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Volumn 75, Issue , 2014, Pages 221-254

Carbonic anhydrase IX as an imaging and therapeutic target for tumors and metastases

Author keywords

Acid mediated invasion; Antibody; Cancer; Carbonic anhydrase IX; Carbonic anhydrase XII; Fluorescent sulfonamide; HIF 1; Imaging; Small molecular probes; Tumor hypoxia

Indexed keywords

CA9 PROTEIN, HUMAN; CARBON DIOXIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE XII; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; TUMOR ANTIGEN; ZINC;

EID: 84899773403     PISSN: 03060225     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-94-007-7359-2_12     Document Type: Article
Times cited : (103)

References (208)
  • 1
    • 38849143765 scopus 로고    scopus 로고
    • Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators
    • Supuran CT (2008) Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov 7:168-181
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 168-181
    • Supuran, C.T.1
  • 2
    • 77954218410 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors
    • Supuran CT (2010) Carbonic anhydrase inhibitors. Bioorg Med Chem Lett 20:3467-3474
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 3467-3474
    • Supuran, C.T.1
  • 3
    • 0035897141 scopus 로고
    • (2001) cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: MRNA expressions of CA-RP X and XI in human brain
    • Okamoto N, Fujikawa-Adachi K, Nishimori I, Taniuchi K, Onishi S (2001) cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain. Biochim Biophys Acta 1518:311-316
    • (1518) Biochim Biophys Acta , pp. 311-316
    • Okamoto, N.1    Fujikawa-Adachi, K.2    Nishimori, I.3    Taniuchi, K.4    Onishi, S.5
  • 4
    • 67650251996 scopus 로고    scopus 로고
    • Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing
    • Picaud SS, Muniz JR, Kramm A, Pilka ES, Kochan G, Oppermann U, Yue WW (2009) Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing. Proteins 76:507-511
    • (2009) Proteins , vol.76 , pp. 507-511
    • Picaud, S.S.1    Muniz, J.R.2    Kramm, A.3    Pilka, E.S.4    Kochan, G.5    Oppermann, U.6    Yue, W.W.7
  • 5
    • 33751100628 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Selective inhibition of human tumor-associated isozymes IX and XII and cytosolic isozymes I and II with some substituted-2-mercapto-benzenesulfonamides
    • Saczewski F, Innocenti A, Brzozowski Z, Slawinski J, Pomarnacka E, Kornicka A, Scozzafava A, Supuran CT (2006) Carbonic anhydrase inhibitors. Selective inhibition of human tumor-associated isozymes IX and XII and cytosolic isozymes I and II with some substituted-2-mercapto-benzenesulfonamides. J Enzyme Inhib Med Chem 21:563-568
    • (2006) J Enzyme Inhib Med Chem , vol.21 , pp. 563-568
    • Saczewski, F.1    Innocenti, A.2    Brzozowski, Z.3    Slawinski, J.4    Pomarnacka, E.5    Kornicka, A.6    Scozzafava, A.7    Supuran, C.T.8
  • 6
    • 33746836508 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors
    • Saczewski F, Slawinski J, Kornicka A, Brzozowski Z, Pomarnacka E, Innocenti A, Scozzafava A, Supuran CT (2006) Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors. Bioorg Med Chem Lett 16:4846-4851
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 4846-4851
    • Saczewski, F.1    Slawinski, J.2    Kornicka, A.3    Brzozowski, Z.4    Pomarnacka, E.5    Innocenti, A.6    Scozzafava, A.7    Supuran, C.T.8
  • 9
    • 50649105780 scopus 로고    scopus 로고
    • Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths
    • Swietach P, Wigfield S, Cobden P, Supuran CT, Harris AL, Vaughan-Jones RD (2008) Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths. J Biol Chem 283:20473-20483
    • (2008) J Biol Chem , vol.283 , pp. 20473-20483
    • Swietach, P.1    Wigfield, S.2    Cobden, P.3    Supuran, C.T.4    Harris, A.L.5    Vaughan-Jones, R.D.6
  • 10
    • 0028111173 scopus 로고
    • Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment
    • Pastorek J, Pastorekova S, Callebaut I, Mornon JP, Zelnik V, Opavsky R, Zat'ovicova M, Liao S, Portetelle D, Stanbridge EJ (1994) Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment. Oncogene 9:2877-2888
    • (1994) Oncogene , vol.9 , pp. 2877-2888
    • Pastorek, J.1    Pastorekova, S.2    Callebaut, I.3    Mornon, J.P.4    Zelnik, V.5    Opavsky, R.6    Zat'ovicova, M.7    Liao, S.8    Portetelle, D.9    Stanbridge, E.J.10
  • 17
    • 0034024783 scopus 로고    scopus 로고
    • Human tumour-associated cell adhesion protein MN/CA IX: Identification of M75 epitope and of the region mediating cell adhesion
    • Zavada J, Zavadova Z, Pastorek J, Biesova Z, Jezek J, Velek J (2000) Human tumour-associated cell adhesion protein MN/CA IX: identification of M75 epitope and of the region mediating cell adhesion. Br J Cancer 82:1808-1813
    • (2000) Br J Cancer , vol.82 , pp. 1808-1813
    • Zavada, J.1    Zavadova, Z.2    Pastorek, J.3    Biesova, Z.4    Jezek, J.5    Velek, J.6
  • 18
    • 74449091486 scopus 로고    scopus 로고
    • Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target
    • De Simone G, Supuran CT (2010) Carbonic anhydrase IX: biochemical and crystallographic characterization of a novel antitumor target. Biochim Biophys Acta 1804:404-409
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 404-409
    • De Simone, G.1    Supuran, C.T.2
  • 19
    • 70349199011 scopus 로고    scopus 로고
    • The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors
    • Innocenti A, Pastorekova S, Pastorek J, Scozzafava A, De Simone G, Supuran CT (2009) The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors. Bioorg Med Chem Lett 19:5825-5828
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 5825-5828
    • Innocenti, A.1    Pastorekova, S.2    Pastorek, J.3    Scozzafava, A.4    De Simone, G.5    Supuran, C.T.6
  • 21
    • 25144484490 scopus 로고    scopus 로고
    • Carbonic anhydrase IX (CA IX) mediates tumor cell interactions with microenvironment
    • Zavadova Z, Zavada J (2005) Carbonic anhydrase IX (CA IX) mediates tumor cell interactions with microenvironment. Oncol Rep 13:977-982
    • (2005) Oncol Rep , vol.13 , pp. 977-982
    • Zavadova, Z.1    Zavada, J.2
  • 24
    • 0035859892 scopus 로고    scopus 로고
    • Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells
    • Whittington DA, Waheed A, Ulmasov B, Shah GN, Grubb JH, Sly WS, Christianson DW (2001) Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells. Proc Natl Acad Sci U S A 98:9545-9550
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 9545-9550
    • Whittington, D.A.1    Waheed, A.2    Ulmasov, B.3    Shah, G.N.4    Grubb, J.H.5    Sly, W.S.6    Christianson, D.W.7
  • 25
    • 78650750585 scopus 로고    scopus 로고
    • Role of hypoxia and EGF on expression, activity, localization and phosphorylation of carbonic anhydrase IX in MDA-MB-231 breast cancer cells
    • Li Y, Wang H, Tu C, Shiverick KT, Silverman DN, Frost SC (2011) Role of hypoxia and EGF on expression, activity, localization and phosphorylation of carbonic anhydrase IX in MDA-MB-231 breast cancer cells. Biochim Biophys Acta 1813:159-167
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 159-167
    • Li, Y.1    Wang, H.2    Tu, C.3    Shiverick, K.T.4    Silverman, D.N.5    Frost, S.C.6
  • 27
    • 0031040821 scopus 로고    scopus 로고
    • Carbonic anhydrase IX, MN/CA IX: Analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts
    • Pastorekova S, Parkkila S, Parkkila AK, Opavsky R, Zelnik V, Saarnio J, Pastorek J (1997) Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts. Gastroenterology 112:398-108
    • (1997) Gastroenterology , vol.112 , pp. 398-408
    • Pastorekova, S.1    Parkkila, S.2    Parkkila, A.K.3    Opavsky, R.4    Zelnik, V.5    Saarnio, J.6    Pastorek, J.7
  • 28
    • 84859870939 scopus 로고    scopus 로고
    • Recent developments in targeting carbonic anhydrase IX for cancer therapeutics
    • McDonald PC, Winum JY, Supuran CT, Dedhar S (2012) Recent developments in targeting carbonic anhydrase IX for cancer therapeutics. Oncotarget 3:84-97
    • (2012) Oncotarget , vol.3 , pp. 84-97
    • McDonald, P.C.1    Winum, J.Y.2    Supuran, C.T.3    Dedhar, S.4
  • 30
    • 62749124795 scopus 로고    scopus 로고
    • Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show?
    • Kaluz S, Kaluzova M, Liao SY, Lerman M, Stanbridge EJ (2009) Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: a one transcription factor (HIF-1) show? Biochim Biophys Acta 1795:162-172
    • (2009) Biochim Biophys Acta , vol.1795 , pp. 162-172
    • Kaluz, S.1    Kaluzova, M.2    Liao, S.Y.3    Lerman, M.4    Stanbridge, E.J.5
  • 33
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
    • Salceda S, Caro J (1997) Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272:22642-22647
    • (1997) J Biol Chem , vol.272 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 35
    • 0033233243 scopus 로고    scopus 로고
    • Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1
    • Semenza GL (1999) Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15:551-578
    • (1999) Annu Rev Cell Dev Biol , vol.15 , pp. 551-578
    • Semenza, G.L.1
  • 36
    • 0030914648 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor 1alpha: Posttranscriptional regulation and conformational change by recruitment ofthe Arnt transcription factor
    • Kallio PJ, Pongratz I, Gradin K, McGuire J, Poellinger L (1997) Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment ofthe Arnt transcription factor. Proc Natl Acad Sci U S A 94:5667-5672
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 5667-5672
    • Kallio, P.J.1    Pongratz, I.2    Gradin, K.3    McGuire, J.4    Poellinger, L.5
  • 38
    • 33751169387 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 (HIF-1)
    • Ke Q, Costa M (2006) Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol 70:1469-1480
    • (2006) Mol Pharmacol , vol.70 , pp. 1469-1480
    • Ke, Q.1    Costa, M.2
  • 39
    • 84859445000 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy
    • Semenza GL (2012) Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci 33:207-214
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 207-214
    • Semenza, G.L.1
  • 40
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • Lu H, Forbes RA, Verma A (2002) Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 277:23111-23115
    • (2002) J Biol Chem , vol.277 , pp. 23111-23115
    • Lu, H.1    Forbes, R.A.2    Verma, A.3
  • 41
    • 2942733275 scopus 로고    scopus 로고
    • DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX
    • Kaluzova M, Kaluz S, Lerman MI, Stanbridge EJ (2004) DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX. Mol Cell Biol 24:5757-5766
    • (2004) Mol Cell Biol , vol.24 , pp. 5757-5766
    • Kaluzova, M.1    Kaluz, S.2    Lerman, M.I.3    Stanbridge, E.J.4
  • 42
    • 0035835819 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene
    • Kondo K, Kaelin WG Jr (2001) The von Hippel-Lindau tumor suppressor gene. Exp Cell Res 264:117-125
    • (2001) Exp Cell Res , vol.264 , pp. 117-125
    • Kondo, K.1    Kaelin, W.G.2
  • 43
    • 0032514685 scopus 로고    scopus 로고
    • Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
    • Ivanov SV, Kuzmin I, Wei MH, Pack S, Geil L, Johnson BE, Stanbridge EJ, Lerman MI (1998) Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. Proc Natl Acad Sci USA 95:12596-12601
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 12596-12601
    • Ivanov, S.V.1    Kuzmin, I.2    Wei, M.H.3    Pack, S.4    Geil, L.5    Johnson, B.E.6    Stanbridge, E.J.7    Lerman, M.I.8
  • 45
    • 54249151684 scopus 로고    scopus 로고
    • Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction
    • Das B, Tsuchida R, Malkin D, Koren G, Baruchel S, Yeger H (2008) Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction. Stem Cells 26:1818-1830
    • (2008) Stem Cells , vol.26 , pp. 1818-1830
    • Das, B.1    Tsuchida, R.2    Malkin, D.3    Koren, G.4    Baruchel, S.5    Yeger, H.6
  • 46
    • 77956224494 scopus 로고    scopus 로고
    • Oxygen in stem cell biology: A critical component of the stem cell niche
    • Mohyeldin A, Garzon-Muvdi T, Quinones-Hinojosa A (2010) Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 7:150-161
    • (2010) Cell Stem Cell , vol.7 , pp. 150-161
    • Mohyeldin, A.1    Garzon-Muvdi, T.2    Quinones-Hinojosa, A.3
  • 49
    • 34447297300 scopus 로고    scopus 로고
    • The invasive front in endometrial carcinoma: Higher proliferation and associated derailment of cell cycle regulators
    • Horree N, van Diest PJ, Sie-Go DM, Heintz AP (2007) The invasive front in endometrial carcinoma: higher proliferation and associated derailment of cell cycle regulators. Hum Pathol 38:1232-1238
    • (2007) Hum Pathol , vol.38 , pp. 1232-1238
    • Horree, N.1    Van Diest, P.J.2    Sie-Go, D.M.3    Heintz, A.P.4
  • 50
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: Migrating cancer stem cells - an integrated concept of malignant tumour progression
    • Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T (2005) Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer 5:744-749
    • (2005) Nat Rev Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3    Hlubek, F.4    Kirchner, T.5
  • 52
    • 27144527814 scopus 로고    scopus 로고
    • Gastric pit cell hyperplasia and glandular atrophy in carbonic anhydrase IX knockout mice: studies on two strains C57/BL6 and BALB/C
    • Leppilampi M, Karttunen TJ, Kivela J, Gut MO, Pastorekova S, Pastorek J, Parkkila S (2005) Gastric pit cell hyperplasia and glandular atrophy in carbonic anhydrase IX knockout mice: studies on two strains C57/BL6 and BALB/C. Transgenic Res 14:655-663
    • (2005) Transgenic Res , vol.14 , pp. 655-663
    • Leppilampi, M.1    Karttunen, T.J.2    Kivela, J.3    Gut, M.O.4    Pastorekova, S.5    Pastorek, J.6    Parkkila, S.7
  • 53
    • 33645921628 scopus 로고    scopus 로고
    • Carbonic anhydrase gene expression in CA II-deficient (Car2—/—) and CA IX-deficient (Car9-/-) mice
    • Pan P, Leppilampi M, Pastorekova S, Pastorek J, Waheed A, Sly WS, Parkkila S (2006) Carbonic anhydrase gene expression in CA II-deficient (Car2—/—) and CA IX-deficient (Car9-/-) mice. J Physiol 571:319-327
    • (2006) J Physiol , vol.571 , pp. 319-327
    • Pan, P.1    Leppilampi, M.2    Pastorekova, S.3    Pastorek, J.4    Waheed, A.5    Sly, W.S.6    Parkkila, S.7
  • 54
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    • Chiche J, Ilc K, Laferriere J, Trottier E, Dayan F, Mazure NM, Brahimi-Horn MC, Pouyssegur J (2009) Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res 69:358-368
    • (2009) Cancer Res , vol.69 , pp. 358-368
    • Chiche, J.1    Ilc, K.2    Laferriere, J.3    Trottier, E.4    Dayan, F.5    Mazure, N.M.6    Brahimi-Horn, M.C.7    Pouyssegur, J.8
  • 55
    • 77955296520 scopus 로고    scopus 로고
    • Membrane-bound carbonic anhy-drases are key pH regulators controlling tumor growth and cell migration
    • Chiche J, Ilc K, Brahimi-Horn MC, Pouyssegur J (2010) Membrane-bound carbonic anhy-drases are key pH regulators controlling tumor growth and cell migration. Adv Enzyme Regul 50:20-33
    • (2010) Adv Enzyme Regul , vol.50 , pp. 20-33
    • Chiche, J.1    Ilc, K.2    Brahimi-Horn, M.C.3    Pouyssegur, J.4
  • 56
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia-a key regulatory factor in tumour growth
    • Harris AL (2002) Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2:38-47
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 57
    • 34447117505 scopus 로고    scopus 로고
    • Review: Implications of in vitro research on the effect of radiotherapy and chemotherapy under hypoxic conditions
    • Wouters A, Pauwels B, Lardon F, Vermorken JB (2007) Review: implications of in vitro research on the effect of radiotherapy and chemotherapy under hypoxic conditions. Oncologist 12:690-712
    • (2007) Oncologist , vol.12 , pp. 690-712
    • Wouters, A.1    Pauwels, B.2    Lardon, F.3    Vermorken, J.B.4
  • 59
    • 79958191830 scopus 로고    scopus 로고
    • Hypoxia-mediated drug resistance: novel insights on the functional interaction ofHIFs and cell death pathways
    • Rohwer N, Cramer T (2011) Hypoxia-mediated drug resistance: novel insights on the functional interaction ofHIFs and cell death pathways. Drug Resist Updat 14:191-201
    • (2011) Drug Resist Updat , vol.14 , pp. 191-201
    • Rohwer, N.1    Cramer, T.2
  • 61
    • 0038293080 scopus 로고    scopus 로고
    • Prognostic significance of tumor oxygenation in humans
    • Evans SM, Koch CJ (2003) Prognostic significance of tumor oxygenation in humans. Cancer Lett 195:1-16
    • (2003) Cancer Lett , vol.195 , pp. 1-16
    • Evans, S.M.1    Koch, C.J.2
  • 66
    • 0033997568 scopus 로고    scopus 로고
    • Hypoxia and necrosis in rat 9L glioma and Morris 7777 hepatoma tumors: Comparative measurements using EF5 binding and the Eppendorf needle electrode
    • Jenkins WT, Evans SM, Koch CJ (2000) Hypoxia and necrosis in rat 9L glioma and Morris 7777 hepatoma tumors: comparative measurements using EF5 binding and the Eppendorf needle electrode. Int J Radiat Oncol Biol Phys 46:1005-1017
    • (2000) Int J Radiat Oncol Biol Phys , vol.46 , pp. 1005-1017
    • Jenkins, W.T.1    Evans, S.M.2    Koch, C.J.3
  • 67
    • 8844229492 scopus 로고    scopus 로고
    • Oncological molecular imaging: Nuclear medicine techniques
    • Cook GJ (2003) Oncological molecular imaging: nuclear medicine techniques. Br J Radiol 76:S152-S158
    • (2003) Br J Radiol , vol.76 , pp. 152-158
    • Cook, G.J.1
  • 68
    • 0242298213 scopus 로고    scopus 로고
    • GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: Relationship with vascularity and proliferation as predictors of outcome of ARCON
    • Hoskin PJ, Sibtain A, Daley FM, Wilson GD (2003) GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: relationship with vascularity and proliferation as predictors of outcome of ARCON. Br J Cancer 89:1290-1297
    • (2003) Br J Cancer , vol.89 , pp. 1290-1297
    • Hoskin, P.J.1    Sibtain, A.2    Daley, F.M.3    Wilson, G.D.4
  • 70
    • 34548018979 scopus 로고    scopus 로고
    • Visualization of hypoxia in microscopic tumors by immunofluorescent microscopy
    • Li XF, Carlin S, Urano M, Russell J, Ling CC, O'Donoghue JA (2007) Visualization of hypoxia in microscopic tumors by immunofluorescent microscopy. Cancer Res 67:7646-7653
    • (2007) Cancer Res , vol.67 , pp. 7646-7653
    • Li, X.F.1    Carlin, S.2    Urano, M.3    Russell, J.4    Ling, C.C.5    O'donoghue, J.A.6
  • 72
    • 23844485492 scopus 로고    scopus 로고
    • Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors
    • Sobhanifar S, Aquino-Parsons C, Stanbridge EJ, Olive P (2005) Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors. Cancer Res 65:7259-7266
    • (2005) Cancer Res , vol.65 , pp. 7259-7266
    • Sobhanifar, S.1    Aquino-Parsons, C.2    Stanbridge, E.J.3    Olive, P.4
  • 73
    • 77956283843 scopus 로고    scopus 로고
    • Molecular targeting of carbonic anhydrase IX in mice with hypoxic HT29 colorectal tumor xenografts
    • Carlin S, Khan N, Ku T, Longo VA, Larson SM, Smith-Jones PM (2010) Molecular targeting of carbonic anhydrase IX in mice with hypoxic HT29 colorectal tumor xenografts. PLoS One 5:e10857
    • (2010) Plos One , vol.5
    • Carlin, S.1    Khan, N.2    Ku, T.3    Longo, V.A.4    Larson, S.M.5    Smith-Jones, P.M.6
  • 74
    • 0035392959 scopus 로고    scopus 로고
    • Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density
    • Beasley NJ, Wykoff CC, Watson PH, Leek R, Turley H, Gatter K, Pastorek J, Cox GJ, Ratcliffe P, Harris AL (2001) Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density. Cancer Res 61:5262-5267
    • (2001) Cancer Res , vol.61 , pp. 5262-5267
    • Beasley, N.J.1    Wykoff, C.C.2    Watson, P.H.3    Leek, R.4    Turley, H.5    Gatter, K.6    Pastorek, J.7    Cox, G.J.8    Ratcliffe, P.9    Harris, A.L.10
  • 75
    • 27144451824 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression and tumor oxygenation status do not correlate at the microregional level in locally advanced cancers of the uterine cervix
    • Mayer A, Hockel M, Vaupel P (2005) Carbonic anhydrase IX expression and tumor oxygenation status do not correlate at the microregional level in locally advanced cancers of the uterine cervix. Clin Cancer Res 11:7220-7225
    • (2005) Clin Cancer Res , vol.11 , pp. 7220-7225
    • Mayer, A.1    Hockel, M.2    Vaupel, P.3
  • 76
    • 1842852597 scopus 로고    scopus 로고
    • Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells
    • Rafajova M, Zatovicova M, Kettmann R, Pastorek J, Pastorekova S (2004) Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells. Int J Oncol 24:995-1004
    • (2004) Int J Oncol , vol.24 , pp. 995-1004
    • Rafajova, M.1    Zatovicova, M.2    Kettmann, R.3    Pastorek, J.4    Pastorekova, S.5
  • 77
    • 77953935500 scopus 로고    scopus 로고
    • Tumour hypoxia induces a metabolic shift causing acidosis: A common feature in cancer
    • Chiche J, Brahimi-Horn MC, Pouyssegur J (2010) Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer. J Cell Mol Med 14:771-794
    • (2010) J Cell Mol Med , vol.14 , pp. 771-794
    • Chiche, J.1    Brahimi-Horn, M.C.2    Pouyssegur, J.3
  • 78
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown JM, Wilson WR (2004) Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 4:437-447
    • (2004) Nat Rev Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 79
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • Dewhirst MW, Cao Y, Moeller B (2008) Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer 8:425-437
    • (2008) Nat Rev Cancer , vol.8 , pp. 425-437
    • Dewhirst, M.W.1    Cao, Y.2    Moeller, B.3
  • 83
    • 34447504549 scopus 로고    scopus 로고
    • Oxygen, a source of life and stress
    • Brahimi-Horn MC, Pouyssegur J (2007) Oxygen, a source of life and stress. FEBS Lett 581:3582-3591
    • (2007) FEBS Lett , vol.581 , pp. 3582-3591
    • Brahimi-Horn, M.C.1    Pouyssegur, J.2
  • 84
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 85
    • 0022481384 scopus 로고
    • Intracellular pH controls growth factor-induced ribosomal protein S6 phosphorylation and protein synthesis in the G0-G1 transition of fibroblasts
    • Chambard JC, Pouyssegur J (1986) Intracellular pH controls growth factor-induced ribosomal protein S6 phosphorylation and protein synthesis in the G0-G1 transition of fibroblasts. Exp Cell Res 164:282-294
    • (1986) Exp Cell Res , vol.164 , pp. 282-294
    • Chambard, J.C.1    Pouyssegur, J.2
  • 86
    • 0345932705 scopus 로고
    • A specific mutation abolishing Na+/H C antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH
    • Pouyssegur J, Sardet C, Franchi A, L'Allemain G, Paris S (1984) A specific mutation abolishing Na+/H C antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH. Proc Natl Acad Sci U S A 81:4833-4837
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 4833-4837
    • Pouyssegur, J.1    Sardet, C.2    Franchi, A.3    L'allemain, G.4    Paris, S.5
  • 87
  • 88
    • 80053563164 scopus 로고    scopus 로고
    • Interfering with pH regulation in tumours as a therapeutic strategy
    • Neri D, Supuran CT (2011) Interfering with pH regulation in tumours as a therapeutic strategy. Nat Rev Drug Discov 10:767-777
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 767-777
    • Neri, D.1    Supuran, C.T.2
  • 89
    • 78649659788 scopus 로고    scopus 로고
    • Pouyssegur J (2011) pH control mechanisms of tumor survival and growth
    • Parks SK, Chiche J, Pouyssegur J (2011) pH control mechanisms of tumor survival and growth. J Cell Physiol 226:299-308
    • J Cell Physiol , vol.226 , pp. 299-308
    • Parks, S.K.1    Chiche, J.2
  • 90
    • 25844528025 scopus 로고    scopus 로고
    • The role of disturbed pH dynamics and the NaC/H C exchanger in metastasis
    • Cardone RA, Casavola V, Reshkin SJ (2005) The role of disturbed pH dynamics and the NaC/H C exchanger in metastasis. Nat Rev Cancer 5:786-795
    • (2005) Nat Rev Cancer , vol.5 , pp. 786-795
    • Cardone, R.A.1    Casavola, V.2    Reshkin, S.J.3
  • 91
    • 0040735606 scopus 로고    scopus 로고
    • The expanding family of eucaryotic Na(C)/H(C) exchangers
    • Counillon L, Pouyssegur J (2000) The expanding family of eucaryotic Na(C)/H(C) exchangers. J Biol Chem 275:1-4
    • (2000) J Biol Chem , vol.275 , pp. 1-4
    • Counillon, L.1    Pouyssegur, J.2
  • 92
    • 33646917296 scopus 로고    scopus 로고
    • The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
    • Ullah MS, Davies AJ, Halestrap AP (2006) The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem 281:9030-9037
    • (2006) J Biol Chem , vol.281 , pp. 9030-9037
    • Ullah, M.S.1    Davies, A.J.2    Halestrap, A.P.3
  • 95
    • 8844224030 scopus 로고    scopus 로고
    • Microenvironmental and cellular consequences of altered blood flow in tumours
    • Raghunand N, Gatenby RA, Gillies RJ (2003) Microenvironmental and cellular consequences of altered blood flow in tumours. Br J Radiol 76:S11-S22
    • (2003) Br J Radiol , vol.76 , pp. 11-22
    • Raghunand, N.1    Gatenby, R.A.2    Gillies, R.J.3
  • 96
    • 79955538507 scopus 로고    scopus 로고
    • Catalysis and pH control by membrane-associated carbonic anhydrase IX in MDA-MB-231 breast cancer cells
    • Li Y, Tu C, Wang H, Silverman DN, Frost SC (2011) Catalysis and pH control by membrane-associated carbonic anhydrase IX in MDA-MB-231 breast cancer cells. J Biol Chem 286:15789-15796
    • (2011) J Biol Chem , vol.286 , pp. 15789-15796
    • Li, Y.1    Tu, C.2    Wang, H.3    Silverman, D.N.4    Frost, S.C.5
  • 98
    • 44449091556 scopus 로고    scopus 로고
    • Molecular mechanisms of carbonic anhydrase IX-mediated pH regulation under hypoxia
    • Pastorekova S, Ratcliffe PJ, Pastorek J (2008) Molecular mechanisms of carbonic anhydrase IX-mediated pH regulation under hypoxia. BJU Int 101(Suppl 4):8-15
    • (2008) BJU Int , vol.101 , pp. 8-15
    • Pastorekova, S.1    Ratcliffe, P.J.2    Pastorek, J.3
  • 99
    • 82955173044 scopus 로고    scopus 로고
    • Drug resistance and cellular adaptation to tumor acidic pH microenvironment
    • Wojtkowiak JW, Verduzco D, Schramm KJ, Gillies RJ (2011) Drug resistance and cellular adaptation to tumor acidic pH microenvironment. Mol Pharm 8:2032-2038
    • (2011) Mol Pharm , vol.8 , pp. 2032-2038
    • Wojtkowiak, J.W.1    Verduzco, D.2    Schramm, K.J.3    Gillies, R.J.4
  • 101
    • 67749145635 scopus 로고    scopus 로고
    • The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths
    • Swietach P, Patiar S, Supuran CT, Harris AL, Vaughan-Jones RD (2009) The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths. J Biol Chem 284:20299-20310
    • (2009) J Biol Chem , vol.284 , pp. 20299-20310
    • Swietach, P.1    Patiar, S.2    Supuran, C.T.3    Harris, A.L.4    Vaughan-Jones, R.D.5
  • 102
    • 78650308850 scopus 로고    scopus 로고
    • New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
    • Swietach P, Hulikova A, Vaughan-Jones RD, Harris AL (2010) New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation. Oncogene 29:6509-6521
    • (2010) Oncogene , vol.29 , pp. 6509-6521
    • Swietach, P.1    Hulikova, A.2    Vaughan-Jones, R.D.3    Harris, A.L.4
  • 106
    • 65549170684 scopus 로고    scopus 로고
    • The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion
    • Silva AS, Yunes JA, Gillies RJ, Gatenby RA (2009) The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res 69:2677-2684
    • (2009) Cancer Res , vol.69 , pp. 2677-2684
    • Silva, A.S.1    Yunes, J.A.2    Gillies, R.J.3    Gatenby, R.A.4
  • 107
    • 68249118615 scopus 로고    scopus 로고
    • Extracellularly activated nanocarriers: A new paradigm of tumor targeted drug delivery
    • Gullotti E, Yeo Y (2009) Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery. Mol Pharm 6:1041-1051
    • (2009) Mol Pharm , vol.6 , pp. 1041-1051
    • Gullotti, E.1    Yeo, Y.2
  • 108
    • 84874075020 scopus 로고    scopus 로고
    • A versatile polymer micelle drug delivery system for encapsulation and in vivo stabilization of hydrophobic anticancer drugs
    • Rios-Doria J, Carie A, Costich T, Burke B, Skaff H, Panicucci R, Sill K (2012) A versatile polymer micelle drug delivery system for encapsulation and in vivo stabilization of hydrophobic anticancer drugs. J Drug Deliv 2012:951741
    • (2012) J Drug Deliv , vol.2012 , pp. 951741
    • Rios-Doria, J.1    Carie, A.2    Costich, T.3    Burke, B.4    Skaff, H.5    Panicucci, R.6    Sill, K.7
  • 109
    • 0037315252 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer
    • Swinson DE, Jones JL, Richardson D, Wykoff C, Turley H, Pastorek J, Taub N, Harris AL, O'Byrne KJ (2003) Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. J Clin Oncol 21:473-482
    • (2003) J Clin Oncol , vol.21 , pp. 473-482
    • Swinson, D.E.1    Jones, J.L.2    Richardson, D.3    Wykoff, C.4    Turley, H.5    Pastorek, J.6    Taub, N.7    Harris, A.L.8    O'byrne, K.J.9
  • 112
    • 0031819881 scopus 로고    scopus 로고
    • Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation
    • Saarnio J, Parkkila S, Parkkila AK, Haukipuro K, Pastorekova S, Pastorek J, Kairaluoma MI, Karttunen TJ (1998) Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Am J Pathol 153:279-285
    • (1998) Am J Pathol , vol.153 , pp. 279-285
    • Saarnio, J.1    Parkkila, S.2    Parkkila, A.K.3    Haukipuro, K.4    Pastorekova, S.5    Pastorek, J.6    Kairaluoma, M.I.7    Karttunen, T.J.8
  • 122
    • 0035418586 scopus 로고    scopus 로고
    • Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
    • Loncaster JA, Harris AL, Davidson SE, Logue JP, Hunter RD, Wycoff CC, Pastorek J, Ratcliffe PJ, Stratford IJ, West CM (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res 61:6394-6399
    • (2001) Cancer Res , vol.61 , pp. 6394-6399
    • Loncaster, J.A.1    Harris, A.L.2    Davidson, S.E.3    Logue, J.P.4    Hunter, R.D.5    Wycoff, C.C.6    Pastorek, J.7    Ratcliffe, P.J.8    Stratford, I.J.9    West, C.M.10
  • 124
    • 33846661210 scopus 로고    scopus 로고
    • Tumor carbonic anhydrase 9 expression is associated with the presence of lymph node metastases in uterine cervical cancer
    • Lee S, Shin HJ, Han IO, Hong EK, Park SY, Roh JW, Shin KH, Kim TH, Kim JY (2007) Tumor carbonic anhydrase 9 expression is associated with the presence of lymph node metastases in uterine cervical cancer. Cancer Sci 98:329-333
    • (2007) Cancer Sci , vol.98 , pp. 329-333
    • Lee, S.1    Shin, H.J.2    Han, I.O.3    Hong, E.K.4    Park, S.Y.5    Roh, J.W.6    Shin, K.H.7    Kim, T.H.8    Kim, J.Y.9
  • 127
    • 80052419706 scopus 로고    scopus 로고
    • Overexpression of carbonic anhydrase IX (CAIX) is an independent unfavorable prognostic marker in endometrioid ovarian cancer
    • Choschzick M, Oosterwijk E, Muller V, Woelber L, Simon R, Moch H, Tennstedt P (2011) Overexpression of carbonic anhydrase IX (CAIX) is an independent unfavorable prognostic marker in endometrioid ovarian cancer. Virchows Arch 459:193-200
    • (2011) Virchows Arch , vol.459 , pp. 193-200
    • Choschzick, M.1    Oosterwijk, E.2    Muller, V.3    Woelber, L.4    Simon, R.5    Moch, H.6    Tennstedt, P.7
  • 128
  • 131
    • 26844468059 scopus 로고    scopus 로고
    • The prognostic value of the hypoxia markers CA IX and GLUT 1 and the cytokines VEGF and IL 6 in head and neck squamous cell carcinoma treated by radiotherapy C/— chemotherapy
    • De Schutter H, Landuyt W, Verbeken E, Goethals L, Hermans R, Nuyts S (2005) The prognostic value of the hypoxia markers CA IX and GLUT 1 and the cytokines VEGF and IL 6 in head and neck squamous cell carcinoma treated by radiotherapy C/— chemotherapy. BMC Cancer 5:42
    • (2005) BMC Cancer , vol.5 , pp. 42
    • De Schutter, H.1    Landuyt, W.2    Verbeken, E.3    Goethals, L.4    Hermans, R.5    Nuyts, S.6
  • 132
    • 33644849887 scopus 로고    scopus 로고
    • Endogenous markers of two separate hypoxia response pathways (Hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial
    • Koukourakis MI, Bentzen SM, Giatromanolaki A, Wilson GD, Daley FM, Saunders MI, Dische S, Sivridis E, Harris AL (2006) Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial. J Clin Oncol 24:727-735
    • (2006) J Clin Oncol , vol.24 , pp. 727-735
    • Koukourakis, M.I.1    Bentzen, S.M.2    Giatromanolaki, A.3    Wilson, G.D.4    Daley, F.M.5    Saunders, M.I.6    Dische, S.7    Sivridis, E.8    Harris, A.L.9
  • 134
    • 84861668879 scopus 로고    scopus 로고
    • Correlation of expression of hypoxia-related proteins with prognosis in oral squamous cell carcinoma patients
    • Eckert AW, Kappler M, Schubert J, Taubert H (2012) Correlation of expression of hypoxia-related proteins with prognosis in oral squamous cell carcinoma patients. Oral Maxillofac Surg 16:189-196
    • (2012) Oral Maxillofac Surg , vol.16 , pp. 189-196
    • Eckert, A.W.1    Kappler, M.2    Schubert, J.3    Taubert, H.4
  • 136
    • 48949096355 scopus 로고    scopus 로고
    • Expression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognosis in surgically treated oral squamous cell carcinoma
    • Choi SW, Kim JY, Park JY, Cha IH, Kim J, Lee S (2008) Expression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognosis in surgically treated oral squamous cell carcinoma. Hum Pathol 39:1317-1322
    • (2008) Hum Pathol , vol.39 , pp. 1317-1322
    • Choi, S.W.1    Kim, J.Y.2    Park, J.Y.3    Cha, I.H.4    Kim, J.5    Lee, S.6
  • 137
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouyssegur J, Dayan F, Mazure NM (2006) Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441:437-443
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 138
    • 0030835515 scopus 로고    scopus 로고
    • Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney
    • Liao SY, Aurelio ON, Jan K, Zavada J, Stanbridge EJ (1997) Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney. Cancer Res 57:2827-2831
    • (1997) Cancer Res , vol.57 , pp. 2827-2831
    • Liao, S.Y.1    Aurelio, O.N.2    Jan, K.3    Zavada, J.4    Stanbridge, E.J.5
  • 140
    • 84884619377 scopus 로고    scopus 로고
    • Value of MN/CAIX in the diagnosis of renal cell carcinoma
    • Jiang YD, Ren F, Zheng SB (2012) Value of MN/CAIX in the diagnosis of renal cell carcinoma. Nan Fang Yi Ke Da Xue Xue Bao 32:412-414
    • (2012) Nan Fang Yi Ke Da Xue Xue Bao , vol.32 , pp. 412-414
    • Jiang, Y.D.1    Ren, F.2    Zheng, S.B.3
  • 142
    • 77956198463 scopus 로고    scopus 로고
    • Carbonic anhydrase IX and pathological features as predictors of outcome in patients with metastatic clear-cell renal cell carcinoma receiving vascular endothelial growth factor-targeted therapy
    • Choueiri TK, Regan MM, Rosenberg JE, Oh WK, Clement J, Amato AM, McDermott D, Cho DC, Atkins MB, Signoretti S (2010) Carbonic anhydrase IX and pathological features as predictors of outcome in patients with metastatic clear-cell renal cell carcinoma receiving vascular endothelial growth factor-targeted therapy. BJU Int 106:772-778
    • (2010) BJU Int , vol.106 , pp. 772-778
    • Choueiri, T.K.1    Regan, M.M.2    Rosenberg, J.E.3    Oh, W.K.4    Clement, J.5    Amato, A.M.6    McDermott, D.7    Cho, D.C.8    Atkins, M.B.9    Signoretti, S.10
  • 143
    • 75349092529 scopus 로고    scopus 로고
    • Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: Prognostic and diagnostic potentials
    • Zhou GX, Ireland J, Rayman P, Finke J, Zhou M (2010) Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: prognostic and diagnostic potentials. Urology 75:257-261
    • (2010) Urology , vol.75 , pp. 257-261
    • Zhou, G.X.1    Ireland, J.2    Rayman, P.3    Finke, J.4    Zhou, M.5
  • 144
    • 34250182435 scopus 로고    scopus 로고
    • Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: An evaluation of the DAHANCA 5 study
    • Eriksen JG, Overgaard J (2007) Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: an evaluation of the DAHANCA 5 study. Radiother Oncol 83:383-388
    • (2007) Radiother Oncol , vol.83 , pp. 383-388
    • Eriksen, J.G.1    Overgaard, J.2
  • 145
    • 84868220610 scopus 로고    scopus 로고
    • Detection of carbonic anhydrase IX protein in the diagnosis of malignant pleural effusion by enzyme-linked immunosorbent assay and immunocytochemistry
    • Liao ND, Lee WY (2012) Detection of carbonic anhydrase IX protein in the diagnosis of malignant pleural effusion by enzyme-linked immunosorbent assay and immunocytochemistry. Cancer Cytopathol 120:269-275
    • (2012) Cancer Cytopathol , vol.120 , pp. 269-275
    • Liao, N.D.1    Lee, W.Y.2
  • 153
    • 0141887319 scopus 로고    scopus 로고
    • Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients
    • Zavada J, Zavadova Z, Zat'ovicova M, Hyrsl L, Kawaciuk I (2003) Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. Br J Cancer 89:1067-1071
    • (2003) Br J Cancer , vol.89 , pp. 1067-1071
    • Zavada, J.1    Zavadova, Z.2    Zat'ovicova, M.3    Hyrsl, L.4    Kawaciuk, I.5
  • 154
    • 46449104314 scopus 로고    scopus 로고
    • Serum carbonic anhydrase 9 level is associated with postoperative recurrence of conventional renal cell cancer
    • Li G, Feng G, Gentil-Perret A, Genin C, Tostain J (2008) Serum carbonic anhydrase 9 level is associated with postoperative recurrence of conventional renal cell cancer. J Urol 180:510-513
    • (2008) J Urol , vol.180 , pp. 510-513
    • Li, G.1    Feng, G.2    Gentil-Perret, A.3    Genin, C.4    Tostain, J.5
  • 155
    • 0032956387 scopus 로고    scopus 로고
    • MN/CA9 gene expression as a potential biomarker in renal cell carcinoma
    • Murakami Y, Kanda K, Tsuji M, Kanayama H, Kagawa S (1999) MN/CA9 gene expression as a potential biomarker in renal cell carcinoma. BJU Int 83:743-747
    • (1999) BJU Int , vol.83 , pp. 743-747
    • Murakami, Y.1    Kanda, K.2    Tsuji, M.3    Kanayama, H.4    Kagawa, S.5
  • 156
    • 68149108604 scopus 로고    scopus 로고
    • Soluble form of carbonic anhydrase IX (CAIX) in transitional cell carcinoma of urinary tract
    • Hyrsl L, Zavada J, Zavadova Z, Kawaciuk I, Vesely S, Skapa P (2009) Soluble form of carbonic anhydrase IX (CAIX) in transitional cell carcinoma of urinary tract. Neoplasma 56:298-302
    • (2009) Neoplasma , vol.56 , pp. 298-302
    • Hyrsl, L.1    Zavada, J.2    Zavadova, Z.3    Kawaciuk, I.4    Vesely, S.5    Skapa, P.6
  • 158
    • 79960074590 scopus 로고    scopus 로고
    • Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer
    • Muller V, Riethdorf S, Rack B, Janni W, Fasching PA, Solomayer E, Aktas B, KasimirBauer S, Zeitz J, Pantel K, Fehm T (2011) Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer. Breast Cancer Res 13:R71
    • (2011) Breast Cancer Res , vol.13 , pp. 71
    • Muller, V.1    Riethdorf, S.2    Rack, B.3    Janni, W.4    Fasching, P.A.5    Solomayer, E.6    Aktas, B.7    Kasimirbauer, S.8    Zeitz, J.9    Pantel, K.10    Fehm, T.11
  • 160
    • 57149142495 scopus 로고    scopus 로고
    • The impact of 02 availability on human cancer
    • Bertout JA, Patel SA, Simon MC (2008) The impact of 02 availability on human cancer. Nat Rev Cancer 8:967-975
    • (2008) Nat Rev Cancer , vol.8 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 161
    • 2942557164 scopus 로고    scopus 로고
    • Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study
    • Scheurer SB, Rybak JN, Rosli C, Neri D, Elia G (2004) Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: a transcriptomic and proteomic study. Proteomics 4:1737-1760
    • (2004) Proteomics , vol.4 , pp. 1737-1760
    • Scheurer, S.B.1    Rybak, J.N.2    Rosli, C.3    Neri, D.4    Elia, G.5
  • 165
    • 79955675294 scopus 로고    scopus 로고
    • Next generation and biosimilar monoclonal antibodies: Essential considerations towards regulatory acceptance in Europe. February 3-4, 2011, Freiburg, Germany
    • Reichert JM (2011) Next generation and biosimilar monoclonal antibodies: essential considerations towards regulatory acceptance in Europe. February 3-4, 2011, Freiburg, Germany. MAbs 3:223-240
    • (2011) Mabs , vol.3 , pp. 223-240
    • Reichert, J.M.1
  • 167
    • 0038118505 scopus 로고    scopus 로고
    • Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma
    • Chrastina A, Zavada J, Parkkila S, Kaluz S, Kaluzova M, Rajcani J, Pastorek J, Pastorekova S (2003) Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma. Int J Cancer 105:873-881
    • (2003) Int J Cancer , vol.105 , pp. 873-881
    • Chrastina, A.1    Zavada, J.2    Parkkila, S.3    Kaluz, S.4    Kaluzova, M.5    Rajcani, J.6    Pastorek, J.7    Pastorekova, S.8
  • 168
    • 0037270299 scopus 로고    scopus 로고
    • Immunotargeting of human cervical carcinoma xenograft expressing CA IX tumor-associated antigen by 125I-labeled M75 monoclonal antibody
    • Chrastina A, Pastorekova S, Pastorek J (2003) Immunotargeting of human cervical carcinoma xenograft expressing CA IX tumor-associated antigen by 125I-labeled M75 monoclonal antibody. Neoplasma 50:13-21
    • (2003) Neoplasma , vol.50 , pp. 13-21
    • Chrastina, A.1    Pastorekova, S.2    Pastorek, J.3
  • 169
    • 68749119336 scopus 로고    scopus 로고
    • Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours
    • Ahlskog JK, Schliemann C, Marlind J, Qureshi U, Ammar A, Pedley RB, Neri D (2009) Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours. Br J Cancer 101:645-657
    • (2009) Br J Cancer , vol.101 , pp. 645-657
    • Ahlskog, J.K.1    Schliemann, C.2    Marlind, J.3    Qureshi, U.4    Ammar, A.5    Pedley, R.B.6    Neri, D.7
  • 170
    • 0141649426 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with anions
    • Vullo D, Franchi M, Gallori E, Pastorek J, Scozzafava A, Pastorekova S, Supuran CT (2003) Carbonic anhydrase inhibitors. inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with anions. J Enzyme Inhib Med Chem 18:403-406
    • (2003) J Enzyme Inhib Med Chem , vol.18 , pp. 403-406
    • Vullo, D.1    Franchi, M.2    Gallori, E.3    Pastorek, J.4    Scozzafava, A.5    Pastorekova, S.6    Supuran, C.T.7
  • 171
    • 40049101317 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: Interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV)
    • Innocenti A, Vullo D, Scozzafava A, Supuran CT (2008) Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV). Bioorg Med Chem Lett 18:1583-1587
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 1583-1587
    • Innocenti, A.1    Vullo, D.2    Scozzafava, A.3    Supuran, C.T.4
  • 173
    • 0842281270 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: The first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX
    • Pastorekova S, Casini A, Scozzafava A, Vullo D, Pastorek J, Supuran CT (2004) Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX. Bioorg Med Chem Lett 14:869-873
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 869-873
    • Pastorekova, S.1    Casini, A.2    Scozzafava, A.3    Vullo, D.4    Pastorek, J.5    Supuran, C.T.6
  • 174
    • 1842628633 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX
    • Casey JR, Morgan PE, Vullo D, Scozzafava A, Mastrolorenzo A, Supuran CT (2004) Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX. J Med Chem 47:2337-2347
    • (2004) J Med Chem , vol.47 , pp. 2337-2347
    • Casey, J.R.1    Morgan, P.E.2    Vullo, D.3    Scozzafava, A.4    Mastrolorenzo, A.5    Supuran, C.T.6
  • 176
    • 79952808077 scopus 로고    scopus 로고
    • Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis
    • Pacchiano F, Carta F, McDonald PC, Lou Y, Vullo D, Scozzafava A, Dedhar S, Supuran CT (2011) Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis. J Med Chem 54:1896-1902
    • (2011) J Med Chem , vol.54 , pp. 1896-1902
    • Pacchiano, F.1    Carta, F.2    McDonald, P.C.3    Lou, Y.4    Vullo, D.5    Scozzafava, A.6    Dedhar, S.7    Supuran, C.T.8
  • 177
    • 69949128698 scopus 로고    scopus 로고
    • Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (Re)-oxygenated cells in a xenograft tumour model
    • Dubois L, Lieuwes NG, Maresca A, Thiry A, Supuran CT, Scozzafava A, Wouters BG, Lambin P (2009) Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model. Radiother Oncol 92:423-128
    • (2009) Radiother Oncol , vol.92 , pp. 423-428
    • Dubois, L.1    Lieuwes, N.G.2    Maresca, A.3    Thiry, A.4    Supuran, C.T.5    Scozzafava, A.6    Wouters, B.G.7    Lambin, P.8
  • 178
    • 22744446294 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors
    • Cecchi A, Hulikova A, Pastorek J, Pastorekova S, Scozzafava A, Winum JY, Montero JL, Supuran CT (2005) Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors. J Med Chem 48:4834-1841
    • (2005) J Med Chem , vol.48 , pp. 4834-4841
    • Cecchi, A.1    Hulikova, A.2    Pastorek, J.3    Pastorekova, S.4    Scozzafava, A.5    Winum, J.Y.6    Montero, J.L.7    Supuran, C.T.8
  • 180
    • 44949190364 scopus 로고    scopus 로고
    • Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs
    • Thiry A, Supuran CT, Masereel B, Dogne JM (2008) Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. J Med Chem 51:3051-3056
    • (2008) J Med Chem , vol.51 , pp. 3051-3056
    • Thiry, A.1    Supuran, C.T.2    Masereel, B.3    Dogne, J.M.4
  • 181
    • 42549148009 scopus 로고    scopus 로고
    • Carbonic anhydrase IX: A new druggable target for the design of antitumor agents
    • Winum JY, Rami M, Scozzafava A, Montero JL, Supuran C (2008) Carbonic anhydrase IX: a new druggable target for the design of antitumor agents. Med Res Rev 28:445-463
    • (2008) Med Res Rev , vol.28 , pp. 445-463
    • Winum, J.Y.1    Rami, M.2    Scozzafava, A.3    Montero, J.L.4    Supuran, C.5
  • 182
    • 67651091693 scopus 로고    scopus 로고
    • In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives
    • Ahlskog JK, Dumelin CE, Trussel S, Marlind J, Neri D (2009) In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives. Bioorg Med Chem Lett 19:4851-4856
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 4851-4856
    • Ahlskog, J.K.1    Dumelin, C.E.2    Trussel, S.3    Marlind, J.4    Neri, D.5
  • 183
    • 0036554644 scopus 로고    scopus 로고
    • Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism
    • Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK (2002) Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. Clin Cancer Res 8:1284-1291
    • (2002) Clin Cancer Res , vol.8 , pp. 1284-1291
    • Helmlinger, G.1    Sckell, A.2    Dellian, M.3    Forbes, N.S.4    Jain, R.K.5
  • 184
  • 187
    • 78751650361 scopus 로고    scopus 로고
    • A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX(R)) and interferon-alpha-2a in metastatic renal cell carcinoma patients
    • Siebels M, Rohrmann K, Oberneder R, Stahler M, Haseke N, Beck J, Hofmann R, Kindler M, Kloepfer P, Stief C (2011) A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX(R)) and interferon-alpha-2a in metastatic renal cell carcinoma patients. World J Urol 29:121-126
    • (2011) World J Urol , vol.29 , pp. 121-126
    • Siebels, M.1    Rohrmann, K.2    Oberneder, R.3    Stahler, M.4    Haseke, N.5    Beck, J.6    Hofmann, R.7    Kindler, M.8    Kloepfer, P.9    Stief, C.10
  • 191
    • 1542399581 scopus 로고    scopus 로고
    • Optimization of radioimmunotherapy of renal cell carcinoma: Labeling of monoclonal antibody cG250 with 131I, 90Y, 177Lu, or 186Re
    • Brouwers AH, van Eerd JE, Frielink C, Oosterwijk E, Oyen WJ, Corstens FH, Boerman OC (2004) Optimization of radioimmunotherapy of renal cell carcinoma: labeling of monoclonal antibody cG250 with 131I, 90Y, 177Lu, or 186Re. J Nucl Med 45:327-337
    • (2004) J Nucl Med , vol.45 , pp. 327-337
    • Brouwers, A.H.1    Van Eerd, J.E.2    Frielink, C.3    Oosterwijk, E.4    Oyen, W.J.5    Corstens, F.H.6    Boerman, O.C.7
  • 192
    • 84855402294 scopus 로고    scopus 로고
    • Dosimetric analysis of 177Lu-cG250 radioimmunotherapy in renal cell carcinoma patients: Correlation with myelotoxicity and pretherapeutic absorbed dose predictions based on 111In-cG250 imaging
    • Stillebroer AB, Zegers CM, Boerman OC, Oosterwijk E, Mulders PF, O'Donoghue JA, Visser EP, Oyen WJ (2012) Dosimetric analysis of 177Lu-cG250 radioimmunotherapy in renal cell carcinoma patients: correlation with myelotoxicity and pretherapeutic absorbed dose predictions based on 111In-cG250 imaging. J Nucl Med 53:82-89
    • (2012) J Nucl Med , vol.53 , pp. 82-89
    • Stillebroer, A.B.1    Zegers, C.M.2    Boerman, O.C.3    Oosterwijk, E.4    Mulders, P.F.5    O'donoghue, J.A.6    Visser, E.P.7    Oyen, W.J.8
  • 194
    • 33646440024 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: First clinical experience
    • Lamers CH, Sleijfer S, Vulto AG, Kruit WH, Kliffen M, Debets R, Gratama JW, Stoter G, Oosterwijk E (2006) Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. J Clin Oncol 24:e20-e22
    • (2006) J Clin Oncol , vol.24 , pp. 20-22
    • Lamers, C.H.1    Sleijfer, S.2    Vulto, A.G.3    Kruit, W.H.4    Kliffen, M.5    Debets, R.6    Gratama, J.W.7    Stoter, G.8    Oosterwijk, E.9
  • 197
    • 57149100954 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II
    • Stiti M, Cecchi A, Rami M, Abdaoui M, Barragan-Montero V, Scozzafava A, Guari Y, Winum JY, Supuran CT (2008) Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II. J Am Chem Soc 130:16130-16131
    • (2008) J am Chem Soc , vol.130 , pp. 16130-16131
    • Stiti, M.1    Cecchi, A.2    Rami, M.3    Abdaoui, M.4    Barragan-Montero, V.5    Scozzafava, A.6    Guari, Y.7    Winum, J.Y.8    Supuran, C.T.9
  • 203
    • 33751277287 scopus 로고    scopus 로고
    • CA IX is an independent prognostic marker in pre-menopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance
    • Brennan DJ, Jirstrom K, Kronblad A, Millikan RC, Landberg G, Duffy MJ, Ryden L, Gallagher WM, O'Brien SL (2006) CA IX is an independent prognostic marker in pre-menopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance. Clin Cancer Res 12:6421-6431
    • (2006) Clin Cancer Res , vol.12 , pp. 6421-6431
    • Brennan, D.J.1    Jirstrom, K.2    Kronblad, A.3    Millikan, R.C.4    Landberg, G.5    Duffy, M.J.6    Ryden, L.7    Gallagher, W.M.8    O'brien, S.L.9
  • 204
    • 0043123069 scopus 로고    scopus 로고
    • Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: Association with treatment outcome
    • Span PN, Bussink J, Manders P, Beex LV, Sweep CG (2003) Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome. Br J Cancer 89:271-276
    • (2003) Br J Cancer , vol.89 , pp. 271-276
    • Span, P.N.1    Bussink, J.2    Manders, P.3    Beex, L.V.4    Sweep, C.G.5
  • 206
    • 82955203458 scopus 로고    scopus 로고
    • Biotechnology techniques for the development of new tumor specific peptides
    • Marr A, Markert A, Altmann A, Askoxylakis V, Haberkorn U (2011) Biotechnology techniques for the development of new tumor specific peptides. Methods 55:215-222
    • (2011) Methods , vol.55 , pp. 215-222
    • Marr, A.1    Markert, A.2    Altmann, A.3    Askoxylakis, V.4    Haberkorn, U.5


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