, C.2
Ramsey, M.R.3
Kovalev, G.I.4
Al-Regaiey, K.5
Su, L.6
Sharpless, N.E.7
-
48
-
-
58149381936
-
Mitochondrial production of reactive oxygen species: role of complex I and quinone analogues
-
Fato R, Bergamini C, Leoni S, Lenaz G. Mitochondrial production of reactive oxygen species: role of complex I and quinone analogues. Biofactors. 2008; 32: 31-39.
-
(2008)
Biofactors
, vol.32
, pp. 31-39
-
-
Fato, R.1
Bergamini, C.2
Leoni, S.3
Lenaz, G.4
-
49
-
-
73949143673
-
Stress-induced responses of human skin fibroblasts in vitro reflect human longevity
-
Dekker P, Maier AB, van Heemst D, de Koning-Treurniet C, Blom J, Dirks RW, Tanke HJ, Westendorp RG. Stress-induced responses of human skin fibroblasts in vitro reflect human longevity. Aging Cell. 2009; 8: 595-603.
-
(2009)
Aging Cell
, vol.8
, pp. 595-603
-
-
Dekker, P.1
Maier, A.B.2
van Heemst, D.3
de Koning-Treurniet, C.4
Blom, J.5
Dirks, R.W.6
Tanke, H.J.7
Westendorp, R.G.8
-
50
-
-
17144371855
-
The cornified envelope: a model of cell death in the skin
-
Candi E, Schmidt R, Melino G. The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol. 2005; 6: 328-340.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 328-340
-
-
Candi, E.1
Schmidt, R.2
Melino, G.3
-
52
-
-
0027324031
-
Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation
-
Leigh, I. M., Purkis, P. E., Whitehead, P. and Lane, E. B. Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation. Br. J. Dermatol. 1993; 129: 110-119.
-
(1993)
Br. J. Dermatol.
, vol.129
, pp. 110-119
-
-
Leigh, I.M.1
Purkis, P.E.2
Whitehead, P.3
Lane, E.B.4
-
53
-
-
0032998902
-
The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis
-
Jensen UB, Lowell S, Watt FM. The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis. Development. 1999; 126: 2409-2418.
-
(1999)
Development
, vol.126
, pp. 2409-2418
-
-
Jensen, U.B.1
Lowell, S.2
Watt, F.M.3
-
54
-
-
79952599163
-
Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue
-
Treiber N, Maity P, Singh K, Kohn M, Keist AF, Ferchiu F, Sante L, Frese S, Bloch W, Kreppel F, Kochanek S, Sindrilaru A, Iben S, Högel J, Ohnmacht M, Claes LE, Ignatius A, Chung JH, Lee MJ, Kamenisch Y, Berneburg M, Nikolaus T, Braunstein K, Sperfeld AD, Ludolph AC, Briviba K, Wlaschek M, Scharffetter- Kochanek K. Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue. Aging Cell. 2011; 10: 239-254.
-
(2011)
Aging Cell
, vol.10
, pp. 239-254
-
-
Treiber, N.1
Maity, P.2
Singh, K.3
Kohn, M.4
Keist, A.F.5
Ferchiu, F.6
Sante, L.7
Frese, S.8
Bloch, W.9
Kreppel, F.10
Kochanek, S.11
Sindrilaru, A.12
Iben, S.13
Högel, J.14
Ohnmacht, M.15
Claes, L.E.16
Ignatius, A.17
Chung, J.H.18
Lee, M.J.19
Kamenisch, Y.20
Berneburg, M.21
Nikolaus, T.22
Braunstein, K.23
Sperfeld, A.D.24
Ludolph, A.C.25
Briviba, K.26
Wlaschek, M.27
Scharffetter-Kochanek, K.28
more..
-
55
-
-
0030694464
-
Tropospheric ozone: an emerging environmental stress to skin
-
Thiele JJ, Podda M, Packer L. Tropospheric ozone: an emerging environmental stress to skin. Biol Chem. 1997; 378: 1299-1305.
-
(1997)
Biol Chem
, vol.378
, pp. 1299-1305
-
-
Thiele, J.J.1
Podda, M.2
Packer, L.3
-
56
-
-
34247273016
-
Human epidermal keratinocytes accumulate superoxide due to low activity of Mn-SOD, leading to mitochondrial functional impairment
-
Hornig-Do HT, von Kleist-Retzow JC, Lanz K, Wickenhauser C, Kudin AP, Kunz WS, Wiesner RJ, Schauen M. Human epidermal keratinocytes accumulate superoxide due to low activity of Mn-SOD, leading to mitochondrial functional impairment. J Invest Dermatol. 2007; 127: 1084-1093.
-
(2007)
J Invest Dermatol
, vol.127
, pp. 1084-1093
-
-
Hornig-Do, H.T.1
von Kleist-Retzow, J.C.2
Lanz, K.3
Wickenhauser, C.4
Kudin, A.P.5
Kunz, W.S.6
Wiesner, R.J.7
Schauen, M.8
-
57
-
-
67651204282
-
Oxygen deprivation inhibits basal keratinocyte proliferation in a model of human skin and induces regio-specific changes in the distribution of epidermal adherens junction proteins, aquaporin-3, and glycogen
-
Straseski JA, Gibson AL, Thomas-Virnig CL, Allen-Hoffmann BL. Oxygen deprivation inhibits basal keratinocyte proliferation in a model of human skin and induces regio-specific changes in the distribution of epidermal adherens junction proteins, aquaporin-3, and glycogen. Wound Repair Regen. 2009; 17: 606- 616.
-
(2009)
Wound Repair Regen
, vol.17
, pp. 606-616
-
-
Straseski, J.A.1
Gibson, A.L.2
Thomas-Virnig, C.L.3
Allen-Hoffmann, B.L.4
-
58
-
-
0343740254
-
The effect of age on mitosis in the human epidermis
-
Thuringer JM, Katzberg AA. The effect of age on mitosis in the human epidermis. J Invest Dermatol. 1959; 33: 35-39.
-
(1959)
J Invest Dermatol
, vol.33
, pp. 35-39
-
-
Thuringer, J.M.1
Katzberg, A.A.2
-
59
-
-
37249009271
-
Motif module map reveals enforcement of aging by continual NF-kappaB activity
-
Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E, Chang HY. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev. 2007; 21: 3244-3257.
-
(2007)
Genes Dev
, vol.21
, pp. 3244-3257
-
-
Adler, A.S.1
Sinha, S.2
Kawahara, T.L.3
Zhang, J.Y.4
Segal, E.5
Chang, H.Y.6
-
60
-
-
70350043754
-
Aging epidermis is maintained by changes in transit-amplifying cell kinetics, not stem cell kinetics
-
Winter MC, Bickenbach JR. Aging epidermis is maintained by changes in transit-amplifying cell kinetics, not stem cell kinetics. J Invest Dermatol. 2009; 129: 2541-2543.
-
(2009)
J Invest Dermatol
, vol.129
, pp. 2541-2543
-
-
Winter, M.C.1
Bickenbach, J.R.2
-
61
-
-
0001214436
-
Distinction between differentiation and senescence and the absence of increased apoptosis in human keratinocytes undergoing cellular aging in vitro
-
Norsgaard H, Clark BF, Rattan SI. Distinction between differentiation and senescence and the absence of increased apoptosis in human keratinocytes undergoing cellular aging in vitro. Exp Gerontol. 1996; 31: 563-570.
-
(1996)
Exp Gerontol
, vol.31
, pp. 563-570
-
-
Norsgaard, H.1
Clark, B.F.2
Rattan, S.I.3
-
62
-
-
79951912532
-
Four faces of cellular senescence
-
Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol. 2011; 192: 547-556.
-
(2011)
J Cell Biol
, vol.192
, pp. 547-556
-
-
Rodier, F.1
Campisi, J.2
-
63
-
-
0018865014
-
Calcium regulation of growth and differentiation of mouse epidermal cells in culture
-
Hennings H, Michael D, Cheng C, Steinert P, Holbrook K, Yuspa SH. Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell. 1980; 19: 245-254.
-
(1980)
Cell
, vol.19
, pp. 245-254
-
-
Hennings, H.1
Michael, D.2
Cheng, C.3
Steinert, P.4
Holbrook, K.5
Yuspa, S.H.6
-
64
-
-
10744233396
-
Terminal differentiation of human epidermal keratinocytes involves mitochondria- and caspase-dependent cell death pathway
-
Allombert-Blaise C, Tamiji S, Mortier L, Fauvel H, Tual M, Delaporte E, Piette F, DeLassale EM, Formstecher P, Marchetti P, Polakowska R. Terminal differentiation of human epidermal keratinocytes involves mitochondria- and caspase-dependent cell death pathway. Cell Death Differ. 2003; 10: 850-852.
-
(2003)
Cell Death Differ
, vol.10
, pp. 850-852
-
-
Allombert-Blaise, C.1
Tamiji, S.2
Mortier, L.3
Fauvel, H.4
Tual, M.5
Delaporte, E.6
Piette, F.7
DeLassale, E.M.8
Formstecher, P.9
Marchetti, P.10
Polakowska, R.11
-
65
-
-
27744601467
-
Induction of apoptosis-like mitochondrial impairment triggers antioxidant and Bcl-2-dependent keratinocyte differentiation
-
Tamiji S, Beauvillain JC, Mortier L, Jouy N, Tual M, Delaporte E, Formstecher P, Marchetti P, Polakowska R. Induction of apoptosis-like mitochondrial impairment triggers antioxidant and Bcl-2-dependent keratinocyte differentiation. J Invest Dermatol. 2005; 125: 647-658.
-
(2005)
J Invest Dermatol
, vol.125
, pp. 647-658
-
-
Tamiji, S.1
Beauvillain, J.C.2
Mortier, L.3
Jouy, N.4
Tual, M.5
Delaporte, E.6
Formstecher, P.7
Marchetti, P.8
Polakowska, R.9
-
66
-
-
43149084824
-
Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice
-
Lichti U, Anders J, Yuspa SH. Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice. Nat Protoc. 2008; 3: 799-810.
-
(2008)
Nat Protoc
, vol.3
, pp. 799-810
-
-
Lichti, U.1
Anders, J.2
Yuspa, S.H.3
|