Dynamic model of CHO cell metabolism

Metabolic Engineering

Volumn 13, Issue 1, 2011, Pages 108-124

  Nolan, Ryan P ^a,b   Lee, Kyongbum ^b  

^a PFIZER INC   (United States)

^b Tufts University   (United States)

Author keywords

Dynamic simulation; Fed batch; Lactate metabolism; Metabolic shift; Redox metabolism

Indexed keywords

DYNAMIC SIMULATION; FED BATCHES; LACTATE METABOLISM; METABOLIC SHIFT; REDOX METABOLISM;

CELL CULTURE; COMPUTER SIMULATION; ENZYME ACTIVITY; MAMMALS; METABOLISM; METABOLITES; OPTIMIZATION; REDOX REACTIONS;

BATCH CELL CULTURE;

REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CELL METABOLISM; CHEMICAL REACTION; CHO CELL; CONCENTRATION (PARAMETERS); CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; CYTOSOL; EXPERIMENTAL STUDY; EXTRACELLULAR SPACE; FED BATCH CULTURE; FEMALE; KINETICS; METABOLISM; METABOLITE; MITOCHONDRION; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIMULATION; STEADY STATE; STOICHIOMETRY; TEMPERATURE;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; COMPUTER SIMULATION; CRICETINAE; CRICETULUS; GENE EXPRESSION REGULATION; METABOLIC CLEARANCE RATE; METABOLOME; MODELS, BIOLOGICAL; PROTEOME; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 78650525718     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2010.09.003     Document Type: Article

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