Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 3, 2005, Pages 579-584

  Winum, Jean Yves ^a,b   Pastorekova, Silvia ^c   Jakubickova, Lydia ^c   Montero, Jean Louis ^b   Scozzafava, Andrea ^a   Pastorek, Jaromir ^c   Vullo, Daniela ^a   Innocenti, Alessio ^a   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIV MONTPELLIER   (France)

^c INSTITUTE OF VIROLOGY   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 DECYLENE BIS SULFAMATE; 1,8 OCTYLENE BIS SULFAMATE; ACETAZOLAMIDE; BIS SULFAMATE DERIVATIVE; BRINZOLAMIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; DICLOFENAMIDE; DORZOLAMIDE; ESTRADIOL 3,17 DISULFAMATE; ETHOXZOLAMIDE; INDISULAM; ISOENZYME; MEMBRANE PROTEIN; METHAZOLAMIDE; PHENYL 1,4 DIMETHYLENE BIS SULFAMATE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL REACTION; CORRELATION ANALYSIS; CYTOSOL; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; OUTCOMES RESEARCH; PHYSIOLOGY; PROGNOSIS; PROTEIN EXPRESSION; TUMOR;

ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CYTOSOL; HUMANS; ISOENZYMES; NEOPLASM PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS;

EID: 12444328856     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.11.058     Document Type: Article

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37. 23 Stock solutions of inhibitor (1 mM) were prepared in distilled-deionized water with 10-20% (v/v) DMSO (which is not inhibitory at these concentrations) and dilutions up to 0.01 nM were done thereafter with distilled-deionized water. Inhibitor and enzyme solutions were preincubated together for 15 min at room temperature prior to assay, in order to allow for the formation of the E-I complex. Triplicate experiments were done for each inhibitor concentration, and the values reported throughout the paper are the mean of such results