메뉴 건너뛰기




Volumn 75, Issue 1-2, 1999, Pages 145-154

Metabolic control analysis of the penicillin biosynthetic pathway: The influence of the LLD-ACV:bisACV ratio on the flux control

Author keywords

ACV; ACVS; BisACV; IPNS; Metabolic control analysis; Penicillin; Penicillium chrysogenum

Indexed keywords

CYSTEINE; DIMER; ISOPENICILLIN N SYNTHETASE; PENICILLIN G; PEPTIDE; VALINE;

EID: 0033019615     PISSN: 00036072     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1001781808150     Document Type: Article
Times cited : (32)

References (20)
  • 1
    • 0026463673 scopus 로고
    • Oxygen utilization by isopenicillin N synthetase from Penicillium chrysogenum
    • Bainbrigde ZA, Scott RI & Perry D (1992) Oxygen utilization by isopenicillin N synthetase from Penicillium chrysogenum. J. Chem. Tech. Biotechnol. 55: 233-238
    • (1992) J. Chem. Tech. Biotechnol. , vol.55 , pp. 233-238
    • Bainbrigde, Z.A.1    Scott, R.I.2    Perry, D.3
  • 3
    • 0028009523 scopus 로고
    • The Thioredoxin System of Penicillium chrysogenum and its possible role in Penicillin Biosynthesis
    • Cohen G, Argaman A, Schreiber R, Mislovati M & Aharonowitz Y (1994) The Thioredoxin System of Penicillium chrysogenum and its possible role in Penicillin Biosynthesis. J. Bacteriol. 176(4): 973-984
    • (1994) J. Bacteriol. , vol.176 , Issue.4 , pp. 973-984
    • Cohen, G.1    Argaman, A.2    Schreiber, R.3    Mislovati, M.4    Aharonowitz, Y.5
  • 4
    • 0031213577 scopus 로고    scopus 로고
    • A general formalism for metabolic control analysis
    • Ehlde M & Zacchi G (1997) A general formalism for metabolic control analysis. Chem. Eng. Sci. 52: 2599-2606
    • (1997) Chem. Eng. Sci. , vol.52 , pp. 2599-2606
    • Ehlde, M.1    Zacchi, G.2
  • 5
    • 0030878151 scopus 로고    scopus 로고
    • Glutathione metabolism and protection against oxidative stress caused by peroxides in P. chrysogenum
    • Emri T, Pócsi I & Szentirmai A (1997) Glutathione metabolism and protection against oxidative stress caused by peroxides in P. chrysogenum. Free Radical Biology & Medicine 23
    • (1997) Free Radical Biology & Medicine , vol.23
    • Emri, T.1    Pócsi, I.2    Szentirmai, A.3
  • 6
    • 0026802334 scopus 로고
    • Metabolic control analysis: A survey of its theoretical and experimental development
    • Fell DA (1992) Metabolic control analysis: a survey of its theoretical and experimental development. Biochem. J. 286: 313-330
    • (1992) Biochem. J. , vol.286 , pp. 313-330
    • Fell, D.A.1
  • 7
    • 0031279445 scopus 로고    scopus 로고
    • Influence of the dissolved oxygen concentration on the penicillin biosynthetic pathway in steady state cultures of Penicillium chrysogenum
    • Henriksen CM, Nielsen J & Villadsen J (1997) Influence of the dissolved oxygen concentration on the penicillin biosynthetic pathway in steady state cultures of Penicillium chrysogenum. Biotechnol. Prog. 13: 776-782
    • (1997) Biotechnol. Prog. , vol.13 , pp. 776-782
    • Henriksen, C.M.1    Nielsen, J.2    Villadsen, J.3
  • 8
    • 0026698060 scopus 로고
    • Oxidized redox state of glutathione in the endoplasmic reticulum
    • Hwang C, Sinsky AJ & Lodish HF (1992) Oxidized redox state of glutathione in the endoplasmic reticulum. Science 257, 1496-1502
    • (1992) Science , vol.257 , pp. 1496-1502
    • Hwang, C.1    Sinsky, A.J.2    Lodish, H.F.3
  • 9
    • 0018195287 scopus 로고
    • The glutathione status of the cells
    • Kosower NS & Kosower EM (1978) The glutathione status of the cells. Int. Rev. Cytol. 54: 109-160
    • (1978) Int. Rev. Cytol. , vol.54 , pp. 109-160
    • Kosower, N.S.1    Kosower, E.M.2
  • 10
    • 0024395862 scopus 로고
    • Enzymes involved in penicillin, cephalosporin and cephamycin biosynthesis
    • Martín JF & Liras P (1989) Enzymes involved in penicillin, cephalosporin and cephamycin biosynthesis. Adv. Biochem. Eng./Biotechnol. 39: 153-187
    • (1989) Adv. Biochem. Eng./Biotechnol. , vol.39 , pp. 153-187
    • Martín, J.F.1    Liras, P.2
  • 11
    • 0345020189 scopus 로고    scopus 로고
    • Mathematica© Wolfram Research, Inc. Champaign, USA
    • Mathematica© Wolfram Research, Inc. Champaign, USA
  • 12
    • 0025701406 scopus 로고
    • Group contributions for estimating standard Gibbs energies of formation of biochemical compounds in aqueous solution
    • Mavrovouniotis ML (1990) Group contributions for estimating standard Gibbs energies of formation of biochemical compounds in aqueous solution. Biotechnol. Bioeng. 36: 1070-1082
    • (1990) Biotechnol. Bioeng. , vol.36 , pp. 1070-1082
    • Mavrovouniotis, M.L.1
  • 13
    • 0031018721 scopus 로고    scopus 로고
    • Metabolic control analysis of biochemical pathways based on a thermokinetic description of reaction rates
    • Nielsen J (1997) Metabolic control analysis of biochemical pathways based on a thermokinetic description of reaction rates. Biochem. J. 321: 133-138
    • (1997) Biochem. J. , vol.321 , pp. 133-138
    • Nielsen, J.1
  • 14
    • 0029294006 scopus 로고
    • Metabolic control analysis of the penicillin biosynthetic pathway in a high-yielding strain of Penicillium chrysogenum
    • Nielsen J & Jørgensen HS (1995) Metabolic control analysis of the penicillin biosynthetic pathway in a high-yielding strain of Penicillium chrysogenum. Biotechnol. Prog. 11: 299-305
    • (1995) Biotechnol. Prog. , vol.11 , pp. 299-305
    • Nielsen, J.1    Jørgensen, H.S.2
  • 15
    • 15844370671 scopus 로고    scopus 로고
    • Pathway kinetics and metabolic control analysis of a high-yielding strain of Penicillium chrysogenum during fed batch cultivations
    • Pissarra PdN, Nielsen J & Bazin MJ (1996) Pathway kinetics and metabolic control analysis of a high-yielding strain of Penicillium chrysogenum during fed batch cultivations. Biotechnol. Bioeng. 51: 168-176
    • (1996) Biotechnol. Bioeng. , vol.51 , pp. 168-176
    • Pissarra, P.1    Nielsen, J.2    Bazin, M.J.3
  • 16
    • 0030941829 scopus 로고    scopus 로고
    • The role of the Thioredoxin and Glutaredoxin Pathways in reducing Protein Disulphide Bonds in the Escherichia Coli Cytoplasm
    • Prinz WA, Åslund F, Holmgren A and Beckwith J (1997) The role of the Thioredoxin and Glutaredoxin Pathways in reducing Protein Disulphide Bonds in the Escherichia Coli Cytoplasm. J. Biol. Chem. 272(25): 15661-15667
    • (1997) J. Biol. Chem. , vol.272 , Issue.25 , pp. 15661-15667
    • Prinz, W.A.1    Åslund, F.2    Holmgren, A.3    Beckwith, J.4
  • 17
    • 0021918078 scopus 로고
    • Isopenicillin N synthetase of Penicillium chrysogenum, an enzyme that converts δ-(L-α-aminoadipyl)-L- Cysteinyl-D-valine to Isopenicillin N
    • Ramos FR, López-Nieto MJ & Martín JF (1985) Isopenicillin N synthetase of Penicillium chrysogenum, an enzyme that converts δ-(L-α-aminoadipyl)-L- cysteinyl-D-valine to Isopenicillin N. Antimicrob. Agents Chemother. 27: 380-387
    • (1985) Antimicrob. Agents Chemother. , vol.27 , pp. 380-387
    • Ramos, F.R.1    López-Nieto, M.J.2    Martín, J.F.3
  • 18
    • 0023709196 scopus 로고
    • Metabolic Control Theory: A structural approach
    • Reder C (1988) Metabolic Control Theory: A structural approach. J. Theor. Biol. 135: 175-201
    • (1988) J. Theor. Biol. , vol.135 , pp. 175-201
    • Reder, C.1
  • 20
    • 0030721441 scopus 로고    scopus 로고
    • Purification and characterization of δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum
    • Theilgaard, HBAa, Kristiansen KN, Henriksen CM & Nielsen J (1997) Purification and characterization of δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum. Biochem. J. 387: 185-191
    • (1997) Biochem. J. , vol.387 , pp. 185-191
    • Theilgaard, H.B.Aa.1    Kristiansen, K.N.2    Henriksen, C.M.3    Nielsen, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.