Genome-based kinetic modeling of cytosolic glucose metabolism in industrially relevant cell lines: Saccharomyces cerevisiae and Chinese hamster ovary cells

Bioprocess and Biosystems Engineering

Volumn 35, Issue 6, 2012, Pages 1023-1033

  Chen, Ning ^a   Koumpouras, Georgios C ^b,c   Polizzi, Karen M ^a   Kontoravdi, Cleo ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b PROCESS SYSTEMS ENTERPRISE LTD   (United Kingdom)

^c NEXANT INC   (United States)

Author keywords

Chinese hamster ovary cells; Genome scale metabolic reconstruction; Glucose metabolism; Kinetic modelling; Saccharomyces cerevisiae

Indexed keywords

BIOLOGICAL PRODUCTS; CELL LINES; CELLULAR METABOLISM; CHINESE HAMSTER OVARY CELLS; CHO CELL; COSUBSTRATES; CYTOSOLIC; EXPERIMENTAL DATA; FINE CHEMICALS; GENE KNOCKOUT; GLUCOSE METABOLISM; KINETIC MODELING; KINETIC MODELLING; KINETIC STUDY; METABOLIC FLUX ANALYSIS; METABOLIC RECONSTRUCTION; METABOLITE CONCENTRATIONS; MODEL-BASED ANALYSIS; S.CEREVISIAE;

CELL CULTURE; CELLS; ENZYMES; GENES; GLUCOSE; KINETIC THEORY; KINETICS; MATHEMATICAL MODELS; METABOLISM; METABOLITES; PHYSIOLOGY;

YEAST;

ANIMAL CELL; ARTICLE; BIOPROCESS; BIOTECHNOLOGICAL PROCEDURES; CELL KINETICS; CELL METABOLISM; CHO CELL; CONTROLLED STUDY; ENZYME SYNTHESIS; GLUCOSE METABOLISM; GLYCOLYSIS; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MICHAELIS MENTEN KINETICS; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SYNTHESIS;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; GENE KNOCKOUT TECHNIQUES; GENOME, FUNGAL; GLUCOSE; MODELS, BIOLOGICAL; SACCHAROMYCES CEREVISIAE;

CRICETULUS GRISEUS; SACCHAROMYCES CEREVISIAE;

EID: 84865337008     PISSN: 16157591     EISSN: 16157605     Source Type: Journal    
DOI: 10.1007/s00449-012-0687-3     Document Type: Article

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