A biochemically defined system for mammalian nonhomologous DNA end joining

Molecular Cell

Volumn 16, Issue 5, 2004, Pages 701-713

  Ma, Yunmei ^a,b   Lu, Haihui ^a,b   Tippin, Brigette ^b   Goodman, Myron F ^b   Shimazaki, Noriko ^c   Koiwai, Osamu ^c   Hsieh, Chih Lin ^b   Schwarz, Klaus ^d   Lieber, Michael R ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

^d UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMIS PROTEIN; BACTERIAL PROTEIN; BRCA1 PROTEIN; DEOXYRIBONUCLEIC ACID LIGASE IV; DNA; DNA DEPENDENT PROTEIN KINASE; DNA POLYMERASE; KU ANTIGEN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; REPETITIVE DNA; UNCLASSIFIED DRUG;

ANTIGEN PURIFICATION; ARTICLE; BACTERIOPHAGE LAMBDA; BACTERIOPHAGE MU; BASE PAIRING; CARBOXY TERMINAL SEQUENCE; DNA STRAND; ENZYME PURIFICATION; GENETIC VARIABILITY; KNOCKOUT MOUSE; LIGATION; MAMMAL; MOLECULAR MODEL; PROTEIN DOMAIN; PROTEIN FUNCTION; SEQUENCE HOMOLOGY;

ANIMALS; ANTIGENS, NUCLEAR; BASE SEQUENCE; DNA; DNA DAMAGE; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI; MODELS, BIOLOGICAL; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; OLIGONUCLEOTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE HOMOLOGY, NUCLEIC ACID;

BACTERIA (MICROORGANISMS); BACTERIOPHAGE LAMBDA; ENTEROBACTERIA PHAGE MU; EUKARYOTA; MAMMALIA;

EID: 9744241712     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2004.11.017     Document Type: Article

References (36)

1. Bertocci B., Smet A.D., Berek C., Weill J.C., Reynaud C.A. Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu. Immunity. 19:2003;203-211
2. Callebaut I., Mornon J.P. From BRCA1 to RAP1. a widespread BRCT module closely associated with DNA repair FEBS Lett. 400:1997;25-30
3. Chang L.M., Bollum F.J. Molecular biology of terminal transferase. CRC Crit. Rev. Biochem. 21:1986;27-52
4. Chang L.M., Rafter E., Rusquet-Valerius R., Roy N.K., Cheung L.C., Bollum F.J. Expression and processing of recombinant human terminal transferase in the baculovirus system. J. Biol. Chem. 263:1988;12509-12513
5. Chen L., Trujillo K., Sung P., Tomkinson A.E. Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase. J. Biol. Chem. 275:2000;26196-26205
6. DeFazio L.G., Stansel R.M., Griffith J.D., Chu G. Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J. 21:2002;3192-3200
7. de Vries E., vanDriel W., Bergsma W.G., Arnberg A.C., van der Vliet P.C. HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex. J. Mol. Biol. 208:1989;65-78
8. Dominguez O., Ruiz J.F., Lain de Lera T., Garcia-Diaz M., Gonzalez M.A., Kirchhoff T., Martinez C., Bernad A., Blanco L. DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells. EMBO J. 19:2000;1731-1742
9. Ferguson D.O., Alt F.W. DNA double-strand break repair and chromosomal translocations. lessons from animal models Oncogene. 20:2001;5572-5579
10. Gauss G.H., Lieber M.R. Mechanistic constraints on diversity in human V(D)J recombination. Mol. Cell. Biol. 16:1996;258-269
11. Gerstein R.M., Lieber M.R. Coding end sequence can markedly affect the initiation of V(D)J recombination. Genes Dev. 7:1993;1459-1469
12. Gottlieb T., Jackson S.P. The DNA-dependent protein kinase. requirement for DNA ends and association with Ku antigen Cell. 72:1993;131-142
13. Grawunder U., Wilm M., Wu X., Kulesza P., Wilson T.E., Mann M., Lieber M.R. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature. 388:1997;492-495
14. Hammarsten O., Chu G. DNA-dependent protein kinase. DNA binding and activation in the absence of Ku Proc. Natl. Acad. Sci. USA. 95:1998;525-530
15. Hanakahi L., Bartlet-Jones M., Chappell C., Pappin D., West S.C. Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair. Cell. 102:2000;721-729
16. Komori T., Okada A., Stewart V., Alt F. Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science. 261:1993;1171-1175
17. Kysela B., Doherty A.J., Chovanec M., Stiff T., Ameer-Beg S.M., Vojnovic B., Girard P.M., Jeggo P.A. Ku stimulation of DNA ligase IV-dependent ligation requires inward movement along the DNA molecule. J. Biol. Chem. 278:2003;22466-22474
18. Lee J.W., Blanco L., Zhou T., Garcia-Diaz M., Bebenek K., Kunkel T.A., Wang Z., Povirk L.F. Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts. J. Biol. Chem. 279:2003;805-811
19. Lieber M.R., Ma Y., Pannicke U., Schwarz K. The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Repair (Amst.). 3:2004;817-826
20. Ma Y., Pannicke U., Schwarz K., Lieber M.R. Hairpin opening and overhang processing by an Artemis:DNA-PKcs complex in V(D)J recombination and in nonhomologous end joining. Cell. 108:2002;781-794
21. Mahajan K.N., Nick McElhinny S.A., Mitchell B.S., Ramsden D.A. Association of DNA polymerase mu with Ku and DNA ligase IV. role of in end-joining double-strand break repair Mol. Cell. Biol. 22:2002;5194-5202
22. Modesti M., Junop M.S., Ghirlando R., van de Rakt M., Gellert M., Yang W., Kanaar R. Tetramerization and DNA ligase IV interaction of the DNA double-strand break protein XRCC4 are mutually exclusive. J. Mol. Biol. 334:2003;215-228
23. Nick McElhinny S.A., Snowden C.M., McCarville J., Ramsden D.A. Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends. Mol. Cell. Biol. 20:2000;2996-3003
24. Pfeiffer P., Goedecke W., Obe G. Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations. Mutagenesis. 15:2000;289-302
25. Ramadan K., Maga G., Shevelev I.V., Villani G., Blanco L., Hubscher U. Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers. implications for novel functions J. Mol. Biol. 328:2003;63-72
26. Ramsden D.A., Gellert M. Ku protein stimulates DNA end joining by mammalian DNA ligases. a direct role for Ku in repair of DNA double-strand breaks EMBO J. 17:1998;609-614
27. Repasky J.A., Corbett E., Boboila C., Schatz D.G. Mutational analysis of terminal deoxynucleotidyl transferase-mediated N-nucleotide addition in V(D)J recombination. J. Immunol. 172:2004;5478-5488
28. Shimazaki N., Yoshida K., Kobayashi T., Toji S., Tamai K., Koiwai O. Over-expression of human DNA polymerase lambda in E. coli and characterization of the recombinant enzyme. Genes Cells. 7:2002;639-651
29. Sobol R.W., Horton J., Kuhn R., Gu H., Singhal R., Prasad R., Rajewsky K., Wilson S. Requirement of mammalian DNA polymerase-beta in base-excision repair. Nature. 379:1996;183-186
30. Tseng H.M., Tomkinson A.E. A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joining. J. Biol. Chem. 277:2002;45630-45637
31. Udayakumar D., Bladen C.L., Hudson F.Z., Dynan W.S. Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation. J. Biol. Chem. 278:2003;1631-1635
32. Walker J.R., Corpina R.A., Goldberg J. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature. 412:2001;607-614
33. West R.B., Yaneva M., Lieber M.R. Productive and Nonproductive Complexes of Ku and DNA-PK at DNA Termini. Mol. Cell. Biol. 18:1998;5908-5920
34. Wilson T., Lieber M.R. Efficient processing of DNA ends during yeast nonhomologous end joining. evidence for a DNA polymerase beta (POL4)-dependent pathway J. Biol. Chem. 274:1999;23599-23609
35. Wilson T.E., Grawunder U., Lieber M.R. Yeast DNA ligase IV mediates non-homologous DNA end joining. Nature. 388:1997;495-498
36. Yaneva M., Kowalewski T., Lieber M.R. Interaction of DNA-dependent protein kinase with DNA and with Ku. biochemical and atomic-force microscopy EMBO J. 16:1997;5098-5112