-
1
-
-
64749094310
-
The cancer genome
-
Stratton, M. R., Campbell, P. J. & Futreal, P. A. The cancer genome. Nature 458, 719-724 (2009).
-
(2009)
Nature
, vol.458
, pp. 719-724
-
-
Stratton, M.R.1
Campbell, P.J.2
Futreal, P.A.3
-
2
-
-
78751696965
-
Environmental exposures and mutational patterns of cancer genomes
-
Pfeifer, G. P. Environmental exposures and mutational patterns of cancer genomes. Genome Med. 2, 54 (2010).
-
(2012)
Genome Med
, vol.2
, pp. 54
-
-
Pfeifer, G.P.1
-
3
-
-
84866265794
-
Noncanonical mismatch repair as a source of genomic instability in human cells
-
Peñ a-Diaz, J. et al. Noncanonical mismatch repair as a source of genomic instability in human cells. Mol. Cell 47, 669-680 (2012).
-
(2012)
Mol. Cell
, vol.47
, pp. 669-680
-
-
Peña-Diaz, J.1
-
4
-
-
77955363995
-
TP53 mutations in human cancers: Origins, consequences, and clinical use
-
Olivier, M., Hollstein, M. & Hainaut, P. TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb. Perspect. Biol. 2, a001008 (2010).
-
(2012)
Cold Spring Harb. Perspect. Biol
, vol.2
-
-
Olivier, M.1
Hollstein, M.2
Hainaut, P.3
-
5
-
-
84873186179
-
Deciphering signatures of mutational processes operative in human cancer
-
Alexandrov, L. B., Nik-Zainal, S., Wedge, D. C., Campbell, P. J. & Stratton, M. R. Deciphering signatures of mutational processes operative in human cancer. Cell Rep. 3, 246-259 (2013).
-
(2013)
Cell Rep
, vol.3
, pp. 246-259
-
-
Alexandrov, L.B.1
Nik-Zainal, S.2
Wedge, D.C.3
Campbell, P.J.4
Stratton, M.R.5
-
6
-
-
84861541343
-
Mutational processes molding the genomes of 21 breast cancers
-
Nik-Zainal, S. et al. Mutational processes molding the genomes of 21 breast cancers. Cell 149, 979-993 (2012).
-
(2012)
Cell
, vol.149
, pp. 979-993
-
-
Nik-Zainal, S.1
-
7
-
-
84861550476
-
The life history of 21 breast cancers
-
Nik-Zainal, S. et al. The life history of 21 breast cancers. Cell 149, 994-1007 (2012).
-
(2012)
Cell
, vol.149
, pp. 994-1007
-
-
Nik-Zainal, S.1
-
8
-
-
77951115122
-
International network of cancer genome projects
-
Hudson, T. J. et al. International network of cancer genome projects. Nature 464, 993-998 (2010).
-
(2012)
Nature
, vol.464
, pp. 993-998
-
-
Hudson, T.J.1
-
9
-
-
29644436410
-
Mutagenesis at methylated CpG sequences
-
Pfeifer, G. P. Mutagenesis at methylated CpG sequences. Curr. Top. Microbiol. Immunol. 301, 259-281 (2006).
-
(2006)
Curr. Top. Microbiol. Immunol
, vol.301
, pp. 259-281
-
-
Pfeifer, G.P.1
-
10
-
-
84864255882
-
The origin and evolution of mutations in acute myeloid leukemia
-
Welch, J. S. et al. The origin and evolution of mutations in acute myeloid leukemia. Cell 150, 264-278 (2012).
-
(2012)
Cell
, vol.150
, pp. 264-278
-
-
Welch, J.S.1
-
11
-
-
34249790004
-
Molecular mechanisms of antibody somatic hypermutation
-
Di Noia, J. M. & Neuberger, M. S. Molecular mechanisms of antibody somatic hypermutation. Annu. Rev. Biochem. 76, 1-22 (2007).
-
(2007)
Annu. Rev. Biochem
, vol.76
, pp. 1-22
-
-
Di Noia, J.M.1
Neuberger, M.S.2
-
12
-
-
56749157389
-
Transcription-coupled DNA repair: Two decades of progress and surprises
-
Hanawalt, P. C. & Spivak, G. Transcription-coupled DNA repair: two decades of progress and surprises. Nature Rev. Mol. Cell Biol. 9, 958-970 (2008).
-
(2008)
Nature Rev. Mol. Cell Biol
, vol.9
, pp. 958-970
-
-
Hanawalt, P.C.1
Spivak, G.2
-
13
-
-
0037152628
-
Tobaccosmoke carcinogens,DNA damage andp53mutations in smoking-associated cancers
-
Pfeifer, G. P. et al. Tobaccosmoke carcinogens,DNA damage andp53mutations in smoking-associated cancers. Oncogene 21, 7435-7451 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 7435-7451
-
-
Pfeifer, G.P.1
-
14
-
-
14644438645
-
Mutations induced by ultraviolet light
-
Pfeifer, G. P., You, Y. H. & Besaratinia, A. Mutations induced by ultraviolet light. Mutat. Res. 571, 19-31 (2005).
-
(2005)
Mutat. Res
, vol.571
, pp. 19-31
-
-
Pfeifer, G.P.1
You, Y.H.2
Besaratinia, A.3
-
15
-
-
77449130761
-
Microsatellite instability in colorectal cancer
-
Boland, C. R. & Goel, A. Microsatellite instability in colorectal cancer. Gastroenterology 138, 2073-2087 (2010).
-
(2012)
Gastroenterology
, vol.138
, pp. 2073-2087
-
-
Boland, C.R.1
Goel, A.2
-
16
-
-
84865620494
-
Recognition signaling, and repair of DNA double-strand breaks produced by ionizing radiation inmammalian cells: The molecular choreography
-
Thompson, L. H. Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation inmammalian cells: the molecular choreography. Mutat. Res. 751, 158-246 (2012).
-
(2012)
Mutat. Res
, vol.751
, pp. 158-246
-
-
Thompson, L.H.1
-
17
-
-
33646256145
-
A hypermutation phenotype and somatic MSH6 mutations in recurrenthuman malignant gliomas after alkylator chemotherapy
-
Hunter, C. et al. A hypermutation phenotype and somatic MSH6 mutations in recurrenthuman malignant gliomas after alkylator chemotherapy. Cancer Res.66, 3987-3991 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 3987-3991
-
-
Hunter, C.1
-
18
-
-
0034733020
-
Mismatch repair deficient human cells: Spontaneous and MNNG-induced mutational spectra in the HPRT gene
-
Tomita-Mitchell, A. et al. Mismatch repair deficient human cells: spontaneous and MNNG-induced mutational spectra in the HPRT gene. Mutat. Res. 450, 125-138 (2000).
-
(2000)
Mutat. Res
, vol.450
, pp. 125-138
-
-
Tomita-Mitchell, A.1
-
19
-
-
84879061509
-
DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis
-
Taylor, B. J. M. et al. DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis. eLife e00534 (2013).
-
(2013)
ELife
-
-
Taylor, B.J.M.1
-
20
-
-
84874188583
-
APOBEC3B is an enzymatic source ofmutation in breast cancer
-
Burns, M. B. et al. APOBEC3B is an enzymatic source ofmutation in breast cancer. Nature 494, 366-370 (2013).
-
(2013)
Nature
, vol.494
, pp. 366-370
-
-
Burns, M.B.1
-
21
-
-
0036863733
-
RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators
-
Harris, R. S., Petersen-Mahrt, S. K. & Neuberger, M. S. RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. Mol. Cell 10, 1247-1253 (2002).
-
(2002)
Mol. Cell
, vol.10
, pp. 1247-1253
-
-
Harris, R.S.1
Petersen-Mahrt, S.K.2
Neuberger, M.S.3
-
22
-
-
84875899565
-
Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases
-
Koito, A. & Ikeda, T. Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases. Front. Microbiol. 4, 28 (2013).
-
(2013)
Front. Microbiol
, vol.4
, pp. 28
-
-
Koito, A.1
Ikeda, T.2
-
23
-
-
79960036578
-
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
-
Puente, X. S. et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 475, 101-105 (2011).
-
(2011)
Nature
, vol.475
, pp. 101-105
-
-
Puente, X.S.1
-
24
-
-
84863922124
-
Comprehensivemolecularcharacterizationof human colon and rectal cancer
-
The Cancer Genome Atlas Network
-
The Cancer Genome AtlasNetwork. Comprehensivemolecularcharacterizationof human colon and rectal cancer. Nature 487, 330-337 (2012).
-
(2012)
Nature
, vol.487
, pp. 330-337
-
-
-
25
-
-
84877254190
-
Integrated genomic characterization of endometrial carcinoma
-
Cancer Genome Atlas Research
-
Cancer Genome Atlas Research. Integrated genomic characterization of endometrial carcinoma. Nature 497, 67-73 (2013).
-
(2013)
Nature
, vol.497
, pp. 67-73
-
-
-
26
-
-
84880507665
-
Mutational heterogeneity in cancer and the search for new cancer-associated genes
-
Lawrence, M. S. et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 499, 214-218 (2013).
-
(2013)
Nature
, vol.499
, pp. 214-218
-
-
Lawrence, M.S.1
-
27
-
-
84874647204
-
The genomic landscape of hypodiploid acute lymphoblastic leukemia
-
Holmfeldt, L. et al. The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nature Genet. 45, 242-252 (2013).
-
(2013)
Nature Genet
, vol.45
, pp. 242-252
-
-
Holmfeldt, L.1
-
28
-
-
84862907593
-
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
-
Zhang, J. et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 481, 157-163 (2012).
-
(2012)
Nature
, vol.481
, pp. 157-163
-
-
Zhang, J.1
-
29
-
-
84873084751
-
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
-
De Keersmaecker, K. et al. Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nature Genet. 45, 186-190 (2013).
-
(2013)
Nature Genet
, vol.45
, pp. 186-190
-
-
De Keersmaecker, K.1
-
30
-
-
84862776906
-
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
-
Ding, L. et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature 481, 506-510 (2012).
-
(2012)
Nature
, vol.481
, pp. 506-510
-
-
Ding, L.1
-
31
-
-
84861576201
-
The landscape of cancer genes and mutational processes in breast cancer
-
Stephens, P. J. et al. The landscape of cancer genes and mutational processes in breast cancer. Nature 486, 400-404 (2012).
-
(2012)
Nature
, vol.486
, pp. 400-404
-
-
Stephens, P.J.1
-
32
-
-
84555171449
-
Exome sequencing identifies recurrentmutations of the splicing factorSF3B1geneinchronic lymphocytic leukemia
-
Quesada, V. et al. Exome sequencing identifies recurrentmutations of the splicing factorSF3B1geneinchronic lymphocytic leukemia. NatureGenet. 44,47-52(2012).
-
(2012)
NatureGenet
, vol.44
, pp. 47-52
-
-
Quesada, V.1
-
33
-
-
84865459654
-
Recurrent R-spondin fusions in colon cancer
-
Seshagiri, S. et al. Recurrent R-spondin fusions in colon cancer. Nature 488, 660-664 (2012).
-
(2012)
Nature
, vol.488
, pp. 660-664
-
-
Seshagiri, S.1
-
34
-
-
84878593111
-
Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
-
Dulak, A. M. et al. Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nature Genet. 45, 478-486 (2013).
-
(2013)
Nature Genet
, vol.45
, pp. 478-486
-
-
Dulak, A.M.1
-
35
-
-
80052177544
-
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
-
Agrawal, N. et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 333, 1154-1157 (2011).
-
(2011)
Science
, vol.333
, pp. 1154-1157
-
-
Agrawal, N.1
-
36
-
-
80052158097
-
The mutational landscape of head and neck squamous cell carcinoma
-
Stransky, N. et al. The mutational landscape of head and neck squamous cell carcinoma. Science 333, 1157-1160 (2011).
-
(2011)
Science
, vol.333
, pp. 1157-1160
-
-
Stransky, N.1
-
37
-
-
84655176646
-
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
-
Guo, G. et al. Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nature Genet. 44, 17-19 (2012).
-
(2012)
Nature Genet
, vol.44
, pp. 17-19
-
-
Guo, G.1
-
38
-
-
84862988411
-
BAP1 loss defines a new class of renal cell carcinoma
-
Peñ a-Llopis, S. et al. BAP1 loss defines a new class of renal cell carcinoma. Nature Genet. 44, 751-759 (2012).
-
(2012)
Nature Genet
, vol.44
, pp. 751-759
-
-
Peña-Llopis, S.1
-
39
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
Ding, L. et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455, 1069-1075 (2008).
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
-
40
-
-
84868309107
-
The transcriptional landscape and mutational profile of lung adenocarcinoma
-
Seo, J. S. et al. The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res. 22, 2109-2119 (2012).
-
(2012)
Genome Res
, vol.22
, pp. 2109-2119
-
-
Seo, J.S.1
-
41
-
-
84866410479
-
Mapping the hallmarks of lung adenocarcinomawith massively parallel sequencing
-
Imielinski, M. et al. Mapping the hallmarks of lung adenocarcinomawith massively parallel sequencing. Cell 150, 1107-1120 (2012).
-
(2012)
Cell
, vol.150
, pp. 1107-1120
-
-
Imielinski, M.1
-
42
-
-
84870538715
-
The genetic landscape of mutations in Burkitt lymphoma
-
Love, C. et al. The genetic landscape of mutations in Burkitt lymphoma. Nature Genet. 44, 1321-1325 (2012).
-
(2012)
Nature Genet
, vol.44
, pp. 1321-1325
-
-
Love, C.1
-
43
-
-
84878723078
-
Whole-genomesequencingidentifies genetic alterations inpediatric low-grade gliomas
-
Zhang, J. et al.Whole-genomesequencingidentifies genetic alterations inpediatric low-grade gliomas. Nature Genet. 45, 602-612 (2013).
-
(2013)
Nature Genet
, vol.45
, pp. 602-612
-
-
Zhang, J.1
-
44
-
-
80052029516
-
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
-
Morin, R. D. et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature 476, 298-303 (2011).
-
(2011)
Nature
, vol.476
, pp. 298-303
-
-
Morin, R.D.1
-
45
-
-
79952279828
-
DAXX/ATRX MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors
-
Jiao, Y. et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science 331, 1199-1203 (2011).
-
(2011)
Science
, vol.331
, pp. 1199-1203
-
-
Jiao, Y.1
-
46
-
-
84874664731
-
The genetic landscape of high-risk neuroblastoma
-
Pugh, T. J. et al. The genetic landscape of high-risk neuroblastoma. Nature Genet. 45, 279-284 (2013).
-
(2013)
Nature Genet
, vol.45
, pp. 279-284
-
-
Pugh, T.J.1
-
47
-
-
77957731999
-
Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma
-
Jones, S. et al. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science 330, 228-231 (2010).
-
(2012)
Science
, vol.330
, pp. 228-231
-
-
Jones, S.1
-
48
-
-
84862907854
-
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
-
Wu, J. et al. Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc. Natl Acad. Sci. USA 108, 21188-21193 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 21188-21193
-
-
Wu, J.1
-
49
-
-
84871982155
-
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma
-
Sausen, M. et al. Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma. Nature Genet. 45, 12-17 (2013).
-
(2013)
Nature Genet
, vol.45
, pp. 12-17
-
-
Sausen, M.1
-
50
-
-
79951497419
-
The genomic complexity of primary human prostate cancer
-
Berger, M. F. et al. The genomic complexity of primary human prostate cancer. Nature 470, 214-220 (2011).
-
(2011)
Nature
, vol.470
, pp. 214-220
-
-
Berger, M.F.1
-
51
-
-
84863723010
-
The mutational landscape of lethal castration-resistant prostate cancer
-
Grasso, C. S. et al. The mutational landscape of lethal castration-resistant prostate cancer. Nature 487, 239-243 (2012).
-
(2012)
Nature
, vol.487
, pp. 239-243
-
-
Grasso, C.S.1
-
52
-
-
84861581164
-
Exome sequencing identifies recurrent SPOP FOXA1 and MED12 mutations in prostate cancer
-
Barbieri, C. E. et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nature Genet. 44, 685-689 (2012).
-
(2012)
Nature Genet
, vol.44
, pp. 685-689
-
-
Barbieri, C.E.1
-
53
-
-
84866849548
-
Comprehensive genomic analysis identifiesSOX2 as a frequently amplified gene in small-cell lung cancer
-
Rudin, C. M. et al.Comprehensive genomic analysis identifiesSOX2 as a frequently amplified gene in small-cell lung cancer. Nature Genet. 44, 1111-1116 (2012).
-
(2012)
Nature Genet
, vol.44
, pp. 1111-1116
-
-
Rudin, C.M.1
-
54
-
-
84866851740
-
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
-
Peifer, M. et al. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nature Genet. 44, 1104-1110 (2012).
-
(2012)
Nature Genet
, vol.44
, pp. 1104-1110
-
-
Peifer, M.1
-
55
-
-
84856273432
-
Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing
-
Stark, M. S. et al. Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nature Genet. 44, 165-169 (2012).
-
(2012)
Nature Genet
, vol.44
, pp. 165-169
-
-
Stark, M.S.1
-
56
-
-
84861427327
-
Melanoma genome sequencing reveals frequent PREX2 mutations
-
Berger, M. F. et al. Melanoma genome sequencing reveals frequent PREX2 mutations. Nature 485, 502-506 (2012).
-
(2012)
Nature
, vol.485
, pp. 502-506
-
-
Berger, M.F.1
-
57
-
-
84864258996
-
A landscape of driver mutations in melanoma
-
Hodis, E. et al. A landscape of driver mutations in melanoma. Cell 150, 251-263 (2012).
-
(2012)
Cell
, vol.150
, pp. 251-263
-
-
Hodis, E.1
-
58
-
-
84860327480
-
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes
-
Zang, Z. J. et al. Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nature Genet. 44, 570-574 (2012).
-
(2012)
Nature Genet
, vol.44
, pp. 570-574
-
-
Zang, Z.J.1
-
59
-
-
82255183148
-
Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer
-
Wang, K. et al. Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer. Nature Genet. 43, 1219-1223 (2011).
-
(2011)
Nature Genet
, vol.43
, pp. 1219-1223
-
-
Wang, K.1
-
60
-
-
0035173378
-
DbSNP: TheNCBI database of genetic variation
-
Sherry, S. T. et al.dbSNP: theNCBI database of genetic variation.Nucleic Acids Res. 29, 308-311 (2001).
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 308-311
-
-
Sherry, S.T.1
-
61
-
-
84975795680
-
An integrated map of genetic variation from 1,092 human genomes
-
Abecasis, G. R. et al. An integrated map of genetic variation from 1,092 human genomes. Nature 491, 56-65 (2012).
-
(2012)
Nature
, vol.491
, pp. 56-65
-
-
Abecasis, G.R.1
-
62
-
-
84872143942
-
Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants
-
Fu, W. et al. Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature 493, 216-220 (2013).
-
(2013)
Nature
, vol.493
, pp. 216-220
-
-
Fu, W.1
-
63
-
-
52249106010
-
Comparison of the AgilentROMA/NimbleGen and Illumina platforms for classification of copy number alterations in human breast tumors
-
Baumbusch, L. O. et al.Comparison of the Agilent,ROMA/NimbleGen and Illumina platforms for classification of copy number alterations in human breast tumors. BMC Genomics 9, 379 (2008).
-
(2008)
BMC Genomics
, vol.9
, pp. 379
-
-
Baumbusch, L.O.1
-
64
-
-
79960398002
-
False positive peaks in ChIPseq and other sequencing-based functional assays caused by unannotated high copy number regions
-
Pickrell, J. K., Gaffney, D. J., Gilad, Y. & Pritchard, J. K. False positive peaks in ChIPseq and other sequencing-based functional assays caused by unannotated high copy number regions. Bioinformatics 27, 2144-2146 (2011).
-
(2011)
Bioinformatics
, vol.27
, pp. 2144-2146
-
-
Pickrell, J.K.1
Gaffney, D.J.2
Gilad, Y.3
Pritchard, J.K.4
|