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Volumn 18, Issue 1, 2011, Pages 5-15

A positive role for c-Abl in Atm and Atr activation in DNA damage response

Author keywords

Atm; Atr; c Abl; DNA repair; phosphorylation

Indexed keywords

ABELSON KINASE; ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; PROTEIN P53; PROTEIN P73;

EID: 78650087114     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2010.106     Document Type: Article
Times cited : (88)

References (38)
  • 1
    • 11144357255 scopus 로고    scopus 로고
    • Cellular machineries for chromosomal DNA repair
    • Peterson CL, Cote J. Cellular machineries for chromosomal DNA repair. Genes Dev 2004; 18: 602-616.
    • (2004) Genes Dev , vol.18 , pp. 602-616
    • Peterson, C.L.1    Cote, J.2
  • 2
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 2001; 15: 2177-2196.
    • (2001) Genes Dev , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 3
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 2003; 3: 155-168.
    • (2003) Nat Rev Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 4
    • 0038557114 scopus 로고    scopus 로고
    • Who's on first in the cellular response to DNA damage?
    • Cline SD, Hanawalt PC. Who's on first in the cellular response to DNA damage? Nat Rev Mol Cell Biol 2003; 4: 361-372.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 361-372
    • Cline, S.D.1    Hanawalt, P.C.2
  • 5
    • 0036276388 scopus 로고    scopus 로고
    • The Mre11 complex: At the crossroads of dna repair and checkpoint signalling
    • D'Amours D, Jackson SP. The Mre11 complex: at the crossroads of dna repair and checkpoint signalling. Nat Rev Mol Cell Biol 2002; 3: 317-327.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 317-327
    • D'Amours, D.1    Jackson, S.P.2
  • 6
    • 2942687831 scopus 로고    scopus 로고
    • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
    • Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB. Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev 2004; 18: 1423-1438.
    • (2004) Genes Dev , vol.18 , pp. 1423-1438
    • Kitagawa, R.1    Bakkenist, C.J.2    McKinnon, P.J.3    Kastan, M.B.4
  • 7
    • 2342527027 scopus 로고    scopus 로고
    • DNA damage checkpoint and repair centers
    • Lisby M, Rothstein R. DNA damage checkpoint and repair centers. Curr Opin Cell Biol 2004; 16: 328-334.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 328-334
    • Lisby, M.1    Rothstein, R.2
  • 8
    • 47949121598 scopus 로고    scopus 로고
    • Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
    • Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V. Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. EMBO J 2008; 27: 1953-1962.
    • (2008) EMBO J , vol.27 , pp. 1953-1962
    • Jazayeri, A.1    Balestrini, A.2    Garner, E.3    Haber, J.E.4    Costanzo, V.5
  • 9
    • 61649093808 scopus 로고    scopus 로고
    • Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks
    • Shiotani B, Zou L. Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. Mol Cell 2009; 33: 547-558.
    • (2009) Mol Cell , vol.33 , pp. 547-558
    • Shiotani, B.1    Zou, L.2
  • 10
    • 52049090123 scopus 로고    scopus 로고
    • ATM acts downstream of ATR in the DNA damage response signaling of bystander cells
    • Burdak-Rothkamm S, Rothkamm K, Prise KM. ATM acts downstream of ATR in the DNA damage response signaling of bystander cells. Cancer Res 2008; 68: 7059-7065.
    • (2008) Cancer Res , vol.68 , pp. 7059-7065
    • Burdak-Rothkamm, S.1    Rothkamm, K.2    Prise, K.M.3
  • 11
    • 44849093460 scopus 로고    scopus 로고
    • TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
    • Mordes DA, Glick GG, Zhao R, Cortez D. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev 2008; 22: 1478-1489.
    • (2008) Genes Dev , vol.22 , pp. 1478-1489
    • Mordes, D.A.1    Glick, G.G.2    Zhao, R.3    Cortez, D.4
  • 12
    • 59649128916 scopus 로고    scopus 로고
    • Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death
    • Tian B, Yang Q, Mao Z. Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death. Nat Cell Biol 2009; 11: 211-218.
    • (2009) Nat Cell Biol , vol.11 , pp. 211-218
    • Tian, B.1    Yang, Q.2    Mao, Z.3
  • 13
    • 44849128194 scopus 로고    scopus 로고
    • How ATR turns on: TopBP1 goes on ATRIP with ATR
    • Burrows AE, Elledge SJ. How ATR turns on: TopBP1 goes on ATRIP with ATR. Genes Dev 2008; 22: 1416-1421.
    • (2008) Genes Dev , vol.22 , pp. 1416-1421
    • Burrows, A.E.1    Elledge, S.J.2
  • 14
    • 47749141560 scopus 로고    scopus 로고
    • ATR: An essential regulator of genome integrity
    • Cimprich KA, Cortez D. ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol 2008; 9: 616-627.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 15
    • 0034064630 scopus 로고    scopus 로고
    • C-Abl: Activation and nuclear targets
    • Shaul Y. c-Abl: activation and nuclear targets. Cell Death Differ 2000; 7: 10-16.
    • (2000) Cell Death Differ , vol.7 , pp. 10-16
    • Shaul, Y.1
  • 16
    • 0030925565 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
    • Baskaran R, Wood LD, Whitaker LL, Canman CE, Morgan SE, Xu Y et al. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 1997; 387: 516-519.
    • (1997) Nature , vol.387 , pp. 516-519
    • Baskaran, R.1    Wood, L.D.2    Whitaker, L.L.3    Canman, C.E.4    Morgan, S.E.5    Xu, Y.6
  • 17
    • 0030992749 scopus 로고    scopus 로고
    • Interaction between ATM protein and c-Abl in response to DNA damage
    • Shafman T, Khanna KK, Kedar P, Spring K, Kozlov S, Yen T et al. Interaction between ATM protein and c-Abl in response to DNA damage. Nature 1997; 387: 520-523.
    • (1997) Nature , vol.387 , pp. 520-523
    • Shafman, T.1    Khanna, K.K.2    Kedar, P.3    Spring, K.4    Kozlov, S.5    Yen, T.6
  • 18
    • 0033600235 scopus 로고    scopus 로고
    • P73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
    • Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang YY et al. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 1999; 399: 814-817.
    • (1999) Nature , vol.399 , pp. 814-817
    • Yuan, Z.M.1    Shioya, H.2    Ishiko, T.3    Sun, X.4    Gu, J.5    Huang, Y.Y.6
  • 19
    • 0029856557 scopus 로고    scopus 로고
    • Three distinct signalling responses by murine fibroblasts to genotoxic stress
    • Liu ZG, Baskaran R, Lea-Chou ET, Wood LD, Chen Y, Karin M et al. Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature 1996; 384: 273-276.
    • (1996) Nature , vol.384 , pp. 273-276
    • Liu, Z.G.1    Baskaran, R.2    Lea-Chou, E.T.3    Wood, L.D.4    Chen, Y.5    Karin, M.6
  • 21
    • 23844549580 scopus 로고    scopus 로고
    • Identification of TopBP1 as a c-Abl-interacting protein and a repressor for c-Abl expression
    • Zeng L, Hu Y, Li B. Identification of TopBP1 as a c-Abl-interacting protein and a repressor for c-Abl expression. J Biol Chem 2005; 280: 29374-29380.
    • (2005) J Biol Chem , vol.280 , pp. 29374-29380
    • Zeng, L.1    Hu, Y.2    Li, B.3
  • 22
    • 36949005417 scopus 로고    scopus 로고
    • DNA damage signalling guards against activated oncogenes and tumour progression
    • Bartek J, Bartkova J, Lukas J. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 2007; 26: 7773-7779.
    • (2007) Oncogene , vol.26 , pp. 7773-7779
    • Bartek, J.1    Bartkova, J.2    Lukas, J.3
  • 23
    • 0035200324 scopus 로고    scopus 로고
    • Transcriptional consequences of topoisomerase inhibition
    • Collins I, Weber A, Levens D. Transcriptional consequences of topoisomerase inhibition. Mol Cell Biol 2001; 21: 8437-8451.
    • (2001) Mol Cell Biol , vol.21 , pp. 8437-8451
    • Collins, I.1    Weber, A.2    Levens, D.3
  • 24
    • 0030764691 scopus 로고    scopus 로고
    • HMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks
    • Maser RS, Monsen KJ, Nelms BE, Petrini JH. hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol Cell Biol 1997; 17: 6087-6096.
    • (1997) Mol Cell Biol , vol.17 , pp. 6087-6096
    • Maser, R.S.1    Monsen, K.J.2    Nelms, B.E.3    Petrini, J.H.4
  • 25
    • 0033621392 scopus 로고    scopus 로고
    • Substrate specificities and identification of putative substrates of ATM kinase family members
    • Kim ST, Lim DS, Canman CE, Kastan MB. Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem 1999; 274: 37538-37543.
    • (1999) J Biol Chem , vol.274 , pp. 37538-37543
    • Kim, S.T.1    Lim, D.S.2    Canman, C.E.3    Kastan, M.B.4
  • 26
    • 0037462453 scopus 로고    scopus 로고
    • The ATRs, ATMs, and TORs are giant HEAT repeat proteins
    • Perry J, Kleckner N. The ATRs, ATMs, and TORs are giant HEAT repeat proteins. Cell 2003; 112: 151-155.
    • (2003) Cell , vol.112 , pp. 151-155
    • Perry, J.1    Kleckner, N.2
  • 27
    • 0034091809 scopus 로고    scopus 로고
    • Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation
    • Li B, Boast S, de los SK, Schieren I, Quiroz M, Teitelbaum SL et al. Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation. Nat Genet 2000; 24: 304-308.
    • (2000) Nat Genet , vol.24 , pp. 304-308
    • Li, B.1    Boast, S.2    De Los, S.K.3    Schieren, I.4    Quiroz, M.5    Teitelbaum, S.L.6
  • 28
    • 0029844048 scopus 로고    scopus 로고
    • Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
    • Xu Y, Ashley T, Brainerd EE, Bronson RT, Meyn MS, Baltimore D. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev 1996; 10: 2411-2422.
    • (1996) Genes Dev , vol.10 , pp. 2411-2422
    • Xu, Y.1    Ashley, T.2    Brainerd, E.E.3    Bronson, R.T.4    Meyn, M.S.5    Baltimore, D.6
  • 29
    • 33745618456 scopus 로고    scopus 로고
    • Atm-deficient mice: An osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesis
    • Rasheed N, Wang X, Niu QT, Yeh J, Li B. Atm-deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesis. Hum Mol Genet 2006; 15: 1938-1948.
    • (2006) Hum Mol Genet , vol.15 , pp. 1938-1948
    • Rasheed, N.1    Wang, X.2    Niu, Q.T.3    Yeh, J.4    Li, B.5
  • 30
    • 11044234004 scopus 로고    scopus 로고
    • Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway
    • Alderton GK, Joenje H, Varon R, Borglum AD, Jeggo PA, O'Driscoll M. Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway. Hum Mol Genet 2004; 13: 3127-3138.
    • (2004) Hum Mol Genet , vol.13 , pp. 3127-3138
    • Alderton, G.K.1    Joenje, H.2    Varon, R.3    Borglum, A.D.4    Jeggo, P.A.5    O'Driscoll, M.6
  • 31
    • 34249012132 scopus 로고    scopus 로고
    • Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals
    • Preyer M, Shu CW, Wang JY. Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals. Cell Death Differ 2007; 14: 1139-1148.
    • (2007) Cell Death Differ , vol.14 , pp. 1139-1148
    • Preyer, M.1    Shu, C.W.2    Wang, J.Y.3
  • 32
    • 0033600240 scopus 로고    scopus 로고
    • Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis
    • Agami R, Blandino G, Oren M, Shaul Y. Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature 1999; 399: 809-813.
    • (1999) Nature , vol.399 , pp. 809-813
    • Agami, R.1    Blandino, G.2    Oren, M.3    Shaul, Y.4
  • 33
    • 0033514993 scopus 로고    scopus 로고
    • Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage
    • Raderschall E, Golub EI, Haaf T. Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage. Proc Natl Acad Sci USA 1999; 96: 1921-1926.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1921-1926
    • Raderschall, E.1    Golub, E.I.2    Haaf, T.3
  • 34
    • 0033617368 scopus 로고    scopus 로고
    • Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl
    • Chen G, Yuan SS, Liu W, Xu Y, Trujillo K, Song B et al. Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl. J Biol Chem 1999; 274: 12748-12752.
    • (1999) J Biol Chem , vol.274 , pp. 12748-12752
    • Chen, G.1    Yuan, S.S.2    Liu, W.3    Xu, Y.4    Trujillo, K.5    Song, B.6
  • 35
    • 47549107231 scopus 로고    scopus 로고
    • Pharmacological inhibition of c-Abl compromises genetic stability and DNA repair in Bcr-Abl-negative cells
    • Fanta S, Sonnenberg M, Skorta I, Duyster J, Miething C, Aulitzky WE et al. Pharmacological inhibition of c-Abl compromises genetic stability and DNA repair in Bcr-Abl-negative cells. Oncogene 2008; 27: 4380-4384.
    • (2008) Oncogene , vol.27 , pp. 4380-4384
    • Fanta, S.1    Sonnenberg, M.2    Skorta, I.3    Duyster, J.4    Miething, C.5    Aulitzky, W.E.6
  • 36
    • 33745081606 scopus 로고    scopus 로고
    • Circumventing resistance to kinase-inhibitor therapy
    • Druker BJ. Circumventing resistance to kinase-inhibitor therapy. N Engl J Med 2006; 354: 2594-2596.
    • (2006) N Engl J Med , vol.354 , pp. 2594-2596
    • Druker, B.J.1
  • 37
    • 2542441665 scopus 로고    scopus 로고
    • The BCR-ABL story: Bench to bedside and back
    • Wong S, Witte ON. The BCR-ABL story: bench to bedside and back. Annu Rev Immunol 2004; 22: 247-306.
    • (2004) Annu Rev Immunol , vol.22 , pp. 247-306
    • Wong, S.1    Witte, O.N.2
  • 38
    • 3543084994 scopus 로고    scopus 로고
    • Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta
    • Li B, Wang X, Rasheed N, Hu Y, Boast S, Ishii T et al. Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta. Genes Dev 2004; 18: 1824-1837.
    • (2004) Genes Dev , vol.18 , pp. 1824-1837
    • Li, B.1    Wang, X.2    Rasheed, N.3    Hu, Y.4    Boast, S.5    Ishii, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.