Ku70 corrupts DNA repair in the absence of the fanconi anemia pathway

Science

Volumn 329, Issue 5988, 2010, Pages 219-223

  Pace, Paul ^a   Mosedale, Georgina ^b   Hodskinson, Michael R ^a   Rosado, Ivan V ^a   Sivasubramaniam, Meera ^a   Patel, Ketan J ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; FANCONI ANEMIA GROUP C PROTEIN; FANCONI ANEMIA GROUP D2 PROTEIN; KU ANTIGEN;

ANEMIA; BIOCHEMISTRY; CHROMOSOME; DNA; GENETICS; MUTATION; PROTEIN; PUBLIC HEALTH; SUBSTRATE;

ANIMAL CELL; ARTICLE; CHROMOSOME BREAKAGE; CONTROLLED STUDY; CROSS LINKING; DNA BINDING; DNA FLANKING REGION; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DRUG SENSITIVITY; FANCONI ANEMIA; GENE INTERACTION; GENE MUTATION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, NUCLEAR; CELL LINE; CHICKENS; CHROMOSOME BREAKAGE; CROSS-LINKING REAGENTS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; FANCONI ANEMIA COMPLEMENTATION GROUP C PROTEIN; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; GENE CONVERSION; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN M; POINT MUTATION; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC;

EID: 77953879925     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1192277     Document Type: Article

References (20)

1. L. J. Niedernhofer, A. S. Lalai, J. H. Hoeijmakers,Cell 123, 1191 (2005).
2. K. J. Patel, H. Joenje, DNA Repair 6, 885 (2007).
3. W. Niedzwiedz et al., Mol. Cell 15, 607 (2004).
4. P. Knipscheer et al., Science 326, 1698 (2009);published online 12 November 2009 (10.1126/science.1182372).
5. S. C. West, Nat. Rev. Mol. Cell Biol. 4, 435 (2003).
6. M. Escarceller et al., J. Mol. Biol. 279, 375 (1998).
7. M. Escarceller, S. Rousset, E. Moustacchi,D. Papadopoulo, Somat. Cell Mol. Genet. 23, 401 (1997).
8. T. Fukushima et al., J. Biol. Chem. 276, 44413 (2001).
9. H. Arakawa, J. Hauschild, J.-M. Buerstedde, Science 295,1301 (2002).
10. J. E. Sale et al., Philos. Trans. R. Soc. London Ser. B 356,21 (2001).
11. S. Houghtaling et al., Hum. Mol. Genet. 14, 3027 (2005).
12. Z. Zhang et al., J. Biol. Chem. 276, 38231 (2001).
13. A. J. Pierce, P. Hu, M. Han, N. Ellis, M. Jasin, Genes Dev.15, 3237 (2001).
14. I. Garcia-Higuera et al., Mol. Cell 7, 249 (2001).
15. N. Matsushita et al., Mol. Cell 19, 841 (2005).
16. W. H. Park et al., J. Biol. Chem. 280, 23593 (2005).
17. N. Mazloum, W. K. Holloman, Mol. Cell 33, 160(2009).
18. N. Mazloum, W. K. Holloman, Mol. Cell 36, 620(2009).
19. N. G. Howlett et al., Science 297, 606 (2002); publishedonline 13 June 2002 (10.1126/science.1073834).
20. We thank M. Takata for the anti-Ku70 antibody and theKu70 cDNA expression vector; H. Koyama and S. Takedafor ΔLig4, ΔKu70, and ΔDNA-PKcs DT40 cell lines;H. Joenje and J. DeWinter for human FANCC cell lines;and W. Niedzwiedz and J. Sale for help with IgMsequence analysis. Supported by the Children'sLeukaemia Trust (G.M.), the Leukaemia and LymphomaResearch Fund (M.R.H.), and a FEBS fellowship (I.V.R.).