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Meinhardt H., de Boer P.A. Pattern formation in Escherichia coli: a model for the pole-to-pole oscillations of Min proteins and the localization of the division site. Proc. Natl. Acad. Sci. U.S.A. 98:2001;14202-14207 Using a model based on autocatalysis and substrate depletion, these authors describe FtsZ ring formation in E. coli, which determines the site of septum formation during cell division. Formation of the FtsZ ring in the midplane of the cell results from a spatial symmetry-breaking instability in the MinC/D/E reaction network.
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Meinhardt, H.1
De Boer, P.A.2
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The IκB-NF-κB signaling module: Temporal control and selective gene activation
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These authors present a satisfying combination of modeling and experimental studies of the NF-κB signaling pathway, whose response is modulated by three isoforms of an inhibitor protein, IκBα, -β and -ε. Expression of IκBα is induced by NF-κB, creating a negative-feedback loop that exhibits sustained oscillations when IκBβ and -ε are missing. An unexpected prediction of the model, that some NF-κB-responsive genes might be efficiently activated by brief stimuli whereas others require longer exposure, was verified experimentally
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Hoffmann A., Levchenko A., Scott M.L., Baltimore D. The IκB-NF-κB signaling module: temporal control and selective gene activation. Science. 298:2002;1241-1245 These authors present a satisfying combination of modeling and experimental studies of the NF-κB signaling pathway, whose response is modulated by three isoforms of an inhibitor protein, IκBα, -β and -ε. Expression of IκBα is induced by NF-κB, creating a negative-feedback loop that exhibits sustained oscillations when IκBβ and -ε are missing. An unexpected prediction of the model, that some NF-κB-responsive genes might be efficiently activated by brief stimuli whereas others require longer exposure, was verified experimentally.
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(2002)
Science
, vol.298
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Hoffmann, A.1
Levchenko, A.2
Scott, M.L.3
Baltimore, D.4
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63
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Modular response analysis of cellular regulatory networks
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•]), Kholodenko and colleagues describe new methods for deducing effective kinetic interactions within a reaction network, by analysing its responses to many small perturbations
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•]), Kholodenko and colleagues describe new methods for deducing effective kinetic interactions within a reaction network, by analysing its responses to many small perturbations.
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(2002)
J. Theor. Biol.
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Bruggeman, F.J.1
Westerhoff, H.V.2
Hoek, J.B.3
Kholodenko, B.N.4
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