Dynamic model for CHO cell engineering

Journal of Biotechnology

Volumn 158, Issue 1-2, 2012, Pages 24-33

  Nolan, Ryan P ^a,b   Lee, Kyongbum ^a  

^a Tufts University   (United States)

^b PFIZER INC   (United States)

Author keywords

CHO cell engineering; Dynamic model; Fed batch; Process simulation

Indexed keywords

ANTIBODY PRODUCTION; CELL LINES; CHO CELL; COMPREHENSIVE EXAMINATION; DYNAMIC NATURE; FED BATCHES; FED-BATCH PROCESS; GENE KNOCK DOWN; IN-PROCESS; METABOLIC ENGINEERING; METABOLIC ENZYMES; MODEL SIMULATION; PROCESS CONDITION; PROCESS PARAMETERS; PROCESS SIMULATIONS; PROCESS VARIABLES; RECOMBINANT PROTEIN; SIMULATED SOLUTION; TEMPERATURE SHIFT; VARYING PRODUCTIVITY;

BATCH DATA PROCESSING; CELL CULTURE; CELL ENGINEERING; COMPUTER SIMULATION; ENZYMES; GENES; METABOLISM;

DYNAMIC MODELS;

ANIMAL CELL; ARTICLE; CELL ENGINEERING; CELL METABOLISM; CELLULAR PARAMETERS; CHO CELL; CHO CELL METABOLISM DYNAMIC MODEL; CONTROLLED STUDY; ENZYME REGULATION; GENE SILENCING; HARVEST DAY; METABOLIC ENGINEERING; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS MODEL; SEED DENSITY; SHIFT TEMPERATURE; TEMPERATURE SHIFT DAY;

ANIMALS; ANTIBODIES; BIOREACTORS; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; GENE KNOCKDOWN TECHNIQUES; GLYCOLYSIS; METABOLIC ENGINEERING; RECOMBINANT PROTEINS; TEMPERATURE;

EID: 84862810503     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2012.01.009     Document Type: Article

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