Metabolic control analysis of monoclonal antibody synthesis

Biotechnology Progress

Volumn 17, Issue 2, 2001, Pages 217-226

  Gonzalez, R ^a   Andrews, B A ^a   Asenjo, J A ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

EUKARYOTIC CELLS;

BINDING KINETICS; BIOCHEMICAL PATHWAY; EUKARYOTIC CELL; GENETIC HETEROGENEITY; GENETIC TRANSCRIPTION; METABOLIC REGULATION; MODEL; MONOCLONAL ANTIBODY; OLIGOSACCHARYLTRANSFERASE; PROTEIN DISULFIDE ISOMERASE; PROTEIN SYNTHESIS;

BIOSYNTHESIS; CELLS; GENES; POLYPEPTIDES; PROTEINS; RNA;

MONOCLONAL ANTIBODIES;

ANTIBODIES, MONOCLONAL; CARRIER PROTEINS; GLYCOSYLATION; HEAT-SHOCK PROTEINS; KINETICS; MOLECULAR CHAPERONES; PROTEIN DISULFIDE-ISOMERASE; PROTEIN TRANSPORT; TRANSCRIPTION, GENETIC;

EUKARYOTA;

EID: 0034914734     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp000165b     Document Type: Article

References (29)

1. Modifying secretion and postranslational processing in insect cells
2. A kinetic model of protein synthesis
3. A structured model for monoclonal antibody synthesis in exponentially growing and stationary phase hybridoma cells
4. Oligosacharyl transferase is a constitutive component of an oligomeric protein complex from pig liver endoplasmic reticulum
5. Mechanism of polypeptide translocation into the endoplasmic reticulum
6. Metabolic control analysis: A survey of its theoretical and experimental development
7. Fermentation pathway kinetics and metabolic flux control in suspended and immobilized Saccharomyces cerevisiae
8. Protein disulfide isomerasa and assisted protein folding
9. The role of mRNA competition in regulating translation
10. Environmental effects on protein glycosylation
11. Mathematical modelling of translation of mRNA in eucaryotes; steady states, time-dependent processes and application to reticulocytes
12. Transcriptional regulation: Contending with complexity
13. Assembly of asparagine-linked oligosacharides
14. Coexpression of molecular chaperone BiP improves immunoglonulin solubility and IgG secretion from Ttrichoplusia ni insect cells
15. Rescue of immunoglobulin from insolubility is facilitated by PDI in the baculovirus expression system
16. Biological significance of carbohydrate chains on monoclonal antibodies
17. A theoretical model for the covalent assembly of immunoglobulins
18. Mathematical modeling of the effects of signal recognition particle on translation and translocation of proteins across the endoplasmic reticulum membrane
19. Assisted protein folding
20. Functional antibody production using cell-free translation: Effects of protein disulfide isomerase and chaperones
21. Eukaryotic protein secretion
22. The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11cells
23. N-Glycosylation of yeast proteins: Characterization of the solubilized oligosacharyl transferase
24. Increasing the secretory capacity of Saccharomyces cerevisiae for production of single-chain antibody fragments
25. Production of monoclonal antibodies in COS and CHO cells
26. Theoretical modelling of protein synthesis
27. Matrix method for determining steps most rate-limiting to metabolic fluxes in biotechnological processes
28. Modeling assembly, aggregation and chaperoning of immunoglobulin G production in insect cells