An empirical modeling platform to evaluate the relative control discrete CHO cell synthetic processes exert over recombinant monoclonal antibody production process titer

Biotechnology and Bioengineering

Volumn 108, Issue 9, 2011, Pages 2193-2204

  Mcleod, Jane ^a   O'Callaghan, Peter M ^a   Pybus, Leon P ^a   Wilkinson, Stephen J ^a   Root, Tracy ^b   Racher, Andrew J ^b   James, David C ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b LONZA AG   (Switzerland)

Author keywords

CHO cells; Fed batch culture; Mathematical modeling; Recombinant monoclonal antibody

Indexed keywords

CELL ENGINEERING; CELL LINES; CELLULAR BIOMASS; CELLULAR PROCESS; CHO CELL; EMPIRICAL MODELING; FED-BATCH CULTURES; GENE TRANSCRIPTIONS; HEAVY CHAIN; MAMMALIAN HOSTS; MATHEMATICAL MODELING; MONOCLONAL ANTIBODY PRODUCTION; PREDICTIVE MODELING; PRODUCTION PROCESS CONTROL; RECOMBINANT MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; SYNTHETIC PROCESS;

BATCH CELL CULTURE; CELLS; GENES; MAMMALS; MATHEMATICAL MODELS; MONOCLONAL ANTIBODIES; PHYSIOLOGY; PRODUCTION ENGINEERING; RATE CONSTANTS; SURFACE PLASMON RESONANCE; TRANSCRIPTION;

PROCESS CONTROL;

MESSENGER RNA; MONOCLONAL ANTIBODY; RECOMBINANT ANTIBODY; RECOMBINANT MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; BIOMASS; BIOSYNTHESIS; CELL CULTURE; CHO CELL; CONTROLLED STUDY; FED BATCH CULTURE; FEMALE; GENETIC TRANSCRIPTION; HOST CELL; MAMMAL CELL; MATHEMATICAL MODEL; NONHUMAN;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOREACTORS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; MODELS, BIOLOGICAL; RECOMBINANT PROTEINS;

MAMMALIA;

EID: 79960446881     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.23146     Document Type: Article

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