Genome-scale metabolic model of methylotrophic yeast Pichia pastoris and its use for in silico analysis of heterologous protein production

Biotechnology Journal

Volumn 5, Issue 7, 2010, Pages 705-715

  Sohn, Seung Bum ^a   Graf, Alexandra B ^b,c   Kim, Tae Yong ^a   Gasser, Brigitte ^b   Maurer, Michael ^c   Ferrer, Pau ^d   Mattanovich, Diethard ^b   Lee, Sang Yup ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^c Fachhochschule Campus Wien   (Austria)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Genome scale metabolic model; Heterologous protein production; HSA; Hsod; Pichia pastoris

Indexed keywords

GENES; METABOLISM; OXYGEN; YEAST;

GENOME SEQUENCES; HETEROLOGOUS PROTEIN PRODUCTION; HETEROLOGOUS PROTEINS; HUMAN SERUM ALBUMINS; IN-DEPTH STUDY; IN-SILICO; METABOLIC MODELS; METABOLIC REACTIONS; METHYLOTROPHIC YEASTS; OXYGEN LIMITATION; P. PASTORIS; PICHIA PASTORIS; POST-TRANSLATIONAL MODIFICATIONS; PROTEIN PRODUCTION; RECOMBINANT PROTEIN; SUPER OXIDE DISMUTASE;

PROTEINS;

ALBUMIN; PROTEIN; SUPEROXIDE DISMUTASE; CULTURE MEDIUM; RECOMBINANT PROTEIN; SERUM ALBUMIN;

ARTICLE; CELL ORGANELLE; FUNGAL STRAIN; GENOME; METABOLISM; METABOLITE; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CULTURE MEDIUM; FERMENTATION; GENETICS; HUMAN; PICHIA; PROTEIN DATABASE; PROTEIN ENGINEERING; PROTEIN PROCESSING; SACCHAROMYCES CEREVISIAE;

EUKARYOTA; PICHIA PASTORIS;

CULTURE MEDIA; DATABASES, PROTEIN; FERMENTATION; HUMANS; MODELS, BIOLOGICAL; PICHIA; PROTEIN ENGINEERING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SERUM ALBUMIN; SUPEROXIDE DISMUTASE;

EID: 77954743150     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201000078     Document Type: Article

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