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Volumn 8, Issue 6, 2007, Pages 437-449

Exploring genetic interactions and networks with yeast

Author keywords

[No Author keywords available]

Indexed keywords

DIPLOIDY; FUNCTIONAL GENOMICS; FUNGAL GENE; GENE DELETION; GENE FUNCTION; GENE INTERACTION; GENE LIBRARY; GENE MAPPING; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC EPISTASIS; HAPLOIDY; HUMAN; INHERITANCE; LETHALITY; METAZOON; MICROARRAY ANALYSIS; MOLECULAR BIOLOGY; MOLECULAR MODEL; NONHUMAN; PREDICTION; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; QUANTITATIVE TRAIT; REVIEW; SACCHAROMYCES CEREVISIAE; YEAST;

EID: 34249041230     PISSN: 14710056     EISSN: 14710064     Source Type: Journal    
DOI: 10.1038/nrg2085     Document Type: Review
Times cited : (479)

References (88)
  • 1
    • 27144434505 scopus 로고    scopus 로고
    • Davierwala, A. P. et al. The synthetic genetic interaction spectrum of essential genes. Nature Genet. 37, 1147-1152 (2005). This paper describes the first major application of SGA analysis to mapping of genetic-interaction networks among essential genes, and reveals that they seem to act as highly connected hubs on the network.
    • Davierwala, A. P. et al. The synthetic genetic interaction spectrum of essential genes. Nature Genet. 37, 1147-1152 (2005). This paper describes the first major application of SGA analysis to mapping of genetic-interaction networks among essential genes, and reveals that they seem to act as highly connected hubs on the network.
  • 2
    • 10744230485 scopus 로고    scopus 로고
    • Tong, A. H. Y. et al. Global mapping of the yeast genetic interaction network. Science 303, 808-813 (2004). This study describes large-scale mapping of synthetic-lethal genetic interactions in yeast by SGA analysis. The results highlight the utility of genetic networks for discovering gene function and define the topology and general properties of genetic networks.
    • Tong, A. H. Y. et al. Global mapping of the yeast genetic interaction network. Science 303, 808-813 (2004). This study describes large-scale mapping of synthetic-lethal genetic interactions in yeast by SGA analysis. The results highlight the utility of genetic networks for discovering gene function and define the topology and general properties of genetic networks.
  • 3
    • 4644309276 scopus 로고    scopus 로고
    • The promise of functional genomics: Completing the encyclopedia of a cell
    • Hughes, T. R., Robinson, M. D., Mitsakakis, N. & Johnston, M. The promise of functional genomics: completing the encyclopedia of a cell. Curr. Opin. Microbiol. 7, 546-554 (2004).
    • (2004) Curr. Opin. Microbiol , vol.7 , pp. 546-554
    • Hughes, T.R.1    Robinson, M.D.2    Mitsakakis, N.3    Johnston, M.4
  • 4
    • 28944450579 scopus 로고    scopus 로고
    • Changing perspective in yeast research nearly a decade after the genome sequence
    • Dolinski, K. & Botstein, D. Changing perspective in yeast research nearly a decade after the genome sequence. Genome Res. 15, 1611-1619 (2006).
    • (2006) Genome Res , vol.15 , pp. 1611-1619
    • Dolinski, K.1    Botstein, D.2
  • 5
    • 0037173615 scopus 로고    scopus 로고
    • Giaever, G. et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature 418, 387-391 (2002). A landmark paper that describes the construction and use of the yeast deletion-mutant collection.
    • Giaever, G. et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature 418, 387-391 (2002). A landmark paper that describes the construction and use of the yeast deletion-mutant collection.
  • 6
    • 0033529707 scopus 로고    scopus 로고
    • Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis
    • Winzeler, E. A. et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285, 901-906 (1999).
    • (1999) Science , vol.285 , pp. 901-906
    • Winzeler, E.A.1
  • 7
    • 34249022552 scopus 로고    scopus 로고
    • The chemical genomic portrait of the cell reveals a phenotype for all genes
    • Submitted
    • Hillenmeyer, M. E. et al. The chemical genomic portrait of the cell reveals a phenotype for all genes. (Submitted).
    • Hillenmeyer, M.E.1
  • 8
    • 18844407538 scopus 로고    scopus 로고
    • Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast
    • Deutschbauer, A. et al. Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast. Genetics 169, 1915-1925 (2005).
    • (2005) Genetics , vol.169 , pp. 1915-1925
    • Deutschbauer, A.1
  • 9
    • 0035830860 scopus 로고    scopus 로고
    • Hartman, J. L., Garvik, B. & Hartwell, L. Principles for the buffering of genetic variation. Science 291, 1001-1004 (2001). An excellent opinion piece that explores how eukaryotic genomes are buffered against genetic and environmental insults and outlines how synthetic-lethal interaction maps can be used to understand the relationship between genotype and phenotype.
    • Hartman, J. L., Garvik, B. & Hartwell, L. Principles for the buffering of genetic variation. Science 291, 1001-1004 (2001). An excellent opinion piece that explores how eukaryotic genomes are buffered against genetic and environmental insults and outlines how synthetic-lethal interaction maps can be used to understand the relationship between genotype and phenotype.
  • 10
    • 0036626032 scopus 로고    scopus 로고
    • Yeast and cancer
    • Hartwell, L. H. Yeast and cancer. Biosci. Rep. 22, 373-394 (2002).
    • (2002) Biosci. Rep , vol.22 , pp. 373-394
    • Hartwell, L.H.1
  • 11
    • 84872625067 scopus 로고
    • Genetics of natural populations, XIII: Recombination and variability in populations of Drosophila pseudoobscura
    • Dobzhansky, T. Genetics of natural populations, XIII: recombination and variability in populations of Drosophila pseudoobscura. Genetics 31, 269-290 (1946).
    • (1946) Genetics , vol.31 , pp. 269-290
    • Dobzhansky, T.1
  • 12
    • 0001758235 scopus 로고
    • A highly specific complementary lethal system in Drosophila melanogaster
    • Sturtevant, A. H. A highly specific complementary lethal system in Drosophila melanogaster. Genetics 41, 118-123 (1956).
    • (1956) Genetics , vol.41 , pp. 118-123
    • Sturtevant, A.H.1
  • 13
    • 0024549504 scopus 로고    scopus 로고
    • Novick, P., Osmond, B. C. & Botstein, D. Suppressors of yeast actin mutants. Genetics 121, 659-674 (1989). One of the first yeast papers to describe synthetic-lethal genetic interactions, with useful references to the early D. melanogaster literature.
    • Novick, P., Osmond, B. C. & Botstein, D. Suppressors of yeast actin mutants. Genetics 121, 659-674 (1989). One of the first yeast papers to describe synthetic-lethal genetic interactions, with useful references to the early D. melanogaster literature.
  • 14
    • 0027515605 scopus 로고
    • Synthetic enhancement in gene interaction: A genetic tool come of age
    • Guarente, L. Synthetic enhancement in gene interaction: a genetic tool come of age. Trends Genet. 9, 362-366 (1993).
    • (1993) Trends Genet , vol.9 , pp. 362-366
    • Guarente, L.1
  • 15
    • 0025959707 scopus 로고    scopus 로고
    • Bender, A. & Pringle, J. R. Use of a screen for synthetic lethal and multicopy suppressor mutants to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae. Mol. Cell. Biol. 11, 1295-1305 (1991). This manuscript describes the first use of a yeast colony sectoring assay as screen for synthetic lethal genetic interactions.
    • Bender, A. & Pringle, J. R. Use of a screen for synthetic lethal and multicopy suppressor mutants to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae. Mol. Cell. Biol. 11, 1295-1305 (1991). This manuscript describes the first use of a yeast colony sectoring assay as screen for synthetic lethal genetic interactions.
  • 16
    • 0023506415 scopus 로고
    • Identifying mutations in duplicated functions in Saccharomyces cerevisiae: Recessive mutations in HMG-CoA reductase genes
    • Basson, M. E., Moore, R. L., O'Rear, J. & Rine, J. Identifying mutations in duplicated functions in Saccharomyces cerevisiae: recessive mutations in HMG-CoA reductase genes. Genetics 117, 645-655 (1987).
    • (1987) Genetics , vol.117 , pp. 645-655
    • Basson, M.E.1    Moore, R.L.2    O'Rear, J.3    Rine, J.4
  • 17
    • 33745482769 scopus 로고    scopus 로고
    • Yeast-based functional genomics and proteomics technologies: The first 15 years and beyond
    • Suter, B., Auerbach, D. & Stagljar, I. Yeast-based functional genomics and proteomics technologies: the first 15 years and beyond. Biotechniques 40, 625-644 (2006).
    • (2006) Biotechniques , vol.40 , pp. 625-644
    • Suter, B.1    Auerbach, D.2    Stagljar, I.3
  • 18
    • 0028676232 scopus 로고
    • New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae
    • Wach, A., Brachat, A., Pohlmann, R. & Philippsen, P. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10, 1793-1808 (1994).
    • (1994) Yeast , vol.10 , pp. 1793-1808
    • Wach, A.1    Brachat, A.2    Pohlmann, R.3    Philippsen, P.4
  • 19
    • 0038349948 scopus 로고    scopus 로고
    • Sequencing and comparison of yeast species to identify genes and regulatory elements
    • Kellis, M., Patterson, N., Endrizzi, M., Birren, B. & Lander, E. S. Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423, 241-254 (2003).
    • (2003) Nature , vol.423 , pp. 241-254
    • Kellis, M.1    Patterson, N.2    Endrizzi, M.3    Birren, B.4    Lander, E.S.5
  • 20
    • 0038724989 scopus 로고    scopus 로고
    • Finding functional features in Saccharomyces genomes by phylogenetic footprinting
    • Cliften, P. et al. Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science 301, 71-76 (2003).
    • (2003) Science , vol.301 , pp. 71-76
    • Cliften, P.1
  • 21
    • 33644641676 scopus 로고    scopus 로고
    • Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae
    • Kastenmayer, J. P. et al. Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae. Genome Res. 16, 365-373 (2006).
    • (2006) Genome Res , vol.16 , pp. 365-373
    • Kastenmayer, J.P.1
  • 22
    • 3142536716 scopus 로고    scopus 로고
    • Exploration of essential gene functions via titrable promoter alleles
    • Mnainmeh, S. et al. Exploration of essential gene functions via titrable promoter alleles. Cell 118, 31-44 (2004).
    • (2004) Cell , vol.118 , pp. 31-44
    • Mnainmeh, S.1
  • 23
    • 28844506010 scopus 로고    scopus 로고
    • Heat-inducible degron and the making of conditional mutants
    • Dohmen, R. J. & Varshavsky, A. Heat-inducible degron and the making of conditional mutants. Methods Enzymol. 399, 799-822 (2005).
    • (2005) Methods Enzymol , vol.399 , pp. 799-822
    • Dohmen, R.J.1    Varshavsky, A.2
  • 24
    • 0038680253 scopus 로고    scopus 로고
    • Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo
    • Kanemaki, M., Sanchez-Diaz, A., Gambus, A. & Labib, K. Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo. Nature 423, 720-724 (2003).
    • (2003) Nature , vol.423 , pp. 720-724
    • Kanemaki, M.1    Sanchez-Diaz, A.2    Gambus, A.3    Labib, K.4
  • 25
    • 26844489762 scopus 로고    scopus 로고
    • Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile
    • Schuldiner, M. et al. Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123, 507-519 (2005).
    • (2005) Cell , vol.123 , pp. 507-519
    • Schuldiner, M.1
  • 26
    • 0037050004 scopus 로고    scopus 로고
    • Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
    • Ho, Y. et al. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 415, 180-183 (2002).
    • (2002) Nature , vol.415 , pp. 180-183
    • Ho, Y.1
  • 27
    • 33644899143 scopus 로고    scopus 로고
    • Microarray-based method for monitoring yeast overexpression strains reveals small-molecular targets in the TOR pathway
    • Butcher, R. A. et al. Microarray-based method for monitoring yeast overexpression strains reveals small-molecular targets in the TOR pathway. Nature Chem. Biol. 2, 103-109 (2006).
    • (2006) Nature Chem. Biol , vol.2 , pp. 103-109
    • Butcher, R.A.1
  • 28
    • 0035860499 scopus 로고    scopus 로고
    • Global analysis of protein activities using proteome chips
    • Zhu, H. et al. Global analysis of protein activities using proteome chips. Science 293, 2101-2105 (2001).
    • (2001) Science , vol.293 , pp. 2101-2105
    • Zhu, H.1
  • 29
    • 28444478789 scopus 로고    scopus 로고
    • Biochemical and genetic analysis of the yeast proteome with a movable ORF collection
    • Gelperin, D. M. et al. Biochemical and genetic analysis of the yeast proteome with a movable ORF collection. Genes Dev. 19, 2816-2826 (2005).
    • (2005) Genes Dev , vol.19 , pp. 2816-2826
    • Gelperin, D.M.1
  • 30
    • 0035861532 scopus 로고    scopus 로고
    • Tong, A. H. Y. et al. Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294, 2364-2368 (2001). This paper describes development of the SGA method and its application to synthetic-lethal genetic-interaction mapping. The study also provides the first glimpse of a genetic-interaction network.
    • Tong, A. H. Y. et al. Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294, 2364-2368 (2001). This paper describes development of the SGA method and its application to synthetic-lethal genetic-interaction mapping. The study also provides the first glimpse of a genetic-interaction network.
  • 31
    • 8644224853 scopus 로고    scopus 로고
    • Pan, X. et al. A robust toolkit for functional profiling of the yeast genome. Mol. Cell 16, 487-496 (2004). A study that describes the development of dSLAM, a transformation-based method of creating double mutants that provides a barcode microarray readout for synthetic-lethal genetic interactions.
    • Pan, X. et al. A robust toolkit for functional profiling of the yeast genome. Mol. Cell 16, 487-496 (2004). A study that describes the development of dSLAM, a transformation-based method of creating double mutants that provides a barcode microarray readout for synthetic-lethal genetic interactions.
  • 32
    • 33644778778 scopus 로고    scopus 로고
    • Pan, X. et al. A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell 124, 1069-1081 (2006). This work describes the application of dSLAM analysis to the study of genes involved in DNA synthesis and repair, and genome integrity.
    • Pan, X. et al. A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell 124, 1069-1081 (2006). This work describes the application of dSLAM analysis to the study of genes involved in DNA synthesis and repair, and genome integrity.
  • 33
    • 0025753515 scopus 로고
    • The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae
    • Surana, U. et al. The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae. Cell 65, 145-161 (1991).
    • (1991) Cell , vol.65 , pp. 145-161
    • Surana, U.1
  • 34
    • 33847064282 scopus 로고    scopus 로고
    • Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae
    • Reguly, T. et al. Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae. J. Biol. 5, 11 (2006).
    • (2006) J. Biol , vol.5 , pp. 11
    • Reguly, T.1
  • 35
    • 0029870293 scopus 로고    scopus 로고
    • Establishing genetic interactions by a synthetic dosage lethality phenotype
    • Kroll, E. S., Hyland, K. M., Hieter, P. & Li, J. J. Establishing genetic interactions by a synthetic dosage lethality phenotype. Genetics 143, 95-102 (1996).
    • (1996) Genetics , vol.143 , pp. 95-102
    • Kroll, E.S.1    Hyland, K.M.2    Hieter, P.3    Li, J.J.4
  • 36
    • 0036276974 scopus 로고    scopus 로고
    • Synthetic dosage lethality
    • Measday, V. & Hieter, P. Synthetic dosage lethality. Methods Enzymol. 350, 316-326 (2002).
    • (2002) Methods Enzymol , vol.350 , pp. 316-326
    • Measday, V.1    Hieter, P.2
  • 37
    • 25444489018 scopus 로고    scopus 로고
    • Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation
    • Measday, V. et al. Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation. Proc. Natl Acad. Sci. USA 102, 13956-13961 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 13956-13961
    • Measday, V.1
  • 38
    • 31544482407 scopus 로고    scopus 로고
    • Mapping pathways and phenotypes by systematic gene overexpression
    • Sopko, R. et al. Mapping pathways and phenotypes by systematic gene overexpression. Mol. Cell 21, 319-330 (2006).
    • (2006) Mol. Cell , vol.21 , pp. 319-330
    • Sopko, R.1
  • 39
    • 0036008552 scopus 로고    scopus 로고
    • Exploring the etiology of haploinsufficiency
    • Veitia, R. A. Exploring the etiology of haploinsufficiency. Bioessays 24, 175-184 (2002).
    • (2002) Bioessays , vol.24 , pp. 175-184
    • Veitia, R.A.1
  • 40
    • 10744225364 scopus 로고    scopus 로고
    • Discovering novel modes of action for therapeutic compounds unsing a genome-wide screen of yeast heterozygotes
    • Lum, P. Y. et al. Discovering novel modes of action for therapeutic compounds unsing a genome-wide screen of yeast heterozygotes. Cell 116, 121-137 (2004).
    • (2004) Cell , vol.116 , pp. 121-137
    • Lum, P.Y.1
  • 41
    • 9144268287 scopus 로고    scopus 로고
    • Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast
    • Giaever, G. et al. Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proc. Natl Acad. Sci. USA 101, 793-798 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.101 , pp. 793-798
    • Giaever, G.1
  • 42
    • 33846528944 scopus 로고    scopus 로고
    • Modeling complex genetic interactions in a simple eukaryotic genome: Actin displays a rich spectrum of complex haploinsufficiencies
    • Haarer, B., Viggiano, S., Hibbs, M. A., Troyanskya, O. G. & Amberg, D. C. Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies. Genes Dev. 21, 148-159 (2007).
    • (2007) Genes Dev , vol.21 , pp. 148-159
    • Haarer, B.1    Viggiano, S.2    Hibbs, M.A.3    Troyanskya, O.G.4    Amberg, D.C.5
  • 43
    • 33645453254 scopus 로고    scopus 로고
    • Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
    • Krogan, N. et al. Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature 440, 637-643 (2006).
    • (2006) Nature , vol.440 , pp. 637-643
    • Krogan, N.1
  • 44
    • 33747367151 scopus 로고    scopus 로고
    • Collins, S. R., Schuldiner, M., Krogan, N. & Weissman, J. S. A strategy for extracting and analyzing large-scale quantitative epistatic interaction data. Genome Biol. 7, R63 (2006). This manuscript describes a method for generating quantitative genetic-interaction data sets using SGA analysis.
    • Collins, S. R., Schuldiner, M., Krogan, N. & Weissman, J. S. A strategy for extracting and analyzing large-scale quantitative epistatic interaction data. Genome Biol. 7, R63 (2006). This manuscript describes a method for generating quantitative genetic-interaction data sets using SGA analysis.
  • 45
    • 33645124487 scopus 로고    scopus 로고
    • Derivation of genetic interaction networks from quanitative phenotype data
    • Drees, B. L. et al. Derivation of genetic interaction networks from quanitative phenotype data. Genome Biol. 6, R38 (2005).
    • (2005) Genome Biol , vol.6
    • Drees, B.L.1
  • 46
    • 11244297914 scopus 로고    scopus 로고
    • Segre, D., Deluna, A., Church, G. M. & Kishony, R. Modular epistasis in yeast metabolism. Nature Genet. 37, 77-83 (2005). This study outlines the general concept that the expected phenotype of a double mutant is a multiplicative combination of two single mutants, and that scoring of deviations from this expected value generates genetic networks to describe functional relationships among metabolic pathways.
    • Segre, D., Deluna, A., Church, G. M. & Kishony, R. Modular epistasis in yeast metabolism. Nature Genet. 37, 77-83 (2005). This study outlines the general concept that the expected phenotype of a double mutant is a multiplicative combination of two single mutants, and that scoring of deviations from this expected value generates genetic networks to describe functional relationships among metabolic pathways.
  • 47
    • 0030932405 scopus 로고    scopus 로고
    • Bni1p, a yeast formin linking Cdc42p and the actin cytoskeleton during polarized morphogenesis
    • Evangelista, M. et al. Bni1p, a yeast formin linking Cdc42p and the actin cytoskeleton during polarized morphogenesis. Science 276, 118-122 (1997).
    • (1997) Science , vol.276 , pp. 118-122
    • Evangelista, M.1
  • 48
    • 0038513959 scopus 로고    scopus 로고
    • Scale-free networks
    • Barabasi, A. L. & Bonabeau, E. Scale-free networks. Sci. Am. 288, 60-69 (2003).
    • (2003) Sci. Am , vol.288 , pp. 60-69
    • Barabasi, A.L.1    Bonabeau, E.2
  • 49
    • 0038581531 scopus 로고    scopus 로고
    • Mutation load, functional overlap, and synthetic lethality in the evolution and treatment of cancer
    • Kamb, A. Mutation load, functional overlap, and synthetic lethality in the evolution and treatment of cancer. J. Theor. Biol. 223, 205-213 (2003).
    • (2003) J. Theor. Biol , vol.223 , pp. 205-213
    • Kamb, A.1
  • 50
    • 0037447257 scopus 로고    scopus 로고
    • Assessing experimentally derived interactions in a small word
    • Goldberg, D. S. & Roth, F. P. Assessing experimentally derived interactions in a small word. Proc. Natl Acad. Sci. USA 100, 4372-4376 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 4372-4376
    • Goldberg, D.S.1    Roth, F.P.2
  • 51
    • 0035836765 scopus 로고    scopus 로고
    • A comprehensive two-hybrid analysis to explore the yeast protein interactome
    • Ito, T. et al. A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc. Natl Acad. Sci. USA 98, 4569-4574 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 4569-4574
    • Ito, T.1
  • 52
    • 0034628508 scopus 로고    scopus 로고
    • A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae
    • Uetz, P. et al. A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403, 623-627 (2000).
    • (2000) Nature , vol.403 , pp. 623-627
    • Uetz, P.1
  • 53
    • 0037050026 scopus 로고    scopus 로고
    • Functional organization of the yeast proteome by systematic analysis of protein complexes
    • Gavin, A. C. et al. Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature 415, 141-147 (2002).
    • (2002) Nature , vol.415 , pp. 141-147
    • Gavin, A.C.1
  • 54
    • 33644555054 scopus 로고    scopus 로고
    • Proteome survey reveals modularity of the yeast cell machinery
    • Gavin, A. C. et al. Proteome survey reveals modularity of the yeast cell machinery. Nature 440, 631-636 (2006).
    • (2006) Nature , vol.440 , pp. 631-636
    • Gavin, A.C.1
  • 55
    • 22844450110 scopus 로고    scopus 로고
    • Systematic interpretation of genetic interactions using protein networks
    • Kelley, R. & Ideker, T. Systematic interpretation of genetic interactions using protein networks. Nature Biotech. 23, 561-566 (2005).
    • (2005) Nature Biotech , vol.23 , pp. 561-566
    • Kelley, R.1    Ideker, T.2
  • 56
    • 0037756723 scopus 로고    scopus 로고
    • Functional genomics and proteomics: Charting a multidimensional map of the yeast cell
    • Bader, G. D. et al. Functional genomics and proteomics: charting a multidimensional map of the yeast cell. Trends Cell Biol. 13, 344-356 (2003).
    • (2003) Trends Cell Biol , vol.13 , pp. 344-356
    • Bader, G.D.1
  • 57
    • 34248998383 scopus 로고    scopus 로고
    • Ye, P. et al. Gene function prediction from congruent synthetic lethal interactions in yeast. Mol. Syst. Biol. 1, 2005.0026 (2005).
    • Ye, P. et al. Gene function prediction from congruent synthetic lethal interactions in yeast. Mol. Syst. Biol. 1, 2005.0026 (2005).
  • 58
    • 33847051248 scopus 로고    scopus 로고
    • Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network
    • Zhang, L. V. et al. Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network. J. Biol. 4, 6 (2005).
    • (2005) J. Biol , vol.4 , pp. 6
    • Zhang, L.V.1
  • 59
    • 0038523874 scopus 로고    scopus 로고
    • Synthetic lethal analysis implicates Ste20p, a p21-activated protein kinase, in polarisome activation
    • Goehring, A. S. et al. Synthetic lethal analysis implicates Ste20p, a p21-activated protein kinase, in polarisome activation. Mol. Biol. Cell 14, 1501-1516 (2003).
    • (2003) Mol. Biol. Cell , vol.14 , pp. 1501-1516
    • Goehring, A.S.1
  • 60
    • 13444306165 scopus 로고    scopus 로고
    • The landscape of genetic complexity across 5,700 gene expression traits in yeast
    • Brem, R. B. & Kruglyak, L. The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc. Natl Acad. Sci. USA 102, 1572-1577 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 1572-1577
    • Brem, R.B.1    Kruglyak, L.2
  • 61
    • 23644434284 scopus 로고    scopus 로고
    • Genetic interactions between polymorphisms that affect gene expression in yeast
    • Brem, R. B., Storey, J. D., Whittle, J. & Kruglyak, L. Genetic interactions between polymorphisms that affect gene expression in yeast. Nature 436, 701-703 (2005).
    • (2005) Nature , vol.436 , pp. 701-703
    • Brem, R.B.1    Storey, J.D.2    Whittle, J.3    Kruglyak, L.4
  • 62
    • 79959524146 scopus 로고    scopus 로고
    • Consortium, I. H. A haplotype map of the human genome. Nature 437, 1299-1320 (2005).
    • Consortium, I. H. A haplotype map of the human genome. Nature 437, 1299-1320 (2005).
  • 63
    • 33645464048 scopus 로고    scopus 로고
    • Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray
    • Gresham, D. et al. Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray. Science 311, 1932-1936 (2006).
    • (2006) Science , vol.311 , pp. 1932-1936
    • Gresham, D.1
  • 64
    • 34047179422 scopus 로고    scopus 로고
    • Genetic basis of individual differences in response to smallmolecule drugs in yeast
    • Perstein, E. O., Ruderfer, D. M., Roberts, D. C., Schreiber, S. L. & Kruglyak, L. Genetic basis of individual differences in response to smallmolecule drugs in yeast. Nature Genet. 39, 496-502 (2007).
    • (2007) Nature Genet , vol.39 , pp. 496-502
    • Perstein, E.O.1    Ruderfer, D.M.2    Roberts, D.C.3    Schreiber, S.L.4    Kruglyak, L.5
  • 65
    • 33644519040 scopus 로고    scopus 로고
    • Building mammalian signalling pathways with RNAi screens
    • Moffat, J. & Sabatini, D. M. Building mammalian signalling pathways with RNAi screens. Nature Rev. Mol. Cell Biol. 7, 177-187 (2006).
    • (2006) Nature Rev. Mol. Cell Biol , vol.7 , pp. 177-187
    • Moffat, J.1    Sabatini, D.M.2
  • 66
    • 33646187810 scopus 로고    scopus 로고
    • High-throughput RNAi screening in cultured cells: A user's guide
    • Echeverri, C. J. & Perrimon, N. High-throughput RNAi screening in cultured cells: a user's guide. Nature Rev. Genet. 7, 373-384 (2006).
    • (2006) Nature Rev. Genet , vol.7 , pp. 373-384
    • Echeverri, C.J.1    Perrimon, N.2
  • 67
    • 26444518627 scopus 로고    scopus 로고
    • Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identified conserved genetic interactions
    • Baugh, L. R. et al. Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identified conserved genetic interactions. Genome Biol. 6, R45 (2005).
    • (2005) Genome Biol , vol.6
    • Baugh, L.R.1
  • 68
    • 4444279075 scopus 로고    scopus 로고
    • Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality
    • van Haaften, G., Vastenhouw, N. L., Nollen, E. A., Plasterk, R. H. & Tijsterman, M. Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. Proc. Natl Acad. Sci. USA 101, 12992-12996 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 12992-12996
    • van Haaften, G.1    Vastenhouw, N.L.2    Nollen, E.A.3    Plasterk, R.H.4    Tijsterman, M.5
  • 69
    • 33746525415 scopus 로고    scopus 로고
    • Lehner, B., Crombie, C., Tischler, J., Fortunato, A. & Fraser, A. G. Systematic mapping of genetic interactions in C. elegans. Nature Genet. 38, 896-903 (2006). This study describes the first large-scale mapping of synthetic genetic networks in a metazoan, generated by feeding hypomorphic C. elegans mutants arrays of bacteria that expressed dsRNAi molecules targeting specific signalling pathways.
    • Lehner, B., Crombie, C., Tischler, J., Fortunato, A. & Fraser, A. G. Systematic mapping of genetic interactions in C. elegans. Nature Genet. 38, 896-903 (2006). This study describes the first large-scale mapping of synthetic genetic networks in a metazoan, generated by feeding hypomorphic C. elegans mutants arrays of bacteria that expressed dsRNAi molecules targeting specific signalling pathways.
  • 71
    • 8144227773 scopus 로고    scopus 로고
    • Wong, S. L. et al. Combining biological networks to predict genetic interactions. Proc. Natl Acad. Sci. USA 101, 15682-25687 (2004). The first paper to show that functional genomics data sets can be used to predict genetic interactions.
    • Wong, S. L. et al. Combining biological networks to predict genetic interactions. Proc. Natl Acad. Sci. USA 101, 15682-25687 (2004). The first paper to show that functional genomics data sets can be used to predict genetic interactions.
  • 72
    • 33644864549 scopus 로고    scopus 로고
    • Genome-wide prediction of C. elegans genetic interactions
    • Zhong, W. & Sternberg, P. Genome-wide prediction of C. elegans genetic interactions. Science 311, 1481-1484 (2006).
    • (2006) Science , vol.311 , pp. 1481-1484
    • Zhong, W.1    Sternberg, P.2
  • 73
    • 0347473810 scopus 로고    scopus 로고
    • Parsons, A. B. et al. Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular targets and pathways. Nature Biotech. 22, 62-69 (2004). This work describes how synthetic-lethal genetic-interaction maps function as a key for deciphering chemical-genetic maps, providing a means of linking compounds to their target pathways.
    • Parsons, A. B. et al. Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular targets and pathways. Nature Biotech. 22, 62-69 (2004). This work describes how synthetic-lethal genetic-interaction maps function as a key for deciphering chemical-genetic maps, providing a means of linking compounds to their target pathways.
  • 75
    • 34249048506 scopus 로고    scopus 로고
    • The identification of combinations of molecules can result in highly effective drug regimens
    • Keith, C. T., Borisy, A. A. & Stockwell, B. R. The identification of combinations of molecules can result in highly effective drug regimens. Nature Rev. Drug Discov. 4, 71-78 (2003).
    • (2003) Nature Rev. Drug Discov , vol.4 , pp. 71-78
    • Keith, C.T.1    Borisy, A.A.2    Stockwell, B.R.3
  • 76
    • 0038610570 scopus 로고    scopus 로고
    • Systematic discovery of multicomponent therapeutics
    • Borisy, A. A. et al. Systematic discovery of multicomponent therapeutics. Proc. Natl Acad. Sci. USA 100, 7977-7982 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 7977-7982
    • Borisy, A.A.1
  • 77
    • 0031827525 scopus 로고    scopus 로고
    • Phillips, P. C. The language of gene interaction. Genetics 149, 1167-1171 (1998). A wonderful review of the language that is used to describe genetic interactions, including terms like epistasis, with historical context.
    • Phillips, P. C. The language of gene interaction. Genetics 149, 1167-1171 (1998). A wonderful review of the language that is used to describe genetic interactions, including terms like epistasis, with historical context.
  • 78
    • 84971185409 scopus 로고
    • The correlations between relatives on the supposition of Mendelian inheritance
    • Fisher, R. A. The correlations between relatives on the supposition of Mendelian inheritance. Trans. R. Soc. Edinb. 52, 399-433 (1918).
    • (1918) Trans. R. Soc. Edinb , vol.52 , pp. 399-433
    • Fisher, R.A.1
  • 79
    • 0023666071 scopus 로고
    • Activation of the yeast HO gene by release from muliple negative controls
    • Sternberg, P., Stern, M. J., Clark, I. & Herskowitz, I. Activation of the yeast HO gene by release from muliple negative controls. Cell 48, 567-577 (1987).
    • (1987) Cell , vol.48 , pp. 567-577
    • Sternberg, P.1    Stern, M.J.2    Clark, I.3    Herskowitz, I.4
  • 80
    • 0015954720 scopus 로고
    • Genetic control of cell division cycle in yeast
    • Hartwell, L. H., Culotti, J., Pringle, J. R. & Reid, B. J. Genetic control of cell division cycle in yeast. Science 183, 46-51 (1974).
    • (1974) Science , vol.183 , pp. 46-51
    • Hartwell, L.H.1    Culotti, J.2    Pringle, J.R.3    Reid, B.J.4
  • 82
    • 0026666791 scopus 로고
    • Ordering gene function: The interpretation of epistasis in regulatory hierarchies
    • Avery, L. & Wasserman, S. Ordering gene function: the interpretation of epistasis in regulatory hierarchies. Trends Genet. 8, 312-316 (1992).
    • (1992) Trends Genet , vol.8 , pp. 312-316
    • Avery, L.1    Wasserman, S.2
  • 83
    • 0019296946 scopus 로고
    • Sex and the single cell. I. On the action of major loci affecting sex determination in Drosophila melanogaster
    • Baker, B. S. & Ridge, K. A. Sex and the single cell. I. On the action of major loci affecting sex determination in Drosophila melanogaster. Genetics 94, 383-423 (1980).
    • (1980) Genetics , vol.94 , pp. 383-423
    • Baker, B.S.1    Ridge, K.A.2
  • 84
    • 33947617347 scopus 로고    scopus 로고
    • Backup without redundancy: Genetic interactions reveal the cost of duplicate gene loss
    • Ihmels, J., Collins, S. R., Schuldiner, M., Krogan, N. & Weissman, J. S. Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss. Mol. Syst. Biol. 3, 86 (2007).
    • (2007) Mol. Syst. Biol , vol.3 , pp. 86
    • Ihmels, J.1    Collins, S.R.2    Schuldiner, M.3    Krogan, N.4    Weissman, J.S.5
  • 86
    • 0035458366 scopus 로고    scopus 로고
    • The art and design of genetic screens: Yeast
    • Forsburg, S. L. The art and design of genetic screens: yeast. Nature Rev. Genet. 2, 659-668 (2001).
    • (2001) Nature Rev. Genet , vol.2 , pp. 659-668
    • Forsburg, S.L.1
  • 87
    • 0025277750 scopus 로고
    • Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway
    • Kaiser, C. A. & Schekman, R. Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway. Cell 61, 723-733 (1990).
    • (1990) Cell , vol.61 , pp. 723-733
    • Kaiser, C.A.1    Schekman, R.2
  • 88
    • 0033761839 scopus 로고    scopus 로고
    • Synthetic interactions of the post-golgi sec mutations of Saccharomyces cerevisiae
    • Finger, F. & Novick, P. Synthetic interactions of the post-golgi sec mutations of Saccharomyces cerevisiae. Genetics 156, 943-951 (2000).
    • (2000) Genetics , vol.156 , pp. 943-951
    • Finger, F.1    Novick, P.2


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