A quantitative study of the Hog1 MAPK Response to fluctuating osmotic stress in saccharomyces cerevisiae

PLoS ONE

Volumn 5, Issue 3, 2010, Pages

  Zi, Zhike ^a   Liebermeister, Wolfram ^b   Klipp, Edda ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HOG1 ENZYME; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; GREEN FLUORESCENT PROTEIN; HOG1 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; MATHEMATICAL MODEL; OSMOTIC STRESS; QUANTITATIVE STUDY; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; YEAST CELL; ALGORITHM; CELL NUCLEUS; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; KINETICS; METABOLISM; OSMOSIS; OSMOTIC PRESSURE; PHOSPHORYLATION; PHYSIOLOGY; STATISTICAL MODEL; THEORETICAL MODEL;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

ALGORITHMS; CELL NUCLEUS; GENE EXPRESSION REGULATION, FUNGAL; GREEN FLUORESCENT PROTEINS; KINETICS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, STATISTICAL; MODELS, THEORETICAL; OSMOSIS; OSMOTIC PRESSURE; PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 77949729619     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009522     Document Type: Article

References (30)

1. Hohmann S (2002) Osmotic stress signaling and osmoadaptation in yeasts. Microbiol Mol Biol Rev 66: 300-372.
2. Westfall PJ, Ballon DR, Thorner J (2004) When the stress of your environment makes you go HOG wild. Science 306: 1511-1512.
3. Westfall PJ, Patterson JC, Chen RE, Thorner J (2008) Stress resistance and signal fidelity independent of nuclear MAPK function. Proc Natl Acad Sci U S A 105: 12212-12217.
4. Elston TC (2008) Probing pathways periodically. Sci Signal 1: pe47.
5. Escote X, Zapater M, Clotet J, Posas F (2004) Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1. Nat Cell Biol 6: 997-1002.
6. Hao N, Behar M, Parnell SC, Torres MP, Borchers CH, et al. (2007) A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress- response pathway. Curr Biol 17: 659-667.
7. Hersen P, McClean MN, Mahadevan L, Ramanathan S (2008) Signal processing by the HOG MAP kinase pathway. Proc Natl Acad Sci U S A 105: 7165-7170.
8. Klipp E, Nordlander B, Kruger R, Gennemark P, Hohmann S (2005) Integrative model of the response of yeast to osmotic shock. Nat Biotechnol 23: 975-982.
9. Macia J, Regot S, Peeters T, Conde N, Sole R, et al. (2009) Dynamic signaling in the Hog1 MAPK pathway relies on high basal signal transduction. Sci Signal 2: ra13.
10. Mettetal JT, Muzzey D, Gomez-Uribe C, van Oudenaarden A (2008) The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae. Science 319: 482-484.
11. Muzzey D, Gomez-Uribe CA, Mettetal JT, van Oudenaarden A (2009) A systems-level analysis of perfect adaptation in yeast osmoregulation. Cell 138: 160-171.
12. O'Rourke SM, Herskowitz I, O'Shea EK (2002) Yeast go the whole HOG for the hyperosmotic response. Trends Genet 18: 405-412.
13. Krantz M, Ahmadpour D, Ottosson LG, Warringer J, Waltermann C, et al. (2009) Robustness and fragility in the yeast high osmolarity glycerol (HOG) signal-transduction pathway. Mol Syst Biol 5: 281.
14. Hao N, Zeng Y, Elston TC, Dohlman HG (2008) Control of MAPK specificity by feedback phosphorylation of shared adaptor protein Ste50. J Biol Chem 283: 33798-33802.
15. Jacoby T, Flanagan H, Faykin A, Seto AG, Mattison C, et al. (1997) Two protein-tyrosine phosphatases inactivate the osmotic stress response pathway in yeast by targeting the mitogen-activated protein kinase, Hog1. J Biol Chem 272: 17749-17755.
16. Wurgler-Murphy SM, Maeda T, Witten EA, Saito H (1997) Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases. Mol Cell Biol 17: 1289-1297.
17. Ferrigno P, Posas F, Koepp D, Saito H, Silver PA (1998) Regulated nucleo/ cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1. EMBO J 17: 5606-5614.
18. Mattison CP, Ota IM (2000) Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast. Genes Dev 14: 1229-1235.
19. Reiser V, Ruis H, Ammerer G (1999) Kinase activity-dependent nuclear export opposes stress-induced nuclear accumulation and retention of Hog1 mitogen-activated protein kinase in the budding yeast Saccharomyces cerevisiae. Mol Biol Cell 10: 1147-1161.
20. Jorgensen P, Edgington NP, Schneider BL, Rupes I, Tyers M, et al. (2007) The size of the nucleus increases as yeast cells grow. Mol Biol Cell 18: 3523-3532.
21. Balsa-Canto E, Peifer M, Banga JR, Timmer J, Fleck C (2008) Hybrid optimization method with general switching strategy for parameter estimation. BMC Syst Biol 2: 26.
22. Tamas MJ, Luyten K, Sutherland FC, Hernandez A, Albertyn J, et al. (1999) Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation. Mol Microbiol 31: 1087-1104.
23. Hucka M, Finney A, Sauro HM, Bolouri H, Doyle JC, et al. (2003) The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics 19: 524-531.
24. Zi Z, Zheng Y, Rundell AE, Klipp E (2008) SBML-SAT: a systems biology markup language (SBML) based sensitivity analysis tool. BMC Bioinformatics 9: 342.
25. Jorgensen P, Nishikawa JL, Breitkreutz BJ, Tyers M (2002) Systematic identification of pathways that couple cell growth and division in yeast. Science 297: 395-400.
26. Tamaki H, Yun CW, Mizutani T, Tsuzuki T, Takagi Y, et al. (2005) Glucose-dependent cell size is regulated by a G protein-coupled receptor system in yeast Saccharomyces cerevisiae. Genes Cells 10: 193-206.
27. Tyson CB, Lord PG, Wheals AE (1979) Dependency of size of Saccharomyces cerevisiae cells on growth rate. J Bacteriol 138: 92-98.
28. Biswas SK, Yamaguchi M, Naoe N, Takashima T, Takeo K (2003) Quantitative three-dimensional structural analysis of Exophiala dermatitidis yeast cells by freeze-substitution and serial ultrathin sectioning. J Electron Microsc (Tokyo) 52: 133-143.
29. Zi Z, Klipp E (2006) SBML-PET: a Systems Biology Markup Language-based parameter estimation tool. Bioinformatics 22: 2704-2705.
30. Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, et al. (2003) Global analysis of protein expression in yeast. Nature 425: 737-741.