A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

EMBO Journal

Volumn 31, Issue 11, 2012, Pages 2511-2527

  Luijsterburg, Martijn S ^a,b   Acs, Klara ^a   Ackermann, Leena ^a   Wiegant, Wouter W ^b   Bekker Jensen, Simon ^c   Larsen, Dorthe H ^d,f   Khanna, Kum Kum ^e   Van Attikum, Haico ^b   Mailand, Niels ^c   Dantuma, Nico P ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c University of Copenhagen   (Denmark)

^d DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^e QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^f UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

chromatin; DNA damage response; DSB repair; histone ubiquitin ligase; RNF8

Indexed keywords

BRCA1 PROTEIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE RNF168; UBIQUITIN PROTEIN LIGASE RNF8; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHROMATIN STRUCTURE; COMPLEX FORMATION; CONJUGATION; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVE SITE; ENZYME ACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN UNFOLDING;

ANIMALS; AUTOANTIGENS; BRCA1 PROTEIN; CELL LINE, TUMOR; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; CRICETINAE; DNA BREAKS, DOUBLE-STRANDED; DNA HELICASES; DNA-BINDING PROTEINS; HUMANS; MI-2 NUCLEOSOME REMODELING AND DEACETYLASE COMPLEX; MICE; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84861895067     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.104     Document Type: Article

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