The unfolded protein response and translation attenuation: a modelling approach

Diabetes, Obesity and Metabolism

Volumn 12, Issue SUPPL. 2, 2010, Pages 27-31

  Trusina, A ^a   Tang, C ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b University of California   (United States)

Author keywords

Diabetes; Feedback loops; Modelling; Translation attenuation; Unfolded protein response

Indexed keywords

CHAPERONE; PROINSULIN; PROTEINASE;

ARTICLE; CELL DEATH; CELLULAR STRESS RESPONSE; CHEMICAL STRESS; ENDOPLASMIC RETICULUM STRESS; ENZYME METABOLISM; MATHEMATICAL MODEL; PANCREAS ISLET BETA CELL; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEIN SYNTHESIS; TRANSLATION ATTENUATION; UNFOLDED PROTEIN RESPONSE;

EID: 77957315898     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2010.01274.x     Document Type: Article

References (13)

1. Marciniak SJ, Ron D. Endoplasmic reticulum stress signaling in disease. Physiol Rev 2006, 86:1133-1149..
2. Bernales S, Papa FR, Walter P. Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol 2006, 22:487-508..
3. Harding HP, Zeng H, Zhang Y. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell 2001, 7:1153-1163..
4. Gass JN, Gunn KE, Sriburi R. Stressed-out B cells? Plasma-cell differentiation and the unfolded protein response. Trends Immunol 2004, 25:17-24..
5. Trusina A, Papa FR, Tang C. Rationalizing translation attenuation in the network architecture of the unfolded protein response. Proc Natl Acad Sci USA 2008, 105:20280-20285..
6. Rutkowski DT, Kaufman RJ. A trip to the ER: coping with stress. Trends Cell Biol 2004, 14:20-28..
7. Xu S. Aggregation drives " misfolding" in protein amyloid fiber formation. Amyloid 2007, 14:119-131..
8. Feder JH, Rossi JM, Solomon J, Solomon N, Lindquist S. The consequences of expressing hsp70 in drosophila cells at normal temperatures. Genes Dev 1992, 6:1402-1413..
9. Landsverk ML, Li S, Hutagalung AH. The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in caenorhabditis elegans. J Cell Biol 2007, 177:205-210..
10. Docherty K, Clark AR. Nutrient regulation of insulin gene expression. FASEB J 1994, 8:20-27..
11. Schmitz O, Brock B, Hollingdal M, Juhl CB, Pørksen N. High frequency insulin pulsatility and type 2 diabetes: from physiology and pathophysiology to clinical pharmacology. Diabetes Metab 2002, 28:14-20..
12. Lang DA, Matthews DR, Burnett M, Ward GM, Turner RC. Pulsatile, synchronous basal insulin and glucagon secretion in man. Diabetes 1982, 31:22-26..
13. Ladiges WC, Knoblaugh SE, Morton JF. Pancreatic β-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK. Diabetes 2005, 54:1074-1081..