RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments

Genes and Development

Volumn 21, Issue 23, 2007, Pages 3073-3084

  Hu, Yiduo ^a,g   Raynard, Steven ^b   Sehorn, Michael G ^b,h   Lu, Xincheng ^a   Bussen, Wendy ^b   Zheng, Lu ^c   Stark, Jeremy M ^d   Barnes, Ellen L ^a   Chi, Peter ^b   Janscak, Pavel ^c   Jasin, Maria ^e   Vogel, Hannes ^f   Sung, Patrick ^b   Luo, Guangbin ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^f STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

^h CLEMSON UNIVERSITY   (United States)

Author keywords

DNA repair; Homologous recombination; Rad51 recombinase; Recql5 helicase; Tumor suppressor

Indexed keywords

ADENOSINE TRIPHOSPHATE; DOUBLE STRANDED DNA; RAD51 PROTEIN; RECQ HELICASE; RECQL PROTEIN; RECQL5 HELICASE; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CANCER INHIBITION; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CHEMICAL ANALYSIS; CHROMOSOME REARRANGEMENT; CHROMOSOME REPLICATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA REPAIR; ELECTRON MICROSCOPY; GENE DELETION; GENE FREQUENCY; HOMOLOGOUS RECOMBINATION; HYDROLYSIS; MOUSE; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEFICIENCY; PROTEIN FAMILY; PROTEIN FUNCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL LINE; DNA BREAKS, DOUBLE-STRANDED; GENOMIC INSTABILITY; HISTONES; HUMANS; HYDROLYSIS; LOSS OF HETEROZYGOSITY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS, EXPERIMENTAL; RAD51 RECOMBINASE; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC; RECQ HELICASES;

MAMMALIA; MUS;

EID: 36849013079     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1609107     Document Type: Article

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