Kinetic models in industrial biotechnology - Improving cell factory performance

Metabolic Engineering

Volumn 24, Issue , 2014, Pages 38-60

  Almquist, Joachim ^a,b   Cvijovic, Marija ^b,c   Hatzimanikatis, Vassily ^d   Nielsen, Jens ^b   Jirstrand, Mats ^a  

^a FRAUNHOFER CHALMERS CENTRE   (Sweden)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d EPFL   (Switzerland)

Author keywords

Cell factory; Dynamic models; Industrial biotechnology; Kinetic models; Mathematical modeling; Parameter estimation

Indexed keywords

BIOSYNTHESIS; BIOTECHNOLOGY; CELL CULTURE; DYNAMIC MODELS; INDUSTRIAL CHEMICALS; KINETIC PARAMETERS; KINETIC THEORY; MAMMALS; MATHEMATICAL MODELS; PARAMETER ESTIMATION; PROTEINS;

DEVELOPMENT AND APPLICATIONS; FERMENTATION PROCESS; IDENTIFIABILITY ANALYSIS; INDUSTRIAL BIOPROCESSES; INDUSTRIAL BIOTECHNOLOGY; KINETIC MODELS; MODELING METHODOLOGY; MOLECULAR COMPONENTS;

CELLS;

CITRIC ACID; MONOCLONAL ANTIBODY; OXIDOREDUCTASE; SERINE; TRYPTOPHAN; XYLITOL; XYLOSE;

ANTIBODY PRODUCTION; APOPTOSIS; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; BIOREACTOR; BIOTECHNOLOGY; CELL CYCLE PROGRESSION; CHEMICAL REACTION KINETICS; CORYNEBACTERIUM GLUTAMICUM; ENVIRONMENTAL FACTOR; ENZYME KINETICS; FERMENTATION; GENE EXPRESSION; GENETIC ENGINEERING; GENETIC MANIPULATION; IMMUNOGENICITY; KINETICS; MATHEMATICAL MODEL; METABOLIC ENGINEERING; METABOLIC REGULATION; MICROBIAL METABOLISM; NONHUMAN; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PROCESS DESIGN; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN SECRETION; PROTEIN SYNTHESIS; SACCHAROMYCES CEREVISIAE; SHORT SURVEY; SIGNAL TRANSDUCTION; THERMODYNAMICS; UNFOLDED PROTEIN RESPONSE; BIOLOGICAL MODEL;

BIOTECHNOLOGY; KINETICS; METABOLIC ENGINEERING; MODELS, BIOLOGICAL;

EID: 84900827538     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2014.03.007     Document Type: Review

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