Versatile modeling and optimization of fed batch processes for the production of secreted heterologous proteins with Pichia pastoris

Microbial Cell Factories

Volumn 5, Issue , 2006, Pages

  Maurer, Michael ^a   Kühleitner, Manfred ^b   Gasser, Brigitte ^a   Mattanovich, Diethard ^a,c  

^a UNIVERSITY OF AGRICULTURAL SCIENCES   (Austria)

^b UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^c Fachhochschule Campus Wien   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN;

ALGORITHM; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BIOMASS; BIOTECHNOLOGICAL PRODUCTION; COMPUTER MODEL; COMPUTER PROGRAM; CONTROLLED STUDY; CORRELATION ANALYSIS; FED BATCH FERMENTATION; MATHEMATICAL COMPUTING; NONHUMAN; PICHIA PASTORIS; PROCESS OPTIMIZATION; PROTEIN SECRETION; VOLUMETRY;

PICHIA PASTORIS;

EID: 33845868785     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/1475-2859-5-37     Document Type: Article

References (12)

1. Sinclair CG, Kristiansen B, Bu'Lock JD: Fermentation kinetics and modelling Milton Keynes: Open University Press; 1987.
2. Modak JM, Lim HC, Tayeb YJ: General characteristics of optimal feed rate profiles for various fed batch fermentation processes. Biotechnol Bioeng 1986, 28:1396-1407.
3. Zhang W, Sinha J, Smith LA, Inan M, Meagher MM: Maximization of production of secreted recombinant proteins in Pichia pastoris fed-batch fermentation. Biotechnol Prog 2005, 21:386-393.
4. Ohno H, Nakanishi E, Takamatsu T: Optimal control of a semi-batch fermentation. Biotechnol Bioeng 1976, 18:847-864.
5. Kobayashi K, Kuwae S, Ohya T, Ohda T, Ohyama M, Tomomitsu K: High level secretion of recombinant human serum albumin by fed-batch fermentation of the methylotrophic yeast, Pichia pastoris, based on optimal methanol feeding strategy. J Biosci Bioeng 2000, 90:280-288.
6. Porro D, Sauer M, Branduardi P, Mattanovich D: Recombinant protein production in yeasts. Mol Biotechnol 2005, 31:245-259.
7. Lasdon LS, Waren AD, Jain A, Ratner M: Design and testing of a generalized reduced gradient code for nonlinear programming. ACM T Math Software 1978, 4:34-49.
8. Werner RG: Economic aspects of commercial manufacture of biopharmaceuticals. J Biotechnol 2004, 113:171-182.
9. Hensing MCM, Rouwenhorst RJ, Heijnen JJ, van Dijken JP, Pronk JT: Physiological and technological aspects of large-scale heterologous-protein production with yeasts. Antonie van Leeuwenhoek 1995, 67:261-279.
10. Ohya T, Morita M, Miura M, Kuwae S, Kobayashi K: High-level production of prourokinase-annexin V chimeras in the methylotrophic yeast Pichia pastoris. J Biosci Bioeng 2002, 94:467-473.
11. Roels JA: Energetics and kinetics in biotechnology Amsterdam, Elsevier Biomedical Press; 1983.
12. Gasser B, Maurer M, Gach J, Kunert R, Mattanovich D: Engineering of Pichia pastoris for improved production of antibody fragments. Biotechnol Bioeng 2006, 94:353-361.