-
1
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
DOI 10.1038/nature03445
-
Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005;434:917-21. (Pubitemid 40559006)
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 917-921
-
-
Farmer, H.1
McCabe, H.2
Lord, C.J.3
Tutt, A.H.J.4
Johnson, D.A.5
Richardson, T.B.6
Santarosa, M.7
Dillon, K.J.8
Hickson, I.9
Knights, C.10
Martin, N.M.B.11
Jackson, S.P.12
Smith, G.C.M.13
Ashworth, A.14
-
2
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
DOI 10.1038/nature03443
-
Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP-ribose) polymerase. Nature 2005;434:913-7. (Pubitemid 40559005)
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
Parker, K.M.4
Flower, D.5
Lopez, E.6
Kyle, S.7
Meuth, M.8
Curtin, N.J.9
Helleday, T.10
-
3
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009;361:123-34.
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
Tutt, A.4
Wu, P.5
Mergui-Roelvink, M.6
-
4
-
-
79955588797
-
Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate
-
Strom CE, Johansson F, Uhlen M, Szigyarto CA, Erixon K, Helleday T. Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate. Nucleic Acids Res 2011;39:3166-75.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 3166-3175
-
-
Strom, C.E.1
Johansson, F.2
Uhlen, M.3
Szigyarto, C.A.4
Erixon, K.5
Helleday, T.6
-
5
-
-
77953636534
-
Homologous recombination in cancer development, treatment and development of drug resistance
-
Helleday T. Homologous recombination in cancer development, treatment and development of drug resistance. Carcinogenesis 2010;31:955-60.
-
(2010)
Carcinogenesis
, vol.31
, pp. 955-960
-
-
Helleday, T.1
-
6
-
-
77954374334
-
Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells
-
Gottipati P, Vischioni B, Schultz N, Solomons J, Bryant HE, Djureinovic T, et al. Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells. Cancer Res 2010;70:5389-98.
-
(2010)
Cancer Res
, vol.70
, pp. 5389-5398
-
-
Gottipati, P.1
Vischioni, B.2
Schultz, N.3
Solomons, J.4
Bryant, H.E.5
Djureinovic, T.6
-
7
-
-
69849097500
-
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
-
Bryant HE, Petermann E, Schultz N, Jemth AS, Loseva O, Issaeva N, et al. PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. EMBO J 2009;28:2601-15.
-
(2009)
EMBO J
, vol.28
, pp. 2601-2615
-
-
Bryant, H.E.1
Petermann, E.2
Schultz, N.3
Jemth, A.S.4
Loseva, O.5
Issaeva, N.6
-
8
-
-
79952747328
-
Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells
-
Patel AG, Sarkaria JN, Kaufmann SH. Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells. Proc Natl Acad Sci U S A 2011;108:3406-11.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 3406-3411
-
-
Patel, A.G.1
Sarkaria, J.N.2
Kaufmann, S.H.3
-
9
-
-
79955799175
-
Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11
-
Schlacher K, Christ N, Siaud N, Egashira A, Wu H, Jasin M. Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell 2011;145:529-42.
-
(2011)
Cell
, vol.145
, pp. 529-542
-
-
Schlacher, K.1
Christ, N.2
Siaud, N.3
Egashira, A.4
Wu, H.5
Jasin, M.6
-
10
-
-
2342524565
-
Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks
-
DOI 10.1038/sj.onc.1207491
-
Yang YG, Cortes U, Patnaik S, Jasin M, Wang ZQ. Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks. Oncogene 2004;23:3872-82. (Pubitemid 38725700)
-
(2004)
Oncogene
, vol.23
, Issue.21
, pp. 3872-3882
-
-
Yang, Y.-G.1
Cortes, U.2
Patnaik, S.3
Jasin, M.4
Wang, Z.-Q.5
-
11
-
-
76849109722
-
Hydroxyureastalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair
-
Petermann E, Orta ML, Issaeva N, Schultz N, Helleday T. Hydroxyureastalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair. Mol Cell 2010;37:492-502.
-
(2010)
Mol Cell
, vol.37
, pp. 492-502
-
-
Petermann, E.1
Orta, M.L.2
Issaeva, N.3
Schultz, N.4
Helleday, T.5
-
12
-
-
34447115757
-
Role for BLM in replication-fork restart and suppression of origin firing after replicative stress
-
DOI 10.1038/nsmb1267, PII NSMB1267
-
Davies SL, North PS, Hickson ID. Role for BLM in replication-fork restart and suppression of origin firing after replicative stress. Nat Struct Mol Biol 2007;14:677-9. (Pubitemid 47037072)
-
(2007)
Nature Structural and Molecular Biology
, vol.14
, Issue.7
, pp. 677-679
-
-
Davies, S.L.1
North, P.S.2
Hickson, I.D.3
-
13
-
-
38149057387
-
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites
-
Haince JF, McDonald D, Rodrigue A, Dery U, Masson JY, Hendzel MJ, et al. PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. J Biol Chem 2008;283:1197-208.
-
(2008)
J Biol Chem
, vol.283
, pp. 1197-1208
-
-
Haince, J.F.1
McDonald, D.2
Rodrigue, A.3
Dery, U.4
Masson, J.Y.5
Hendzel, M.J.6
-
14
-
-
78549251695
-
Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis
-
Hashimoto Y, Chaudhuri AR, Lopes M, Costanzo V. Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis. Nat Struct Mol Biol 2010;17:1305-11.
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 1305-1311
-
-
Hashimoto, Y.1
Chaudhuri, A.R.2
Lopes, M.3
Costanzo, V.4
-
15
-
-
0036136316
-
Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions
-
DOI 10.1128/MCB.22.2.669-679.2002
-
Kraakman-van der Zwet M, Overkamp WJ, van Lange RE, Essers J, van Duijn-Goedhart A, Wiggers I, et al. Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions. Mol Cell Biol 2002;22:669-79. (Pubitemid 34027510)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.2
, pp. 669-679
-
-
Kraakman-Van, D.Z.M.1
Overkamp, W.J.I.2
Van Lange, R.E.E.3
Essers, J.4
Van Duijn-Goedhart, A.5
Wiggers, I.6
Swaminathan, S.7
Van Buul, P.P.W.8
Errami, A.9
Tan, R.T.L.10
Jaspers, N.G.J.11
Sharan, S.K.12
Kanaar, R.13
Zdzienicka, M.Z.14
-
16
-
-
77955407605
-
6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance
-
Issaeva N, Thomas HD, Djureinovic T, Jaspers JE, Stoimenov I, Kyle S, et al. 6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance. Cancer Res 2010;70:6268-76.
-
(2010)
Cancer Res
, vol.70
, pp. 6268-6276
-
-
Issaeva, N.1
Thomas, H.D.2
Djureinovic, T.3
Jaspers, J.E.4
Stoimenov, I.5
Kyle, S.6
-
17
-
-
34547225606
-
Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase
-
DOI 10.1128/MCB.02248-06
-
Fisher AE, Hochegger H, Takeda S, Caldecott KW. Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase. Mol Cell Biol 2007;27:5597-605. (Pubitemid 47124411)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.15
, pp. 5597-5605
-
-
Fisher, A.E.O.1
Hochegger, H.2
Takeda, S.3
Caldecott, K.W.4
-
18
-
-
33646777679
-
Rapid activation of ATR by ionizing radiation requires ATM and Mre11
-
DOI 10.1074/jbc.M513265200
-
Myers JS, Cortez D. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J Biol Chem 2006;281:9346-50. (Pubitemid 43864651)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.14
, pp. 9346-9350
-
-
Myers, J.S.1
Cortez, D.2
-
19
-
-
70449659953
-
Cohesin acetylation speeds the replication fork
-
Terret ME, Sherwood R, Rahman S, Qin J, Jallepalli PV. Cohesin acetylation speeds the replication fork. Nature 2009;462:231-4.
-
(2009)
Nature
, vol.462
, pp. 231-234
-
-
Terret, M.E.1
Sherwood, R.2
Rahman, S.3
Qin, J.4
Jallepalli, P.V.5
-
20
-
-
48249084972
-
Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication
-
Ibarra A, Schwob E, Mendez J. Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. Proc Natl Acad Sci U S A 2008;105:8956-61.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 8956-8961
-
-
Ibarra, A.1
Schwob, E.2
Mendez, J.3
-
21
-
-
0038298811
-
XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes
-
DOI 10.1016/S1097-2765(03)00132-1
-
Henry-Mowatt J, Jackson D, Masson JY, Johnson PA, Clements PM, Benson FE, et al. XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Mol Cell 2003;11:1109-17. (Pubitemid 36566331)
-
(2003)
Molecular Cell
, vol.11
, Issue.4
, pp. 1109-1117
-
-
Henry-Mowatt, J.1
Jackson, D.2
Masson, J.-Y.3
Johnson, P.A.4
Clements, P.M.5
Benson, F.E.6
Thompson, L.H.7
Takeda, S.8
West, S.C.9
Caldecott, K.W.10
-
22
-
-
38349008365
-
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
-
Dupre A, Boyer-Chatenet L, Sattler RM, Modi AP, Lee JH, Nicolette ML, et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol 2008;4:119-25.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 119-125
-
-
Dupre, A.1
Boyer-Chatenet, L.2
Sattler, R.M.3
Modi, A.P.4
Lee, J.H.5
Nicolette, M.L.6
-
23
-
-
0347991859
-
Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein
-
DOI 10.1101/gad.279003
-
Lomonosov M, Anand S, Sangrithi M, Davies R, Venkitaraman AR. Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein. Genes Dev 2003;17:3017-22. (Pubitemid 38040765)
-
(2003)
Genes and Development
, vol.17
, Issue.24
, pp. 3017-3022
-
-
Lomonosov, M.1
Anand, S.2
Sangrithi, M.3
Davies, R.4
Venkitaraman, A.R.5
-
24
-
-
39849106300
-
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
-
DOI 10.1038/nature06633, PII NATURE06633
-
Sakai W, Swisher EM, Karlan BY, Agarwal MK, Higgins J, Friedman C, et al. Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers. Nature 2008;451:1116-20. (Pubitemid 351317449)
-
(2008)
Nature
, vol.451
, Issue.7182
, pp. 1116-1120
-
-
Sakai, W.1
Swisher, E.M.2
Karlan, B.Y.3
Agarwal, M.K.4
Higgins, J.5
Friedman, C.6
Villegas, E.7
Jacquemont, C.8
Farrugia, D.J.9
Couch, F.J.10
Urban, N.11
Taniguchi, T.12
-
25
-
-
39849097680
-
Resistance to therapy caused by intragenic deletion in BRCA2
-
DOI 10.1038/nature06548, PII NATURE06548
-
Edwards SL, Brough R, Lord CJ, Natrajan R, Vatcheva R, Levine DA, et al. Resistance to therapy caused by intragenic deletion in BRCA2. Nature 2008;451:1111-5. (Pubitemid 351317441)
-
(2008)
Nature
, vol.451
, Issue.7182
, pp. 1111-1115
-
-
Edwards, S.L.1
Brough, R.2
Lord, C.J.3
Natrajan, R.4
Vatcheva, R.5
Levine, D.A.6
Boyd, J.7
Reis-Filho, J.S.8
Ashworth, A.9
-
26
-
-
0344875495
-
Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination
-
DOI 10.1093/nar/gkg703
-
Schultz N, Lopez E, Saleh-Gohari N, Helleday T. Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids Res 2003;31:4959-64. (Pubitemid 37441861)
-
(2003)
Nucleic Acids Research
, vol.31
, Issue.17
, pp. 4959-4964
-
-
Schultz, N.1
Lopez, E.2
Saleh-Gohari, N.3
Helleday, T.4
-
27
-
-
77957123627
-
Pathways of mammalian replication fork restart
-
Petermann E, Helleday T. Pathways of mammalian replication fork restart. Nat Rev Mol Cell Biol 2010;11:683-7.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 683-687
-
-
Petermann, E.1
Helleday, T.2
|