-
1
-
-
64749094310
-
The cancer genome
-
Stratton, M. R., Campbell, P. J. & Futreal, P. A. The cancer genome. Nature 458, 719-724 (2009).
-
(2009)
Nature
, vol.458
, pp. 719-724
-
-
Stratton, M.R.1
Campbell, P.J.2
Futreal, P.A.3
-
2
-
-
33747869580
-
Statistical analysis of pathogenicity of somatic mutations in cancer
-
DOI 10.1534/genetics.105.044677
-
Greenman, C., Wooster, R., Futreal, P. A., Stratton, M. R. & Easton, D. F. Statistical analysis of pathogenicity of somatic mutations in cancer. Genetics 173, 2187-2198 (2006). (Pubitemid 44285695)
-
(2006)
Genetics
, vol.173
, Issue.4
, pp. 2187-2198
-
-
Greenman, C.1
Wooster, R.2
Futreal, P.A.3
Stratton, M.R.4
Easton, D.F.5
-
3
-
-
79251635938
-
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
-
Varela, I. et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 469, 539-542 (2011).
-
(2011)
Nature
, vol.469
, pp. 539-542
-
-
Varela, I.1
-
4
-
-
79952112019
-
TheMAP kinase signaling cascades: A systemof hundreds of components regulates a diverse array ofphysiological functions
-
Keshet, Y.& Seger, R. TheMAP kinase signaling cascades: a systemof hundreds of components regulates a diverse array ofphysiological functions.Methods Mol. Biol. 661, 3-38 (2010).
-
(2010)
Methods Mol. Biol.
, vol.661
, pp. 3-38
-
-
Keshet, Y.1
Seger, R.2
-
5
-
-
0032100617
-
Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene
-
Su, G. H. et al. Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. Cancer Res. 58, 2339-2342 (1998). (Pubitemid 28252690)
-
(1998)
Cancer Research
, vol.58
, Issue.11
, pp. 2339-2342
-
-
Su, G.H.1
Hilgers, W.2
Shekher, M.C.3
Tang, D.J.4
Yeo, C.J.5
Hruban, R.H.6
Kern, S.E.7
-
6
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
DOI 10.1038/nature05933, PII NATURE05933
-
Carpten, J. D. et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448, 439-444 (2007). (Pubitemid 47123510)
-
(2007)
Nature
, vol.448
, Issue.7152
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
Donoho, G.P.4
Briggs, S.L.5
Robbins, C.M.6
Hostetter, G.7
Boguslawski, S.8
Moses, T.Y.9
Savage, S.10
Uhlik, M.11
Lin, A.12
Du, J.13
Qian, Y.-W.14
Zeckner, D.J.15
Tucker-Kellogg, G.16
Touchman, J.17
Patel, K.18
Mousses, S.19
Bittner, M.20
Schevitz, R.21
Lai, M.-H.T.22
Blanchard, K.L.23
Thomas, J.E.24
more..
-
7
-
-
0037169526
-
Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation
-
Park, H. S. et al. Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation. J. Biol. Chem. 277, 2573-2578 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 2573-2578
-
-
Park, H.S.1
-
8
-
-
43749120732
-
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
-
DOI 10.2174/156800908784293659
-
Carnero, A., Blanco-Aparicio, C., Renner, O., Link, W. & Leal, J. F. The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr. Cancer Drug Targets 8, 187-198 (2008). (Pubitemid 351688437)
-
(2008)
Current Cancer Drug Targets
, vol.8
, Issue.3
, pp. 187-198
-
-
Carnero, A.1
Blanco-Aparicio, C.2
Renner, O.3
Link, W.4
Leal, J.F.M.5
-
9
-
-
77958479166
-
The functional interactions between the MAPK and p53 signaling pathways
-
Wu, G. S. The functional interactions between the MAPK and p53 signaling pathways. Cancer Biol. Ther. 3, 146-151 (2004).
-
(2004)
Cancer Biol. Ther.
, vol.3
, pp. 146-151
-
-
Wu, G.S.1
-
10
-
-
0029132202
-
Ligand-independent repressionby the thyroidhormonereceptor mediated by a nuclear receptor co-repressor
-
Horlein, A. J. et al. Ligand-independent repressionby the thyroidhormonereceptor mediated by a nuclear receptor co-repressor. Nature 377, 397-404 (1995).
-
(1995)
Nature
, vol.377
, pp. 397-404
-
-
Horlein, A.J.1
-
11
-
-
79953171856
-
Differential recruitment of nuclear receptor coregulators in ligand-dependent transcriptional repression by estrogen receptor-alpha
-
Merrell, K. W. et al. Differential recruitment of nuclear receptor coregulators in ligand-dependent transcriptional repression by estrogen receptor-alpha. Oncogene 30, 1608-1614 (2010).
-
(2010)
Oncogene
, vol.30
, pp. 1608-1614
-
-
Merrell, K.W.1
-
12
-
-
77957731999
-
Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma
-
Jones, S. et al. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science 330, 228-231 (2010).
-
(2010)
Science
, vol.330
, pp. 228-231
-
-
Jones, S.1
-
13
-
-
64949113367
-
The SWI/SNF complex and cancer
-
Reisman, D., Glaros, S. & Thompson, E. A. The SWI/SNF complex and cancer. Oncogene 28, 1653-1668 (2009).
-
(2009)
Oncogene
, vol.28
, pp. 1653-1668
-
-
Reisman, D.1
Glaros, S.2
Thompson, E.A.3
-
14
-
-
77957946398
-
ARID1A mutations in endometriosis-associated ovarian carcinomas
-
Wiegand, K. C. et al. ARID1A mutations in endometriosis-associated ovarian carcinomas. N. Engl. J. Med. 363, 1532-1543 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 1532-1543
-
-
Wiegand, K.C.1
-
15
-
-
0030002553
-
P27/Kip1 mutation found in breast cancer
-
Spirin, K. S. et al. p27/Kip1 mutation found in breast cancer. Cancer Res. 56, 2400-2404 (1996). (Pubitemid 26154089)
-
(1996)
Cancer Research
, vol.56
, Issue.10
, pp. 2400-2404
-
-
Spirin, K.S.1
Simpson, J.F.2
Takeuchi, S.3
Kawamata, N.4
Miller, C.W.5
Koeffler, H.P.6
-
16
-
-
26944464295
-
Molecular analysis of the P27/Kip1 gene in breast cancer
-
DOI 10.2165/00066982-200509010-00003
-
Tigli, H., Buyru, N. & Dalay, N. Molecular analysis of the p27/kip1 gene in breast cancer. Mol. Diagn. 9, 17-21 (2005). (Pubitemid 43066365)
-
(2005)
Molecular Diagnosis
, vol.9
, Issue.1
, pp. 17-21
-
-
Tigli, H.1
Buyru, N.2
Dalay, N.3
-
17
-
-
41149150219
-
The Cdk inhibitor p27 in human cancer: Prognostic potential and relevance to anticancer therapy
-
DOI 10.1038/nrc2347, PII NRC2347
-
Chu, I. M., Hengst, L. & Slingerland, J. M. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nature Rev. Cancer 8, 253-267 (2008). (Pubitemid 351430863)
-
(2008)
Nature Reviews Cancer
, vol.8
, Issue.4
, pp. 253-267
-
-
Chu, I.M.1
Hengst, L.2
Slingerland, J.M.3
-
18
-
-
77649191794
-
Tbx3improves the germ-line competency of induced pluripotent stem cells
-
Han, J. et al. Tbx3improves the germ-line competency of induced pluripotent stem cells. Nature 463, 1096-1100 (2010).
-
(2010)
Nature
, vol.463
, pp. 1096-1100
-
-
Han, J.1
-
19
-
-
33748069145
-
Signalling pathways implicated in early mammary gland morphogenesis and breast cancer
-
Howard, B. & Ashworth, A. Signalling pathways implicated in early mammary gland morphogenesis and breast cancer. PLoS Genet. 2, e112 (2006).
-
(2006)
PLoS Genet.
, vol.2
-
-
Howard, B.1
Ashworth, A.2
-
20
-
-
0030986873
-
Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome
-
DOI 10.1038/ng0797-311
-
Bamshad, M. et al. Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Nature Genet. 16, 311-315 (1997). (Pubitemid 27280219)
-
(1997)
Nature Genetics
, vol.16
, Issue.3
, pp. 311-315
-
-
Bamshad, M.1
Lin, R.C.2
Law, D.J.3
Watkins, W.S.4
Krakowiak, P.A.5
Moore, M.E.6
Franceschini, P.7
Lala, R.8
Holmes, L.B.9
Gebuhr, T.C.10
Bruneau, B.G.11
Schinzel, A.12
Seidman, J.G.13
Seidman, C.E.14
Jorde, L.B.15
-
21
-
-
78650732630
-
Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling
-
Fillmore, C. M. et al. Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc. Natl Acad. Sci. USA 107, 21737-21742 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 21737-21742
-
-
Fillmore, C.M.1
-
22
-
-
84862776961
-
Genome-wide association analysis identifies three new breast cancer susceptibility loci
-
Ghoussaini, M. et al. Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nature Genet. 44, 312-318 (2012).
-
(2012)
Nature Genet.
, vol.44
, pp. 312-318
-
-
Ghoussaini, M.1
-
23
-
-
77953616544
-
Genome-wide association studies in common cancers-what have we learnt?
-
Varghese, J. S. & Easton, D. F. Genome-wide association studies in common cancers-what have we learnt? Curr. Opin. Genet. Dev. 20, 201-209 (2010).
-
(2010)
Curr. Opin. Genet. Dev.
, vol.20
, pp. 201-209
-
-
Varghese, J.S.1
Easton, D.F.2
-
24
-
-
0019183253
-
On the nature of susceptibility to cancer
-
Miller, D. On the nature of susceptibility to cancer. Cancer 46, 1307-1318 (1980).
-
(1980)
Cancer
, vol.46
, pp. 1307-1318
-
-
Miller, D.1
-
25
-
-
38449094794
-
Oncogenic transformation and experimental models of human cancer
-
DOI 10.2741/2661
-
Schinzel, A. C. & Hahn, W. C. Oncogenic transformation and experimental models of human cancer. Front. Biosci. 13, 71-84 (2008). (Pubitemid 351594764)
-
(2008)
Frontiers in Bioscience
, vol.13
, Issue.1
, pp. 71-84
-
-
Schinzel, A.C.1
Hahn, W.C.2
-
26
-
-
38049164275
-
Eukaryotic nucleotide excision repair: From understanding mechanisms to influencing biology
-
Shuck, S. C., Short, E. A. & Turchi, J. J. Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology. Cell Res. 18, 64-72 (2008).
-
(2008)
Cell Res.
, vol.18
, pp. 64-72
-
-
Shuck, S.C.1
Short, E.A.2
Turchi, J.J.3
-
27
-
-
38049178545
-
Transcription-coupled nucleotide excisionrepair in mammalian cells: Molecular mechanisms and biological effects
-
Fousteri, M.&Mullenders, L. H. Transcription-coupled nucleotide excisionrepair in mammalian cells: molecular mechanisms and biological effects. Cell Res. 18, 73-84 (2008).
-
(2008)
Cell Res.
, vol.18
, pp. 73-84
-
-
Fousteri, M.1
Mullenders, L.H.2
-
28
-
-
77949587649
-
Fast and accurate long-read alignment with Burrows-Wheeler transform
-
Li, H. & Durbin, R. Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics 26, 589-595 (2010).
-
(2010)
Bioinformatics
, vol.26
, pp. 589-595
-
-
Li, H.1
Durbin, R.2
-
29
-
-
70350694443
-
Pindel: A pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short reads
-
Ye, K., Schulz, M. H., Long, Q., Apweiler, R. & Ning, Z. Pindel: a pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short reads. Bioinformatics 25, 2865-2871 (2009).
-
(2009)
Bioinformatics
, vol.25
, pp. 2865-2871
-
-
Ye, K.1
Schulz, M.H.2
Long, Q.3
Apweiler, R.4
Ning, Z.5
-
30
-
-
78049248432
-
Allele-specific copy number analysis of tumors
-
Van Loo, P. et al. Allele-specific copy number analysis of tumors. Proc. Natl Acad. Sci. USA 107, 16910-16915 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 16910-16915
-
-
Van Loo, P.1
-
31
-
-
79251635938
-
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
-
Varela, I. et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 469, 539-542 (2011).
-
(2011)
Nature
, vol.469
, pp. 539-542
-
-
Varela, I.1
-
32
-
-
77949587649
-
Fast and accurate long-read alignment with Burrows-Wheeler transform
-
Li, H. & Durbin, R. Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics 26, 589-595 (2010).
-
(2010)
Bioinformatics
, vol.26
, pp. 589-595
-
-
Li, H.1
Durbin, R.2
-
33
-
-
70350694443
-
Pindel: A pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short reads
-
Ye, K., Schulz, M. H., Long, Q., Apweiler, R. & Ning, Z. Pindel: a pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short reads. Bioinformatics 25, 2865-2871 (2009).
-
(2009)
Bioinformatics
, vol.25
, pp. 2865-2871
-
-
Ye, K.1
Schulz, M.H.2
Long, Q.3
Apweiler, R.4
Ning, Z.5
-
34
-
-
78049248432
-
Allele-specific copy number analysis of tumors
-
Van Loo, P. et al. Allele-specific copy number analysis of tumors. Proc. Natl Acad. Sci. USA 107, 16910-16915 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 16910-16915
-
-
Van Loo, P.1
-
35
-
-
77249119762
-
The landscape of somatic copy-number alteration across human cancers
-
Beroukhim, R. et al. The landscape of somatic copy-number alteration across human cancers. Nature 463, 899-905 (2010).
-
(2010)
Nature
, vol.463
, pp. 899-905
-
-
Beroukhim, R.1
-
36
-
-
1542515338
-
A census of human cancer genes
-
Futreal, P. A. et al. A census of human cancer genes. Nature Rev. Cancer 4, 177-183 (2004). (Pubitemid 38337497)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.3
, pp. 177-183
-
-
Futreal, P.A.1
Coin, L.2
Marshall, M.3
Down, T.4
Hubbard, T.5
Wooster, R.6
Rahman, N.7
Stratton, M.R.8
-
37
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
DOI 10.1038/nature05610, PII NATURE05610
-
Greenman, C. et al. Patterns of somatic mutation in human cancer genomes. Nature 446, 153-158 (2007). (Pubitemid 46398669)
-
(2007)
Nature
, vol.446
, Issue.7132
, pp. 153-158
-
-
Greenman, C.1
Stephens, P.2
Smith, R.3
Dalgliesh, G.L.4
Hunter, C.5
Bignell, G.6
Davies, H.7
Teague, J.8
Butler, A.9
Stevens, C.10
Edkins, S.11
O'Meara, S.12
Vastrik, I.13
Schmidt, E.E.14
Avis, T.15
Barthorpe, S.16
Bhamra, G.17
Buck, G.18
Choudhury, B.19
Clements, J.20
Cole, J.21
Dicks, E.22
Forbes, S.23
Gray, K.24
Halliday, K.25
Harrison, R.26
Hills, K.27
Hinton, J.28
Jenkinson, A.29
Jones, D.30
Menzies, A.31
Mironenko, T.32
Perry, J.33
Raine, K.34
Richardson, D.35
Shepherd, R.36
Small, A.37
Tofts, C.38
Varian, J.39
Webb, T.40
West, S.41
Widaa, S.42
Yates, A.43
Cahill, D.P.44
Louis, D.N.45
Goldstraw, P.46
Nicholson, A.G.47
Brasseur, F.48
Looijenga, L.49
Weber, B.L.50
Chiew, Y.-E.51
DeFazio, A.52
Greaves, M.F.53
Green, A.R.54
Campbell, P.55
Birney, E.56
Easton, D.F.57
Chenevix-Trench, G.58
Tan, M.-H.59
Khoo, S.K.60
Teh, B.T.61
Yuen, S.T.62
Leung, S.Y.63
Wooster, R.64
Futreal, P.A.65
Stratton, M.R.66
more..
|