-
1
-
-
0035093737
-
DNA double-strand breaks: Signaling, repair and the cancer connection
-
Khanna, K.K. and Jackson, S.P. (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet., 27, 247-254.
-
(2001)
Nat. Genet.
, vol.27
, pp. 247-254
-
-
Khanna, K.K.1
Jackson, S.P.2
-
2
-
-
0034641963
-
Defying death after DNA damage
-
Rich, T., Allen, R.L. and Wyllie, A.H. (2000) Defying death after DNA damage. Nature, 407, 777-783.
-
(2000)
Nature
, vol.407
, pp. 777-783
-
-
Rich, T.1
Allen, R.L.2
Wyllie, A.H.3
-
3
-
-
72949119310
-
Complex landscapes of somatic rearrangement in human breast cancer genomes
-
Stephens, P.J., McBride, D.J., Lin, M.-L., Varela, I., Pleasance, E.D., Simpson, J.T., Stebbings, L.A., Leroy, C., Edkins, S., Mudie, L.J. et al. (2009) Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature, 462, 1005-1010.
-
(2009)
Nature
, vol.462
, pp. 1005-1010
-
-
Stephens, P.J.1
McBride, D.J.2
Lin, M.-L.3
Varela, I.4
Pleasance, E.D.5
Simpson, J.T.6
Stebbings, L.A.7
Leroy, C.8
Edkins, S.9
Mudie, L.J.10
-
4
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein, B., Papadopoulos, N., Velculescu, V.E., Zhou, S., Diaz, L.A. and Kinzler, K.W. (2013) Cancer genome landscapes. Science, 339, 1546-1558.
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
Papadopoulos, N.2
Velculescu, V.E.3
Zhou, S.4
Diaz, L.A.5
Kinzler, K.W.6
-
5
-
-
0035802180
-
Cancer, DNA repair mechanisms, and resistance to chemotherapy
-
Fojo, T. (2001) Cancer, DNA repair mechanisms, and resistance to chemotherapy. J. Natl. Cancer Inst., 93, 1434-1436.
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 1434-1436
-
-
Fojo, T.1
-
6
-
-
84856019858
-
The DNA damage response and cancer therapy
-
Lord, C.J. and Ashworth, A. (2012) The DNA damage response and cancer therapy. Nature, 481, 287-294.
-
(2012)
Nature
, vol.481
, pp. 287-294
-
-
Lord, C.J.1
Ashworth, A.2
-
7
-
-
78649336706
-
The DNA damage response: Making it safe to play with knives
-
Ciccia, A. and Elledge, S.J. (2010) The DNA damage response: making it safe to play with knives. Mol. Cell, 40, 179-204.
-
(2010)
Mol. Cell
, vol.40
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
8
-
-
84882450932
-
Various modes of cell death induced by DNA damage
-
Surova, O. and Zhivotovsky, B. (2013) Various modes of cell death induced by DNA damage. Oncogene, 32, 3789-3797.
-
(2013)
Oncogene
, vol.32
, pp. 3789-3797
-
-
Surova, O.1
Zhivotovsky, B.2
-
9
-
-
84875423827
-
The ATM protein kinase: Regulating the cellular response to genotoxic stress, and more
-
Shiloh, Y. and Ziv, Y. (2013) The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat. Rev. Mol. Cell Biol., 14, 197-210.
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 197-210
-
-
Shiloh, Y.1
Ziv, Y.2
-
10
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham, R.T. (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev., 15, 2177-2196.
-
(2001)
Genes Dev.
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
11
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
Matsuoka, S., Ballif, B.A., Smogorzewska, A., McDonald, E.R., Hurov, K.E., Luo, J., Bakalarski, C.E., Zhao, Z., Solimini, N., Lerenthal, Y. et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science, 316, 1160-1166.
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
McDonald, E.R.4
Hurov, K.E.5
Luo, J.6
Bakalarski, C.E.7
Zhao, Z.8
Solimini, N.9
Lerenthal, Y.10
-
12
-
-
78649938817
-
ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage
-
Bensimon, A., Schmidt, A., Ziv, Y., Elkon, R., Wang, S.-Y., Chen, D.J., Aebersold, R. and Shiloh, Y. (2010) ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Sci. Signal, 3, rs3.
-
(2010)
Sci. Signal
, vol.3
-
-
Bensimon, A.1
Schmidt, A.2
Ziv, Y.3
Elkon, R.4
Wang, S.-Y.5
Chen, D.J.6
Aebersold, R.7
Shiloh, Y.8
-
13
-
-
77953148666
-
Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response
-
Bennetzen, M.V., Larsen, D.H., Bunkenborg, J., Bartek, J., Lukas, J. and Andersen, J.S. (2010) Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response. Mol. Cell. Proteomics, 9, 1314-1323.
-
(2010)
Mol. Cell. Proteomics
, vol.9
, pp. 1314-1323
-
-
Bennetzen, M.V.1
Larsen, D.H.2
Bunkenborg, J.3
Bartek, J.4
Lukas, J.5
Andersen, J.S.6
-
14
-
-
77958498222
-
The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
-
Smith, J., Tho, L.M., Xu, N. and Gillespie, D.A. (2010) The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv. Cancer Res., 108, 73-112.
-
(2010)
Adv. Cancer Res.
, vol.108
, pp. 73-112
-
-
Smith, J.1
Tho, L.M.2
Xu, N.3
Gillespie, D.A.4
-
15
-
-
0026656853
-
Wild-type p53 is a cell cycle checkpoint determinant following irradiation
-
Kuerbitz, S.J., Plunkett, B.S., Walsh, W.V. and Kastan, M.B. (1992) Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. U.S.A., 89, 7491-7495.
-
(1992)
Proc. Natl. Acad. Sci. U.S.A.
, vol.89
, pp. 7491-7495
-
-
Kuerbitz, S.J.1
Plunkett, B.S.2
Walsh, W.V.3
Kastan, M.B.4
-
16
-
-
0029103598
-
P53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage
-
Macleod, K.F., Sherry, N., Hannon, G., Beach, D., Tokino, T., Kinzler, K., Vogelstein, B. and Jacks, T. (1995) p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev., 9, 935-944.
-
(1995)
Genes Dev.
, vol.9
, pp. 935-944
-
-
MacLeod, K.F.1
Sherry, N.2
Hannon, G.3
Beach, D.4
Tokino, T.5
Kinzler, K.6
Vogelstein, B.7
Jacks, T.8
-
17
-
-
11344286593
-
MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation
-
Manke, I.A., Nguyen, A., Lim, D., Stewart, M.Q., Elia, A.E.H. and Yaffe, M.B. (2005) MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol. Cell, 17, 37-48.
-
(2005)
Mol. Cell
, vol.17
, pp. 37-48
-
-
Manke, I.A.1
Nguyen, A.2
Lim, D.3
Stewart, M.Q.4
Elia, A.E.H.5
Yaffe, M.B.6
-
18
-
-
84878639159
-
UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway
-
Warmerdam, D.O., Brinkman, E.K., Marteijn, J.A., Medema, R.H., Kanaar, R. and Smits, V.A.J. (2013) UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway. J. Cell Sci., 126, 1923-1930.
-
(2013)
J. Cell Sci.
, vol.126
, pp. 1923-1930
-
-
Warmerdam, D.O.1
Brinkman, E.K.2
Marteijn, J.A.3
Medema, R.H.4
Kanaar, R.5
Smits, V.A.J.6
-
19
-
-
78650087114
-
A positive role for c-Abl in Atm and Atr activation in DNA damage response
-
Wang, X., Zeng, L., Wang, J., Chau, J.F.L., Lai, K.P., Jia, D., Poonepalli, A., Hande, M.P., Liu, H., He, G. et al. (2011) A positive role for c-Abl in Atm and Atr activation in DNA damage response. Cell Death Differ., 18, 5-15.
-
(2011)
Cell Death Differ.
, vol.18
, pp. 5-15
-
-
Wang, X.1
Zeng, L.2
Wang, J.3
Chau, J.F.L.4
Lai, K.P.5
Jia, D.6
Poonepalli, A.7
Hande, M.P.8
Liu, H.9
He, G.10
-
20
-
-
84878677036
-
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling
-
Kaidi, A. and Jackson, S.P. (2013) KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. Nature, 498, 70-74.
-
(2013)
Nature
, vol.498
, pp. 70-74
-
-
Kaidi, A.1
Jackson, S.P.2
-
21
-
-
84870218588
-
DNA repair dysregulation from cancer driver to therapeutic target
-
Curtin, N.J. (2012) DNA repair dysregulation from cancer driver to therapeutic target. Nat. Rev. Cancer, 12, 801-817.
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 801-817
-
-
Curtin, N.J.1
-
22
-
-
84862491113
-
Mechanisms for recurrent and complex human genomic rearrangements
-
Liu, P., Carvalho, C.M.B., Hastings, P.J. and Lupski, J.R. (2012) Mechanisms for recurrent and complex human genomic rearrangements. Curr. Opin. Genet. Dev., 22, 211-220.
-
(2012)
Curr. Opin. Genet. Dev.
, vol.22
, pp. 211-220
-
-
Liu, P.1
Carvalho, C.M.B.2
Hastings, P.J.3
Lupski, J.R.4
-
23
-
-
77957123627
-
Pathways of mammalian replication fork restart
-
Petermann, E. and Helleday, T. (2010) Pathways of mammalian replication fork restart. Nat. Rev. Mol. Cell Biol., 11, 683-687.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 683-687
-
-
Petermann, E.1
Helleday, T.2
-
24
-
-
84873320525
-
Mechanisms of programmed DNA lesions and genomic instability in the immune system
-
Alt, F.W., Zhang, Y., Meng, F.-L., Guo, C. and Schwer, B. (2013) Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell, 152, 417-429.
-
(2013)
Cell
, vol.152
, pp. 417-429
-
-
Alt, F.W.1
Zhang, Y.2
Meng, F.-L.3
Guo, C.4
Schwer, B.5
-
25
-
-
84875198804
-
Chromatin remodeling at DNA double-strand breaks
-
Price, B.D. and D'Andrea, A.D. (2013) Chromatin remodeling at DNA double-strand breaks. Cell, 152, 1344-1354.
-
(2013)
Cell
, vol.152
, pp. 1344-1354
-
-
Price, B.D.1
D'Andrea, A.D.2
-
26
-
-
84866935347
-
The heterochromatic barrier to DNA double strand break repair: How to get the entry visa
-
Goodarzi, A.A. and Jeggo, P.A. (2012) The heterochromatic barrier to DNA double strand break repair: how to get the entry visa. Int. J. Mol. Sci., 13, 11844-11860.
-
(2012)
Int. J. Mol. Sci.
, vol.13
, pp. 11844-11860
-
-
Goodarzi, A.A.1
Jeggo, P.A.2
-
27
-
-
79959947909
-
Chromatin response to DNA double-strand break damage
-
Bao, Y. (2011) Chromatin response to DNA double-strand break damage. Epigenomics, 3, 307-321.
-
(2011)
Epigenomics
, vol.3
, pp. 307-321
-
-
Bao, Y.1
-
28
-
-
78649349810
-
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
-
Chou, D.M., Adamson, B., Dephoure, N.E., Tan, X., Nottke, A.C., Hurov, K.E., Gygi, S.P., Colaiácovo, M.P. and Elledge, S.J. (2010) A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc. Natl. Acad. Sci. U.S.A., 107, 18475-18480.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 18475-18480
-
-
Chou, D.M.1
Adamson, B.2
Dephoure, N.E.3
Tan, X.4
Nottke, A.C.5
Hurov, K.E.6
Gygi, S.P.7
Colaiácovo, M.P.8
Elledge, S.J.9
-
29
-
-
69949123856
-
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1
-
Ahel, D., Horejsí, Z., Wiechens, N., Polo, S.E., Garcia-Wilson, E., Ahel, I., Flynn, H., Skehel, M., West, S.C., Jackson, S.P. et al. (2009) Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science, 325, 1240-1243.
-
(2009)
Science
, vol.325
, pp. 1240-1243
-
-
Ahel, D.1
Horejsí, Z.2
Wiechens, N.3
Polo, S.E.4
Garcia-Wilson, E.5
Ahel, I.6
Flynn, H.7
Skehel, M.8
West, S.C.9
Jackson, S.P.10
-
30
-
-
69549083315
-
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler
-
Gottschalk, A.J., Timinszky, G., Kong, S.E., Jin, J., Cai, Y., Swanson, S.K., Washburn, M.P., Florens, L., Ladurner, A.G., Conaway, J.W. et al. (2009) Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler. Proc. Natl. Acad. Sci. U.S.A., 106, 13770-13774.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 13770-13774
-
-
Gottschalk, A.J.1
Timinszky, G.2
Kong, S.E.3
Jin, J.4
Cai, Y.5
Swanson, S.K.6
Washburn, M.P.7
Florens, L.8
Ladurner, A.G.9
Conaway, J.W.10
-
31
-
-
84861895067
-
A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure
-
Luijsterburg, M.S., Acs, K., Ackermann, L., Wiegant, W.W., Bekker-Jensen, S., Larsen, D.H., Khanna, K.K., van Attikum, H., Mailand, N. and Dantuma, N.P. (2012) A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure. EMBO J., 31, 2511-2527.
-
(2012)
EMBO J.
, vol.31
, pp. 2511-2527
-
-
Luijsterburg, M.S.1
Acs, K.2
Ackermann, L.3
Wiegant, W.W.4
Bekker-Jensen, S.5
Larsen, D.H.6
Khanna, K.K.7
Van Attikum, H.8
Mailand, N.9
Dantuma, N.P.10
-
32
-
-
77957748289
-
BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair
-
Ismail, I.H., Andrin, C., McDonald, D. and Hendzel, M.J. (2010) BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair. J. Cell Biol., 191, 45-60.
-
(2010)
J. Cell Biol.
, vol.191
, pp. 45-60
-
-
Ismail, I.H.1
Andrin, C.2
McDonald, D.3
Hendzel, M.J.4
-
33
-
-
79956086415
-
BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair
-
Ginjala, V., Nacerddine, K., Kulkarni, A., Oza, J., Hill, S.J., Yao, M., Citterio, E., van Lohuizen, M. and Ganesan, S. (2011) BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair. Mol. Cell. Biol., 31, 1972-1982.
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 1972-1982
-
-
Ginjala, V.1
Nacerddine, K.2
Kulkarni, A.3
Oza, J.4
Hill, S.J.5
Yao, M.6
Citterio, E.7
Van Lohuizen, M.8
Ganesan, S.9
-
34
-
-
84884201421
-
A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks
-
Ismail, I.H., McDonald, D., Strickfaden, H., Xu, Z. and Hendzel, M.J. (2013) A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks. J. Biol. Chem., 288, 26944-26954.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 26944-26954
-
-
Ismail, I.H.1
McDonald, D.2
Strickfaden, H.3
Xu, Z.4
Hendzel, M.J.5
-
35
-
-
77957738825
-
The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair
-
Xu, Y., Sun, Y., Jiang, X., Ayrapetov, M.K., Moskwa, P., Yang, S., Weinstock, D.M. and Price, B.D. (2010) The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. J. Cell Biol., 191, 31-43.
-
(2010)
J. Cell Biol.
, vol.191
, pp. 31-43
-
-
Xu, Y.1
Sun, Y.2
Jiang, X.3
Ayrapetov, M.K.4
Moskwa, P.5
Yang, S.6
Weinstock, D.M.7
Price, B.D.8
-
36
-
-
84870904979
-
Histone H2A.Z controls a critical chromatin remodeling step required for DNA double-strand break repair
-
Xu, Y., Ayrapetov, M.K., Xu, C., Gursoy-Yuzugullu, O., Hu, Y. and Price, B.D. (2012) Histone H2A.Z controls a critical chromatin remodeling step required for DNA double-strand break repair. Mol. Cell, 48, 723-733.
-
(2012)
Mol. Cell
, vol.48
, pp. 723-733
-
-
Xu, Y.1
Ayrapetov, M.K.2
Xu, C.3
Gursoy-Yuzugullu, O.4
Hu, Y.5
Price, B.D.6
-
37
-
-
77953495958
-
Tip60: Connecting chromatin to DNA damage signaling
-
Sun, Y., Jiang, X. and Price, B.D. (2010) Tip60: connecting chromatin to DNA damage signaling. Cell Cycle, 9, 930-936.
-
(2010)
Cell Cycle
, vol.9
, pp. 930-936
-
-
Sun, Y.1
Jiang, X.2
Price, B.D.3
-
38
-
-
79951974992
-
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks
-
Moyal, L., Lerenthal, Y., Gana-Weisz, M., Mass, G., So, S., Wang, S.-Y., Eppink, B., Chung, Y.M., Shalev, G., Shema, E. et al. (2011) Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol. Cell, 41, 529-542.
-
(2011)
Mol. Cell
, vol.41
, pp. 529-542
-
-
Moyal, L.1
Lerenthal, Y.2
Gana-Weisz, M.3
Mass, G.4
So, S.5
Wang, S.-Y.6
Eppink, B.7
Chung, Y.M.8
Shalev, G.9
Shema, E.10
-
39
-
-
84856107676
-
The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination
-
Hahn, M.A., Dickson, K.-A., Jackson, S., Clarkson, A., Gill, A.J. and Marsh, D.J. (2012) The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination. Hum. Mol. Genet., 21, 559-568.
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 559-568
-
-
Hahn, M.A.1
Dickson, K.-A.2
Jackson, S.3
Clarkson, A.4
Gill, A.J.5
Marsh, D.J.6
-
40
-
-
84856691330
-
A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20
-
Blank, M., Tang, Y., Yamashita, M., Burkett, S.S., Cheng, S.Y. and Zhang, Y.E. (2012) A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. Nat. Med., 18, 227-234.
-
(2012)
Nat. Med.
, vol.18
, pp. 227-234
-
-
Blank, M.1
Tang, Y.2
Yamashita, M.3
Burkett, S.S.4
Cheng, S.Y.5
Zhang, Y.E.6
-
41
-
-
77955841725
-
The MRN complex in double-strand break repair and telomere maintenance
-
Lamarche, B.J., Orazio, N.I. and Weitzman, M.D. (2010) The MRN complex in double-strand break repair and telomere maintenance. FEBS Lett., 584, 3682-3695.
-
(2010)
FEBS Lett.
, vol.584
, pp. 3682-3695
-
-
Lamarche, B.J.1
Orazio, N.I.2
Weitzman, M.D.3
-
43
-
-
70449518412
-
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
-
Sun, Y., Jiang, X., Xu, Y., Ayrapetov, M.K., Moreau, L.A., Whetstine, J.R. and Price, B.D. (2009) Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nat. Cell Biol., 11, 1376-1382.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1376-1382
-
-
Sun, Y.1
Jiang, X.2
Xu, Y.3
Ayrapetov, M.K.4
Moreau, L.A.5
Whetstine, J.R.6
Price, B.D.7
-
44
-
-
24944516931
-
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
-
Sun, Y., Jiang, X., Chen, S., Fernandes, N. and Price, B.D. (2005) A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc. Natl. Acad. Sci. U.S.A., 102, 13182-13187.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 13182-13187
-
-
Sun, Y.1
Jiang, X.2
Chen, S.3
Fernandes, N.4
Price, B.D.5
-
45
-
-
80052273503
-
ATM protein kinase: The linchpin of cellular defenses to stress
-
Bhatti, S., Kozlov, S., Farooqi, A.A., Naqi, A., Lavin, M. and Khanna, K.K. (2011) ATM protein kinase: the linchpin of cellular defenses to stress. Cell. Mol. Life Sci., 68, 2977-3006.
-
(2011)
Cell. Mol. Life Sci.
, vol.68
, pp. 2977-3006
-
-
Bhatti, S.1
Kozlov, S.2
Farooqi, A.A.3
Naqi, A.4
Lavin, M.5
Khanna, K.K.6
-
46
-
-
65149084552
-
Crosstalk between histone modifications during the DNA damage response
-
van Attikum, H. and Gasser, S.M. (2009) Crosstalk between histone modifications during the DNA damage response. Trends Cell Biol., 19, 207-217.
-
(2009)
Trends Cell Biol.
, vol.19
, pp. 207-217
-
-
Van Attikum, H.1
Gasser, S.M.2
-
47
-
-
84858147489
-
Ubiquitin and SUMO in DNA repair at a glance
-
Ulrich, H.D. (2012) Ubiquitin and SUMO in DNA repair at a glance. J. Cell Sci., 125, 249-254.
-
(2012)
J. Cell Sci.
, vol.125
, pp. 249-254
-
-
Ulrich, H.D.1
-
48
-
-
84883492690
-
It takes two to tango: Ubiquitin and SUMO in the DNA damage response
-
Bologna, S. and Ferrari, S. (2013) It takes two to tango: Ubiquitin and SUMO in the DNA damage response. Front Genet., 4, 106.
-
(2013)
Front Genet.
, vol.4
, pp. 106
-
-
Bologna, S.1
Ferrari, S.2
-
49
-
-
42449115711
-
Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin
-
Spycher, C., Miller, E.S., Townsend, K., Pavic, L., Morrice, N.A., Janscak, P., Stewart, G.S. and Stucki, M. (2008) Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. J. Cell Biol., 181, 227-240.
-
(2008)
J. Cell Biol.
, vol.181
, pp. 227-240
-
-
Spycher, C.1
Miller, E.S.2
Townsend, K.3
Pavic, L.4
Morrice, N.A.5
Janscak, P.6
Stewart, G.S.7
Stucki, M.8
-
50
-
-
48649100438
-
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
-
Chapman, J.R. and Jackson, S.P. (2008) Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage. EMBO Rep., 9, 795-801.
-
(2008)
EMBO Rep.
, vol.9
, pp. 795-801
-
-
Chapman, J.R.1
Jackson, S.P.2
-
51
-
-
84883506815
-
Put a RING on it: Regulation and inhibition of RNF8 and RNF168 RING finger E3 ligases at DNA damage sites
-
Bartocci, C. and Denchi, E.L. (2013) Put a RING on it: regulation and inhibition of RNF8 and RNF168 RING finger E3 ligases at DNA damage sites. Front Genet., 4, 128.
-
(2013)
Front Genet.
, vol.4
, pp. 128
-
-
Bartocci, C.1
Denchi, E.L.2
-
52
-
-
84903124095
-
Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair
-
doi:10.1016/j.tcb.2014.01.005
-
Zhao, Y, Brickner, JR, Majid, MC and N, Mosammaparast(2014). Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair. Trends Cell Biol, doi:10.1016/j.tcb.2014.01.005.
-
(2014)
Trends Cell Biol
-
-
Zhao, Y.1
Brickner, J.R.2
Majid, M.C.3
Mosammaparast, N.4
-
53
-
-
79952235291
-
Dynamics of DNA damage response proteins at DNA breaks: A focus on protein modifications
-
Polo, S.E. and Jackson, S.P. (2011) Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev., 25, 409-433.
-
(2011)
Genes Dev.
, vol.25
, pp. 409-433
-
-
Polo, S.E.1
Jackson, S.P.2
-
54
-
-
84877803084
-
To spread or not to spread-chromatin modifications in response to DNA damage
-
Altmeyer, M. and Lukas, J. (2013) To spread or not to spread-chromatin modifications in response to DNA damage. Curr. Opin. Genet. Dev., 23, 156-165.
-
(2013)
Curr. Opin. Genet. Dev.
, vol.23
, pp. 156-165
-
-
Altmeyer, M.1
Lukas, J.2
-
55
-
-
84862986431
-
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
-
Bekker-Jensen, S., Rendtlew Danielsen, J., Fugger, K., Gromova, I., Nerstedt, A., Lukas, C., Bartek, J., Lukas, J. and Mailand, N. (2010) HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes. Nat. Cell Biol., 12, 80-86.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 80-86
-
-
Bekker-Jensen, S.1
Rendtlew Danielsen, J.2
Fugger, K.3
Gromova, I.4
Nerstedt, A.5
Lukas, C.6
Bartek, J.7
Lukas, J.8
Mailand, N.9
-
56
-
-
84861941745
-
DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger
-
Danielsen, J.R., Povlsen, L.K., Villumsen, B.H., Streicher, W., Nilsson, J., Wikström, M., Bekker-Jensen, S. and Mailand, N. (2012) DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger. J. Cell Biol., 197, 179-187.
-
(2012)
J. Cell Biol.
, vol.197
, pp. 179-187
-
-
Danielsen, J.R.1
Povlsen, L.K.2
Villumsen, B.H.3
Streicher, W.4
Nilsson, J.5
Wikström, M.6
Bekker-Jensen, S.7
Mailand, N.8
-
57
-
-
77950958141
-
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
-
Bunting, S.F., Callen, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L. et al. (2010) 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell, 141, 243-254.
-
(2010)
Cell
, vol.141
, pp. 243-254
-
-
Bunting, S.F.1
Callen, E.2
Wong, N.3
Chen, H.-T.4
Polato, F.5
Gunn, A.6
Bothmer, A.7
Feldhahn, N.8
Fernandez-Capetillo, O.9
Cao, L.10
-
58
-
-
77953291328
-
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
-
Bouwman, P., Aly, A., Escandell, J.M., Pieterse, M., Bartkova, J., van der Gulden, H., Hiddingh, S., Thanasoula, M., Kulkarni, A., Yang, Q. et al. (2010) 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat. Struct. Mol. Biol., 17, 688-695.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 688-695
-
-
Bouwman, P.1
Aly, A.2
Escandell, J.M.3
Pieterse, M.4
Bartkova, J.5
Van Der-Gulden, H.6
Hiddingh, S.7
Thanasoula, M.8
Kulkarni, A.9
Yang, Q.10
-
59
-
-
84873050707
-
BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells
-
Grotsky, D.A., Gonzalez-Suarez, I., Novell, A., Neumann, M.A., Yaddanapudi, S.C., Croke, M., Martinez-Alonso, M., Redwood, A.B., Ortega-Martinez, S., Feng, Z. et al., (2013) BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells. J. Cell Biol., 200, 187-202.
-
(2013)
J. Cell Biol.
, vol.200
, pp. 187-202
-
-
Grotsky, D.A.1
Gonzalez-Suarez, I.2
Novell, A.3
Neumann, M.A.4
Yaddanapudi, S.C.5
Croke, M.6
Martinez-Alonso, M.7
Redwood, A.B.8
Ortega-Martinez, S.9
Feng, Z.10
-
60
-
-
29944434644
-
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes
-
Greenberg, R.A., Sobhian, B., Pathania, S., Cantor, S.B., Nakatani, Y. and Livingston, D.M. (2006) Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev., 20, 34-46.
-
(2006)
Genes Dev.
, vol.20
, pp. 34-46
-
-
Greenberg, R.A.1
Sobhian, B.2
Pathania, S.3
Cantor, S.B.4
Nakatani, Y.5
Livingston, D.M.6
-
61
-
-
75149189204
-
BRCA1 and its toolbox for the maintenance of genome integrity
-
Huen, M.S.Y., Sy, S.M.H. and Chen, J. (2010) BRCA1 and its toolbox for the maintenance of genome integrity. Nat. Rev. Mol. Cell Biol., 11, 138-148.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 138-148
-
-
Huen, M.S.Y.1
Sy, S.M.H.2
Chen, J.3
-
62
-
-
80053108088
-
BRCA1 A-complex fine tunes repair functions of BRCA1
-
Harris, J.L. and Khanna, K.K. (2011) BRCA1 A-complex fine tunes repair functions of BRCA1. Aging (Albany N.Y.), 3, 461-463.
-
(2011)
Aging (Albany N.Y.)
, vol.3
, pp. 461-463
-
-
Harris, J.L.1
Khanna, K.K.2
-
63
-
-
34249949779
-
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites
-
Sobhian, B., Shao, G., Lilli, D.R., Culhane, A.C., Moreau, L.A., Xia, B., Livingston, D.M. and Greenberg, R.A. (2007) RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science, 316, 1198-1202.
-
(2007)
Science
, vol.316
, pp. 1198-1202
-
-
Sobhian, B.1
Shao, G.2
Lilli, D.R.3
Culhane, A.C.4
Moreau, L.A.5
Xia, B.6
Livingston, D.M.7
Greenberg, R.A.8
-
64
-
-
34249946686
-
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
-
Wang, B., Matsuoka, S., Ballif, B.A., Zhang, D., Smogorzewska, A., Gygi, S.P. and Elledge, S.J. (2007) Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science, 316, 1194-1198.
-
(2007)
Science
, vol.316
, pp. 1194-1198
-
-
Wang, B.1
Matsuoka, S.2
Ballif, B.A.3
Zhang, D.4
Smogorzewska, A.5
Gygi, S.P.6
Elledge, S.J.7
-
65
-
-
34249950879
-
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response
-
Kim, H., Chen, J. and Yu, X. (2007) Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science, 316, 1202-1205.
-
(2007)
Science
, vol.316
, pp. 1202-1205
-
-
Kim, H.1
Chen, J.2
Yu, X.3
-
66
-
-
72449163470
-
The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
-
Morris, J.R., Boutell, C., Keppler, M., Densham, R., Weekes, D., Alamshah, A., Butler, L., Galanty, Y., Pangon, L., Kiuchi, T. et al. (2009) The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. Nature, 462, 886-890.
-
(2009)
Nature
, vol.462
, pp. 886-890
-
-
Morris, J.R.1
Boutell, C.2
Keppler, M.3
Densham, R.4
Weekes, D.5
Alamshah, A.6
Butler, L.7
Galanty, Y.8
Pangon, L.9
Kiuchi, T.10
-
67
-
-
72449175818
-
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
-
Galanty, Y., Belotserkovskaya, R., Coates, J., Polo, S., Miller, K.M. and Jackson, S.P. (2009) Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature, 462, 935-939.
-
(2009)
Nature
, vol.462
, pp. 935-939
-
-
Galanty, Y.1
Belotserkovskaya, R.2
Coates, J.3
Polo, S.4
Miller, K.M.5
Jackson, S.P.6
-
68
-
-
33845666681
-
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
-
Botuyan, M.V., Lee, J., Ward, I.M., Kim, J.-E., Thompson, J.R., Chen, J. and Mer, G. (2006) Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell, 127, 1361-1373.
-
(2006)
Cell
, vol.127
, pp. 1361-1373
-
-
Botuyan, M.V.1
Lee, J.2
Ward, I.M.3
Kim, J.-E.4
Thompson, J.R.5
Chen, J.6
Mer, G.7
-
69
-
-
84879888213
-
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
-
Fradet-Turcotte, A., Canny, M.D., Escribano-Diaz, C., Orthwein, A., Leung, C.C.Y., Huang, H., Landry, M.-C., Kitevski-LeBlanc, J., Noordermeer, S.M., Sicheri, F. et al., (2013) 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature, 499, 50-54.
-
(2013)
Nature
, vol.499
, pp. 50-54
-
-
Fradet-Turcotte, A.1
Canny, M.D.2
Escribano-Diaz, C.3
Orthwein, A.4
Leung, C.C.Y.5
Huang, H.6
Landry, M.-C.7
Kitevski-Leblanc, J.8
Noordermeer, S.M.9
Sicheri, F.10
-
70
-
-
84876527317
-
RIF1 counteracts BRCA1-mediated end resection during DNA repair
-
Feng, L., Fong, K.-W., Wang, J., Wang, W. and Chen, J. (2013) RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair. J. Biol. Chem., 288, 11135-11143.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 11135-11143
-
-
Feng, L.1
Fong, K.-W.2
Wang, J.3
Wang, W.4
Chen, J.5
-
71
-
-
84876877091
-
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
-
Escribano-Diaz, C., Orthwein, A., Fradet-Turcotte, A., Xing, M., Young, J.T.F., Tkac, J., Cook, M.A., Rosebrock, A.P., Munro, M., Canny, M.D. et al. (2013) A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol. Cell, 49, 872-883.
-
(2013)
Mol. Cell
, vol.49
, pp. 872-883
-
-
Escribano-Diaz, C.1
Orthwein, A.2
Fradet-Turcotte, A.3
Xing, M.4
Young, J.T.F.5
Tkac, J.6
Cook, M.A.7
Rosebrock, A.P.8
Munro, M.9
Canny, M.D.10
-
72
-
-
84876855215
-
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection
-
Chapman, J.R., Barral, P., Vannier, J.-B., Borel, V., Steger, M., Tomas-Loba, A., Sartori, A.A., Adams, I.R., Batista, F.D. and Boulton, S.J. (2013) RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection. Mol. Cell, 49, 858-871.
-
(2013)
Mol. Cell
, vol.49
, pp. 858-871
-
-
Chapman, J.R.1
Barral, P.2
Vannier, J.-B.3
Borel, V.4
Steger, M.5
Tomas-Loba, A.6
Sartori, A.A.7
Adams, I.R.8
Batista, F.D.9
Boulton, S.J.10
-
73
-
-
84873488846
-
53BP1 regulates DSB repair using Rif1 to control 5' end resection
-
Zimmermann, M., Lottersberger, F., Buonomo, S.B., Sfeir, A. and de Lange, T. (2013) 53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science, 339, 700-704.
-
(2013)
Science
, vol.339
, pp. 700-704
-
-
Zimmermann, M.1
Lottersberger, F.2
Buonomo, S.B.3
Sfeir, A.4
De Lange, T.5
-
74
-
-
84878893538
-
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions
-
Callen, E., Di Virgilio, M., Kruhlak, M.J., Nieto-Soler, M., Wong, N., Chen, H.-T., Faryabi, R.B., Polato, F., Santos, M., Starnes, L.M. et al., (2013) 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell, 153, 1266-1280.
-
(2013)
Cell
, vol.153
, pp. 1266-1280
-
-
Callen, E.1
Di Virgilio, M.2
Kruhlak, M.J.3
Nieto-Soler, M.4
Wong, N.5
Chen, H.-T.6
Faryabi, R.B.7
Polato, F.8
Santos, M.9
Starnes, L.M.10
-
75
-
-
84863846456
-
Sumoylation of MDC1 is important for proper DNA damage response
-
Luo, K., Zhang, H., Wang, L., Yuan, J. and Lou, Z. (2012) Sumoylation of MDC1 is important for proper DNA damage response. EMBO J., 31, 3008-3019.
-
(2012)
EMBO J.
, vol.31
, pp. 3008-3019
-
-
Luo, K.1
Zhang, H.2
Wang, L.3
Yuan, J.4
Lou, Z.5
-
76
-
-
84861765707
-
RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair
-
Galanty, Y., Belotserkovskaya, R., Coates, J. and Jackson, S.P. (2012) RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. Genes Dev., 26, 1179-1195.
-
(2012)
Genes Dev.
, vol.26
, pp. 1179-1195
-
-
Galanty, Y.1
Belotserkovskaya, R.2
Coates, J.3
Jackson, S.P.4
-
77
-
-
84861784690
-
SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage
-
Yin, Y., Seifert, A., Chua, J.S., Maure, J.-F., Golebiowski, F. and Hay, R.T. (2012) SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage. Genes Dev., 26, 1196-1208.
-
(2012)
Genes Dev.
, vol.26
, pp. 1196-1208
-
-
Yin, Y.1
Seifert, A.2
Chua, J.S.3
Maure, J.-F.4
Golebiowski, F.5
Hay, R.T.6
-
78
-
-
84875224166
-
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination
-
Tang, J., Cho, N.W., Cui, G., Manion, E.M., Shanbhag, N.M., Botuyan, M.V., Mer, G. and Greenberg, R.A. (2013) Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat. Struct. Mol. Biol., 20, 317-325.
-
(2013)
Nat. Struct. Mol. Biol.
, vol.20
, pp. 317-325
-
-
Tang, J.1
Cho, N.W.2
Cui, G.3
Manion, E.M.4
Shanbhag, N.M.5
Botuyan, M.V.6
Mer, G.7
Greenberg, R.A.8
-
79
-
-
30344463835
-
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
-
Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G.C.M., Lukas, J. and Jackson, S.P. (2006) ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol., 8, 37-45.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 37-45
-
-
Jazayeri, A.1
Falck, J.2
Lukas, C.3
Bartek, J.4
Smith, G.C.M.5
Lukas, J.6
Jackson, S.P.7
-
80
-
-
80755187806
-
Double-strand break end resection and repair pathway choice
-
Symington, L.S. and Gautier, J. (2011) Double-strand break end resection and repair pathway choice. Annu. Rev. Genet., 45, 247-271.
-
(2011)
Annu. Rev. Genet.
, vol.45
, pp. 247-271
-
-
Symington, L.S.1
Gautier, J.2
-
81
-
-
84871192059
-
Initiation of DNA double strand break repair: Signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining
-
Grabarz, A., Barascu, A., Guirouilh-Barbat, J. and Lopez, B.S. (2012) Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining. Am. J. Cancer Res., 2, 249-268.
-
(2012)
Am. J. Cancer Res.
, vol.2
, pp. 249-268
-
-
Grabarz, A.1
Barascu, A.2
Guirouilh-Barbat, J.3
Lopez, B.S.4
-
82
-
-
43149118369
-
Cell cycle-dependent complex formation of BRCA1. CtIP.MRN is important for DNA double-strand break repair
-
Chen, L., Nievera, C.J., Lee, A.Y.-L. and Wu, X. (2008) Cell cycle-dependent complex formation of BRCA1. CtIP.MRN is important for DNA double-strand break repair. J. Biol. Chem., 283, 7713-7720.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 7713-7720
-
-
Chen, L.1
Nievera, C.J.2
Lee, A.Y.-L.3
Wu, X.4
-
83
-
-
36549060102
-
Human CtIP promotes DNA end resection
-
Sartori, A.A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J. and Jackson, S.P. (2007) Human CtIP promotes DNA end resection. Nature, 450, 509-514.
-
(2007)
Nature
, vol.450
, pp. 509-514
-
-
Sartori, A.A.1
Lukas, C.2
Coates, J.3
Mistrik, M.4
Fu, S.5
Bartek, J.6
Baer, R.7
Lukas, J.8
Jackson, S.P.9
-
84
-
-
84892369333
-
DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities
-
Shibata, A., Moiani, D., Arvai, A.S., Perry, J., Harding, S.M., Genois, M.-M., Maity, R., van Rossum-Fikkert, S., Kertokalio, A., Romoli, F. et al. (2014) DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol. Cell, 53, 7-18.
-
(2014)
Mol. Cell
, vol.53
, pp. 7-18
-
-
Shibata, A.1
Moiani, D.2
Arvai, A.S.3
Perry, J.4
Harding, S.M.5
Genois, M.-M.6
Maity, R.7
Van Rossum-Fikkert, S.8
Kertokalio, A.9
Romoli, F.10
-
85
-
-
9144230636
-
SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway
-
Germani, A., Prabel, A., Mourah, S., Podgorniak, M.-P., Di Carlo, A., Ehrlich, R., Gisselbrecht, S., Varin-Blank, N., Calvo, F. and Bruzzoni-Giovanelli, H. (2003) SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway. Oncogene, 22, 8845-8851.
-
(2003)
Oncogene
, vol.22
, pp. 8845-8851
-
-
Germani, A.1
Prabel, A.2
Mourah, S.3
Podgorniak, M.-P.4
Di Carlo, A.5
Ehrlich, R.6
Gisselbrecht, S.7
Varin-Blank, N.8
Calvo, F.9
Bruzzoni-Giovanelli, H.10
-
86
-
-
6344264992
-
DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains
-
Yu, X. and Chen, J. (2004) DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol. Cell. Biol., 24, 9478-9486.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 9478-9486
-
-
Yu, X.1
Chen, J.2
-
87
-
-
66149114020
-
Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
-
Huertas, P. and Jackson, S.P. (2009) Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J. Biol. Chem., 284, 9558-9565.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 9558-9565
-
-
Huertas, P.1
Jackson, S.P.2
-
88
-
-
84883599853
-
Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection
-
Steger, M., Murina, O., Hühn, D., Ferretti, L.P., Walser, R., Hänggi, K., Lafranchi, L., Neugebauer, C., Paliwal, S., Janscak, P. et al. (2013) Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection. Mol. Cell, 50, 333-343.
-
(2013)
Mol. Cell
, vol.50
, pp. 333-343
-
-
Steger, M.1
Murina, O.2
Hühn, D.3
Ferretti, L.P.4
Walser, R.5
Hänggi, K.6
Lafranchi, L.7
Neugebauer, C.8
Paliwal, S.9
Janscak, P.10
-
89
-
-
79951688343
-
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
-
Nimonkar, A.V., Genschel, J., Kinoshita, E., Polaczek, P., Campbell, J.L., Wyman, C., Modrich, P. and Kowalczykowski, S.C. (2011) BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev., 25, 350-362.
-
(2011)
Genes Dev.
, vol.25
, pp. 350-362
-
-
Nimonkar, A.V.1
Genschel, J.2
Kinoshita, E.3
Polaczek, P.4
Campbell, J.L.5
Wyman, C.6
Modrich, P.7
Kowalczykowski, S.C.8
-
90
-
-
84859004905
-
Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions
-
Tomimatsu, N., Mukherjee, B., Deland, K., Kurimasa, A., Bolderson, E., Khanna, K.K. and Burma, S. (2012) Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair (Amst.), 11, 441-448.
-
(2012)
DNA Repair (Amst.)
, vol.11
, pp. 441-448
-
-
Tomimatsu, N.1
Mukherjee, B.2
Deland, K.3
Kurimasa, A.4
Bolderson, E.5
Khanna, K.K.6
Burma, S.7
-
91
-
-
77951251067
-
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
-
Bolderson, E., Tomimatsu, N., Richard, D.J., Boucher, D., Kumar, R., Pandita, T.K., Burma, S. and Khanna, K.K. (2010) Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Res., 38, 1821-1831.
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 1821-1831
-
-
Bolderson, E.1
Tomimatsu, N.2
Richard, D.J.3
Boucher, D.4
Kumar, R.5
Pandita, T.K.6
Burma, S.7
Khanna, K.K.8
-
92
-
-
84930948486
-
Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice
-
Tomimatsu, N., Mukherjee, B., Hardebeck, M.C., Ilcheva, M., Camacho, C.V., Harris, J.L., Porteus, M., Llorente, B., Khanna, K.K. and Burma, S. (2014) Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice. Nat. Commun., 5, 3561.
-
(2014)
Nat. Commun.
, vol.5
, pp. 3561
-
-
Tomimatsu, N.1
Mukherjee, B.2
Hardebeck, M.C.3
Ilcheva, M.4
Camacho, C.V.5
Harris, J.L.6
Porteus, M.7
Llorente, B.8
Khanna, K.K.9
Burma, S.10
-
93
-
-
84890013296
-
PCNA promotes processive DNA end resection by Exo1
-
Chen, X., Paudyal, S.C., Chin, R.-I. and You, Z. (2013) PCNA promotes processive DNA end resection by Exo1. Nucleic Acids Res., 41, 9325-9338.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 9325-9338
-
-
Chen, X.1
Paudyal, S.C.2
Chin, R.-I.3
You, Z.4
-
94
-
-
0035225868
-
Molecular mechanism of PCNA-dependent base excision repair
-
Matsumoto, Y. (2001) Molecular mechanism of PCNA-dependent base excision repair. Prog. Nucleic Acids Res. Mol. Biol., 68, 129-138.
-
(2001)
Prog. Nucleic Acids Res. Mol. Biol.
, vol.68
, pp. 129-138
-
-
Matsumoto, Y.1
-
95
-
-
84869077981
-
Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA
-
Gilljam, K.M., Müller, R., Liabakk, N.B. and Otterlei, M. (2012) Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA. PLoS One, 7, e49199.
-
(2012)
PLoS One
, vol.7
-
-
Gilljam, K.M.1
Müller, R.2
Liabakk, N.B.3
Otterlei, M.4
-
96
-
-
0030271999
-
Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis
-
Umar, A., Buermeyer, A.B., Simon, J.A., Thomas, D.C., Clark, A.B., Liskay, R.M. and Kunkel, T.A. (1996) Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. Cell, 87, 65-73.
-
(1996)
Cell
, vol.87
, pp. 65-73
-
-
Umar, A.1
Buermeyer, A.B.2
Simon, J.A.3
Thomas, D.C.4
Clark, A.B.5
Liskay, R.M.6
Kunkel, T.A.7
-
97
-
-
2442417331
-
Interaction of human DNA polymerase eta with monoubiquitinated PCNA: A possible mechanism for the polymerase switch in response to DNA damage
-
Kannouche, P.L., Wing, J. and Lehmann, A.R. (2004) Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. Mol. Cell, 14, 491-500.
-
(2004)
Mol. Cell
, vol.14
, pp. 491-500
-
-
Kannouche, P.L.1
Wing, J.2
Lehmann, A.R.3
-
98
-
-
77958499239
-
RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network
-
Geng, L., Huntoon, C.J. and Karnitz, L.M. (2010) RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network. J. Cell Biol., 191, 249-257.
-
(2010)
J. Cell Biol.
, vol.191
, pp. 249-257
-
-
Geng, L.1
Huntoon, C.J.2
Karnitz, L.M.3
-
99
-
-
84880948378
-
Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans
-
Sebesta, M., Burkovics, P., Juhasz, S., Zhang, S., Szabo, J.E., Lee, M.Y.W.T., Haracska, L. and Krejci, L. (2013) Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans. DNA Repair (Amst.), 12, 691-698.
-
(2013)
DNA Repair (Amst.)
, vol.12
, pp. 691-698
-
-
Sebesta, M.1
Burkovics, P.2
Juhasz, S.3
Zhang, S.4
Szabo, J.E.5
Lee, M.Y.W.T.6
Haracska, L.7
Krejci, L.8
-
100
-
-
50649100744
-
Mechanism of eukaryotic homologous recombination
-
San Filippo, J., Sung, P. and Klein, H. (2008) Mechanism of eukaryotic homologous recombination. Annu. Rev. Biochem., 77, 229-257.
-
(2008)
Annu. Rev. Biochem.
, vol.77
, pp. 229-257
-
-
San Filippo, J.1
Sung, P.2
Klein, H.3
-
101
-
-
84864487729
-
Homologous recombination and its regulation
-
Krejci, L., Altmannova, V., Spirek, M. and Zhao, X. (2012) Homologous recombination and its regulation. Nucleic Acids Res., 40, 5795-5818.
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 5795-5818
-
-
Krejci, L.1
Altmannova, V.2
Spirek, M.3
Zhao, X.4
-
102
-
-
79960066235
-
Unraveling the mechanism of BRCA2 in homologous recombination
-
Holloman, W.K. (2011) Unraveling the mechanism of BRCA2 in homologous recombination. Nat. Struct. Mol. Biol., 18, 748-754.
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 748-754
-
-
Holloman, W.K.1
-
103
-
-
67651166786
-
PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2
-
Zhang, F., Fan, Q., Ren, K. and Andreassen, P.R. (2009) PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2. Mol. Cancer Res., 7, 1110-1118.
-
(2009)
Mol. Cancer Res.
, vol.7
, pp. 1110-1118
-
-
Zhang, F.1
Fan, Q.2
Ren, K.3
Andreassen, P.R.4
-
104
-
-
66349096607
-
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
-
Sy, S.M.H., Huen, M.S.Y. and Chen, J. (2009) PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc. Natl. Acad. Sci. U.S.A., 106, 7155-7160.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 7155-7160
-
-
Sy, S.M.H.1
Huen, M.S.Y.2
Chen, J.3
-
105
-
-
33644521786
-
DSS1 is required for the stability of BRCA2
-
Li, J., Zou, C., Bai, Y., Wazer, D.E., Band, V. and Gao, Q. (2006) DSS1 is required for the stability of BRCA2. Oncogene, 25, 1186-1194.
-
(2006)
Oncogene
, vol.25
, pp. 1186-1194
-
-
Li, J.1
Zou, C.2
Bai, Y.3
Wazer, D.E.4
Band, V.5
Gao, Q.6
-
106
-
-
77957804215
-
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA
-
Liu, J., Doty, T., Gibson, B. and Heyer, W.-D. (2010) Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. Nat. Struct. Mol. Biol., 17, 1260-1262.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 1260-1262
-
-
Liu, J.1
Doty, T.2
Gibson, B.3
Heyer, W.-D.4
-
107
-
-
79953232004
-
The role of the human SWI5-MEI5 complex in homologous recombination repair
-
Yuan, J. and Chen, J. (2011) The role of the human SWI5-MEI5 complex in homologous recombination repair. J. Biol. Chem., 286, 9888-9893.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 9888-9893
-
-
Yuan, J.1
Chen, J.2
-
108
-
-
84891809269
-
Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complex
-
Su, G.-C., Chung, C.-I., Liao, C.-Y., Lin, S.-W., Tsai, C.-T., Huang, T., Li, H.-W. and Chi, P. (2013) Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complex. Nucleic Acids Res., 42, 349-358.
-
(2013)
Nucleic Acids Res.
, vol.42
, pp. 349-358
-
-
Su, G.-C.1
Chung, C.-I.2
Liao, C.-Y.3
Lin, S.-W.4
Tsai, C.-T.5
Huang, T.6
Li, H.-W.7
Chi, P.8
-
109
-
-
81955162971
-
RAD51 paralogs: Roles in DNA damage signalling, recombinational repair and tumorigenesis
-
Suwaki, N., Klare, K. and Tarsounas, M. (2011) RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis. Semin. Cell Dev. Biol., 22, 898-905.
-
(2011)
Semin. Cell Dev. Biol.
, vol.22
, pp. 898-905
-
-
Suwaki, N.1
Klare, K.2
Tarsounas, M.3
-
110
-
-
79551658805
-
Rad52 inactivation is synthetically lethal with BRCA2 deficiency
-
Feng, Z., Scott, S.P., Bussen, W., Sharma, G.G., Guo, G., Pandita, T.K. and Powell, S.N. (2011) Rad52 inactivation is synthetically lethal with BRCA2 deficiency. Proc. Natl. Acad. Sci. U.S.A., 108, 686-691.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 686-691
-
-
Feng, Z.1
Scott, S.P.2
Bussen, W.3
Sharma, G.G.4
Guo, G.5
Pandita, T.K.6
Powell, S.N.7
-
111
-
-
76749102971
-
Rad54, the motor of homologous recombination
-
Mazin, A.V., Mazina, O.M., Bugreev, D.V. and Rossi, M.J. (2010) Rad54, the motor of homologous recombination. DNA Repair (Amst.), 9, 286-302.
-
(2010)
DNA Repair (Amst.)
, vol.9
, pp. 286-302
-
-
Mazin, A.V.1
Mazina, O.M.2
Bugreev, D.V.3
Rossi, M.J.4
-
112
-
-
35649012427
-
RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination
-
Modesti, M., Budzowska, M., Baldeyron, C., Demmers, J.A.A., Ghirlando, R. and Kanaar, R. (2007) RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination. Mol. Cell, 28, 468-481.
-
(2007)
Mol. Cell
, vol.28
, pp. 468-481
-
-
Modesti, M.1
Budzowska, M.2
Baldeyron, C.3
Demmers, J.A.A.4
Ghirlando, R.5
Kanaar, R.6
-
113
-
-
35648975439
-
Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement
-
Wiese, C., Dray, E., Groesser, T., San Filippo, J., Shi, I., Collins, D.W., Tsai, M.-S., Williams, G.J., Rydberg, B., Sung, P. et al. (2007) Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement. Mol. Cell, 28, 482-490.
-
(2007)
Mol. Cell
, vol.28
, pp. 482-490
-
-
Wiese, C.1
Dray, E.2
Groesser, T.3
San Filippo, J.4
Shi, I.5
Collins, D.W.6
Tsai, M.-S.7
Williams, G.J.8
Rydberg, B.9
Sung, P.10
-
114
-
-
44449118949
-
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability
-
Richard, D.J., Bolderson, E., Cubeddu, L., Wadsworth, R.I.M., Savage, K., Sharma, G.G., Nicolette, M.L., Tsvetanov, S., McIlwraith, M.J., Pandita, R.K. et al., (2008) Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature, 453, 677-681.
-
(2008)
Nature
, vol.453
, pp. 677-681
-
-
Richard, D.J.1
Bolderson, E.2
Cubeddu, L.3
Wadsworth, R.I.M.4
Savage, K.5
Sharma, G.G.6
Nicolette, M.L.7
Tsvetanov, S.8
McIlwraith, M.J.9
Pandita, R.K.10
-
115
-
-
69949138464
-
HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response
-
Li, Y., Bolderson, E., Kumar, R., Muniandy, P.A., Xue, Y., Richard, D.J., Seidman, M., Pandita, T.K., Khanna, K.K. and Wang, W. (2009) HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. J. Biol. Chem., 284, 23525-23531.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 23525-23531
-
-
Li, Y.1
Bolderson, E.2
Kumar, R.3
Muniandy, P.A.4
Xue, Y.5
Richard, D.J.6
Seidman, M.7
Pandita, T.K.8
Khanna, K.K.9
Wang, W.10
-
116
-
-
84855901029
-
Inhibition of homologous recombination by the PCNA-interacting protein PARI
-
Moldovan, G.-L., Dejsuphong, D., Petalcorin, M.I.R., Hofmann, K., Takeda, S., Boulton, S.J. and D'Andrea, A.D. (2012) Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol. Cell, 45, 75-86.
-
(2012)
Mol. Cell
, vol.45
, pp. 75-86
-
-
Moldovan, G.-L.1
Dejsuphong, D.2
Petalcorin, M.I.R.3
Hofmann, K.4
Takeda, S.5
Boulton, S.J.6
D'Andrea, A.D.7
-
117
-
-
84876915012
-
PARI overexpression promotes genomic instability and pancreatic tumorigenesis
-
O'Connor, K.W., Dejsuphong, D., Park, E., Nicolae, C.M., Kimmelman, A.C., D'Andrea, A.D. and Moldovan, G.-L. (2013) PARI overexpression promotes genomic instability and pancreatic tumorigenesis. Cancer Res., 73, 2529-2539.
-
(2013)
Cancer Res.
, vol.73
, pp. 2529-2539
-
-
O'Connor, K.W.1
Dejsuphong, D.2
Park, E.3
Nicolae, C.M.4
Kimmelman, A.C.5
D'Andrea, A.D.6
Moldovan, G.-L.7
-
118
-
-
36849013079
-
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments
-
Hu, Y., Raynard, S., Sehorn, M.G., Lu, X., Bussen, W., Zheng, L., Stark, J.M., Barnes, E.L., Chi, P., Janscak, P. et al. (2007) RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev., 21, 3073-3084.
-
(2007)
Genes Dev.
, vol.21
, pp. 3073-3084
-
-
Hu, Y.1
Raynard, S.2
Sehorn, M.G.3
Lu, X.4
Bussen, W.5
Zheng, L.6
Stark, J.M.7
Barnes, E.L.8
Chi, P.9
Janscak, P.10
-
119
-
-
69949166903
-
Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities
-
Fugger, K., Mistrik, M., Danielsen, J.R., Dinant, C., Falck, J., Bartek, J., Lukas, J. and Mailand, N. (2009) Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities. J. Cell Biol., 186, 655-663.
-
(2009)
J. Cell Biol.
, vol.186
, pp. 655-663
-
-
Fugger, K.1
Mistrik, M.2
Danielsen, J.R.3
Dinant, C.4
Falck, J.5
Bartek, J.6
Lukas, J.7
Mailand, N.8
-
120
-
-
84880528179
-
The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells
-
Bacquin, A., Pouvelle, C., Siaud, N., Perderiset, M., Salomé-Desnoulez, S., Tellier-Lebegue, C., Lopez, B., Charbonnier, J.-B. and Kannouche, P.L. (2013) The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells. Nucleic Acids Res., 41, 6501-6513.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 6501-6513
-
-
Bacquin, A.1
Pouvelle, C.2
Siaud, N.3
Perderiset, M.4
Salomé-Desnoulez, S.5
Tellier-Lebegue, C.6
Lopez, B.7
Charbonnier, J.-B.8
Kannouche, P.L.9
-
121
-
-
53549122238
-
RTEL1 maintains genomic stability by suppressing homologous recombination
-
Barber, L.J., Youds, J.L., Ward, J.D., McIlwraith, M.J., O'Neil, N.J., Petalcorin, M.I.R., Martin, J.S., Collis, S.J., Cantor, S.B., Auclair, M. et al. (2008) RTEL1 maintains genomic stability by suppressing homologous recombination. Cell, 135, 261-271.
-
(2008)
Cell
, vol.135
, pp. 261-271
-
-
Barber, L.J.1
Youds, J.L.2
Ward, J.D.3
McIlwraith, M.J.4
O'Neil, N.J.5
Petalcorin, M.I.R.6
Martin, J.S.7
Collis, S.J.8
Cantor, S.B.9
Auclair, M.10
-
122
-
-
33646843592
-
Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase
-
Bachrati, C.Z., Borts, R.H. and Hickson, I.D. (2006) Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase. Nucleic Acids Res., 34, 2269-2279.
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 2269-2279
-
-
Bachrati, C.Z.1
Borts, R.H.2
Hickson, I.D.3
-
123
-
-
42149183549
-
Crystal structure of the Mus81-Eme1 complex
-
Chang, J.H., Kim, J.J., Choi, J.M., Lee, J.H. and Cho, Y. (2008) Crystal structure of the Mus81-Eme1 complex. Genes Dev., 22, 1093-1106.
-
(2008)
Genes Dev.
, vol.22
, pp. 1093-1106
-
-
Chang, J.H.1
Kim, J.J.2
Choi, J.M.3
Lee, J.H.4
Cho, Y.5
-
124
-
-
50649091874
-
Structural and functional relationships of the XPF/MUS81 family of proteins
-
Ciccia, A., McDonald, N. and West, S.C. (2008) Structural and functional relationships of the XPF/MUS81 family of proteins. Annu. Rev. Biochem., 77, 259-287.
-
(2008)
Annu. Rev. Biochem.
, vol.77
, pp. 259-287
-
-
Ciccia, A.1
McDonald, N.2
West, S.C.3
-
125
-
-
54349099705
-
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability
-
Xu, D., Guo, R., Sobeck, A., Bachrati, C.Z., Yang, J., Enomoto, T., Brown, G.W., Hoatlin, M.E., Hickson, I.D. and Wang, W. (2008) RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Genes Dev., 22, 2843-2855.
-
(2008)
Genes Dev.
, vol.22
, pp. 2843-2855
-
-
Xu, D.1
Guo, R.2
Sobeck, A.3
Bachrati, C.Z.4
Yang, J.5
Enomoto, T.6
Brown, G.W.7
Hoatlin, M.E.8
Hickson, I.D.9
Wang, W.10
-
126
-
-
77954838714
-
Mechanism of Holliday junction resolution by the human GEN1 protein
-
Rass, U., Compton, S.A., Matos, J., Singleton, M.R., Ip, S.C.Y., Blanco, M.G., Griffith, J.D. and West, S.C. (2010) Mechanism of Holliday junction resolution by the human GEN1 protein. Genes Dev., 24, 1559-1569.
-
(2010)
Genes Dev.
, vol.24
, pp. 1559-1569
-
-
Rass, U.1
Compton, S.A.2
Matos, J.3
Singleton, M.R.4
Ip, S.C.Y.5
Blanco, M.G.6
Griffith, J.D.7
West, S.C.8
-
127
-
-
67649655402
-
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases
-
Fekairi, S., Scaglione, S., Chahwan, C., Taylor, E.R., Tissier, A., Coulon, S., Dong, M.-Q., Ruse, C., Yates, J.R., Russell, P. et al. (2009) Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. Cell, 138, 78-89.
-
(2009)
Cell
, vol.138
, pp. 78-89
-
-
Fekairi, S.1
Scaglione, S.2
Chahwan, C.3
Taylor, E.R.4
Tissier, A.5
Coulon, S.6
Dong, M.-Q.7
Ruse, C.8
Yates, J.R.9
Russell, P.10
-
128
-
-
35748981213
-
Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex
-
Bussen, W., Raynard, S., Busygina, V., Singh, A.K. and Sung, P. (2007) Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex. J. Biol. Chem., 282, 31484-31492.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 31484-31492
-
-
Bussen, W.1
Raynard, S.2
Busygina, V.3
Singh, A.K.4
Sung, P.5
-
129
-
-
77954382263
-
Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1
-
Yang, J., Bachrati, C.Z., Ou, J., Hickson, I.D. and Brown, G.W. (2010) Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1. J. Biol. Chem., 285, 21426-21436.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 21426-21436
-
-
Yang, J.1
Bachrati, C.Z.2
Ou, J.3
Hickson, I.D.4
Brown, G.W.5
-
130
-
-
84886241606
-
Coordinated Actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells
-
Wyatt, H.D.M., Sarbajna, S., Matos, J. and West, S.C. (2013) Coordinated Actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells. Mol. Cell, 52, 234-247.
-
(2013)
Mol. Cell
, vol.52
, pp. 234-247
-
-
Wyatt, H.D.M.1
Sarbajna, S.2
Matos, J.3
West, S.C.4
-
131
-
-
84885855405
-
Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced holliday junctions
-
Garner, E., Kim, Y., Lach, F.P., Kottemann, M.C. and Smogorzewska, A. (2013) Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced holliday junctions. Cell Rep., 5, 207-215.
-
(2013)
Cell Rep.
, vol.5
, pp. 207-215
-
-
Garner, E.1
Kim, Y.2
Lach, F.P.3
Kottemann, M.C.4
Smogorzewska, A.5
-
132
-
-
6344234817
-
Genetic steps of mammalian homologous repair with distinct mutagenic consequences
-
Stark, J.M., Pierce, A.J., Oh, J., Pastink, A. and Jasin, M. (2004) Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Mol. Cell. Biol., 24, 9305-9316.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 9305-9316
-
-
Stark, J.M.1
Pierce, A.J.2
Oh, J.3
Pastink, A.4
Jasin, M.5
-
133
-
-
77953280876
-
Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52-ssDNA complexes
-
Grimme, J.M., Honda, M., Wright, R., Okuno, Y., Rothenberg, E., Mazin, A.V., Ha, T. and Spies, M. (2010) Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52-ssDNA complexes. Nucleic Acids Res., 38, 2917-2930.
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 2917-2930
-
-
Grimme, J.M.1
Honda, M.2
Wright, R.3
Okuno, Y.4
Rothenberg, E.5
Mazin, A.V.6
Ha, T.7
Spies, M.8
-
134
-
-
38349098477
-
The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells
-
Al-Minawi, A.Z., Saleh-Gohari, N. and Helleday, T. (2008) The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells. Nucleic Acids Res., 36, 1-9.
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 1-9
-
-
Al-Minawi, A.Z.1
Saleh-Gohari, N.2
Helleday, T.3
-
135
-
-
0032403914
-
Rejoining of DNA double-strand breaks in vitro by single-strand annealing
-
Göttlich, B., Reichenberger, S., Feldmann, E. and Pfeiffer, P. (1998) Rejoining of DNA double-strand breaks in vitro by single-strand annealing. Eur. J. Biochem., 258, 387-395.
-
(1998)
Eur. J. Biochem.
, vol.258
, pp. 387-395
-
-
Göttlich, B.1
Reichenberger, S.2
Feldmann, E.3
Pfeiffer, P.4
-
136
-
-
84888330687
-
Alternative end-joining and classical nonhomologous end-joining pathways repair different types of double-strand breaks during class-switch recombination
-
Cortizas, E.M., Zahn, A., Hajjar, M.E., Patenaude, A.-M., Di Noia, J.M. and Verdun, R.E. (2013) Alternative End-Joining and Classical Nonhomologous End-Joining Pathways Repair Different Types of Double-Strand Breaks during Class-Switch Recombination. J. Immunol., 191, 5751-5763.
-
(2013)
J. Immunol.
, vol.191
, pp. 5751-5763
-
-
Cortizas, E.M.1
Zahn, A.2
Hajjar, M.E.3
Patenaude, A.-M.4
Di Noia, J.M.5
Verdun, R.E.6
-
137
-
-
84867386682
-
Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks
-
Boboila, C., Alt, F.W. and Schwer, B. (2012) Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv. Immunol., 116, 1-49.
-
(2012)
Adv. Immunol.
, vol.116
, pp. 1-49
-
-
Boboila, C.1
Alt, F.W.2
Schwer, B.3
-
138
-
-
84964063204
-
DNA double strand break repair via non-homologous end-joining
-
Davis, A.J. and Chen, D.J. (2013) DNA double strand break repair via non-homologous end-joining. Transl. Cancer Res., 2, 130-143.
-
(2013)
Transl. Cancer Res.
, vol.2
, pp. 130-143
-
-
Davis, A.J.1
Chen, D.J.2
-
139
-
-
77953229115
-
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
-
Lieber, M.R. (2010) The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu. Rev. Biochem., 79, 181-211.
-
(2010)
Annu. Rev. Biochem.
, vol.79
, pp. 181-211
-
-
Lieber, M.R.1
-
140
-
-
79956215808
-
Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways
-
Mladenov, E. and Iliakis, G. (2011) Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways. Mutat. Res., 711, 61-72.
-
(2011)
Mutat. Res.
, vol.711
, pp. 61-72
-
-
Mladenov, E.1
Iliakis, G.2
-
141
-
-
0035833552
-
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
-
Walker, J.R., Corpina, R.A. and Goldberg, J. (2001) Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature, 412, 607-614.
-
(2001)
Nature
, vol.412
, pp. 607-614
-
-
Walker, J.R.1
Corpina, R.A.2
Goldberg, J.3
-
142
-
-
34247477667
-
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks
-
Uematsu, N., Weterings, E., Yano, K.-I., Morotomi-Yano, K., Jakob, B., Taucher-Scholz, G., Mari, P.-O., van Gent, D.C., Chen, B.P.C. and Chen, D.J. (2007) Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J. Cell Biol., 177, 219-229.
-
(2007)
J. Cell Biol.
, vol.177
, pp. 219-229
-
-
Uematsu, N.1
Weterings, E.2
Yano, K.-I.3
Morotomi-Yano, K.4
Jakob, B.5
Taucher-Scholz, G.6
Mari, P.-O.7
Van Gent, D.C.8
Chen, B.P.C.9
Chen, D.J.10
-
143
-
-
33646714595
-
Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair
-
Spagnolo, L., Rivera-Calzada, A., Pearl, L.H. and Llorca, O. (2006) Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair. Mol. Cell, 22, 511-519.
-
(2006)
Mol. Cell
, vol.22
, pp. 511-519
-
-
Spagnolo, L.1
Rivera-Calzada, A.2
Pearl, L.H.3
Llorca, O.4
-
144
-
-
33646090620
-
Artemis phosphorylated by DNA-dependent protein kinase associates preferentially with discrete regions of chromatin
-
Soubeyrand, S., Pope, L., De Chasseval, R., Gosselin, D., Dong, F., de Villartay, J.-P. and Haché, R.J.G. (2006) Artemis phosphorylated by DNA-dependent protein kinase associates preferentially with discrete regions of chromatin. J. Mol. Biol., 358, 1200-1211.
-
(2006)
J. Mol. Biol.
, vol.358
, pp. 1200-1211
-
-
Soubeyrand, S.1
Pope, L.2
De Chasseval, R.3
Gosselin, D.4
Dong, F.5
De Villartay, J.-P.6
Haché, R.J.G.7
-
145
-
-
0034001205
-
Ku recruits the XRCC4-ligase IV complex to DNA ends
-
Nick McElhinny, S.A., Snowden, C.M., McCarville, J. and Ramsden, D.A. (2000) Ku recruits the XRCC4-ligase IV complex to DNA ends. Mol. Cell. Biol., 20, 2996-3003.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 2996-3003
-
-
Nick McElhinny, S.A.1
Snowden, C.M.2
McCarville, J.3
Ramsden, D.A.4
-
146
-
-
33845484385
-
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4
-
Mari, P.-O., Florea, B.I., Persengiev, S.P., Verkaik, N.S., Brüggenwirth, H.T., Modesti, M., Giglia-Mari, G., Bezstarosti, K., Demmers, J.A.A., Luider, T.M. et al., (2006) Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc. Natl. Acad. Sci. U.S.A., 103, 18597-18602.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 18597-18602
-
-
Mari, P.-O.1
Florea, B.I.2
Persengiev, S.P.3
Verkaik, N.S.4
Brüggenwirth, H.T.5
Modesti, M.6
Giglia-Mari, G.7
Bezstarosti, K.8
Demmers, J.A.A.9
Luider, T.M.10
-
147
-
-
77956210664
-
Delineation of the Xrcc4-interacting region in the globular head domain of cernunnos/XLF
-
Malivert, L., Ropars, V., Nunez, M., Drevet, P., Miron, S., Faure, G., Guerois, R., Mornon, J.-P., Revy, P., Charbonnier, J.-B. et al. (2010) Delineation of the Xrcc4-interacting region in the globular head domain of cernunnos/XLF. J. Biol. Chem., 285, 26475-26483.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 26475-26483
-
-
Malivert, L.1
Ropars, V.2
Nunez, M.3
Drevet, P.4
Miron, S.5
Faure, G.6
Guerois, R.7
Mornon, J.-P.8
Revy, P.9
Charbonnier, J.-B.10
-
148
-
-
20044390734
-
The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase
-
Bernstein, N.K., Williams, R.S., Rakovszky, M.L., Cui, D., Green, R., Karimi-Busheri, F., Mani, R.S., Galicia, S., Koch, C.A., Cass, C.E. et al. (2005) The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase. Mol. Cell, 17, 657-670.
-
(2005)
Mol. Cell
, vol.17
, pp. 657-670
-
-
Bernstein, N.K.1
Williams, R.S.2
Rakovszky, M.L.3
Cui, D.4
Green, R.5
Karimi-Busheri, F.6
Mani, R.S.7
Galicia, S.8
Koch, C.A.9
Cass, C.E.10
-
149
-
-
33749821755
-
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates
-
Ahel, I., Rass, U., El-Khamisy, S.F., Katyal, S., Clements, P.M., McKinnon, P.J., Caldecott, K.W. and West, S.C. (2006) The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature, 443, 713-716.
-
(2006)
Nature
, vol.443
, pp. 713-716
-
-
Ahel, I.1
Rass, U.2
El-Khamisy, S.F.3
Katyal, S.4
Clements, P.M.5
McKinnon, P.J.6
Caldecott, K.W.7
West, S.C.8
-
150
-
-
77951621112
-
Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends
-
Roberts, S.A., Strande, N., Burkhalter, M.D., Strom, C., Havener, J.M., Hasty, P. and Ramsden, D.A. (2010) Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends. Nature, 464, 1214-1217.
-
(2010)
Nature
, vol.464
, pp. 1214-1217
-
-
Roberts, S.A.1
Strande, N.2
Burkhalter, M.D.3
Strom, C.4
Havener, J.M.5
Hasty, P.6
Ramsden, D.A.7
-
151
-
-
80054683238
-
Polynucleotide kinase and aprataxin-like forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3' exonuclease and can participate in DNA end joining in a biochemical system
-
Li, S., Kanno, S.-I., Watanabe, R., Ogiwara, H., Kohno, T., Watanabe, G., Yasui, A. and Lieber, M.R. (2011) Polynucleotide kinase and aprataxin-like forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3' exonuclease and can participate in DNA end joining in a biochemical system. J. Biol. Chem., 286, 36368-36377.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 36368-36377
-
-
Li, S.1
Kanno, S.-I.2
Watanabe, R.3
Ogiwara, H.4
Kohno, T.5
Watanabe, G.6
Yasui, A.7
Lieber, M.R.8
-
152
-
-
0037155703
-
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
-
Ma, Y., Pannicke, U., Schwarz, K. and Lieber, M.R. (2002) Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell, 108, 781-794.
-
(2002)
Cell
, vol.108
, pp. 781-794
-
-
Ma, Y.1
Pannicke, U.2
Schwarz, K.3
Lieber, M.R.4
-
153
-
-
33947541157
-
Processing of 3'-phosphoglycolate-terminated DNA double strand breaks by Artemis nuclease
-
Povirk, L.F., Zhou, T., Zhou, R., Cowan, M.J. and Yannone, S.M. (2007) Processing of 3'-phosphoglycolate-terminated DNA double strand breaks by Artemis nuclease. J. Biol. Chem., 282, 3547-3558.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 3547-3558
-
-
Povirk, L.F.1
Zhou, T.2
Zhou, R.3
Cowan, M.J.4
Yannone, S.M.5
-
154
-
-
33745084835
-
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing
-
Perry, J.J.P., Yannone, S.M., Holden, L.G., Hitomi, C., Asaithamby, A., Han, S., Cooper, P.K., Chen, D.J. and Tainer, J.A. (2006) WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat. Struct. Mol. Biol., 13, 414-422.
-
(2006)
Nat. Struct. Mol. Biol.
, vol.13
, pp. 414-422
-
-
Perry, J.J.P.1
Yannone, S.M.2
Holden, L.G.3
Hitomi, C.4
Asaithamby, A.5
Han, S.6
Cooper, P.K.7
Chen, D.J.8
Tainer, J.A.9
-
155
-
-
84872853376
-
APLF promotes the assembly and activity of non-homologous end joining protein complexes
-
Grundy, G.J., Rulten, S.L., Zeng, Z., Arribas-Bosacoma, R., Iles, N., Manley, K., Oliver, A. and Caldecott, K.W. (2013) APLF promotes the assembly and activity of non-homologous end joining protein complexes. EMBO J., 32, 112-125.
-
(2013)
EMBO J.
, vol.32
, pp. 112-125
-
-
Grundy, G.J.1
Rulten, S.L.2
Zeng, Z.3
Arribas-Bosacoma, R.4
Iles, N.5
Manley, K.6
Oliver, A.7
Caldecott, K.W.8
-
156
-
-
9744241712
-
A biochemically defined system for mammalian nonhomologous DNA end joining
-
Ma, Y., Lu, H., Tippin, B., Goodman, M.F., Shimazaki, N., Koiwai, O., Hsieh, C.-L., Schwarz, K. and Lieber, M.R. (2004) A biochemically defined system for mammalian nonhomologous DNA end joining. Mol. Cell, 16, 701-713.
-
(2004)
Mol. Cell
, vol.16
, pp. 701-713
-
-
Ma, Y.1
Lu, H.2
Tippin, B.3
Goodman, M.F.4
Shimazaki, N.5
Koiwai, O.6
Hsieh, C.-L.7
Schwarz, K.8
Lieber, M.R.9
-
157
-
-
84964045835
-
Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer
-
Dueva, R. and Iliakis, G. (2013) Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer. Transl. Cancer Res., 2, 163-177.
-
(2013)
Transl. Cancer Res.
, vol.2
, pp. 163-177
-
-
Dueva, R.1
Iliakis, G.2
-
158
-
-
84877321963
-
Microhomology-mediated end joining and homologous recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells
-
Truong, L.N., Li, Y., Shi, L.Z., Hwang, P.Y.-H., He, J., Wang, H., Razavian, N., Berns, M.W. and Wu, X. (2013) Microhomology-mediated end joining and homologous recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proc. Nat. Acad. Sci. U.S.A., 110, 7720-7725.
-
(2013)
Proc. Nat. Acad. Sci. U.S.A.
, vol.110
, pp. 7720-7725
-
-
Truong, L.N.1
Li, Y.2
Shi, L.Z.3
Hwang, P.Y.-H.4
He, J.5
Wang, H.6
Razavian, N.7
Berns, M.W.8
Wu, X.9
-
159
-
-
78049446968
-
The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies
-
Mansour, W.Y., Rhein, T. and Dahm-Daphi, J. (2010) The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies. Nucleic Acids Res., 38, 6065-6077.
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 6065-6077
-
-
Mansour, W.Y.1
Rhein, T.2
Dahm-Daphi, J.3
-
160
-
-
33845657443
-
PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
-
Wang, M., Wu, W., Wu, W., Rosidi, B., Zhang, L., Wang, H. and Iliakis, G. (2006) PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res., 34, 6170-6182.
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 6170-6182
-
-
Wang, M.1
Wu, W.2
Wu, W.3
Rosidi, B.4
Zhang, L.5
Wang, H.6
Iliakis, G.7
-
161
-
-
83755224388
-
Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks
-
Cheng, Q., Barboule, N., Frit, P., Gomez, D., Bombarde, O., Couderc, B., Ren, G.S., Salles, B. and Calsou, P. (2011) Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks. Nucleic Acids Res., 39, 9605-9619.
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 9605-9619
-
-
Cheng, Q.1
Barboule, N.2
Frit, P.3
Gomez, D.4
Bombarde, O.5
Couderc, B.6
Ren, G.S.7
Salles, B.8
Calsou, P.9
-
162
-
-
0037047387
-
BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks
-
Zhong, Q., Chen, C.-F., Chen, P.-L. and Lee, W.-H. (2002) BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. J. Biol. Chem., 277, 28641-28647.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 28641-28647
-
-
Zhong, Q.1
Chen, C.-F.2
Chen, P.-L.3
Lee, W.-H.4
-
163
-
-
78650988959
-
CtIP promotes microhomology-mediated alternative end joining during class-switch recombination
-
Lee-Theilen, M., Matthews, A.J., Kelly, D., Zheng, S. and Chaudhuri, J. (2011) CtIP promotes microhomology-mediated alternative end joining during class-switch recombination. Nat. Struct. Mol. Biol., 18, 75-79.
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 75-79
-
-
Lee-Theilen, M.1
Matthews, A.J.2
Kelly, D.3
Zheng, S.4
Chaudhuri, J.5
-
164
-
-
78650995499
-
An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway
-
Zhang, Y. and Jasin, M. (2011) An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway. Nat. Struct. Mol. Biol., 18, 80-84.
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 80-84
-
-
Zhang, Y.1
Jasin, M.2
-
165
-
-
68249146431
-
Role of mammalian Mre11 in classical and alternative nonhomologous end joining
-
Xie, A., Kwok, A. and Scully, R. (2009) Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nat. Struct. Mol. Biol., 16, 814-818.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 814-818
-
-
Xie, A.1
Kwok, A.2
Scully, R.3
-
166
-
-
68249138694
-
Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells
-
Rass, E., Grabarz, A., Plo, I., Gautier, J., Bertrand, P. and Lopez, B.S. (2009) Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Nat. Struct. Mol. Biol., 16, 819-824.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 819-824
-
-
Rass, E.1
Grabarz, A.2
Plo, I.3
Gautier, J.4
Bertrand, P.5
Lopez, B.S.6
-
167
-
-
77951057068
-
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
-
Bothmer, A., Robbiani, D.F., Feldhahn, N., Gazumyan, A., Nussenzweig, A. and Nussenzweig, M.C. (2010) 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J. Exp. Med., 207, 855-865.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 855-865
-
-
Bothmer, A.1
Robbiani, D.F.2
Feldhahn, N.3
Gazumyan, A.4
Nussenzweig, A.5
Nussenzweig, M.C.6
-
168
-
-
79955502009
-
Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1
-
Bothmer, A., Robbiani, D.F., Di Virgilio, M., Bunting, S.F., Klein, I.A., Feldhahn, N., Barlow, J., Chen, H.-T., Bosque, D., Callen, E. et al. (2011) Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. Mol. Cell, 42, 319-329.
-
(2011)
Mol. Cell
, vol.42
, pp. 319-329
-
-
Bothmer, A.1
Robbiani, D.F.2
Di Virgilio, M.3
Bunting, S.F.4
Klein, I.A.5
Feldhahn, N.6
Barlow, J.7
Chen, H.-T.8
Bosque, D.9
Callen, E.10
-
169
-
-
20144363082
-
DNA ligase III as a candidate component of backup pathways of nonhomologous end joining
-
Wang, H., Rosidi, B., Perrault, R., Wang, M., Zhang, L., Windhofer, F. and Iliakis, G. (2005) DNA ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Res., 65, 4020-4030.
-
(2005)
Cancer Res.
, vol.65
, pp. 4020-4030
-
-
Wang, H.1
Rosidi, B.2
Perrault, R.3
Wang, M.4
Zhang, L.5
Windhofer, F.6
Iliakis, G.7
-
170
-
-
45549094090
-
Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks
-
Liang, L., Deng, L., Nguyen, S.C., Zhao, X., Maulion, C.D., Shao, C. and Tischfield, J.A. (2008) Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks. Nucleic Acids Res., 36, 3297-3310.
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 3297-3310
-
-
Liang, L.1
Deng, L.2
Nguyen, S.C.3
Zhao, X.4
Maulion, C.D.5
Shao, C.6
Tischfield, J.A.7
-
171
-
-
80053212145
-
Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway
-
Della-Maria, J., Zhou, Y., Tsai, M.-S., Kuhnlein, J., Carney, J.P., Paull, T.T. and Tomkinson, A.E. (2011) Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway. J. Biol. Chem., 286, 33845-33853.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 33845-33853
-
-
Della-Maria, J.1
Zhou, Y.2
Tsai, M.-S.3
Kuhnlein, J.4
Carney, J.P.5
Paull, T.T.6
Tomkinson, A.E.7
-
172
-
-
84875484920
-
DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates
-
Paul, K., Wang, M., Mladenov, E., Bencsik-Theilen, A., Bednar, T., Wu, W., Arakawa, H. and Iliakis, G. (2013) DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates. PLoS One, 8, e59505.
-
(2013)
PLoS One
, vol.8
-
-
Paul, K.1
Wang, M.2
Mladenov, E.3
Bencsik-Theilen, A.4
Bednar, T.5
Wu, W.6
Arakawa, H.7
Iliakis, G.8
-
173
-
-
84891301320
-
Causes and consequences of replication stress
-
Zeman, M.K. and Cimprich, K.A. (2014) Causes and consequences of replication stress. Nat. Cell Biol., 16, 2-9.
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 2-9
-
-
Zeman, M.K.1
Cimprich, K.A.2
-
174
-
-
77649165394
-
Maintaining genome stability at the replication fork
-
Branzei, D. and Foiani, M. (2010) Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol, 11, 208-219.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 208-219
-
-
Branzei, D.1
Foiani, M.2
-
175
-
-
35848930133
-
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks
-
Hanada, K., Budzowska, M., Davies, S.L., van Drunen, E., Onizawa, H., Beverloo, H.B., Maas, A., Essers, J., Hickson, I.D. and Kanaar, R. (2007) The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks. Nat. Struct. Mol. Biol., 14, 1096-1104.
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 1096-1104
-
-
Hanada, K.1
Budzowska, M.2
Davies, S.L.3
Van Drunen, E.4
Onizawa, H.5
Beverloo, H.B.6
Maas, A.7
Essers, J.8
Hickson, I.D.9
Kanaar, R.10
-
176
-
-
34248170114
-
Meta-analysis of BRCA1 and BRCA2 penetrance
-
Chen, S. and Parmigiani, G. (2007) Meta-analysis of BRCA1 and BRCA2 penetrance. J. Clin. Oncol., 25, 1329-1333.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 1329-1333
-
-
Chen, S.1
Parmigiani, G.2
-
177
-
-
84863035912
-
-
seer.cancer.gov
-
Howlader, N., Noone, A.M., Krapcho, M., Garshell, J., Neyman, N., Altekruse, S.F., Kosary, C.L., Yu, M., Ruhl, J., Tatalovich, Z. et al., SEER Cancer Statistics Review, 1975-2010. seer.cancer.gov.
-
(1975)
SEER Cancer Statistics Review
-
-
Howlader, N.1
Noone, A.M.2
Krapcho, M.3
Garshell, J.4
Neyman, N.5
Altekruse, S.F.6
Kosary, C.L.7
Yu, M.8
Ruhl, J.9
Tatalovich, Z.10
-
178
-
-
84856316429
-
Defective homologous recombination in human cancers
-
Cerbinskaite, A., Mukhopadhyay, A., Plummer, E.R., Curtin, N.J. and Edmondson, R.J. (2012) Defective homologous recombination in human cancers. Cancer Treat. Rev., 38, 89-100.
-
(2012)
Cancer Treat. Rev.
, vol.38
, pp. 89-100
-
-
Cerbinskaite, A.1
Mukhopadhyay, A.2
Plummer, E.R.3
Curtin, N.J.4
Edmondson, R.J.5
-
179
-
-
9144251637
-
ATM and genome maintenance: Defining its role in breast cancer susceptibility
-
Khanna, K.K. and Chenevix-Trench, G. (2004) ATM and genome maintenance: defining its role in breast cancer susceptibility. J. Mammary Gland Biol. Neoplasia, 9, 247-262.
-
(2004)
J. Mammary Gland Biol. Neoplasia
, vol.9
, pp. 247-262
-
-
Khanna, K.K.1
Chenevix-Trench, G.2
-
180
-
-
0023244806
-
Breast and other cancers in families with ataxia-telangiectasia
-
Swift, M., Reitnauer, P.J., Morrell, D. and Chase, C.L. (1987) Breast and other cancers in families with ataxia-telangiectasia. N. Engl. J. Med., 316, 1289-1294.
-
(1987)
N. Engl. J. Med.
, vol.316
, pp. 1289-1294
-
-
Swift, M.1
Reitnauer, P.J.2
Morrell, D.3
Chase, C.L.4
-
181
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones, S., Zhang, X., Parsons, D.W., Lin, J.C.-H., Leary, R.J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A. et al. (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science, 321, 1801-1806.
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
Lin, J.C.-H.4
Leary, R.J.5
Angenendt, P.6
Mankoo, P.7
Carter, H.8
Kamiyama, H.9
Jimeno, A.10
-
182
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumours
-
Koboldt, D.C., Fulton, R.S., McLellan, M.D., Schmidt, H., Kalicki-Veizer, J., McMichael, J.F., Fulton, L.L., Dooling, D.J., Ding, L., Mardis, E.R. et al. (2012) Comprehensive molecular portraits of human breast tumours. Nature, 490, 61-70.
-
(2012)
Nature
, vol.490
, pp. 61-70
-
-
Koboldt, D.C.1
Fulton, R.S.2
McLellan, M.D.3
Schmidt, H.4
Kalicki-Veizer, J.5
McMichael, J.F.6
Fulton, L.L.7
Dooling, D.J.8
Ding, L.9
Mardis, E.R.10
-
183
-
-
84861527388
-
The genomic and transcriptomic architecture of 2, 000 breast tumours reveals novel subgroups
-
Curtis, C., Shah, S.P., Chin, S.-F., Turashvili, G., Rueda, O.M., Dunning, M.J., Speed, D., Lynch, A.G., Samarajiwa, S., Yuan, Y. et al. (2012) The genomic and transcriptomic architecture of 2, 000 breast tumours reveals novel subgroups. Nature, 486, 346-352.
-
(2012)
Nature
, vol.486
, pp. 346-352
-
-
Curtis, C.1
Shah, S.P.2
Chin, S.-F.3
Turashvili, G.4
Rueda, O.M.5
Dunning, M.J.6
Speed, D.7
Lynch, A.G.8
Samarajiwa, S.9
Yuan, Y.10
-
184
-
-
84862526929
-
The clonal and mutational evolution spectrum of primary triple-negative breast cancers
-
Shah, S.P., Roth, A., Goya, R., Oloumi, A., Ha, G., Zhao, Y., Turashvili, G., Ding, J., Tse, K., Haffari, G. et al. (2012) The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature, 486, 395-399.
-
(2012)
Nature
, vol.486
, pp. 395-399
-
-
Shah, S.P.1
Roth, A.2
Goya, R.3
Oloumi, A.4
Ha, G.5
Zhao, Y.6
Turashvili, G.7
Ding, J.8
Tse, K.9
Haffari, G.10
-
185
-
-
84861576201
-
The landscape of cancer genes and mutational processes in breast cancer
-
Stephens, P.J., Tarpey, P.S., Davies, H., Van Loo, P., Greenman, C., Wedge, D.C., Nik-Zainal, S., Martin, S., Varela, I., Bignell, G.R. et al. (2012) The landscape of cancer genes and mutational processes in breast cancer. Nature, 486, 400-404.
-
(2012)
Nature
, vol.486
, pp. 400-404
-
-
Stephens, P.J.1
Tarpey, P.S.2
Davies, H.3
Van Loo, P.4
Greenman, C.5
Wedge, D.C.6
Nik-Zainal, S.7
Martin, S.8
Varela, I.9
Bignell, G.R.10
-
186
-
-
84862523863
-
Sequence analysis of mutations and translocations across breast cancer subtypes
-
Banerji, S., Cibulskis, K., Rangel-Escareno, C., Brown, K.K., Carter, S.L., Frederick, A.M., Lawrence, M.S., Sivachenko, A.Y., Sougnez, C., Zou, L. et al. (2012) Sequence analysis of mutations and translocations across breast cancer subtypes. Nature, 486, 405-409.
-
(2012)
Nature
, vol.486
, pp. 405-409
-
-
Banerji, S.1
Cibulskis, K.2
Rangel-Escareno, C.3
Brown, K.K.4
Carter, S.L.5
Frederick, A.M.6
Lawrence, M.S.7
Sivachenko, A.Y.8
Sougnez, C.9
Zou, L.10
-
187
-
-
1542515338
-
A census of human cancer genes
-
Futreal, P.A., Coin, L., Marshall, M., Down, T., Hubbard, T., Wooster, R., Rahman, N. and Stratton, M.R. (2004) A census of human cancer genes. Nat. Rev. Cancer, 4, 177-183.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 177-183
-
-
Futreal, P.A.1
Coin, L.2
Marshall, M.3
Down, T.4
Hubbard, T.5
Wooster, R.6
Rahman, N.7
Stratton, M.R.8
-
188
-
-
78650959663
-
Massive genomic rearrangement acquired in a single catastrophic event during cancer development
-
Stephens, P.J., Greenman, C.D., Fu, B., Yang, F., Bignell, G.R., Mudie, L.J., Pleasance, E.D., Lau, K.W., Beare, D., Stebbings, L.A. et al. (2011) Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell, 144, 27-40.
-
(2011)
Cell
, vol.144
, pp. 27-40
-
-
Stephens, P.J.1
Greenman, C.D.2
Fu, B.3
Yang, F.4
Bignell, G.R.5
Mudie, L.J.6
Pleasance, E.D.7
Lau, K.W.8
Beare, D.9
Stebbings, L.A.10
-
189
-
-
84877722178
-
Diverse mechanisms of somatic structural variations in human cancer genomes
-
Yang, L., Luquette, L.J., Gehlenborg, N., Xi, R., Haseley, P.S., Hsieh, C.-H., Zhang, C., Ren, X., Protopopov, A., Chin, L. et al. (2013) Diverse mechanisms of somatic structural variations in human cancer genomes. Cell, 153, 919-929.
-
(2013)
Cell
, vol.153
, pp. 919-929
-
-
Yang, L.1
Luquette, L.J.2
Gehlenborg, N.3
Xi, R.4
Haseley, P.S.5
Hsieh, C.-H.6
Zhang, C.7
Ren, X.8
Protopopov, A.9
Chin, L.10
-
190
-
-
84888869068
-
Chromothripsis and beyond: Rapid genome evolution from complex chromosomal rearrangements
-
Zhang, C.-Z., Leibowitz, M.L. and Pellman, D. (2013) Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements. Genes Dev., 27, 2513-2530.
-
(2013)
Genes Dev.
, vol.27
, pp. 2513-2530
-
-
Zhang, C.-Z.1
Leibowitz, M.L.2
Pellman, D.3
-
191
-
-
84880513002
-
Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer
-
Iwakawa, R., Takenaka, M., Kohno, T., Shimada, Y., Totoki, Y., Shibata, T., Tsuta, K., Nishikawa, R., Noguchi, M., Sato-Otsubo, A. et al. (2013) Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer. Genes Chromosomes Cancer, 52, 802-816.
-
(2013)
Genes Chromosomes Cancer
, vol.52
, pp. 802-816
-
-
Iwakawa, R.1
Takenaka, M.2
Kohno, T.3
Shimada, Y.4
Totoki, Y.5
Shibata, T.6
Tsuta, K.7
Nishikawa, R.8
Noguchi, M.9
Sato-Otsubo, A.10
-
192
-
-
84877113990
-
Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms
-
Malhotra, A., Lindberg, M., Faust, G.G., Leibowitz, M.L., Clark, R.A., Layer, R.M., Quinlan, A.R. and Hall, I.M. (2013) Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms. Genome Res., 23, 762-776.
-
(2013)
Genome Res.
, vol.23
, pp. 762-776
-
-
Malhotra, A.1
Lindberg, M.2
Faust, G.G.3
Leibowitz, M.L.4
Clark, R.A.5
Layer, R.M.6
Quinlan, A.R.7
Hall, I.M.8
-
193
-
-
84862907577
-
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
-
Rausch, T., Jones, D.T.W., Zapatka, M., Stütz, A.M., Zichner, T., Weischenfeldt, J., Jäger, N., Remke, M., Shih, D., Northcott, P.A. et al. (2012) Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell, 148, 59-71.
-
(2012)
Cell
, vol.148
, pp. 59-71
-
-
Rausch, T.1
Jones, D.T.W.2
Zapatka, M.3
Stütz, A.M.4
Zichner, T.5
Weischenfeldt, J.6
Jäger, N.7
Remke, M.8
Shih, D.9
Northcott, P.A.10
-
194
-
-
79955416773
-
Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline
-
Kloosterman, W.P., Guryev, V., van Roosmalen, M., Duran, K.J., de Bruijn, E., Bakker, S.C.M., Letteboer, T., van Nesselrooij, B., Hochstenbach, R., Poot, M. et al. (2011) Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline. Hum. Mol. Genet., 20, 1916-1924.
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 1916-1924
-
-
Kloosterman, W.P.1
Guryev, V.2
Van Roosmalen, M.3
Duran, K.J.4
De Bruijn, E.5
Bakker, S.C.M.6
Letteboer, T.7
Van Nesselrooij, B.8
Hochstenbach, R.9
Poot, M.10
-
195
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov, L.B., Nik-Zainal, S., Wedge, D.C., Aparicio, S.A.J.R., Behjati, S., Biankin, A.V., Bignell, G.R., Bolli, N., Borg, A., Børresen-Dale, A.-L. et al. (2013) Signatures of mutational processes in human cancer. Nature, 500, 415-421.
-
(2013)
Nature
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
Nik-Zainal, S.2
Wedge, D.C.3
Aparicio, S.A.J.R.4
Behjati, S.5
Biankin, A.V.6
Bignell, G.R.7
Bolli, N.8
Borg, A.9
Børresen-Dale, A.-L.10
-
196
-
-
84884997982
-
Emerging landscape of oncogenic signatures across human cancers
-
Ciriello, G., Miller, M.L., Aksoy, B.A., Senbabaoglu, Y., Schultz, N. and Sander, C. (2013) Emerging landscape of oncogenic signatures across human cancers. Nat. Genet., 45, 1127-1133.
-
(2013)
Nat. Genet.
, vol.45
, pp. 1127-1133
-
-
Ciriello, G.1
Miller, M.L.2
Aksoy, B.A.3
Senbabaoglu, Y.4
Schultz, N.5
Sander, C.6
-
197
-
-
84861541343
-
Mutational processes molding the genomes of 21 breast cancers
-
Nik-Zainal, S., Alexandrov, L.B., Wedge, D.C., Van Loo, P., Greenman, C.D., Raine, K., Jones, D., Hinton, J., Marshall, J., Stebbings, L.A. et al. (2012) Mutational processes molding the genomes of 21 breast cancers. Cell, 149, 979-993.
-
(2012)
Cell
, vol.149
, pp. 979-993
-
-
Nik-Zainal, S.1
Alexandrov, L.B.2
Wedge, D.C.3
Van Loo, P.4
Greenman, C.D.5
Raine, K.6
Jones, D.7
Hinton, J.8
Marshall, J.9
Stebbings, L.A.10
-
198
-
-
84861550476
-
The life history of 21 breast cancers
-
Nik-Zainal, S., Van Loo, P., Wedge, D.C., Alexandrov, L.B., Greenman, C.D., Lau, K.W., Raine, K., Jones, D., Marshall, J., Ramakrishna, M. et al., (2012) The life history of 21 breast cancers. Cell, 149, 994-1007.
-
(2012)
Cell
, vol.149
, pp. 994-1007
-
-
Nik-Zainal, S.1
Van Loo, P.2
Wedge, D.C.3
Alexandrov, L.B.4
Greenman, C.D.5
Lau, K.W.6
Raine, K.7
Jones, D.8
Marshall, J.9
Ramakrishna, M.10
-
199
-
-
84875899565
-
Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases
-
Koito, A. and Ikeda, T. (2013) Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases. Front. Microbiol., 4, 28.
-
(2013)
Front. Microbiol.
, vol.4
, pp. 28
-
-
Koito, A.1
Ikeda, T.2
-
200
-
-
84874188583
-
APOBEC3B is an enzymatic source of mutation in breast cancer
-
Burns, M.B., Lackey, L., Carpenter, M.A., Rathore, A., Land, A.M., Leonard, B., Refsland, E.W., Kotandeniya, D., Tretyakova, N., Nikas, J.B. et al. (2013) APOBEC3B is an enzymatic source of mutation in breast cancer. Nature, 494, 366-370.
-
(2013)
Nature
, vol.494
, pp. 366-370
-
-
Burns, M.B.1
Lackey, L.2
Carpenter, M.A.3
Rathore, A.4
Land, A.M.5
Leonard, B.6
Refsland, E.W.7
Kotandeniya, D.8
Tretyakova, N.9
Nikas, J.B.10
-
201
-
-
78650215702
-
Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes
-
Al-Ejeh, F., Kumar, R., Wiegmans, A., Lakhani, S.R., Brown, M.P. and Khanna, K.K. (2010) Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes. Oncogene, 29, 6085-6098.
-
(2010)
Oncogene
, vol.29
, pp. 6085-6098
-
-
Al-Ejeh, F.1
Kumar, R.2
Wiegmans, A.3
Lakhani, S.R.4
Brown, M.P.5
Khanna, K.K.6
-
202
-
-
77955278619
-
Targeting homologous recombination repair defects in cancer
-
Evers, B., Helleday, T. and Jonkers, J. (2010) Targeting homologous recombination repair defects in cancer. Trends Pharmacol. Sci., 31, 372-380.
-
(2010)
Trends Pharmacol. Sci.
, vol.31
, pp. 372-380
-
-
Evers, B.1
Helleday, T.2
Jonkers, J.3
-
203
-
-
70350222210
-
Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair
-
Bolderson, E., Richard, D.J., Zhou, B.-B.S. and Khanna, K.K. (2009) Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair. Clin. Cancer Res., 15, 6314-6320.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 6314-6320
-
-
Bolderson, E.1
Richard, D.J.2
Zhou, B.-B.S.3
Khanna, K.K.4
-
204
-
-
84878235773
-
DNA-damaging agents in cancer chemotherapy: Serendipity and chemical biology
-
Cheung-Ong, K., Giaever, G. and Nislow, C. (2013) DNA-damaging agents in cancer chemotherapy: serendipity and chemical biology. Chem. Biol., 20, 648-659.
-
(2013)
Chem. Biol.
, vol.20
, pp. 648-659
-
-
Cheung-Ong, K.1
Giaever, G.2
Nislow, C.3
-
205
-
-
34249041230
-
Exploring genetic interactions and networks with yeast
-
Boone, C., Bussey, H. and Andrews, B.J. (2007) Exploring genetic interactions and networks with yeast. Nat. Rev. Genet., 8, 437-449.
-
(2007)
Nat. Rev. Genet.
, vol.8
, pp. 437-449
-
-
Boone, C.1
Bussey, H.2
Andrews, B.J.3
-
206
-
-
78650890720
-
Synthetic lethality: General principles, utility and detection using genetic screens in human cells
-
Nijman, S.M.B. (2011) Synthetic lethality: general principles, utility and detection using genetic screens in human cells. FEBS Lett., 585, 1-6.
-
(2011)
FEBS Lett.
, vol.585
, pp. 1-6
-
-
Nijman, S.M.B.1
-
207
-
-
84876787714
-
Synthetic lethality and cancer: Cohesin and PARP at the replication fork
-
O'Neil, N.J., van Pel, D.M. and Hieter, P. (2013) Synthetic lethality and cancer: cohesin and PARP at the replication fork. Trends Genet., 29, 290-297.
-
(2013)
Trends Genet.
, vol.29
, pp. 290-297
-
-
O'Neil, N.J.1
Van Pel, D.M.2
Hieter, P.3
-
208
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D. and Weinberg, R.A. (2011) Hallmarks of cancer: the next generation. Cell, 144, 646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
209
-
-
84858440807
-
Screens, maps & networks: From genome sequences to personalized medicine
-
Sandmann, T. and Boutros, M. (2012) Screens, maps & networks: from genome sequences to personalized medicine. Curr. Opin. Genet. Dev., 22, 36-44.
-
(2012)
Curr. Opin. Genet. Dev.
, vol.22
, pp. 36-44
-
-
Sandmann, T.1
Boutros, M.2
-
210
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer, H., McCabe, N., Lord, C.J., Tutt, A.N.J., Johnson, D.A., Richardson, T.B., Santarosa, M., Dillon, K.J., Hickson, I., Knights, C. et al. (2005) Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature, 434, 917-921.
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
Tutt, A.N.J.4
Johnson, D.A.5
Richardson, T.B.6
Santarosa, M.7
Dillon, K.J.8
Hickson, I.9
Knights, C.10
-
211
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
Bryant, H.E., Schultz, N., Thomas, H.D., Parker, K.M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N.J. and Helleday, T. (2005) Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature, 434, 913-917.
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
Parker, K.M.4
Flower, D.5
Lopez, E.6
Kyle, S.7
Meuth, M.8
Curtin, N.J.9
Helleday, T.10
-
212
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong, P.C., Boss, D.S., Yap, T.A., Tutt, A., Wu, P., Mergui-Roelvink, M., Mortimer, P., Swaisland, H., Lau, A., O'Connor, M.J. et al. (2009) Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N. Engl. J. Med., 361, 123-134.
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
Tutt, A.4
Wu, P.5
Mergui-Roelvink, M.6
Mortimer, P.7
Swaisland, H.8
Lau, A.9
O'Connor, M.J.10
-
213
-
-
0035132977
-
Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity
-
Tsutsumi, M., Masutani, M., Nozaki, T., Kusuoka, O., Tsujiuchi, T., Nakagama, H., Suzuki, H., Konishi, Y. and Sugimura, T. (2001) Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity. Carcinogenesis, 22, 1-3.
-
(2001)
Carcinogenesis
, vol.22
, pp. 1-3
-
-
Tsutsumi, M.1
Masutani, M.2
Nozaki, T.3
Kusuoka, O.4
Tsujiuchi, T.5
Nakagama, H.6
Suzuki, H.7
Konishi, Y.8
Sugimura, T.9
-
214
-
-
0034733928
-
Poly(ADP-ribose) polymerase-1: What have we learned from the deficient mouse model?
-
Shall, S. and de Murcia, G. (2000) Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model? Mutat. Res., 460, 1-15.
-
(2000)
Mutat. Res.
, vol.460
, pp. 1-15
-
-
Shall, S.1
De Murcia, G.2
-
215
-
-
77954374334
-
Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells
-
Gottipati, P., Vischioni, B., Schultz, N., Solomons, J., Bryant, H.E., Djureinovic, T., Issaeva, N., Sleeth, K., Sharma, R.A. and Helleday, T. (2010) Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination- defective cells. Cancer Res., 70, 5389-5398.
-
(2010)
Cancer Res.
, vol.70
, pp. 5389-5398
-
-
Gottipati, P.1
Vischioni, B.2
Schultz, N.3
Solomons, J.4
Bryant, H.E.5
Djureinovic, T.6
Issaeva, N.7
Sleeth, K.8
Sharma, R.A.9
Helleday, T.10
-
216
-
-
79952747328
-
Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells
-
Patel, A.G., Sarkaria, J.N. and Kaufmann, S.H. (2011) Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells. Proc. Natl. Acad. Sci. U.S.A., 108, 3406-3411.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 3406-3411
-
-
Patel, A.G.1
Sarkaria, J.N.2
Kaufmann, S.H.3
-
217
-
-
80052168685
-
The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
-
Helleday, T. (2011) The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings. Mol. Oncol., 5, 387-393.
-
(2011)
Mol. Oncol.
, vol.5
, pp. 387-393
-
-
Helleday, T.1
-
218
-
-
2342524565
-
Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks
-
Yang, Y.-G., Cortes, U., Patnaik, S., Jasin, M. and Wang, Z.-Q. (2004) Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks. Oncogene, 23, 3872-3882.
-
(2004)
Oncogene
, vol.23
, pp. 3872-3882
-
-
Yang, Y.-G.1
Cortes, U.2
Patnaik, S.3
Jasin, M.4
Wang, Z.-Q.5
-
219
-
-
84861888851
-
Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1
-
Ying, S., Hamdy, F.C. and Helleday, T. (2012) Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1. Cancer Res., 72, 2814-2821.
-
(2012)
Cancer Res.
, vol.72
, pp. 2814-2821
-
-
Ying, S.1
Hamdy, F.C.2
Helleday, T.3
-
220
-
-
69849097500
-
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
-
Bryant, H.E., Petermann, E., Schultz, N., Jemth, A.-S., Loseva, O., Issaeva, N., Johansson, F., Fernandez, S., McGlynn, P. and Helleday, T. (2009) PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. EMBO J., 28, 2601-2615.
-
(2009)
EMBO J.
, vol.28
, pp. 2601-2615
-
-
Bryant, H.E.1
Petermann, E.2
Schultz, N.3
Jemth, A.-S.4
Loseva, O.5
Issaeva, N.6
Johansson, F.7
Fernandez, S.8
McGlynn, P.9
Helleday, T.10
-
221
-
-
85016343160
-
Strategies for the use of Poly(adenosine diphosphate ribose) Polymerase (PARP) inhibitors in Cancer therapy
-
Ström, C. and Helleday, T. (2012) Strategies for the use of Poly(adenosine diphosphate ribose) Polymerase (PARP) inhibitors in Cancer therapy. Biomolecules, 2, 635-649.
-
(2012)
Biomolecules
, vol.2
, pp. 635-649
-
-
Ström, C.1
Helleday, T.2
-
222
-
-
31044446360
-
PARP inhibitors for cancer therapy
-
Curtin, N.J. (2005) PARP inhibitors for cancer therapy. Expert Rev. Mol. Med., 7, 1-20.
-
(2005)
Expert Rev. Mol. Med.
, vol.7
, pp. 1-20
-
-
Curtin, N.J.1
-
223
-
-
84868221110
-
Trapping of PARP1 and PARP2 by clinical PARP inhibitors
-
Murai, J., Huang, S.-Y.N., Das, B.B., Renaud, A., Zhang, Y., Doroshow, J.H., Ji, J., Takeda, S. and Pommier, Y. (2012) Trapping of PARP1 and PARP2 by clinical PARP inhibitors. Cancer Res., 72, 5588-5599.
-
(2012)
Cancer Res.
, vol.72
, pp. 5588-5599
-
-
Murai, J.1
Huang, S.-Y.N.2
Das, B.B.3
Renaud, A.4
Zhang, Y.5
Doroshow, J.H.6
Ji, J.7
Takeda, S.8
Pommier, Y.9
-
224
-
-
33845235459
-
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
-
Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.-V.F., Kolettas, E., Niforou, K., Zoumpourlis, V.C. et al. (2006) Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature, 444, 633-637.
-
(2006)
Nature
, vol.444
, pp. 633-637
-
-
Bartkova, J.1
Rezaei, N.2
Liontos, M.3
Karakaidos, P.4
Kletsas, D.5
Issaeva, N.6
Vassiliou, L.-V.F.7
Kolettas, E.8
Niforou, K.9
Zoumpourlis, V.C.10
-
225
-
-
0040984333
-
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
-
de Murcia, J.M., Niedergang, C., Trucco, C., Ricoul, M., Dutrillaux, B., Mark, M., Oliver, F.J., Masson, M., Dierich, A., LeMeur, M. et al. (1997) Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc. Natl. Acad. Sci. U.S.A., 94, 7303-7307.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 7303-7307
-
-
De Murcia, J.M.1
Niedergang, C.2
Trucco, C.3
Ricoul, M.4
Dutrillaux, B.5
Mark, M.6
Oliver, F.J.7
Masson, M.8
Dierich, A.9
Lemeur, M.10
-
226
-
-
0030984490
-
PARP is important for genomic stability but dispensable in apoptosis
-
Wang, Z.Q., Stingl, L., Morrison, C., Jantsch, M., Los, M., Schulze-Osthoff, K. and Wagner, E.F. (1997) PARP is important for genomic stability but dispensable in apoptosis. Genes Dev., 11, 2347-2358.
-
(1997)
Genes Dev.
, vol.11
, pp. 2347-2358
-
-
Wang, Z.Q.1
Stingl, L.2
Morrison, C.3
Jantsch, M.4
Los, M.5
Schulze-Osthoff, K.6
Wagner, E.F.7
-
227
-
-
33748065304
-
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition
-
McCabe, N., Turner, N.C., Lord, C.J., Kluzek, K., Bialkowska, A., Swift, S., Giavara, S., O'Connor, M.J., Tutt, A.N., Zdzienicka, M.Z. et al. (2006) Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. Cancer Res., 66, 8109-8115.
-
(2006)
Cancer Res.
, vol.66
, pp. 8109-8115
-
-
McCabe, N.1
Turner, N.C.2
Lord, C.J.3
Kluzek, K.4
Bialkowska, A.5
Swift, S.6
Giavara, S.7
O'Connor, M.J.8
Tutt, A.N.9
Zdzienicka, M.Z.10
-
228
-
-
83455229693
-
BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance
-
Drost, R., Bouwman, P., Rottenberg, S., Boon, U., Schut, E., Klarenbeek, S., Klijn, C., van der Heijden, I., van der Gulden, H., Wientjens, E. et al. (2011) BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance. Cancer Cell, 20, 797-809.
-
(2011)
Cancer Cell
, vol.20
, pp. 797-809
-
-
Drost, R.1
Bouwman, P.2
Rottenberg, S.3
Boon, U.4
Schut, E.5
Klarenbeek, S.6
Klijn, C.7
Van Der-Heijden, I.8
Van Der-Gulden, H.9
Wientjens, E.10
-
229
-
-
84904667448
-
Opportunities and hurdles in the treatment of BRCA1-related breast cancer
-
Drost, R. and Jonkers, J. (2013) Opportunities and hurdles in the treatment of BRCA1-related breast cancer. Oncogene, 10, 1-11.
-
(2013)
Oncogene
, vol.10
, pp. 1-11
-
-
Drost, R.1
Jonkers, J.2
-
230
-
-
42349096328
-
Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance
-
Swisher, E.M., Sakai, W., Karlan, B.Y., Wurz, K., Urban, N. and Taniguchi, T. (2008) Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance. Cancer Res., 68, 2581-2586.
-
(2008)
Cancer Res.
, vol.68
, pp. 2581-2586
-
-
Swisher, E.M.1
Sakai, W.2
Karlan, B.Y.3
Wurz, K.4
Urban, N.5
Taniguchi, T.6
-
231
-
-
80051642095
-
Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas
-
Norquist, B., Wurz, K.A., Pennil, C.C., Garcia, R., Gross, J., Sakai, W., Karlan, B.Y., Taniguchi, T. and Swisher, E.M. (2011) Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas. J. Clin. Oncol., 29, 3008-3015.
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 3008-3015
-
-
Norquist, B.1
Wurz, K.A.2
Pennil, C.C.3
Garcia, R.4
Gross, J.5
Sakai, W.6
Karlan, B.Y.7
Taniguchi, T.8
Swisher, E.M.9
-
232
-
-
84866358168
-
The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance
-
Bouwman, P. and Jonkers, J. (2012) The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance. Nat. Rev. Cancer, 12, 587-598.
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 587-598
-
-
Bouwman, P.1
Jonkers, J.2
-
233
-
-
39849097680
-
Resistance to therapy caused by intragenic deletion in BRCA2
-
Edwards, S.L., Brough, R., Lord, C.J., Natrajan, R., Vatcheva, R., Levine, D.A., Boyd, J., Reis-Filho, J.S. and Ashworth, A. (2008) Resistance to therapy caused by intragenic deletion in BRCA2. Nature, 451, 1111-1115.
-
(2008)
Nature
, vol.451
, pp. 1111-1115
-
-
Edwards, S.L.1
Brough, R.2
Lord, C.J.3
Natrajan, R.4
Vatcheva, R.5
Levine, D.A.6
Boyd, J.7
Reis-Filho, J.S.8
Ashworth, A.9
-
234
-
-
39849106300
-
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
-
Sakai, W., Swisher, E.M., Karlan, B.Y., Agarwal, M.K., Higgins, J., Friedman, C., Villegas, E., Jacquemont, C., Farrugia, D.J., Couch, F.J. et al. (2008) Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers. Nature, 451, 1116-1120.
-
(2008)
Nature
, vol.451
, pp. 1116-1120
-
-
Sakai, W.1
Swisher, E.M.2
Karlan, B.Y.3
Agarwal, M.K.4
Higgins, J.5
Friedman, C.6
Villegas, E.7
Jacquemont, C.8
Farrugia, D.J.9
Couch, F.J.10
-
235
-
-
84872837247
-
Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors
-
Jaspers, J.E., Kersbergen, A., Boon, U., Sol, W., van Deemter, L., Zander, S.A., Drost, R., Wientjens, E., Ji, J., Aly, A. et al., (2013) Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov., 3, 68-81.
-
(2013)
Cancer Discov.
, vol.3
, pp. 68-81
-
-
Jaspers, J.E.1
Kersbergen, A.2
Boon, U.3
Sol, W.4
Van Deemter, L.5
Zander, S.A.6
Drost, R.7
Wientjens, E.8
Ji, J.9
Aly, A.10
-
236
-
-
84885770237
-
Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance
-
Johnson, N., Johnson, S.F., Yao, W., Li, Y.-C., Choi, Y.-E., Bernhardy, A.J., Wang, Y., Capelletti, M., Sarosiek, K.A., Moreau, L.A. et al. (2013) Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance. Proc. Natl. Acad. Sci. U.S.A., 110, 17041-17046.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 17041-17046
-
-
Johnson, N.1
Johnson, S.F.2
Yao, W.3
Li, Y.-C.4
Choi, Y.-E.5
Bernhardy, A.J.6
Wang, Y.7
Capelletti, M.8
Sarosiek, K.A.9
Moreau, L.A.10
-
237
-
-
77953879925
-
Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway
-
Pace, P., Mosedale, G., Hodskinson, M.R., Rosado, I.V., Sivasubramaniam, M. and Patel, K.J. (2010) Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway. Science, 329, 219-223.
-
(2010)
Science
, vol.329
, pp. 219-223
-
-
Pace, P.1
Mosedale, G.2
Hodskinson, M.R.3
Rosado, I.V.4
Sivasubramaniam, M.5
Patel, K.J.6
-
238
-
-
77954310242
-
Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia
-
Adamo, A., Collis, S.J., Adelman, C.A., Silva, N., Horejsí, Z., Ward, J.D., Martinez-Perez, E., Boulton, S.J. and La Volpe, A. (2010) Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. Mol. Cell, 39, 25-35.
-
(2010)
Mol. Cell
, vol.39
, pp. 25-35
-
-
Adamo, A.1
Collis, S.J.2
Adelman, C.A.3
Silva, N.4
Horejsí, Z.5
Ward, J.D.6
Martinez-Perez, E.7
Boulton, S.J.8
La Volpe, A.9
-
239
-
-
78650373804
-
Network medicine: A network-based approach to human disease
-
Barabási, A.-L., Gulbahce, N. and Loscalzo, J. (2011) Network medicine: a network-based approach to human disease. Nat. Rev. Genet., 12, 56-68.
-
(2011)
Nat. Rev. Genet.
, vol.12
, pp. 56-68
-
-
Barabási, A.-L.1
Gulbahce, N.2
Loscalzo, J.3
-
240
-
-
21744462100
-
Dynamics of chronic myeloid leukaemia
-
Michor, F., Hughes, T.P., Iwasa, Y., Branford, S., Shah, N.P., Sawyers, C.L. and Nowak, M.A. (2005) Dynamics of chronic myeloid leukaemia. Nature, 435, 1267-1270.
-
(2005)
Nature
, vol.435
, pp. 1267-1270
-
-
Michor, F.1
Hughes, T.P.2
Iwasa, Y.3
Branford, S.4
Shah, N.P.5
Sawyers, C.L.6
Nowak, M.A.7
-
241
-
-
84878889746
-
Systematic tracking of dysregulated modules identifies novel genes in cancer
-
Srihari, S. and Ragan, M.A. (2013) Systematic tracking of dysregulated modules identifies novel genes in cancer. Bioinformatics, 29(12)1553-1561.
-
(2013)
Bioinformatics
, vol.29
, Issue.12
, pp. 1553-1561
-
-
Srihari, S.1
Ragan, M.A.2
-
242
-
-
67249117049
-
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
-
Hindorff, L.A., Sethupathy, P., Junkins, H.A., Ramos, E.M., Mehta, J.P., Collins, F.S. and Manolio, T.A. (2009) Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl. Acad. Sci. U.S.A., 106, 9362-9367.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 9362-9367
-
-
Hindorff, L.A.1
Sethupathy, P.2
Junkins, H.A.3
Ramos, E.M.4
Mehta, J.P.5
Collins, F.S.6
Manolio, T.A.7
-
243
-
-
0023715595
-
A cancer family syndrome in twenty-four kindreds
-
Li, F.P., Fraumeni, J.F., Mulvihill, J.J., Blattner, W.A., Dreyfus, M.G., Tucker, M.A. and Miller, R.W. (1988) A cancer family syndrome in twenty-four kindreds. Cancer Res., 48, 5358-5362.
-
(1988)
Cancer Res.
, vol.48
, pp. 5358-5362
-
-
Li, F.P.1
Fraumeni, J.F.2
Mulvihill, J.J.3
Blattner, W.A.4
Dreyfus, M.G.5
Tucker, M.A.6
Miller, R.W.7
-
244
-
-
84863717944
-
Breast cancer phenotype in women with TP53 germline mutations: A Li-Fraumeni syndrome consortium effort
-
Masciari, S., Dillon, D.A., Rath, M., Robson, M., Weitzel, J.N., Balmana, J., Gruber, S.B., Ford, J.M., Euhus, D., Lebensohn, A. et al. (2012) Breast cancer phenotype in women with TP53 germline mutations: a Li-Fraumeni syndrome consortium effort. Breast Cancer Res. Treat., 133, 1125-1130.
-
(2012)
Breast Cancer Res. Treat.
, vol.133
, pp. 1125-1130
-
-
Masciari, S.1
Dillon, D.A.2
Rath, M.3
Robson, M.4
Weitzel, J.N.5
Balmana, J.6
Gruber, S.B.7
Ford, J.M.8
Euhus, D.9
Lebensohn, A.10
-
245
-
-
66649120472
-
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4
-
Lee, J., Kim, D.-H., Lee, S., Yang, Q.-H., Lee, D.K., Lee, S.-K., Roeder, R.G. and Lee, J.W. (2009) A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. Proc. Natl. Acad. Sci. U.S.A., 106, 8513-8518.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 8513-8518
-
-
Lee, J.1
Kim, D.-H.2
Lee, S.3
Yang, Q.-H.4
Lee, D.K.5
Lee, S.-K.6
Roeder, R.G.7
Lee, J.W.8
-
246
-
-
84878524313
-
Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response
-
Bennetzen, M.V., Larsen, D.H., Dinant, C., Watanabe, S., Bartek, J., Lukas, J. and Andersen, J.S. (2013) Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response. Cell Cycle, 12, 1688-1695.
-
(2013)
Cell Cycle
, vol.12
, pp. 1688-1695
-
-
Bennetzen, M.V.1
Larsen, D.H.2
Dinant, C.3
Watanabe, S.4
Bartek, J.5
Lukas, J.6
Andersen, J.S.7
-
247
-
-
0006713602
-
Identification of the breast cancer susceptibility gene BRCA2
-
Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S., Gumbs, C. and Micklem, G. (1995) Identification of the breast cancer susceptibility gene BRCA2. Nature, 378, 789-792.
-
(1995)
Nature
, vol.378
, pp. 789-792
-
-
Wooster, R.1
Bignell, G.2
Lancaster, J.3
Swift, S.4
Seal, S.5
Mangion, J.6
Collins, N.7
Gregory, S.8
Gumbs, C.9
Micklem, G.10
-
248
-
-
0031004088
-
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
-
Liaw, D., Marsh, D.J., Li, J., Dahia, P.L., Wang, S.I., Zheng, Z., Bose, S., Call, K.M., Tsou, H.C., Peacocke, M. et al. (1997) Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet., 16, 64-67.
-
(1997)
Nat. Genet.
, vol.16
, pp. 64-67
-
-
Liaw, D.1
Marsh, D.J.2
Li, J.3
Dahia, P.L.4
Wang, S.I.5
Zheng, Z.6
Bose, S.7
Call, K.M.8
Tsou, H.C.9
Peacocke, M.10
-
249
-
-
70350490327
-
Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer
-
Tavtigian, S.V., Oefner, P.J., Babikyan, D., Hartmann, A., Healey, S., Le Calvez-Kelm, F., Lesueur, F., Byrnes, G.B., Chuang, S.-C., Forey, N. et al. (2009) Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer. Am. J. Hum. Genet., 85, 427-446.
-
(2009)
Am. J. Hum. Genet.
, vol.85
, pp. 427-446
-
-
Tavtigian, S.V.1
Oefner, P.J.2
Babikyan, D.3
Hartmann, A.4
Healey, S.5
Le Calvez-Kelm, F.6
Lesueur, F.7
Byrnes, G.B.8
Chuang, S.-C.9
Forey, N.10
-
250
-
-
11244335534
-
The ATM gene is a target for epigenetic silencing in locally advanced breast cancer
-
Vo, Q.N., Kim, W.-J., Cvitanovic, L., Boudreau, D.A., Ginzinger, D.G. and Brown, K.D. (2004) The ATM gene is a target for epigenetic silencing in locally advanced breast cancer. Oncogene, 23, 9432-9437.
-
(2004)
Oncogene
, vol.23
, pp. 9432-9437
-
-
Vo, Q.N.1
Kim, W.-J.2
Cvitanovic, L.3
Boudreau, D.A.4
Ginzinger, D.G.5
Brown, K.D.6
-
251
-
-
84860516671
-
Intragenic ATM methylation in peripheral blood DNA as a biomarker of breast cancer risk
-
Brennan, K., García-Closas, M., Orr, N., Fletcher, O., Jones, M., Ashworth, A., Swerdlow, A., Thorne, H. and kConFab InvestigatorskConFab Investigators and Riboli, E. et al., (2012) Intragenic ATM methylation in peripheral blood DNA as a biomarker of breast cancer risk. Cancer Res., 72, 2304-2313.
-
(2012)
Cancer Res.
, vol.72
, pp. 2304-2313
-
-
Brennan, K.1
García-Closas, M.2
Orr, N.3
Fletcher, O.4
Jones, M.5
Ashworth, A.6
Swerdlow, A.7
Thorne, H.8
Investigatorskconfab Investigators, K.9
Riboli, E.10
-
252
-
-
0028113345
-
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
-
Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P.A., Harshman, K., Tavtigian, S., Liu, Q., Cochran, C., Bennett, L.M. and Ding, W. (1994) A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science, 266, 66-71.
-
(1994)
Science
, vol.266
, pp. 66-71
-
-
Miki, Y.1
Swensen, J.2
Shattuck-Eidens, D.3
Futreal, P.A.4
Harshman, K.5
Tavtigian, S.6
Liu, Q.7
Cochran, C.8
Bennett, L.M.9
Ding, W.10
-
253
-
-
0034607234
-
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors
-
Esteller, M., Silva, J.M., Dominguez, G., Bonilla, F., Matias-Guiu, X., Lerma, E., Bussaglia, E., Prat, J., Harkes, I.C., Repasky, E.A. et al. (2000) Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J. Natl. Cancer Inst., 92, 564-569.
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, pp. 564-569
-
-
Esteller, M.1
Silva, J.M.2
Dominguez, G.3
Bonilla, F.4
Matias-Guiu, X.5
Lerma, E.6
Bussaglia, E.7
Prat, J.8
Harkes, I.C.9
Repasky, E.A.10
-
254
-
-
13844251972
-
Lack of PTEN sequesters CHK1 and initiates genetic instability
-
Puc, J., Keniry, M., Li, H.S., Pandita, T.K., Choudhury, A.D., Memeo, L., Mansukhani, M., Murty, V.V.V.S., Gaciong, Z., Meek, S.E.M. et al. (2005) Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell, 7, 193-204.
-
(2005)
Cancer Cell
, vol.7
, pp. 193-204
-
-
Puc, J.1
Keniry, M.2
Li, H.S.3
Pandita, T.K.4
Choudhury, A.D.5
Memeo, L.6
Mansukhani, M.7
Murty, V.V.V.S.8
Gaciong, Z.9
Meek, S.E.M.10
-
255
-
-
58049202910
-
Risk of second malignancies in survivors of retinoblastoma: More than 40 years of follow-up
-
Marees, T., Moll, A.C., Imhof, S.M., de Boer, M.R., Ringens, P.J. and van Leeuwen, F.E. (2008) Risk of second malignancies in survivors of retinoblastoma: more than 40 years of follow-up. J. Natl. Cancer Inst., 100, 1771-1779.
-
(2008)
J. Natl. Cancer Inst.
, vol.100
, pp. 1771-1779
-
-
Marees, T.1
Moll, A.C.2
Imhof, S.M.3
De Boer, M.R.4
Ringens, P.J.5
Van Leeuwen, F.E.6
-
256
-
-
33750465216
-
Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles
-
Seal, S., Thompson, D., Renwick, A., Elliott, A., Kelly, P., Barfoot, R., Chagtai, T., Jayatilake, H., Ahmed, M., Spanova, K. et al. (2006) Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles. Nat. Genet., 38, 1239-1241.
-
(2006)
Nat. Genet.
, vol.38
, pp. 1239-1241
-
-
Seal, S.1
Thompson, D.2
Renwick, A.3
Elliott, A.4
Kelly, P.5
Barfoot, R.6
Chagtai, T.7
Jayatilake, H.8
Ahmed, M.9
Spanova, K.10
-
257
-
-
18544389716
-
Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations
-
Meijers-Heijboer, H., van den Ouweland, A., Klijn, J., Wasielewski, M., de Snoo, A., Oldenburg, R., Hollestelle, A., Houben, M., Crepin, E., van Veghel-Plandsoen, M. et al., (2002) Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat. Genet., 31, 55-59.
-
(2002)
Nat. Genet.
, vol.31
, pp. 55-59
-
-
Meijers-Heijboer, H.1
Van Den-Ouweland, A.2
Klijn, J.3
Wasielewski, M.4
De Snoo, A.5
Oldenburg, R.6
Hollestelle, A.7
Houben, M.8
Crepin, E.9
Van Veghel-Plandsoen, M.10
-
258
-
-
84869417534
-
Toward an improved definition of the tumor spectrum associated with BAP1 germline mutations
-
Wiesner, T., Fried, I., Ulz, P., Stacher, E., Popper, H., Murali, R., Kutzner, H., Lax, S., Smolle-Jüttner, F., Geigl, J.B. et al. (2012) Toward an improved definition of the tumor spectrum associated with BAP1 germline mutations. J. Clin. Oncol., 30, e337-e340.
-
(2012)
J. Clin. Oncol.
, vol.30
-
-
Wiesner, T.1
Fried, I.2
Ulz, P.3
Stacher, E.4
Popper, H.5
Murali, R.6
Kutzner, H.7
Lax, S.8
Smolle-Jüttner, F.9
Geigl, J.B.10
-
259
-
-
79958254560
-
A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
-
Jirawatnotai, S., Hu, Y., Michowski, W., Elias, J.E., Becks, L., Bienvenu, F., Zagozdzon, A., Goswami, T., Wang, Y.E., Clark, A.B. et al. (2011) A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature, 474, 230-234.
-
(2011)
Nature
, vol.474
, pp. 230-234
-
-
Jirawatnotai, S.1
Hu, Y.2
Michowski, W.3
Elias, J.E.4
Becks, L.5
Bienvenu, F.6
Zagozdzon, A.7
Goswami, T.8
Wang, Y.E.9
Clark, A.B.10
-
260
-
-
84875933011
-
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers
-
French, J.D., Ghoussaini, M., Edwards, S.L., Meyer, K.B., Michailidou, K., Ahmed, S., Khan, S., Maranian, M.J., O'Reilly, M., Hillman, K.M. et al. (2013) Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am. J. Hum. Genet., 92, 489-503.
-
(2013)
Am. J. Hum. Genet.
, vol.92
, pp. 489-503
-
-
French, J.D.1
Ghoussaini, M.2
Edwards, S.L.3
Meyer, K.B.4
Michailidou, K.5
Ahmed, S.6
Khan, S.7
Maranian, M.J.8
O'Reilly, M.9
Hillman, K.M.10
-
261
-
-
33846625493
-
PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene
-
Rahman, N., Seal, S., Thompson, D., Kelly, P., Renwick, A., Elliott, A., Reid, S., Spanova, K., Barfoot, R., Chagtai, T. et al. (2007) PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nat. Genet., 39, 165-167.
-
(2007)
Nat. Genet.
, vol.39
, pp. 165-167
-
-
Rahman, N.1
Seal, S.2
Thompson, D.3
Kelly, P.4
Renwick, A.5
Elliott, A.6
Reid, S.7
Spanova, K.8
Barfoot, R.9
Chagtai, T.10
|