-
1
-
-
33845896020
-
Carbonic anhydrase inhibitors and activators and their use in therapy
-
Scozzafava, A., Mastrolorenzo, A. & Supuran, C. T. Carbonic anhydrase inhibitors and activators and their use in therapy. Expert Opin. Ther. Pat. 16, 1627-1664 (2006).
-
(2006)
Expert Opin. Ther. Pat
, vol.16
, pp. 1627-1664
-
-
Scozzafava, A.1
Mastrolorenzo, A.2
Supuran, C.T.3
-
2
-
-
1242303231
-
-
CRC, Boca Raton
-
Supuran, C. T., Scozzafava, A. & Conway, J. Carbonic Anbydrase - Its inhibitors and Activators 1-363 (CRC, Boca Raton, 2004).
-
(2004)
Carbonic Anbydrase - Its inhibitors and Activators
, pp. 1-363
-
-
Supuran, C.T.1
Scozzafava, A.2
Conway, J.3
-
3
-
-
0037369153
-
Carbonic anhydrase inhibitors
-
Supuran, C. T., Scozzafava, A. & Casini, A Carbonic anhydrase inhibitors. Med. Res. Rev. 23, 146-189 (2003).
-
(2003)
Med. Res. Rev
, vol.23
, pp. 146-189
-
-
Supuran, C.T.1
Scozzafava, A.2
Casini, A.3
-
4
-
-
0033823229
-
Prokaryotic carbonic anhydrases
-
Smith, K. S. & Ferry. J. G. Prokaryotic carbonic anhydrases. FEMS Microbiol. Rev. 24, 335-366 (2000).
-
(2000)
FEMS Microbiol. Rev
, vol.24
, pp. 335-366
-
-
Smith, K.S.1
Ferry, J.G.2
-
5
-
-
33750082400
-
Targeting tumor-associated carbonic anhydrase IX in cancer therapy
-
Thiry A. et al. Targeting tumor-associated carbonic anhydrase IX in cancer therapy. Trends Pharmacol. Sci, 27, 566-573 (2006).
-
(2006)
Trends Pharmacol. Sci
, vol.27
, pp. 566-573
-
-
Thiry, A.1
-
6
-
-
0034573012
-
-
New Horizons eds Chegwidden, W. R, Carter, N. D. & Edwards, Y. H, Birkhauser, Basel
-
Stams, T. & Christianson, D. W. in The Carbonic Anhydroses - New Horizons (eds Chegwidden, W. R., Carter, N. D. & Edwards, Y. H.) 159-174 (Birkhauser, Basel, 2000).
-
(2000)
The Carbonic Anhydroses
, pp. 159-174
-
-
Stams, T.1
Christianson, D.W.2
-
7
-
-
3442883664
-
Carbonic anhydrases: Current state of the art, therapeutic applications and future prospects
-
Pastorekava, S. et al. Carbonic anhydrases: Current state of the art, therapeutic applications and future prospects. J. Enzyme Inhib. Med. Chem. 19, 199-229 (2004).
-
(2004)
J. Enzyme Inhib. Med. Chem
, vol.19
, pp. 199-229
-
-
Pastorekava, S.1
-
8
-
-
35148870672
-
Carbonic anhydrase inhibitors. Cloning. characterization and inhibition studies of the cytosolic isozyme III with sulfonamides
-
Nishimori, I. et al. Carbonic anhydrase inhibitors. Cloning. characterization and inhibition studies of the cytosolic isozyme III with sulfonamides. Bioorg. Med. Chem. 15, 7229-7236 (2007).
-
(2007)
Bioorg. Med. Chem
, vol.15
, pp. 7229-7236
-
-
Nishimori, I.1
-
9
-
-
1242318777
-
Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides
-
Vullo, D. et al. Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides, J. Med. Chem. 47, 1272-1279 (2004).
-
(2004)
J. Med. Chem
, vol.47
, pp. 1272-1279
-
-
Vullo, D.1
-
10
-
-
28144452672
-
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors
-
Nishimori, I. et al. Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors. J. Med. Chem. 48, 7860-7866 (2005).
-
(2005)
J. Med. Chem
, vol.48
, pp. 7860-7866
-
-
Nishimori, I.1
-
11
-
-
33846458646
-
Carbonic anhydrase inhibitors. DNA cloning, characterization and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors
-
Nishimori, I. et al. Carbonic anhydrase inhibitors. DNA cloning, characterization and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors. J. Med. Chem. 50, 381-388 (2007).
-
(2007)
J. Med. Chem
, vol.50
, pp. 381-388
-
-
Nishimori, I.1
-
12
-
-
16244364782
-
Carbonic anhydrase inhibitors, Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides
-
Vullo. D. et al. Carbonic anhydrase inhibitors, Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. Bioorg. Med. Chem. Lett. 15, 971-976 (2005).
-
(2005)
Bioorg. Med. Chem. Lett
, vol.15
, pp. 971-976
-
-
Vullo, D.1
-
13
-
-
14844356668
-
-
eds Supuran, C. T, Soozzafava, A. & Conway J, CRC, Boca Raton
-
Nishimori, I. in Carbonic Anhydrose - Its Inhibitors and Activators (eds Supuran, C. T., Soozzafava, A. & Conway J.) 25-43 (CRC, Boca Raton, 2004).
-
(2004)
Carbonic Anhydrose - Its Inhibitors and Activators
, pp. 25-43
-
-
Nishimori, I.1
-
14
-
-
0037463790
-
Carbonic anhydrase inhibitors. Inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides
-
Vullo, D., et al. Carbonic anhydrase inhibitors. Inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides. Bioorg. Med. Chem. Lett. 13. 1005-1009 (2003).
-
(2003)
Bioorg. Med. Chem. Lett
, vol.13
, pp. 1005-1009
-
-
Vullo, D.1
-
15
-
-
16244377468
-
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides - a new target for the design of antitumor and antiglaucoma drugs?
-
Vullo, D. et al. Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides - a new target for the design of antitumor and antiglaucoma drugs? Bioorg. Med. Chem. Lett. 15, 963-969 (2005).
-
(2005)
Bioorg. Med. Chem. Lett
, vol.15
, pp. 963-969
-
-
Vullo, D.1
-
16
-
-
9144220136
-
Characterization of CA XIII. a novel member of the carbonic anhydrase isozyme family
-
Lehtonen, J. et al. Characterization of CA XIII. a novel member of the carbonic anhydrase isozyme family. J. Biol. Chem. 279, 2719-2727 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 2719-2727
-
-
Lehtonen, J.1
-
17
-
-
23244438502
-
Carbonic anhydrase inhibitors. inhibition of the transmembrane isozyme XIV with sulfonamides
-
Nishimori, I. et al. Carbonic anhydrase inhibitors. inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg. Med. Chem. Lett. 15, 3828-3833 (2005).
-
(2005)
Bioorg. Med. Chem. Lett
, vol.15
, pp. 3828-3833
-
-
Nishimori, I.1
-
18
-
-
33745644458
-
Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX
-
Alterio, V. et al. Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX. J. Am. Chem. Soc. 128, 8329-8335 (2006).
-
(2006)
J. Am. Chem. Soc
, vol.128
, pp. 8329-8335
-
-
Alterio, V.1
-
19
-
-
35048900931
-
Saccharin inhibits carbonic anhydrases: Possible explanation for its unpleasant metallic attertaste
-
Köhler, K. et al. Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic attertaste. Angew. Chem. Int. Ed. Engl. 46, 7697-7699 (2007).
-
(2007)
Angew. Chem. Int. Ed. Engl
, vol.46
, pp. 7697-7699
-
-
Köhler, K.1
-
20
-
-
0032433303
-
Carbonic anhydrase inhibitors. Part 29. Interaction of isozymes I, II and IV with benzolamide-like derivatives
-
Supuran, C. T., Ilies M. A. & Scozzafava, A. Carbonic anhydrase inhibitors. Part 29. Interaction of isozymes I, II and IV with benzolamide-like derivatives. Eur J. Med. Chem. 33, 739-752 (1998).
-
(1998)
Eur J. Med. Chem
, vol.33
, pp. 739-752
-
-
Supuran, C.T.1
Ilies, M.A.2
Scozzafava, A.3
-
21
-
-
0033919901
-
Carbonic anhydrase inhibitors. Synthesis of sulfonamides incorporating 2,4,6-trisubstituted-pyridinium-ethylcarboxamido moieties possessing membrane-impermeability and in vivo selectivity for the membrane-bound (CA IV) virsus the cytosolic (CA I and CA II) isozymes
-
Supuran, C. T, Scozzafava. A., Ilies M. A. & Briganti, F Carbonic anhydrase inhibitors. Synthesis of sulfonamides incorporating 2,4,6-trisubstituted-pyridinium-ethylcarboxamido moieties possessing membrane-impermeability and in vivo selectivity for the membrane-bound (CA IV) virsus the cytosolic (CA I and CA II) isozymes. J. Enz. Inhib. 15, 381-401 (2000).
-
(2000)
J. Enz. Inhib
, vol.15
, pp. 381-401
-
-
Supuran, C.T.1
Scozzafava, A.2
Ilies, M.A.3
Briganti, F.4
-
22
-
-
0034719437
-
Carbonic anhydrase inhibitors. Synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus the cytosolic isozymes
-
Scozzafava, A., Briganti, F, Ilies, M. A. & Supuran, C. T Carbonic anhydrase inhibitors. Synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus the cytosolic isozymes. J. Med Chem. 43 292-300 (2000).
-
(2000)
J. Med Chem
, vol.43
, pp. 292-300
-
-
Scozzafava, A.1
Briganti, F.2
Ilies, M.A.3
Supuran, C.T.4
-
23
-
-
33845353402
-
Carbonic anhydrase inhibitors: Clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue
-
Winum, J. Y. et al. Carbonic anhydrase inhibitors: Clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue. J. Med. Chem. 49, 7024-7031 (2006).
-
(2006)
J. Med. Chem
, vol.49
, pp. 7024-7031
-
-
Winum, J.Y.1
-
24
-
-
33746836508
-
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors
-
Saczewski, F. et al. Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors. Bioorg. Med. Chem. Lett. 16, 4846-4851 (2006).
-
(2006)
Bioorg. Med. Chem. Lett
, vol.16
, pp. 4846-4851
-
-
Saczewski, F.1
-
25
-
-
33748541296
-
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX
-
De Simone, G. et al. Carbonic anhydrase inhibitors: hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX. J. Med. Chem. 49, 5544-5551 (2006).
-
(2006)
J. Med. Chem
, vol.49
, pp. 5544-5551
-
-
De Simone, G.1
-
26
-
-
10444281634
-
Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: Towards antimalarials with a novel mechanism of action?
-
Krungkrai, J. et al. Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: Towards antimalarials with a novel mechanism of action? Bioorg. Med. Chem. 13, 483-489 (2005).
-
(2005)
Bioorg. Med. Chem
, vol.13
, pp. 483-489
-
-
Krungkrai, J.1
-
27
-
-
33645402549
-
Carbonic anhydrase inhibitors. DNA cloning and inhibition studies of the α-carbonic anhydrase from Helicobacter pylori: A new target for developing sulfonamide and sulfamate gastric drugs
-
Nishimori, I. et al. Carbonic anhydrase inhibitors. DNA cloning and inhibition studies of the α-carbonic anhydrase from Helicobacter pylori: A new target for developing sulfonamide and sulfamate gastric drugs. J. Med. Chem. 49, 2117-2126 (2006).
-
(2006)
J. Med. Chem
, vol.49
, pp. 2117-2126
-
-
Nishimori, I.1
-
28
-
-
34250171776
-
Carbonic anhydrase inhibitors. The β-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors
-
Nishimori, I. et al. Carbonic anhydrase inhibitors. The β-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors. Bioong. Med. Chem. Lett. 17, 3585-3594 (2007).
-
(2007)
Bioong. Med. Chem. Lett
, vol.17
, pp. 3585-3594
-
-
Nishimori, I.1
-
29
-
-
21444449107
-
Structure and function of carbonic anhydrases from Mycobacterium tuberculosis
-
Suarez Cavarrubias, A. et al. Structure and function of carbonic anhydrases from Mycobacterium tuberculosis. J. Biol. Chem. 280 18782-18789 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 18782-18789
-
-
Suarez Cavarrubias, A.1
-
30
-
-
27844459081
-
2 sensing with cAMP signaling and virulence
-
2 sensing with cAMP signaling and virulence. Curr. Biol. 15, 2021-2026 (2005).
-
(2005)
Curr. Biol
, vol.15
, pp. 2021-2026
-
-
Klengel, T.1
-
31
-
-
30944437608
-
2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac 1
-
2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac 1. Eukaryot. Cell 5, 103-111 (2006).
-
(2006)
Eukaryot. Cell
, vol.5
, pp. 103-111
-
-
Morgensen, E.G.1
-
32
-
-
27844610829
-
2 sensing during Cryptocococcus neoformans growth differentiation, and virulence
-
2 sensing during Cryptocococcus neoformans growth differentiation, and virulence. Curr. Biol. 15, 2013-2020 (2005).
-
(2005)
Curr. Biol
, vol.15
, pp. 2013-2020
-
-
Bahn, Y.S.1
-
33
-
-
33747375866
-
Identification and preliminary characterization of two cDNAs encoding unique carbonic anhydrases from the marine alga Emiliania huxleyi
-
Soto, A. R. et al. Identification and preliminary characterization of two cDNAs encoding unique carbonic anhydrases from the marine alga Emiliania huxleyi. Appl. Environ. Microbiol. 72, 5500-5511 (2006).
-
(2006)
Appl. Environ. Microbiol
, vol.72
, pp. 5500-5511
-
-
Soto, A.R.1
-
34
-
-
27444438834
-
Carbonic anhydrase (Nce103p): An essential biosynthetic enzyme for growth of Saccharomyces cerevisiae at atmospheric carbon dioxide pressure
-
Agiilera, J. et al. Carbonic anhydrase (Nce103p): An essential biosynthetic enzyme for growth of Saccharomyces cerevisiae at atmospheric carbon dioxide pressure. Biochem. J. 391, 311-316 (2005).
-
(2005)
Biochem. J
, vol.391
, pp. 311-316
-
-
Agiilera, J.1
-
35
-
-
0034569335
-
-
New Horizons eds Chegwidden, W. R, Carter, N. D. & Edwards, Y. H, Birkhauser, Basel
-
Supuran, C. T. & Scozzafava, A. in The Carbonic Anhydrases - New Horizons (eds Chegwidden, W. R., Carter, N. D. & Edwards, Y. H.) 197-219 (Birkhauser, Basel, 2000).
-
(2000)
The Carbonic Anhydrases
, pp. 197-219
-
-
Supuran, C.T.1
Scozzafava, A.2
-
36
-
-
7044228995
-
Carbonic anhydrase activators
-
eds Supuran, C. T, Scozzafava, A. & Conway, J, CRC, Boca Raton
-
Ilies, M. et al. Carbonic anhydrase activators. in Carbonic Anhydrase - Its Inhibitors and Activators (eds Supuran, C. T., Scozzafava, A. & Conway, J.) 317-352 (CRC, Boca Raton, 2004).
-
(2004)
Carbonic Anhydrase - Its Inhibitors and Activators
, pp. 317-352
-
-
Ilies, M.1
-
37
-
-
0030772018
-
Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine
-
Briganti, F. et al. Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine. Biochemistry 36, 10384-10392 (1997).
-
(1997)
Biochemistry
, vol.36
, pp. 10384-10392
-
-
Briganti, F.1
-
38
-
-
33749039202
-
-
Temperini, C. et al. Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII and XIV with L- and D-histidine and crystallographic analysis of their adducts with isoform II: Engineering proton transfer processes within the active site of an enzyme. Chemistry 12, 7057-7066 (2006).
-
Temperini, C. et al. Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII and XIV with L- and D-histidine and crystallographic analysis of their adducts with isoform II: Engineering proton transfer processes within the active site of an enzyme. Chemistry 12, 7057-7066 (2006).
-
-
-
-
39
-
-
33646751543
-
-
Temperini, C. et al. Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D-phenylalanine and crystallographic analysis of their aciducts with isozyme II: sterospecific recognition within the active site of an enzyme and its consequences for the drug design. J. Med. Chem. 49, 3019-3027 (2006).
-
Temperini, C. et al. Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L- and D-phenylalanine and crystallographic analysis of their aciducts with isozyme II: sterospecific recognition within the active site of an enzyme and its consequences for the drug design. J. Med. Chem. 49, 3019-3027 (2006).
-
-
-
-
40
-
-
0036468837
-
Carbonic anhydrase gating of attention: Memory therapy and enhancement
-
Sun, M.-K. & Alkon, D. L. Carbonic anhydrase gating of attention: Memory therapy and enhancement. Trends Pharmacol. Sci. 23, 83-89 (2002).
-
(2002)
Trends Pharmacol. Sci
, vol.23
, pp. 83-89
-
-
Sun, M.-K.1
Alkon, D.L.2
-
41
-
-
33846283799
-
-
Temperini, C. et al. Carbonic anhydrase activators: L-adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV. Bioorg. Med. Chem. Lett. 17, 628-635 (2007).
-
Temperini, C. et al. Carbonic anhydrase activators: L-adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV. Bioorg. Med. Chem. Lett. 17, 628-635 (2007).
-
-
-
-
42
-
-
33746387986
-
Diuretic therapy in heart failure
-
Splendiani, G. & Condo, S. Diuretic therapy in heart failure. G. Ital. Nefrol. 23, S74-S76 (2006).
-
(2006)
G. Ital. Nefrol
, vol.23
-
-
Splendiani, G.1
Condo, S.2
-
43
-
-
0042320596
-
+-secreting cells of mouse and rat kidney
-
+-secreting cells of mouse and rat kidney. J. Histochem. Cytochem. 51, 1217-1224 (2003).
-
(2003)
J. Histochem. Cytochem
, vol.51
, pp. 1217-1224
-
-
Kyllonen, M.S.1
-
44
-
-
34249739237
-
The development of topically acting carbonic anhydrase inhibitors as anti-glaucoma agents
-
Mincione, F. et al. The development of topically acting carbonic anhydrase inhibitors as anti-glaucoma agents. Curr. Top. Med. Chem. 7, 849-854 (2007).
-
(2007)
Curr. Top. Med. Chem
, vol.7
, pp. 849-854
-
-
Mincione, F.1
-
45
-
-
0033990833
-
Pharmacological and ocular hypotensive properties of topical carbonic anhydrase inhibitors
-
Sugrue, M. F. Pharmacological and ocular hypotensive properties of topical carbonic anhydrase inhibitors. Prog. Retin. Eye Res. 19 87-112 (2000).
-
(2000)
Prog. Retin. Eye Res
, vol.19
, pp. 87-112
-
-
Sugrue, M.F.1
-
46
-
-
0033566151
-
Carbonic anhydrase inhibitors. Part 74. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: Is the tail more important than the ring?
-
Scozzafava, A. et al. Carbonic anhydrase inhibitors. Part 74. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: Is the tail more important than the ring? J. Med. Chem. 42, 2641-2650 (1999).
-
(1999)
J. Med. Chem
, vol.42
, pp. 2641-2650
-
-
Scozzafava, A.1
-
47
-
-
0033539043
-
Carbonic anhydrase inhibitors: Synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route
-
Scozzafava, A. et al. Carbonic anhydrase inhibitors: Synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route. J. Med. Chem. 42, 3690-3700 (1999).
-
(1999)
J. Med. Chem
, vol.42
, pp. 3690-3700
-
-
Scozzafava, A.1
-
48
-
-
0033866735
-
Carbonic anhydrase inhibitors: Sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions
-
Ilies, M. et al. Carbonic anhydrase inhibitors: Sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions. Bioorg. Med. Chem. 8, 2145-2155 (2000).
-
(2000)
Bioorg. Med. Chem
, vol.8
, pp. 2145-2155
-
-
Ilies, M.1
-
49
-
-
0034676310
-
Carbonic anhydrase inhibitors: Perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action
-
Scozzafava, A. et al. Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action. J. Med. Chem. 43, 4542-4551 (2000).
-
(2000)
J. Med. Chem
, vol.43
, pp. 4542-4551
-
-
Scozzafava, A.1
-
50
-
-
0037187391
-
Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties
-
Scozzafava, A. et al. Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties. J. Med. Chem. 45, 1466-1476 (2002).
-
(2002)
J. Med. Chem
, vol.45
, pp. 1466-1476
-
-
Scozzafava, A.1
-
51
-
-
0347517808
-
Carbonic anhydrase inhibitors: N (p-sulfamoylphenyl)-α-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits
-
Winum, J. Y. et al. Carbonic anhydrase inhibitors: N (p-sulfamoylphenyl)-α-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits. Bioorg. Med. Chem. Lett. 14, 225-229 (2004).
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 225-229
-
-
Winum, J.Y.1
-
52
-
-
0023793580
-
Treatment of chronic macular edema with acetazolamide
-
Cox, S. N. et al. Treatment of chronic macular edema with acetazolamide. Arch. Ophthalmol. 106, 1190-1195 (1988).
-
(1988)
Arch. Ophthalmol
, vol.106
, pp. 1190-1195
-
-
Cox, S.N.1
-
53
-
-
33846991924
-
Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation
-
Gao, B. B. et al. Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. Nature Med. 13, 181-188 (2007).
-
(2007)
Nature Med
, vol.13
, pp. 181-188
-
-
Gao, B.B.1
-
54
-
-
5144224910
-
-
eds Supuran, C. T, Scozzafava, A. & Conway, J, CRC, Boca Raton
-
Supuran, C. T. et al. in Carbonic Anhydrase - Its Inhibitors and Activators (eds Supuran, C. T., Scozzafava, A. & Conway, J.) 67-147 (CRC, Boca Raton, 2004).
-
(2004)
Carbonic Anhydrase - Its Inhibitors and Activators
, pp. 67-147
-
-
Supuran, C.T.1
-
55
-
-
0028928792
-
The development of topical carbonic anhydrase inhibitors
-
Maren, T. H. The development of topical carbonic anhydrase inhibitors. J. Glaucoma 4, 49-62 (1995).
-
(1995)
J. Glaucoma
, vol.4
, pp. 49-62
-
-
Maren, T.H.1
-
56
-
-
16244381734
-
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides
-
Innocenti, X et al. Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg. Med. Chem. Lett. 15, 1149-1154 (2005).
-
(2005)
Bioorg. Med. Chem. Lett
, vol.15
, pp. 1149-1154
-
-
Innocenti, X.1
-
57
-
-
0037374846
-
Expression of cell surface transmembrane carbonic anhydrase genes CA9-and CA12 in the human eye: Overexpression of CA12 (CA XII) in glaucoma
-
Liao, S. Y. et al. Expression of cell surface transmembrane carbonic anhydrase genes CA9-and CA12 in the human eye: Overexpression of CA12 (CA XII) in glaucoma. J. Med. Genet. 40, 257-261 (2003).
-
(2003)
J. Med. Genet
, vol.40
, pp. 257-261
-
-
Liao, S.Y.1
-
58
-
-
0242551296
-
Carbonic anhydrase inhibitors in the treatment and prophylaxis of obesity
-
Supuran, C. T. Carbonic anhydrase inhibitors in the treatment and prophylaxis of obesity. Expert Opin. Ther. Pat. 13, 1545-1550 (2003).
-
(2003)
Expert Opin. Ther. Pat
, vol.13
, pp. 1545-1550
-
-
Supuran, C.T.1
-
59
-
-
0344193512
-
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/ sulfamides with isozymes I. II and IV
-
Casini, A. et al. Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/ sulfamides with isozymes I. II and IV. Bioorg. Med. Chem. Lett. 113, 841-845 (2003).
-
(2003)
Bioorg. Med. Chem. Lett
, vol.113
, pp. 841-845
-
-
Casini, A.1
-
60
-
-
0034576649
-
Topiramate reduces energy and fat gains in lean (Fal?) and obese (fa/fa) Zucker rats
-
Picard, F. et al. Topiramate reduces energy and fat gains in lean (Fal?) and obese (fa/fa) Zucker rats. Obesity Res. 8, 656-663 (2000).
-
(2000)
Obesity Res
, vol.8
, pp. 656-663
-
-
Picard, F.1
-
61
-
-
17144375722
-
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: Solution and X-ray crystallographic studies
-
De Simone, G. et a. Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: Solution and X-ray crystallographic studies. Bioorg. Med. Chem. Lett. 15, 2315-2320 (2005).
-
(2005)
Bioorg. Med. Chem. Lett
, vol.15
, pp. 2315-2320
-
-
De Simone, G.1
et a2
-
62
-
-
0038516857
-
Zonisamide for weight loss in obese adults: A randomized controlled trial
-
Gadde, K. M. et al. Zonisamide for weight loss in obese adults: A randomized controlled trial. JAMA 289, 1820-1825 (2003).
-
(2003)
JAMA
, vol.289
, pp. 1820-1825
-
-
Gadde, K.M.1
-
63
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell, P. H., et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271-275 (1999).
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
-
64
-
-
4544388351
-
-
eds Supuran, C. T, Scozzafava, A. & Conway, J, CRC, Boca Raton
-
Pastorekava, S. & Pastorek. J. in Carbonic Anhydrase - Its Inhibitors and Activators (eds Supuran, C. T., Scozzafava, A. & Conway, J.) 255-281 (CRC, Boca Raton, 2004).
-
(2004)
Carbonic Anhydrase - Its Inhibitors and Activators
, pp. 255-281
-
-
Pastorekava, S.1
Pastorek, J.2
-
66
-
-
34447504549
-
Oxygen, a source of life and stress
-
Brahimi-Hom, M. C. & Pouyssegur, J. Oxygen, a source of life and stress. FEBS Lett. 581, 3582-3591 (2007).
-
(2007)
FEBS Lett
, vol.581
, pp. 3582-3591
-
-
Brahimi-Hom, M.C.1
Pouyssegur, J.2
-
67
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science 292, 468-472 (2001).
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
-
68
-
-
18444368709
-
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
-
Hon, W. C. et al. Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL. Nature 417, 975-978 (2002).
-
(2002)
Nature
, vol.417
, pp. 975-978
-
-
Hon, W.C.1
-
69
-
-
0034533143
-
Targeting tumors through the HIF system
-
Ratcliffe, P. J. et al. Targeting tumors through the HIF system. Nature Med. 6, 1315-1316 (2000).
-
(2000)
Nature Med
, vol.6
, pp. 1315-1316
-
-
Ratcliffe, P.J.1
-
70
-
-
33847649279
-
HIF-1α and CA IX staining in invasive breast carcinomas: Prognosis and treatment outcome
-
Trastour, C. et al. HIF-1α and CA IX staining in invasive breast carcinomas: Prognosis and treatment outcome. Int. J. Cancer 120 1451-1458 (2007).
-
(2007)
Int. J. Cancer
, vol.120
, pp. 1451-1458
-
-
Trastour, C.1
-
71
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
Pouyssegur, J. et al. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441, 437-443 (2006).
-
(2006)
Nature
, vol.441
, pp. 437-443
-
-
Pouyssegur, J.1
-
72
-
-
34447109377
-
An investigation into the prognostic significance of necrosis and hypoxia in high grade and invasive bladder cancer
-
Ord, J. J. et al. An investigation into the prognostic significance of necrosis and hypoxia in high grade and invasive bladder cancer. J. Urol. 178, 677-682 (2007).
-
(2007)
J. Urol
, vol.178
, pp. 677-682
-
-
Ord, J.J.1
-
73
-
-
34447547148
-
Regulation of tumor pH and the role of carbonic anhydrase 9
-
Swietach, P. et al. Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Rev. 26, 299-310 (2007).
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 299-310
-
-
Swietach, P.1
-
74
-
-
19944429962
-
Hypoxia-inducible factor 1-α expression as an intrinsic marker of hypoxia: Correlation with tumor oxygen, pimonidazole measurements and outcome in locally advanced carcinoma of the cervix
-
Hutchison, G. J. et al. Hypoxia-inducible factor 1-α expression as an intrinsic marker of hypoxia: Correlation with tumor oxygen, pimonidazole measurements and outcome in locally advanced carcinoma of the cervix. Clin. Cancer Res. 10, 8405-8412 (2004).
-
(2004)
Clin. Cancer Res
, vol.10
, pp. 8405-8412
-
-
Hutchison, G.J.1
-
75
-
-
34250029178
-
Genome-wide expression analysis using microarray identified complex signaling pathways modulated by hypoxia in gasopharyngeal carcinoma
-
Sung, F. L. et al. Genome-wide expression analysis using microarray identified complex signaling pathways modulated by hypoxia in gasopharyngeal carcinoma. Cancer Lett. 253, 74-88 (2007).
-
(2007)
Cancer Lett
, vol.253
, pp. 74-88
-
-
Sung, F.L.1
-
76
-
-
10444271234
-
Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer
-
Koukourakis, M. I. et al. Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 59, 67-71 (2004).
-
(2004)
Int. J. Radiat. Oncol. Biol. Phys
, vol.59
, pp. 67-71
-
-
Koukourakis, M.I.1
-
77
-
-
0042847064
-
Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer
-
Potter, C. P. & Harris, A.-L Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer. Br. J. Cancer 89 2-7 (2003).
-
(2003)
Br. J. Cancer
, vol.89
, pp. 2-7
-
-
Potter, C.P.1
Harris, A.-L.2
-
78
-
-
33846211525
-
Hypoxia regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer
-
Hussain, S. A. et al. Hypoxia regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer. Br. J. Cancer 96, 104-109 (2007).
-
(2007)
Br. J. Cancer
, vol.96
, pp. 104-109
-
-
Hussain, S.A.1
-
79
-
-
0037315252
-
Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer
-
Swinson, D. E. et al. Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. J. Clin. Oncol. 21, 473-482 (2003).
-
(2003)
J. Clin. Oncol
, vol.21
, pp. 473-482
-
-
Swinson, D.E.1
-
80
-
-
33845654683
-
Role of carbonic anhydrases in the progression of renal cell carcinoma subtypes: Proposal of a unified hypothesis
-
Dorai, T. et al. Role of carbonic anhydrases in the progression of renal cell carcinoma subtypes: Proposal of a unified hypothesis. Cancer Invest. 24, 754-779 (2006).
-
(2006)
Cancer Invest
, vol.24
, pp. 754-779
-
-
Dorai, T.1
-
81
-
-
0346252639
-
Carbonic anhydrase inhibitors: X ray crystallographic structure of the adduct of human isozyme II with a EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase
-
Abbate, F. et al. Carbonic anhydrase inhibitors: X ray crystallographic structure of the adduct of human isozyme II with a EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase. Bioorg. Med. Chem. Lett. 14, 231-234 (2004).
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 231-234
-
-
Abbate, F.1
-
82
-
-
27944498514
-
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related, cyclooxygenase II "selective" inhibitor celecoxib
-
Di Fiore, A. et al. Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related, cyclooxygenase II "selective" inhibitor celecoxib. Bioorg. Med. Chem. Lett. 16, 437-442 (2006).
-
(2006)
Bioorg. Med. Chem. Lett
, vol.16
, pp. 437-442
-
-
Di Fiore, A.1
-
83
-
-
0347360282
-
Carbonic anhydrase inhibitors: X ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride
-
Abbate, F. et al. Carbonic anhydrase inhibitors: X ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride. Bioorg. Med. Chem. Lett. 14, 337-341 (2004).
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 337-341
-
-
Abbate, F.1
-
84
-
-
8844249356
-
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH
-
Svastova, E. et al. Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Lett. 577, 439-445 (2004).
-
(2004)
FEBS Lett
, vol.577
, pp. 439-445
-
-
Svastova, E.1
-
85
-
-
22744446294
-
Carbonic anhydrase inhibitors. Sulfonamides inhibit isozyme IX mediated acidification of hypoxic tumors. Fluorescent sulfonamides design as probes of membrane-bound carbonic anhydrase isozymes involvement in tumorigenesis
-
Cecchi, A. et al. Carbonic anhydrase inhibitors. Sulfonamides inhibit isozyme IX mediated acidification of hypoxic tumors. Fluorescent sulfonamides design as probes of membrane-bound carbonic anhydrase isozymes involvement in tumorigenesis. J. Med. Chem. 48, 4834-4841 (2005).
-
(2005)
J. Med. Chem
, vol.48
, pp. 4834-4841
-
-
Cecchi, A.1
-
86
-
-
24744467784
-
Carbonic anhydrase inhibitors: Stacking with Phe 131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II
-
Menchise, V. et al. Carbonic anhydrase inhibitors: Stacking with Phe 131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II. J. Med. Chem. 48, 5721-5727 (2005).
-
(2005)
J. Med. Chem
, vol.48
, pp. 5721-5727
-
-
Menchise, V.1
-
87
-
-
0037911231
-
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives
-
Ilies, M. A., et al. Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives. J. Med. Chem. 46 2187-2196 (2003).
-
(2003)
J. Med. Chem
, vol.46
, pp. 2187-2196
-
-
Ilies, M.A.1
-
88
-
-
0038587356
-
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors
-
Winum, J. Y. et al. Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors. J. Med. Chem. 46, 2197-2204 (2003).
-
(2003)
J. Med. Chem
, vol.46
, pp. 2197-2204
-
-
Winum, J.Y.1
-
89
-
-
0344981308
-
Carbonic anhydrase inhibitors: Inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates
-
Winum, J. Y. et al. Carbonic anhydrase inhibitors: Inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates. J. Med. Chem. 46, 5471-5477 (2003).
-
(2003)
J. Med. Chem
, vol.46
, pp. 5471-5477
-
-
Winum, J.Y.1
-
90
-
-
0842281270
-
Carbonic anhydrase inhibitors: The first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX
-
Pastorekova, S. et al. Carbonic anhydrase inhibitors: The first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX Bioorg. Med. Chem. Lett. 14, 869-873 (2004).
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 869-873
-
-
Pastorekova, S.1
-
91
-
-
1842790839
-
Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered
-
Vullo, D. et al. Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered. Bioorg. Med. Chem. Lett. 14, 2351-2356 (2004).
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 2351-2356
-
-
Vullo, D.1
-
92
-
-
1842628633
-
Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX
-
Casey, J. R. et al. Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX. J. Med. Chem. 47, 2337-2347 (2004).
-
(2004)
J. Med. Chem
, vol.47
, pp. 2337-2347
-
-
Casey, J.R.1
-
93
-
-
3242668792
-
COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents
-
Supuran, C. T. et al. COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents. Mini Rev. Med. Chem. 4 625-632 (2004).
-
(2004)
Mini Rev. Med. Chem
, vol.4
, pp. 625-632
-
-
Supuran, C.T.1
-
94
-
-
5344225272
-
-
Garaj, V. et al. Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties. Bioorg. Med. Chem. Lett. 14, 5427-5433 (2004).
-
Garaj, V. et al. Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties. Bioorg. Med. Chem. Lett. 14, 5427-5433 (2004).
-
-
-
-
95
-
-
4744371616
-
Carbonic anhydrase inhibitors: The first on-resin screening of a 4-sulfamoylphenylthiourea library
-
Innocenti, A. et al. Carbonic anhydrase inhibitors: The first on-resin screening of a 4-sulfamoylphenylthiourea library. J. Med. Chem. 47, 5224-5229 (2004).
-
(2004)
J. Med. Chem
, vol.47
, pp. 5224-5229
-
-
Innocenti, A.1
-
96
-
-
7044241041
-
-
Cecchi, A. et al. Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfanamides derived from 4-isothiocyanato-benzolamide. Bioorg. Med. Chem. Lett. 14, 5775-5780 (2004).
-
Cecchi, A. et al. Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfanamides derived from 4-isothiocyanato-benzolamide. Bioorg. Med. Chem. Lett. 14, 5775-5780 (2004).
-
-
-
-
97
-
-
15444377021
-
-
Winum, J. Y. et al. Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfanamides incorporating hydrazino moieties. J. Med. Chem. 48, 2121-2125 (2005).
-
Winum, J. Y. et al. Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfanamides incorporating hydrazino moieties. J. Med. Chem. 48, 2121-2125 (2005).
-
-
-
-
98
-
-
12444328856
-
-
Winum, J. Y. et al. Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg. Med. Chem. Lett. 15, 579-584 (2005).
-
Winum, J. Y. et al. Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg. Med. Chem. Lett. 15, 579-584 (2005).
-
-
-
-
99
-
-
17244376080
-
-
Winum, J. Y. et al. Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides - a new zinc-binding function in the design of inhibitors. Bioorg. Med. Chem. Lett. 15, 2353-2358 (2005).
-
Winum, J. Y. et al. Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides - a new zinc-binding function in the design of inhibitors. Bioorg. Med. Chem. Lett. 15, 2353-2358 (2005).
-
-
-
-
100
-
-
20444409690
-
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II. and IX with boron-containing sulfanamides, sulfamides, and sulfamates: Toward agents for boron neutron capture therapy of hypoxic tumors
-
Winum, J. Y. et al. Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II. and IX with boron-containing sulfanamides, sulfamides, and sulfamates: Toward agents for boron neutron capture therapy of hypoxic tumors. Bioorg. Med. Chem. Lett. 15, 3302-3306 (2005).
-
(2005)
Bioorg. Med. Chem. Lett
, vol.15
, pp. 3302-3306
-
-
Winum, J.Y.1
-
101
-
-
33646446585
-
Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX
-
Thiry, A. et al. Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J. Med. Chem. 49, 2743-2749 (2006).
-
(2006)
J. Med. Chem
, vol.49
, pp. 2743-2749
-
-
Thiry, A.1
-
102
-
-
33750471952
-
A novel class of carbonic anhydrase inhibitors: Glycoconjugate benzene sulfonamides prepared by "click-tailing
-
Wilkinson, B. L. et al. A novel class of carbonic anhydrase inhibitors: Glycoconjugate benzene sulfonamides prepared by "click-tailing". J. Med. Chem. 49, 6539-6548 (2006).
-
(2006)
J. Med. Chem
, vol.49
, pp. 6539-6548
-
-
Wilkinson, B.L.1
-
103
-
-
34147144592
-
-
Wilkinson, B, L. et al. Carbonic anhydrase inhibitors: Inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides. J. Med. Chem. 50, 1651-1657 (2007).
-
Wilkinson, B, L. et al. Carbonic anhydrase inhibitors: Inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides. J. Med. Chem. 50, 1651-1657 (2007).
-
-
-
-
104
-
-
34250322126
-
Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors
-
Dubois, L. et al. Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors. Radiother. Oncol. 83, 367-373 (2007).
-
(2007)
Radiother. Oncol
, vol.83
, pp. 367-373
-
-
Dubois, L.1
-
105
-
-
0348147633
-
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX
-
Abbate, F. et al. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg. Med. Chem. Lett. 14, 217-223 (2004).
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 217-223
-
-
Abbate, F.1
-
106
-
-
0037168033
-
Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl)-amino]-3-pyridinyl]-4-methoxy- benzenesulfonamide and N-(3-chloro-7-indolyl)-1, 4-benzenedisulfonamide
-
Owa, T. et al. Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl)-amino]-3-pyridinyl]-4-methoxy- benzenesulfonamide and N-(3-chloro-7-indolyl)-1, 4-benzenedisulfonamide. J. Med. Chem. 45, 4913-4922 (2002).
-
(2002)
J. Med. Chem
, vol.45
, pp. 4913-4922
-
-
Owa, T.1
-
107
-
-
0033598320
-
Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle
-
Owa, T. et al. Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle. J. Med. Chem. 42, 3789-3799 (1999).
-
(1999)
J. Med. Chem
, vol.42
, pp. 3789-3799
-
-
Owa, T.1
-
108
-
-
34250167232
-
A randomized phase II pharmacokinetic and pharmacodynamic studly of indisulam as second-line therapy in patients with advanced non-small cell lung cancer
-
Talbot, D. C. et al. A randomized phase II pharmacokinetic and pharmacodynamic studly of indisulam as second-line therapy in patients with advanced non-small cell lung cancer. Clin. Cancer Res. 13 1816-1822 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 1816-1822
-
-
Talbot, D.C.1
-
109
-
-
33847741352
-
Membrane-bound carbonic anhydrases in osteoclasts
-
Riihonen, R. et al. Membrane-bound carbonic anhydrases in osteoclasts. Bone 40, 1021-1031 (2007).
-
(2007)
Bone
, vol.40
, pp. 1021-1031
-
-
Riihonen, R.1
-
110
-
-
3843150633
-
Carbonic anhydrase inhibitors. Inhibition of the β-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions
-
Innocenti, A. et al. Carbonic anhydrase inhibitors. Inhibition of the β-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions. Bioorg. Med. Chem. Lett. 14, 4563-4567 (2004).
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 4563-4567
-
-
Innocenti, A.1
-
111
-
-
8844286179
-
Carbonic anhydrase inhibitors. Inhibition of the prokariotic β and γ-class enzymes from Archaea with sulfonamides
-
Zimmerman, S. A. et al. Carbonic anhydrase inhibitors. Inhibition of the prokariotic β and γ-class enzymes from Archaea with sulfonamides. Bioorg. Med. Chem. Lett. 14, 6001-6006 (2004).
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 6001-6006
-
-
Zimmerman, S.A.1
-
112
-
-
34249720676
-
Inhibition of the archaeal β-Class (Cab) and γ-Class (Cam) carbonic anhydrases
-
Zimmerman, S. A., Ferry, J. G. & Supuran C. T. Inhibition of the archaeal β-Class (Cab) and γ-Class (Cam) carbonic anhydrases. Curr. Top. Med. Chem. 7, 901-908 (2007).
-
(2007)
Curr. Top. Med. Chem
, vol.7
, pp. 901-908
-
-
Zimmerman, S.A.1
Ferry, J.G.2
Supuran, C.T.3
-
113
-
-
0342468068
-
Pharmacological enhancement of synaptic efficacy, spatial learning, and memory through carbonic anhydrase activation in rats
-
Sun, M. K. & Alkon, D. L. Pharmacological enhancement of synaptic efficacy, spatial learning, and memory through carbonic anhydrase activation in rats. J. Pharmacol. Exp. Ther. 297, 961-967 (2001).
-
(2001)
J. Pharmacol. Exp. Ther
, vol.297
, pp. 961-967
-
-
Sun, M.K.1
Alkon, D.L.2
-
114
-
-
0028142654
-
Carbonic anhydrase activators. Part 3. Structure-activity correlations for a series of isozyme II activators
-
Supuran, C. T. & Clare, B. W. Carbonic anhydrase activators. Part 3. Structure-activity correlations for a series of isozyme II activators. J. Pharm. Sci. 83, 768-773 (1994).
-
(1994)
J. Pharm. Sci
, vol.83
, pp. 768-773
-
-
Supuran, C.T.1
Clare, B.W.2
-
115
-
-
0033384171
-
Carbonic anhydrase activators: Amino acyl/dipeptidyl histamine derivatives bind with high affinity to isozymes I, II and IV and act as efficient activators
-
Supuran, C. T. & Scozzafava, A. Carbonic anhydrase activators: Amino acyl/dipeptidyl histamine derivatives bind with high affinity to isozymes I, II and IV and act as efficient activators. Bioorg. Med. Chem. 7, 2915-2923 (1999).
-
(1999)
Bioorg. Med. Chem
, vol.7
, pp. 2915-2923
-
-
Supuran, C.T.1
Scozzafava, A.2
-
116
-
-
0037122754
-
-
Scozzafava, A. & Supuran, C. T. Carbonic anhydrase activators: High affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scafold. J. Med. Chem. 45, 284-291 (2002).
-
Scozzafava, A. & Supuran, C. T. Carbonic anhydrase activators: High affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scafold. J. Med. Chem. 45, 284-291 (2002).
-
-
-
-
117
-
-
0037122755
-
-
Ilies, M. et al. Carbonic anhydrase activators: Design of high affinity isozymes I, II, and IV activators, incorporating tri-/ tetrasubstituted-pyridinium-azole moieties. J. Med. Chem. 45 504-510 (2002).
-
Ilies, M. et al. Carbonic anhydrase activators: Design of high affinity isozymes I, II, and IV activators, incorporating tri-/ tetrasubstituted-pyridinium-azole moieties. J. Med. Chem. 45 504-510 (2002).
-
-
-
-
118
-
-
0037156347
-
Carbonic anhydrase activators: Human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1
-
Scozzafava, A. & Supuran, C. T. Carbonic anhydrase activators: Human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1. Bioorg. Med. Chem. Lett. 12, 1177-1180 (2002).
-
(2002)
Bioorg. Med. Chem. Lett
, vol.12
, pp. 1177-1180
-
-
Scozzafava, A.1
Supuran, C.T.2
-
119
-
-
33746918325
-
Carbonic anhydrase activators: Activation of isozyme XIII with amino acids and amines
-
Parkkila, S. et al. Carbonic anhydrase activators: Activation of isozyme XIII with amino acids and amines. Bioorg. Med. Chem. Lett. 16, 3955-3959 (2006).
-
(2006)
Bioorg. Med. Chem. Lett
, vol.16
, pp. 3955-3959
-
-
Parkkila, S.1
-
120
-
-
33747520016
-
Carbonic anhydrase activators: The first X-ray crystallographic study of an adduct of isoform I
-
Temperini, C. et al. Carbonic anhydrase activators: The first X-ray crystallographic study of an adduct of isoform I. Bioorg. Med. Chem. Lett. 16, 5152-5156 (2006).
-
(2006)
Bioorg. Med. Chem. Lett
, vol.16
, pp. 5152-5156
-
-
Temperini, C.1
-
121
-
-
34249946261
-
Carbonic anhydrase activators: The first activation study of the human secretory isoform VI with amino acids and amines
-
Nishimori, I. et al. Carbonic anhydrase activators: The first activation study of the human secretory isoform VI with amino acids and amines. Bioorg. Med. Chem. Lett. 17, 5351-5357 (2007).
-
(2007)
Bioorg. Med. Chem. Lett
, vol.17
, pp. 5351-5357
-
-
Nishimori, I.1
|