Metabolic flux-based modeling of mAb production during batch and fed-batch operations

Bioprocess and Biosystems Engineering

Volumn 32, Issue 2, 2009, Pages 183-196

  Dorka, Penny ^a   Fischer, Christian ^a   Budman, Hector ^a   Scharer, Jeno M ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Apoptosis; Biological models; Correlation analysis; Dynamic model; MAb production; Metabolic flux analysis; Necrosis; Quadratic programming

Indexed keywords

APOPTOSIS; BIOLOGICAL MODELS; CORRELATION ANALYSIS; DYNAMIC MODEL; MAB PRODUCTION; METABOLIC FLUX ANALYSIS; NECROSIS; QUADRATIC PROGRAMMING;

ANTIBODIES; BIOLOGICAL MATERIALS; BIOMASS; BIOMOLECULES; CELL DEATH; DYNAMIC ANALYSIS; DYNAMIC MODELS; DYNAMIC PROGRAMMING; FUNCTIONS; METABOLISM; METABOLITES; MONOCLONAL ANTIBODIES; PROGRAMMING THEORY; RENEWABLE ENERGY RESOURCES;

MATHEMATICAL MODELS;

MONOCLONAL ANTIBODY;

ACCURACY; ALGORITHM; ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; BIOMASS; CELL GROWTH; CONTROLLED STUDY; EXTRACELLULAR SPACE; FED BATCH REACTOR; HYBRIDOMA CELL CULTURE; MATHEMATICAL MODEL; METABOLIC ENGINEERING; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOMASS; CALIBRATION; MICE; MODELS, THEORETICAL;

MURINAE;

EID: 58549117474     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-008-0236-2     Document Type: Article

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