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Volumn 5, Issue 10, 2005, Pages 786-795

The role of disturbed pH dynamics and the NA+/H+ exchanger in metastasis

Author keywords

[No Author keywords available]

Indexed keywords

COTRANSPORTER; HYDROGEN LACTATE COTRANSPORTER; PROTEIN INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN 1; UNCLASSIFIED DRUG;

EID: 25844528025     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1713     Document Type: Review
Times cited : (773)

References (77)
  • 1
    • 0036793223 scopus 로고    scopus 로고
    • MRI of the tumor microenvironment
    • Gillies, R. J., Raghunand, N., Karczmar, G. S. & Bhujwalla, Z. M. MRI of the tumor microenvironment. J. Magn. Reson. Imaging 16, 430-450 (2002). A comprehensive review of the distribution, role and methods of measuring the metabolic microenvironment
    • (2002) J. Magn. Reson. Imaging , vol.16 , pp. 430-450
    • Gillies, R.J.1    Raghunand, N.2    Karczmar, G.S.3    Bhujwalla, Z.M.4
  • 2
    • 0030754527 scopus 로고    scopus 로고
    • Breast cancer cells have a high capacity to acidify extracellular milieu by a dual mechanism
    • Montcourrier, P., Silver, I., Farnoud, R., Bird, I. & Rochefort, H. Breast cancer cells have a high capacity to acidify extracellular milieu by a dual mechanism. Clin. Exp. Metastasis 15, 382-392 (1997).
    • (1997) Clin. Exp. Metastasis , vol.15 , pp. 382-392
    • Montcourrier, P.1    Silver, I.2    Farnoud, R.3    Bird, I.4    Rochefort, H.5
  • 3
    • 0031033146 scopus 로고    scopus 로고
    • The relationship between extracellular lactate and tumour pH in a murine tumour model of ischaemia-reperfusion
    • Parkins, C. S., Stratford, M. R., Dennis, M. F., Stubbs, M. & Chaplin, D. J. The relationship between extracellular lactate and tumour pH in a murine tumour model of ischaemia-reperfusion. Br. J. Cancer 75, 319-323 (1997).
    • (1997) Br. J. Cancer , vol.75 , pp. 319-323
    • Parkins, C.S.1    Stratford, M.R.2    Dennis, M.F.3    Stubbs, M.4    Chaplin, D.J.5
  • 4
    • 0024286746 scopus 로고
    • Regulation of intracellular pH in eukaryotic cells
    • Madshus, I. H. Regulation of intracellular pH in eukaryotic cells. Biochem. J. 250, 1-8 (1988).
    • (1988) Biochem. J. , vol.250 , pp. 1-8
    • Madshus, I.H.1
  • 5
    • 0023111890 scopus 로고
    • Microinjection of ras p21 induces a rapid rise in intracellular pH
    • Hagag, N., Lacal, J. C., Graber, M., Aaronson, S. & Viola, M. V. Microinjection of ras p21 induces a rapid rise in intracellular pH. Mol. Cell. Biol. 7, 1984-1988 (1987). The first paper to show directly that microinjection of oncogenic RAS causes a rapid alkalinization of cells.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 1984-1988
    • Hagag, N.1    Lacal, J.C.2    Graber, M.3    Aaronson, S.4    Viola, M.V.5
  • 6
    • 0028156363 scopus 로고
    • + antiporter in normal and transformed human lymphocytes and fibroblasts
    • + antiporter in normal and transformed human lymphocytes and fibroblasts. Am. J. Physiol. 267, C745-C752 (1994).
    • (1994) Am. J. Physiol. , vol.267
    • Siczkowski, M.1    Davies, J.E.2    Ng, L.L.3
  • 7
  • 8
    • 0023223937 scopus 로고
    • Intracellular pH is increased after transformation of Chinese hamster embryo fibroblasts
    • Ober, S. S. & Pardee, A. B. Intracellular pH is increased after transformation of Chinese hamster embryo fibroblasts. Proc. Natl Acad. Sci. USA 84, 2766-2770 (1987).
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , pp. 2766-2770
    • Ober, S.S.1    Pardee, A.B.2
  • 9
    • 0033746761 scopus 로고    scopus 로고
    • + exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes
    • + exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation- associated phenotypes. FASEB J. 14, 2185-2197 (2000). This study showed that in HPV16E7-transformed cells, NHE1-dependent cellular alkalinization is an early event in neoplastic transformation that drives aerobic glycolysis, proliferation, serum- and anchorage-independent growth and formation of keratinocyte tumours in nude mice.
    • (2000) FASEB J. , vol.14 , pp. 2185-2197
    • Reshkin, S.J.1
  • 10
    • 0024254916 scopus 로고
    • +-antiporter and mobilization of intracellular calcium
    • +-antiporter and mobilization of intracellular calcium. Adv. Enzyme Regul. 27, 121-131 (1988).
    • (1988) Adv. Enzyme Regul. , vol.27 , pp. 121-131
    • Maly, K.1
  • 12
    • 0030698096 scopus 로고    scopus 로고
    • Role of intracellular pH in proliferation, transformation, and apoptosis
    • Shrode, L. D., Tapper, H. & Grinstein, S. Role of intracellular pH in proliferation, transformation, and apoptosis. J. Bioenerg. Biomembr. 29, 393-399 (1997).
    • (1997) J. Bioenerg. Biomembr. , vol.29 , pp. 393-399
    • Shrode, L.D.1    Tapper, H.2    Grinstein, S.3
  • 13
    • 0030933001 scopus 로고    scopus 로고
    • Lactate-proton cotransport in skeletal muscle
    • Juel, C. Lactate-proton cotransport in skeletal muscle. Physiol. Rev. 77, 321-358 (1997).
    • (1997) Physiol. Rev. , vol.77 , pp. 321-358
    • Juel, C.1
  • 14
    • 0029971428 scopus 로고    scopus 로고
    • Cellular pH gradient in tumor versus normal tissue: Potential exploitation for the treatment of cancer
    • Gerweck, L. E. & Seetharaman, K. Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res. 56, 1194-1198 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 1194-1198
    • Gerweck, L.E.1    Seetharaman, K.2
  • 15
    • 9144231428 scopus 로고    scopus 로고
    • Expression profile of genes regulated by activity of the Na-H exchanger NHE1
    • Putney, L. K. & Barber, D. L. Expression profile of genes regulated by activity of the Na-H exchanger NHE1. BMC Genomics 5, 46 (2004).
    • (2004) BMC Genomics , vol.5 , pp. 46
    • Putney, L.K.1    Barber, D.L.2
  • 16
    • 0030945198 scopus 로고    scopus 로고
    • Aerobic glycolysis by proliferating cells: A protective strategy against reactive oxygen species
    • Brand, K. A. & Hermfisse, U. Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species. FASEB J. 11, 388-395 (1997).
    • (1997) FASEB J. , vol.11 , pp. 388-395
    • Brand, K.A.1    Hermfisse, U.2
  • 17
    • 0023186613 scopus 로고
    • Induction of v-mos and activated Ha-ras oncogene expression in quiescent NIH 3T3 cells causes intracellular alkalinisation and cell-cycle progression
    • Doppler, W., Jaggi, R. & Groner, B. Induction of v-mos and activated Ha-ras oncogene expression in quiescent NIH 3T3 cells causes intracellular alkalinisation and cell-cycle progression. Gene 54, 147-153 (1987).
    • (1987) Gene , vol.54 , pp. 147-153
    • Doppler, W.1    Jaggi, R.2    Groner, B.3
  • 18
    • 0035237389 scopus 로고    scopus 로고
    • pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth
    • Pouyssegur, J., Franchi, A. & Pages, G. pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth. Novartis Found. Symp. 240, 186-196 (2001). A study showing that in vivo tumour growth is dependent primarily on NHE1.
    • (2001) Novartis Found. Symp. , vol.240 , pp. 186-196
    • Pouyssegur, J.1    Franchi, A.2    Pages, G.3
  • 19
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan, D. & Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86, 353-364 (1996).
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 20
    • 0035237544 scopus 로고    scopus 로고
    • The physiological environment in cancer vascularization, invasion and metastasis
    • Bhujwalla, Z. M. et al. The physiological environment in cancer vascularization, invasion and metastasis. Novartis Found. Symp. 240, 23-38 (2001).
    • (2001) Novartis Found. Symp. , vol.240 , pp. 23-38
    • Bhujwalla, Z.M.1
  • 21
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • Gatenby, R. A. & Gillies, R. J. Why do cancers have high aerobic glycolysis? Nature Rev. Cancer 4, 891-899 (2004).
    • (2004) Nature Rev. Cancer , vol.4 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 22
    • 0036272649 scopus 로고    scopus 로고
    • + exchange subtype 1 inhibition during extracellular acidification and hypoxia in glioma cells
    • + exchange subtype 1 inhibition during extracellular acidification and hypoxia in glioma cells. J. Neurochem. 80, 36-44 (2002).
    • (2002) J. Neurochem. , vol.80 , pp. 36-44
    • Glunde, K.1    Dussmann, H.2    Juretschke, H.P.3    Leibfritz, D.4
  • 23
    • 0031748828 scopus 로고    scopus 로고
    • The contribution of lactic acid to acidification of tumours: Studies of variant cells lacking lactate dehydrogenase
    • Yamagata, M., Hasuda, K., Stamato, T. & Tannock, I. F. The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase. Br. J. Cancer 77, 1726-1731 (1998).
    • (1998) Br. J. Cancer , vol.77 , pp. 1726-1731
    • Yamagata, M.1    Hasuda, K.2    Stamato, T.3    Tannock, I.F.4
  • 24
    • 0034058373 scopus 로고    scopus 로고
    • + exchange, motility, and invasion induced by serum deprivation
    • + exchange, motility, and invasion induced by serum deprivation. J. Biol. Chem. 275, 5361-5369 (2000). The first demonstration that tumour cell invasion requires NHE1 activity, and that serum deprivation stimulates NHE1 activity in tumour cells but not in normal cells.
    • (2000) J. Biol. Chem. , vol.275 , pp. 5361-5369
    • Reshkin, S.J.1
  • 25
    • 21644447431 scopus 로고    scopus 로고
    • + exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells
    • + exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells. Breast Cancer Res. 6, R616-R628 (2004).
    • (2004) Breast Cancer Res. , vol.6
    • Paradiso, A.1
  • 26
    • 21844438240 scopus 로고    scopus 로고
    • Gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines
    • Cardone, R. A. et. al. Gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines. Mol. Biol. Cell 16, 3117-3127 (2005).
    • (2005) Mol. Biol. Cell , vol.16 , pp. 3117-3127
    • Cardone, R.A.1
  • 27
    • 3042692979 scopus 로고    scopus 로고
    • + exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion
    • + exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. J. Biol. Chem. 279, 26991-27007 (2004). Shows that ECM interaction with CD44 acidifies the microenvironment and promotes cell invasion, via stimulation of NHE1.
    • (2004) J. Biol. Chem. , vol.279 , pp. 26991-27007
    • Bourguignon, L.Y.1    Singleton, P.A.2    Diedrich, F.3    Stern, R.4    Gilad, E.5
  • 28
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers, A. F., Groom, A. C. & MacDonald, I. C. Dissemination and growth of cancer cells in metastatic sites. Nature Rev. Cancer 2, 563-572 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 29
    • 0034092011 scopus 로고    scopus 로고
    • Tumor angiogenesis: Past, present and the near future
    • Kerbel, R. S. Tumor angiogenesis: past, present and the near future. Carcinogenesis 21, 505-515 (2000).
    • (2000) Carcinogenesis , vol.21 , pp. 505-515
    • Kerbel, R.S.1
  • 32
    • 0037379779 scopus 로고    scopus 로고
    • Clinical, cellular, and molecular aspects of cancer invasion
    • Mareel, M. & Leroy, A. Clinical, cellular, and molecular aspects of cancer invasion. Physiol. Rev. 83, 337-376 (2003).
    • (2003) Physiol. Rev. , vol.83 , pp. 337-376
    • Mareel, M.1    Leroy, A.2
  • 33
    • 0029751950 scopus 로고    scopus 로고
    • A reaction-diffusion model of cancer invasion
    • Gatenby, R. A. & Gawlinski, E. T. A reaction-diffusion model of cancer invasion. Cancer Res. 56, 5745-5753 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 5745-5753
    • Gatenby, R.A.1    Gawlinski, E.T.2
  • 34
    • 0032900276 scopus 로고    scopus 로고
    • 31P nuclear magnetic resonance study in vivo and in vitro
    • 31P nuclear magnetic resonance study in vivo and in vitro. Magn. Reson. Med. 41, 897-903 (1999).
    • (1999) Magn. Reson. Med. , vol.41 , pp. 897-903
    • Bhujwalla, Z.M.1
  • 35
    • 0033057962 scopus 로고    scopus 로고
    • Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis
    • Vlodavsky, I. et al. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. Nature Med. 5, 793-802 (1999).
    • (1999) Nature Med. , vol.5 , pp. 793-802
    • Vlodavsky, I.1
  • 36
    • 2442505682 scopus 로고    scopus 로고
    • Pericellular proteolysis by leukocytes and tumor cells on substrates: Focal activation and the role of urokinase-type plasminogen activator
    • Kindzelskii, A. L. et al. Pericellular proteolysis by leukocytes and tumor cells on substrates: focal activation and the role of urokinase-type plasminogen activator. Histochem. Cell Biol. 121, 299-310 (2004).
    • (2004) Histochem. Cell Biol. , vol.121 , pp. 299-310
    • Kindzelskii, A.L.1
  • 37
    • 0035870263 scopus 로고    scopus 로고
    • An intracellular form of cathepsin B contributes to invasiveness in cancer
    • Szpaderska, A. M. & Frankfater, A. An intracellular form of cathepsin B contributes to invasiveness in cancer. Cancer Res. 61, 3493-3500 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 3493-3500
    • Szpaderska, A.M.1    Frankfater, A.2
  • 38
    • 0030872194 scopus 로고    scopus 로고
    • Release of the aspartyl protease cathepsin D is associated with and facilitates human breast cancer cell invasion
    • Tedone, T. et al. Release of the aspartyl protease cathepsin D is associated with and facilitates human breast cancer cell invasion. FASEB J. 11, 785-792 (1997).
    • (1997) FASEB J. , vol.11 , pp. 785-792
    • Tedone, T.1
  • 39
    • 9944258056 scopus 로고    scopus 로고
    • The role of gelatinases in colorectal cancer progression and metastasis
    • Mook, O. R., Frederiks, W. M. & Van Noorden C. J. The role of gelatinases in colorectal cancer progression and metastasis. Biochim. Biophys. Acta. 1705, 69-89 (2004).
    • (2004) Biochim. Biophys. Acta. , vol.1705 , pp. 69-89
    • Mook, O.R.1    Frederiks, W.M.2    Van Noorden, C.J.3
  • 40
    • 19344366798 scopus 로고    scopus 로고
    • Gelatinase-mediated migration and invasion of cancer cells
    • Bjorklund, M. & Koivunen, E. Gelatinase-mediated migration and invasion of cancer cells. Biochim. Biophys. Acta. 1755, 37-69 (2005).
    • (2005) Biochim. Biophys. Acta , vol.1755 , pp. 37-69
    • Bjorklund, M.1    Koivunen, E.2
  • 41
    • 0034651996 scopus 로고    scopus 로고
    • Unraveling the role of proteases in cancer
    • Koblinski, J. E., Ahram, M. & Sloane, B. F. Unraveling the role of proteases in cancer. Clin. Chim. Acta. 291, 113-135 (2000).
    • (2000) Clin. Chim. Acta , vol.291 , pp. 113-135
    • Koblinski, J.E.1    Ahram, M.2    Sloane, B.F.3
  • 42
    • 0028618307 scopus 로고
    • Pericellular pH affects distribution and secretion of cathepsin B in malignant cells
    • Rozhin, J., Sameni, M., Ziegler, G. & Sloane, B. F. Pericellular pH affects distribution and secretion of cathepsin B in malignant cells. Cancer Res. 54, 6517-6525 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 6517-6525
    • Rozhin, J.1    Sameni, M.2    Ziegler, G.3    Sloane, B.F.4
  • 43
    • 20144378365 scopus 로고    scopus 로고
    • Acidic extracellular pH induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase D-mitogen-activated protein kinase signaling
    • Kato, Y. et al. Acidic extracellular pH induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase D-mitogen-activated protein kinase signaling. J. Biol. Chem. 280, 10938-10944 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 10938-10944
    • Kato, Y.1
  • 44
    • 0345791482 scopus 로고    scopus 로고
    • Extracellular acidification alters lysosomal trafficking in human breast cancer cells
    • Glunde, K. et al. Extracellular acidification alters lysosomal trafficking in human breast cancer cells. Neoplasia 5, 533-545 (2003). Reports that reduced pHe stimulates both pseudopod formation and localized trafficking of lysosomes within the pseudopodia, creating a positive-feedback link between the processes of extracellular acidification, protease secretion and invasion.
    • (2003) Neoplasia , vol.5 , pp. 533-545
    • Glunde, K.1
  • 45
    • 0037455576 scopus 로고    scopus 로고
    • Compensation mechanism in tumor cell migration: Mesenchymal-amoeboid transition after blocking of pericellular proteolysis
    • Wolf, K. et al. Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J. Cell Biol. 160, 267-277 (2003). Describes the use of intravital multiphoton microscopy in cultured cells to study the association between secreted protease activity and cellular functional morphology.
    • (2003) J. Cell Biol. , vol.160 , pp. 267-277
    • Wolf, K.1
  • 46
    • 20244390565 scopus 로고    scopus 로고
    • Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration
    • Iwasaki, T. et al. Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration, Int. J. Cancer 97, 330-335 (2002).
    • (2002) Int. J. Cancer , vol.97 , pp. 330-335
    • Iwasaki, T.1
  • 47
    • 0033739497 scopus 로고    scopus 로고
    • + exchanger NHE1
    • + exchanger NHE1. J. Cell Sci: 113, 3649-3662 (2000). The first study to demonstrate that transformation results in a dramatic remodelling of cellular morphology with a redistribution of NHE1 to the tip of the pseudopod, and that motility and transformed cell shape depend on NHE1 activity.
    • (2000) J. Cell Sci. , vol.113 , pp. 3649-3662
    • Lagana, A.1
  • 49
    • 0042354574 scopus 로고    scopus 로고
    • Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
    • Sahai, E. & Marshall, C. J. Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nature Cell Biol. 5, 711-719 (2003). Demonstrates that RHOA-ROCK1 signalling differs between cells that undergo mesenchymal and amoeboid dependent movement, and that cells with the mesenchymal cell shape are more invasive.
    • (2003) Nature Cell Biol. , vol.5 , pp. 711-719
    • Sahai, E.1    Marshall, C.J.2
  • 50
    • 1642282882 scopus 로고    scopus 로고
    • Prespecification and plasticity: Shifting mechanisms of cell migration
    • Friedl, P. Prespecification and plasticity: shifting mechanisms of cell migration. Curr. Opin. Cell Biol. 16, 14-23 (2004).
    • (2004) Curr. Opin. Cell Biol. , vol.16 , pp. 14-23
    • Friedl, P.1
  • 51
    • 12344252751 scopus 로고    scopus 로고
    • Mechanisms of cancer cell invasion
    • Sahai, E. Mechanisms of cancer cell invasion. Curr. Opin. Genet. Dev. 15, 87-96 (2005). References 50 and 51 are recent reviews of invasive cell morphology.
    • (2005) Curr. Opin. Genet. Dev. , vol.15 , pp. 87-96
    • Sahai, E.1
  • 52
    • 0035044816 scopus 로고    scopus 로고
    • 1 integrin and matrix metalloproteinases activity for migration and invasion
    • 1 integrin and matrix metalloproteinases activity for migration and invasion. Lab. Invest. 81, 613-627 (2001).
    • (2001) Lab. Invest. , vol.81 , pp. 613-627
    • Giannelli, G.1
  • 53
    • 0030813029 scopus 로고    scopus 로고
    • Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants
    • Laudanna, C., Campbell, J. J. & Butcher, E. C. Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants. J. Biol. Chem. 272, 24141-24144 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 24141-24144
    • Laudanna, C.1    Campbell, J.J.2    Butcher, E.C.3
  • 54
    • 0034682315 scopus 로고    scopus 로고
    • Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases
    • Taguchi, A. et al. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature 405, 354-360 (2000).
    • (2000) Nature , vol.405 , pp. 354-360
    • Taguchi, A.1
  • 55
    • 0345059766 scopus 로고    scopus 로고
    • Intravital imaging of cell movement in tumours
    • Condeelis, J. & Segall, J. E. Intravital imaging of cell movement in tumours. Nature Rev. Cancer 3, 921-930 (2003).
    • (2003) Nature Rev. Cancer , vol.3 , pp. 921-930
    • Condeelis, J.1    Segall, J.E.2
  • 56
    • 0037073684 scopus 로고    scopus 로고
    • Autocrine activation of the hepatocyte growth factor receptor/met tyrosine kinase induces tumor cell motility by regulating pseudopodial protrusion
    • Vadnais, J. et al. Autocrine activation of the hepatocyte growth factor receptor/met tyrosine kinase induces tumor cell motility by regulating pseudopodial protrusion. J. Biol. Chem. 277, 48342-48350 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 48342-48350
    • Vadnais, J.1
  • 57
    • 0031808063 scopus 로고    scopus 로고
    • 3,8-10 is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells
    • 3,8-10 is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells. J. Cell. Physiol. 176, 206-215 (1998).
    • (1998) J. Cell. Physiol. , vol.176 , pp. 206-215
    • Bourguignon, L.Y.1
  • 58
    • 23844449323 scopus 로고    scopus 로고
    • + exchange
    • + exchange. J. Physiol. 567, 225-238 (2005).
    • (2005) J. Physiol. , vol.567 , pp. 225-238
    • Stock, C.1
  • 59
    • 0037164808 scopus 로고    scopus 로고
    • Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1
    • Denker, S. P. & Barber, D. L. Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1. J. Cell Biol. 159, 1087-1096 (2002).
    • (2002) J. Cell Biol. , vol.159 , pp. 1087-1096
    • Denker, S.P.1    Barber, D.L.2
  • 60
    • 18544363096 scopus 로고    scopus 로고
    • A developmentally regulated Na-H exchanger in Dictyostelium discoideum is necessary for cell polarity during chemotaxis
    • Patel, H. & Barber, D. L. A developmentally regulated Na-H exchanger in Dictyostelium discoideum is necessary for cell polarity during chemotaxis. J. Cell Biol. 169, 321-329 (2005).
    • (2005) J. Cell Biol. , vol.169 , pp. 321-329
    • Patel, H.1    Barber, D.L.2
  • 61
    • 3543114271 scopus 로고    scopus 로고
    • Foot and mouth: Podosomes, invadopodia and circular dorsal ruffles
    • Buccione, R., Orth, J. D. & McNiven, M. A. Foot and mouth: podosomes, invadopodia and circular dorsal ruffles. Nature Rev. Mol. Cell Biol. 5, 647-657 (2004). A recent review of invadopodia structure and function.
    • (2004) Nature Rev. Mol. Cell Biol. , vol.5 , pp. 647-657
    • Buccione, R.1    Orth, J.D.2    McNiven, M.A.3
  • 62
    • 0037356318 scopus 로고    scopus 로고
    • Calcitonin inhibits proton extrusion in resorbing rat osteoclasts via protein kinase A
    • Kajiya, H., Okamoto, F., Fukushima, H. & Okabe, K. Calcitonin inhibits proton extrusion in resorbing rat osteoclasts via protein kinase A. Pflugers Arch. 445, 651-658 (2003).
    • (2003) Pflugers Arch. , vol.445 , pp. 651-658
    • Kajiya, H.1    Okamoto, F.2    Fukushima, H.3    Okabe, K.4
  • 64
    • 4544280986 scopus 로고    scopus 로고
    • + exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes
    • + exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes. Am. J. Physiol. Cell Physiol. 287, C844-C850 (2004). Describes a scaffolding function for NHE1.
    • (2004) Am. J. Physiol. Cell Physiol. , vol.287
    • Baumgartner, M.1    Patel, H.2    Barber, D.L.3
  • 65
    • 1242272754 scopus 로고    scopus 로고
    • Diversity of the mammalian sodium/proton exchanger SLC9 gene family
    • Orlowski, J. & Grinstein, S. Diversity of the mammalian sodium/proton exchanger SLC9 gene family. Pflugers Arch. 447, 549-565 (2004).
    • (2004) Pflugers Arch. , vol.447 , pp. 549-565
    • Orlowski, J.1    Grinstein, S.2
  • 66
    • 5444248307 scopus 로고    scopus 로고
    • Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac
    • De Wever, O. et al. Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac. FASEB J. 18, 1016-1018 (2004).
    • (2004) FASEB J. , vol.18 , pp. 1016-1018
    • De Wever, O.1
  • 67
    • 0034695446 scopus 로고    scopus 로고
    • CD44 interaction with Tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration
    • Bourguignon, L. Y., Zhu, H., Shao, L. & Chen, Y. W. CD44 interaction with Tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration. J. Biol. Chem. 275, 1829-1838 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 1829-1838
    • Bourguignon, L.Y.1    Zhu, H.2    Shao, L.3    Chen, Y.W.4
  • 68
    • 0043032859 scopus 로고    scopus 로고
    • Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression
    • Bourguignon, L. Y., Singleton, P. A., Zhu, H. & Diedrich, F. Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression. J. Biol. Chem. 278, 29420-29434 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 29420-29434
    • Bourguignon, L.Y.1    Singleton, P.A.2    Zhu, H.3    Diedrich, F.4
  • 69
    • 0030908882 scopus 로고    scopus 로고
    • Cytosolic alkalinization increases stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) activity and p38 mitogen-activated protein kinase activity by a calcium-independent mechanism
    • Shrode, L. D., Rubie, E. A., Woodgett, J. R. & Grinstein, S. Cytosolic alkalinization increases stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) activity and p38 mitogen-activated protein kinase activity by a calcium-independent mechanism. J. Biol. Chem. 272, 13653-13659 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 13653-13659
    • Shrode, L.D.1    Rubie, E.A.2    Woodgett, J.R.3    Grinstein, S.4
  • 70
    • 0032541338 scopus 로고    scopus 로고
    • p160ROCK mediates RhoA activation of Na-H exchange
    • Tominaga, T., Ishizaki, T., Narumiya, S. & Barber, D. L. p160ROCK mediates RhoA activation of Na-H exchange. EMBO J. 17, 4712-4722 (1998).
    • (1998) EMBO J. , vol.17 , pp. 4712-4722
    • Tominaga, T.1    Ishizaki, T.2    Narumiya, S.3    Barber, D.L.4
  • 71
    • 2342477964 scopus 로고    scopus 로고
    • Ezrin, a key component in tumor metastasis
    • Hunter, K. W. Ezrin, a key component in tumor metastasis. Trends Mol. Med. 10, 201-204 (2004).
    • (2004) Trends Mol. Med. , vol.10 , pp. 201-204
    • Hunter, K.W.1
  • 72
    • 0031457622 scopus 로고    scopus 로고
    • Signaling through scaffold, anchoring, and adaptor proteins
    • Pawson, T. & Scott, J. D. Signaling through scaffold, anchoring, and adaptor proteins. Science 278, 2075-2080 (1997).
    • (1997) Science , vol.278 , pp. 2075-2080
    • Pawson, T.1    Scott, J.D.2
  • 73
    • 0036594889 scopus 로고    scopus 로고
    • Regulation of intracellular pH in human melanoma: Potential therapeutic implications
    • Wahl, M. L. et al. Regulation of intracellular pH in human melanoma: potential therapeutic implications. Mol. Cancer Ther. 1, 617-628 (2002).
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 617-628
    • Wahl, M.L.1
  • 74
    • 20244388917 scopus 로고    scopus 로고
    • Cellular pH regulators: Potentially promising molecular targets for cancer chemotherapy
    • Izumi, H. et al. Cellular pH regulators: potentially promising molecular targets for cancer chemotherapy. Cancer Treat. Rev. 29, 541-549 (2003).
    • (2003) Cancer Treat. Rev. , vol.29 , pp. 541-549
    • Izumi, H.1
  • 75
    • 0032997486 scopus 로고    scopus 로고
    • Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG)
    • Kuin, A. et al. Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG). Br. J. Cancer 79, 793-801 (1999).
    • (1999) Br. J. Cancer , vol.79 , pp. 793-801
    • Kuin, A.1
  • 76
    • 0037105733 scopus 로고    scopus 로고
    • The possible role of postoperative azotemia in enhanced survival of patients with metastatic renal cancer after cytoreductive nephrectomy
    • Gatenby, R. A. et al. The possible role of postoperative azotemia in enhanced survival of patients with metastatic renal cancer after cytoreductive nephrectomy. Cancer Res. 62, 5218-5222 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 5218-5222
    • Gatenby, R.A.1
  • 77
    • 0034920855 scopus 로고    scopus 로고
    • Role of sodium-hydrogen exchange in cardiac hypertrophy and heart failure: A novel and promising therapeutic target
    • Karmazyn, M. Role of sodium-hydrogen exchange in cardiac hypertrophy and heart failure: a novel and promising therapeutic target. Basic Res. Cardiol. 96, 325-328 (2001).
    • (2001) Basic Res. Cardiol. , vol.96 , pp. 325-328
    • Karmazyn, M.1


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