Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering

Metabolic Engineering

Volumn 11, Issue 6, 2009, Pages 328-334

  Asadollahi, Mohammad A ^a,b   Maury, Jérôme ^a   Patil, Kiran Raosaheb ^a   Schalk, Michel ^c   Clark, Anthony ^d   Nielsen, Jens ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b UNIVERSITY OF ISFAHAN   (Iran)

^c Analysis and Perception Department   (Switzerland)

^d Firmenich Inc   (United States)

Author keywords

Cubebol; Flux balance analysis; Glutamate dehydrogenase; In silico metabolic engineering; Isoprenoid; Minimization of metabolic adjustments; NADPH availability; Saccharomyces cerevisiae; Sesquiterpene

Indexed keywords

CUBEBOL; FLUX BALANCE ANALYSIS; GLUTAMATE DEHYDROGENASE; IN SILICO METABOLIC ENGINEERING; ISOPRENOID; MINIMIZATION OF METABOLIC ADJUSTMENTS; NADPH AVAILABILITY; SACCHAROMYCES CEREVISIAE; SESQUITERPENE;

BIOCHEMISTRY; BIOSYNTHESIS; ENZYMES; GENES; OLEFINS; OPTIMIZATION; YEAST;

METABOLISM;

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; GLUTAMATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SESQUITERPENE;

ARTICLE; BACTERIAL STRAIN; COMPUTER MODEL; DRUG SYNTHESIS; GENE DELETION; GROWTH RATE; METABOLIC ENGINEERING; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

COMPUTER SIMULATION; GENETIC ENHANCEMENT; MODELS, BIOLOGICAL; PROTEIN ENGINEERING; PROTEOME; SACCHAROMYCES CEREVISIAE; SESQUITERPENES;

SACCHAROMYCES CEREVISIAE;

EID: 70449592325     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2009.07.001     Document Type: Article

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