-
1
-
-
0036359548
-
Hypoxia - A key regulatory factor in tumour growth
-
Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2: 38-47
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
2
-
-
33845983692
-
Understanding hypoxia signalling in cells - A new therapeutic opportunity?
-
Ratcliffe PJ. Understanding hypoxia signalling in cells - a new therapeutic opportunity? Clin Med 2006; 6: 573-578
-
(2006)
Clin Med
, vol.6
, pp. 573-578
-
-
Ratcliffe, P.J.1
-
3
-
-
35248824187
-
Oxygen sensing and hypoxia-induced responses
-
Coleman ML, Ratcliffe PJ. Oxygen sensing and hypoxia-induced responses. Essays Biochem 2007; 43: 1-15
-
(2007)
Essays Biochem
, vol.43
, pp. 1-15
-
-
Coleman, M.L.1
Ratcliffe, P.J.2
-
4
-
-
37049002653
-
Hypoxia up-regulates hypoxia-inducible factor-la transcription by involving phosphatidylinositol 3-kinase and nuclear factor κB in pulmonary artery smooth muscle cells
-
Belaiba RS, Bonello S, Zähringer C etal. Hypoxia up-regulates hypoxia-inducible factor-la transcription by involving phosphatidylinositol 3-kinase and nuclear factor κB in pulmonary artery smooth muscle cells. Mol Biol Cell 2007; 18: 46917
-
(2007)
Mol Biol Cell
, vol.18
, pp. 46917
-
-
Belaiba, R.S.1
Bonello, S.2
Zähringer, C.3
-
5
-
-
33746899015
-
Akt1 activation can augment hypoxia-inducible factor-1α expression by increasing protein translation through a mammalian target of rapamycin-independent pathway
-
DOI 10.1158/1541-7786.MCR-05-0234
-
Pore N, Jiang Z, Shu HK, Bernhard E, Kao GD, Maity A. Akt 1 activation can augment hypoxia-inducible factor-1α expression by increasing protein translation through a mammalian target of rapamycin-independent pathway. Mol Cancer Res 2006; 4: 471-479 (Pubitemid 44197042)
-
(2006)
Molecular Cancer Research
, vol.4
, Issue.7
, pp. 471-479
-
-
Pore, N.1
Jiang, Z.2
Shu, H.-K.3
Bernhard, E.4
Kao, G.D.5
Maity, A.6
-
6
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
DOI 10.1128/MCB.21.12.3995-4004.2001
-
Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 2001 ; 21: 3995-4004 (Pubitemid 32476461)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.12
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
7
-
-
28844433666
-
Mitochondria: Oxygen sinks rather than sensors?
-
Wenger RH. Mitochondria: oxygen sinks rather than sensors? Med Hypotheses 2006; 66: 380-383
-
(2006)
Med Hypotheses
, vol.66
, pp. 380-383
-
-
Wenger, R.H.1
-
8
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721-732
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
9
-
-
34147170511
-
HIF-1 and HIF-2: Working alone or together in hypoxia?
-
Ratcliffe PJ. HIF-1 and HIF-2: working alone or together in hypoxia? J Clin Invest 2007; 117: 862-865
-
(2007)
J Clin Invest
, vol.117
, pp. 862-865
-
-
Ratcliffe, P.J.1
-
10
-
-
34247219188
-
Target gene selectivity of hypoxia-inducible factor-a in renal cancer cells is conveyed by post-DNAbinding mechanisms
-
Lau KW, Tian YM, Raval RR, Ratcliffe PJ, Pugh CW. Target gene selectivity of hypoxia-inducible factor-a in renal cancer cells is conveyed by post-DNAbinding mechanisms. Br J Cancer 2007; 96:1284-1292
-
(2007)
Br J Cancer
, vol.96
, pp. 1284-1292
-
-
Lau, K.W.1
Tian, Y.M.2
Raval, R.R.3
Ratcliffe, P.J.4
Pugh, C.W.5
-
12
-
-
20744445650
-
Contrasting properties of hypoxiainducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
-
Raval RR, Lau KW, Tran MG et al. Contrasting properties of hypoxiainducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol 2005; 25: 567586
-
(2005)
Mol Cell Biol
, vol.25
, pp. 567586
-
-
Raval, R.R.1
Lau, K.W.2
Tran, M.G.3
-
13
-
-
33749478922
-
Cancer's molecular sweet tooth and the Warburg effect
-
Kim JW, Dang CV. Cancer's molecular sweet tooth and the Warburg effect. Concerte2006; 66: 8927-8930
-
(2006)
Concerte
, vol.66
, pp. 8927-8930
-
-
Kim, J.W.1
Dang, C.V.2
-
15
-
-
35248828654
-
Hypoxia in cancer cell metabolism and pH regulation
-
Brahimi-Horn MC, Pouysségur J. Hypoxia in cancer cell metabolism and pH regulation. Essays Biochem 2007; 43: 165-178
-
(2007)
Essays Biochem
, vol.43
, pp. 165-178
-
-
Brahimi-Horn, M.C.1
Pouysségur, J.2
-
16
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004; 4: 891-899
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
17
-
-
35649014840
-
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
-
DOI 10.1128/MCB.00440-07
-
Kim JW, Gao P, Liu YC, Semenza GL, Dang CV. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 2007; 27: 7381-7393 (Pubitemid 350033646)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.21
, pp. 7381-7393
-
-
Kim, J.-W.1
Gao, P.2
Liu, Y.-C.3
Semenza, G.L.4
Dang, C.V.5
-
18
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
DOI 10.1016/j.cmet.2006.02.002, PII S1550413106000623
-
Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006; 3: 177-185 (Pubitemid 43316523)
-
(2006)
Cell Metabolism
, vol.3
, Issue.3
, pp. 177-185
-
-
Kim, J.-W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
19
-
-
0033986761
-
Causes and consequences of tumour acidity and implications for treatment
-
DOI 10.1016/S1357-4310(99)01615-9, PII S1357431099016159
-
Stubbs M, McSheehy PMJ, Griffiths JR, Bashford CL. Causes and consequences of tumor acidity and implications for treatment. Mol Med Today 2000; 6: 15-19 (Pubitemid 30010232)
-
(2000)
Molecular Medicine Today
, vol.6
, Issue.1
, pp. 15-19
-
-
Stubbs, M.1
McSheehy, P.M.J.2
Griffiths, J.R.3
Bashford, C.L.4
-
20
-
-
3142588858
-
Lactate: Mirror and motor of tumor malignancy
-
DOI 10.1016/j.semradonc.2004.04.004, PII S1053429604000554
-
Walenta S, Mueller-Klieser WF. Lactate: mirror and motor of tumor malignancy. Semin Radiat Oncol 2004; 14: 267-274 (Pubitemid 38903231)
-
(2004)
Seminars in Radiation Oncology
, vol.14
, Issue.3
, pp. 267-274
-
-
Walenta, S.1
Mueller-Klieser, W.F.2
-
21
-
-
25844528025
-
The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis
-
Cardone RA, Casavola V, Reshkin SJ. The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis. Nat Rev Cancer 2005; 5: 786-795
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 786-795
-
-
Cardone, R.A.1
Casavola, V.2
Reshkin, S.J.3
-
22
-
-
0030754527
-
Breast cancer cells have a high capacity to acidify extracellular milieu by a dual mechanism
-
DOI 10.1023/A:1018446104071
-
Montcourrier P, Silver I, Farnoud R, Bird I, Rochefort H. Breast cancer cells have a high capacity to acidify extracellular milieu by a dual mechanism. Clin Exp Metastasis 1997; 15: 382-392 (Pubitemid 27285811)
-
(1997)
Clinical and Experimental Metastasis
, vol.15
, Issue.4
, pp. 382-392
-
-
Montcourrier, P.1
Silver, I.2
Farnoud, R.3
Bird, I.4
Rochefort, H.5
-
23
-
-
0036554644
-
Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism
-
Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK. Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. Clin Cancer Res 2002; 8: 1284-1291 (Pubitemid 35177386)
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.4
, pp. 1284-1291
-
-
Helmlinger, G.1
Sckell, A.2
Dellian, M.3
Forbes, N.S.4
Jain, R.K.5
-
24
-
-
0035795336
-
VHL tumor suppressor regulates CI-/HC03-exchange and Na+/ H+ exchange activities in renal carcinoma cells
-
Karumanchi SA, Jiang L, Knebelmann B, Stuart-Tilley AK, Alper SL, Sukhatme VP. VHL tumor suppressor regulates CI-/HC03-exchange and Na+/ H+ exchange activities in renal carcinoma cells. Physiol Genomics 2001; 5: 119-128
-
(2001)
Physiol Genomics
, vol.5
, pp. 119-128
-
-
Karumanchi, S.A.1
Jiang, L.2
Knebelmann, B.3
Stuart-Tilley, A.K.4
Alper, S.L.5
Sukhatme, V.P.6
-
25
-
-
33751117499
-
HIF-1 regulates hypoxic induction of NHE1 expression and alkalinisation of intracellular pH in pulmonary arterial myocytes
-
Shimoda LA, Fallon M, Pisarcik S, Wang J, Semenza GL HIF-1 regulates hypoxic induction of NHE1 expression and alkalinisation of intracellular pH in pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol 2006; 291 : L941-9
-
(2006)
Am J Physiol Lung Cell Mol Physiol
, vol.291
-
-
Shimoda, L.A.1
Fallon, M.2
Pisarcik, S.3
Wang, J.4
Semenza, G.L.5
-
26
-
-
33646917296
-
The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1α-dependent mechanism
-
Ullah MS. Davies AJ. Halestrap AP. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1α-dependent mechanism. J Biol Chem 2006; 281: 9030-9037
-
(2006)
J Biol Chem
, vol.281
, pp. 9030-9037
-
-
Ullah, M.S.1
Davies, A.J.2
Halestrap, A.P.3
-
27
-
-
8844224030
-
Microenvironmental and cellular consequences of altered blood flow in tumours
-
DOI 10.1259/bjr/12913493, Angiogenesis Imaging
-
Raghunand N, Gatenby RA, Gillies RJ. Microenvironmental and cellular consequences of altered blood flow in tumours. Br J Radiol 2003; 76: S11-22 (Pubitemid 39530312)
-
(2003)
British Journal of Radiology
, vol.76
, Issue.SPEC. ISS. 1
-
-
Raghunand, N.1
Gatenby, R.A.2
Gillies, R.J.3
-
28
-
-
2442579987
-
Carbonic anhydrases. Catalytic mechanisms, distribution and physiological roles
-
Supuran CT, Scozzafava A, Conway J eds, Boca Raton-London-New YorkWashington, DC: CRC Press
-
Supuran CT. Carbonic anhydrases. Catalytic mechanisms, distribution and physiological roles. In Supuran CT, Scozzafava A, Conway J eds, Carbonic Anhydrase: Its Inhibitors and Activators. Boca Raton-London-New YorkWashington, DC: CRC Press, 2004: 1-24
-
(2004)
Carbonic Anhydrase: Its Inhibitors and Activators.
, pp. 1-24
-
-
Supuran, C.T.1
-
29
-
-
3442883664
-
Carbonic anhydrases: Current state of the art, therapeutic applications and future prospects
-
DOI 10.1080/14756360410001689540
-
Pastorekova S, Parkkila S, Pastorek J, Supuran CT. Carbonic anhydrases: current state of the art, therapeutic applications and future prospects. J Enzyme Inhib Med Chem 2004; 19: 199-229 (Pubitemid 39004275)
-
(2004)
Journal of Enzyme Inhibition and Medicinal Chemistry
, vol.19
, Issue.3
, pp. 199-229
-
-
Pastorekova, S.1
Parkkila, S.2
Pastorek, J.3
Supuran, C.T.4
-
30
-
-
0028111173
-
Cloning and characterisation of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and putative helix-loop-helix DNA binding segment
-
Pastorek J, Pastorekova S, Callebaut l et al. Cloning and characterisation of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and putative helix-loop-helix DNA binding segment. Oncogene 1994; 9: 2877-2888
-
(1994)
Oncogene
, vol.9
, pp. 2877-2888
-
-
Pastorek, J.1
Pastorekova, S.2
-
31
-
-
0027153461
-
Expression of MaTu-MN protein in human tumor cultures and in clinical specimens
-
DOI 10.1002/ijc.2910540218
-
Zavada J Zavadova Z, Pastorekova S, Ciampor F, Pastorek J, Zelnik V. Expression of MaTu-MN protein in human tumor cultures and in clinical specimens. Int J Cancer 1993; 54: 268-274 (Pubitemid 23154893)
-
(1993)
International Journal of Cancer
, vol.54
, Issue.2
, pp. 268-274
-
-
Zavada, J.1
Zavadova, Z.2
Pastorekova, S.3
Ciampor, F.4
Pastorek, J.5
Zelnik, V.6
-
32
-
-
0029975564
-
Human MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships
-
Opavsky R, Pastorekova S, Zelnik Metal. Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships. Genomics 1996; 33: 480-487
-
(1996)
Genomics
, vol.33
, pp. 480-487
-
-
Opavsky, R.1
Pastorekova, S.2
Zelnik, M.3
-
33
-
-
0022502868
-
Monoclonal antibody G 250 recognizes a determinant present in renal-cell carcinoma and absent from normal kidney
-
Oosterwijk E, Ruiter DJ, Hoedemaeker PJ et al. Monoclonal antibody G250 recognizes determinant present in renal cell carcinoma and absent from normal kidney. Int J Cancer 1986; 38: 489-494 (Pubitemid 16006918)
-
(1986)
International Journal of Cancer
, vol.38
, Issue.4
, pp. 489-494
-
-
Oosterwijk, E.1
Ruiter, D.J.2
Hoedemaeker, P.J.3
-
34
-
-
0034099829
-
Molecular cloning and immunogenicity of renal cell carcinomaassociated antigen G250
-
Grabmaier K, Vissers JL, De Weijert MC et al. Molecular cloning and immunogenicity of renal cell carcinomaassociated antigen G250. Int J Cancer 2000; 85: 865-870
-
(2000)
Int J Cancer
, vol.85
, pp. 865-870
-
-
Grabmaier, K.1
Vissers, J.L.2
De Weijert, M.C.3
-
35
-
-
0034024783
-
Human tumour-associated cell adhesion protein MN/CA IX: Identification of M75 epitope and of the region mediating cell adhesion
-
Zavada J, Zavadova Z, Pastorek J, Biesova Z, Jezek K, Velek J. Human tumour-associated cell adhesion protein MN/CA IX: identification of M75 epitope and of the region mediating cell adhesion. Br J Cancer 2000; 82: 1808-1813 (Pubitemid 30307393)
-
(2000)
British Journal of Cancer
, vol.82
, Issue.11
, pp. 1808-1813
-
-
Zavada, J.1
Zavadova, Z.2
Pastorek, J.3
Biesova, Z.4
Jezek, J.5
Velek, J.6
-
37
-
-
0031040821
-
Carbonic anhydrase IX, MN/CA IX: Analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts
-
Pastorekova S, Parkkila S, Parkkila AK et al. Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts. Gastroenterology 1997; 112:398-408
-
(1997)
Gastroenterology
, vol.112
, pp. 398-408
-
-
Pastorekova, S.1
Parkkila, S.2
Parkkila, A.K.3
-
38
-
-
0034671307
-
Hypoxia-inducible expression of tumorassociated carbonic anhydrases
-
Wykoff CC, Beasley NJ, Watson PH et al. Hypoxia-inducible expression of tumorassociated carbonic anhydrases. Cancer Res 2000; 60: 7075-7083
-
(2000)
Cancer Res
, vol.60
, pp. 7075-7083
-
-
Wykoff, C.C.1
Beasley, N.J.2
Watson, P.H.3
-
39
-
-
0036682009
-
Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1α stabilization: A role for phosphatidylinositol 3′-kinase
-
Kaluz S, Kaluzova M, Chrastina A et al. Lowered oxygen tension induces expression of the hypoxia marker MN/ carbonic anhydrase IX in the absence of hypoxia-inducible factor 1α stabilization: a role for phosphatidylinositol 3'-kinase. Cancer Res 2002; 62: 4469-4477 (Pubitemid 34827310)
-
(2002)
Cancer Research
, vol.62
, Issue.15
, pp. 4469-4477
-
-
Kaluz, S.1
Kaluzova, M.2
Chrastina, A.3
Olive, P.L.4
Pastorekova, S.5
Pastorek, J.6
Lerman, M.I.7
Stanbridge, E.J.8
-
40
-
-
19544381887
-
MAPK pathway contributes to density- And hypoxia-induced expression of the tumor-associated carbonic anhydrase IX
-
DOI 10.1016/j.bbaexp.2005.03.003, PII S0167478105000710
-
Kopacek J, Barathova M, Dequiedt F et al. MAPK pathway contributes to density- and hypoxia-induced expression of the tumor-associated carbonic anhydrase IX. Biochim Biophys Acta 2005; 1729: 41-49 (Pubitemid 40732423)
-
(2005)
Biochimica et Biophysica Acta - Gene Structure and Expression
, vol.1729
, Issue.1
, pp. 41-49
-
-
Kopacek, J.1
Barathova, M.2
Dequiedt, F.3
Sepelakova, J.4
Kettmann, R.5
Pastorek, J.6
Pastorekova, S.7
-
41
-
-
17044452288
-
HIF activation identifies early lesions in VHL kidneys: Evidence for site-specific tumor suppressor function in the nephron
-
Mandriota SJ, Turner KJ, Davies DR et al. HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell 2002; 1: 459-468
-
(2002)
Cancer Cell
, vol.1
, pp. 459-468
-
-
Mandriota, S.J.1
Turner, K.J.2
Davies, D.R.3
-
42
-
-
0032514685
-
Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
-
DOI 10.1073/pnas.95.21.12596
-
Ivanov SV, Kuzmin I, Wei MH et al. Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. Proc Natl Acad Sci USA 1998; 95: 12596-12601 (Pubitemid 28483810)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.21
, pp. 12596-12601
-
-
Ivanov, S.V.1
Kuzmin, I.2
Wei, M.-H.3
Pack, S.4
Geil, L.5
Johnson, B.E.6
Stanbridge, E.J.7
Lerman, M.I.8
-
43
-
-
38049077062
-
Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype
-
Barathova M, Takacova M, Holotnakova T et al. Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype. Br J Cancer 2008; 98: 129-136
-
(2008)
Br J Cancer
, vol.98
, pp. 129-136
-
-
Barathova, M.1
Takacova, M.2
Holotnakova, T.3
-
44
-
-
27944500753
-
Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17
-
DOI 10.1038/sj.bjc.6602861, PII 6602861
-
Zatovicova M, Sedlakova O, Svastova E et al. Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17. Br J Cancer 2005; 93: 1267-1276 (Pubitemid 41679413)
-
(2005)
British Journal of Cancer
, vol.93
, Issue.11
, pp. 1267-1276
-
-
Zatovicova, M.1
Sedlakova, O.2
Svastova, E.3
Ohradanova, A.4
Ciampor, F.5
Arribas, J.6
Pastorek, J.7
Pastorekova, S.8
-
45
-
-
0142121458
-
Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with β-catenin
-
DOI 10.1016/S0014-4827(03)00351-3
-
Svastova E, Zilka N, Zatovicova M et al. Carbonic anhydrase IX reduces Ecadherin-mediated adhesion of MDCK cells via interaction with ß-catenin. Exp Cell Res 2002; 290: 332-345 (Pubitemid 37272176)
-
(2003)
Experimental Cell Research
, vol.290
, Issue.2
, pp. 332-345
-
-
Svastova, E.1
Zilka, N.2
Zat'Ovicova, M.3
Gibadulinova, A.4
Ciampor, F.5
Pastorek, J.6
Pastorekova, S.7
-
46
-
-
12444339728
-
Lnnocenti A, Vullo D, Scozzafava A, Casey JR, Supuran CT. Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates
-
lnnocenti A, Vullo D, Scozzafava A, Casey JR, Supuran CT. Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Medi Chem Lett 2005; 15: 573-578
-
(2005)
Bioorg Medi Chem Lett
, vol.15
, pp. 573-578
-
-
-
47
-
-
0032561466
-
Carbonic anhydrase ll binds to the carboxylterminus of human band 3, the erythrocyte CI-/HC03- Exchanger
-
Vince JW, Reithmeier RAF. Carbonic anhydrase ll binds to the carboxylterminus of human band 3, the erythrocyte CI-/HC03- exchanger. J Biol Chem 1998; 273: 28430-28437
-
(1998)
J Biol Chem
, vol.273
, pp. 28430-28437
-
-
Vince, J.W.1
Reithmeier, R.A.F.2
-
49
-
-
8844249356
-
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH
-
DOI 10.1016/j.febslet.2004.10.043, PII S0014579304012943
-
Svastova E, Hulikova A, Rafajova M et al. Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Lett 2004; 577: 439-445 (Pubitemid 39535327)
-
(2004)
FEBS Letters
, vol.577
, Issue.3
, pp. 439-445
-
-
Svastova, E.1
Hulikova, A.2
Rafajova, M.3
Zat'Ovicova, M.4
Gibadulinova, A.5
Casini, A.6
Cecchi, A.7
Scozzafava, A.8
Supuran, C.T.9
Pastorek, J.10
Pastorekova, S.11
-
51
-
-
8844224030
-
Microenvironmental and cellular consequences of altered blood flow in tumours
-
DOI 10.1259/bjr/12913493, Angiogenesis Imaging
-
Raghunand N, Gatenby RA, Gillies RJ, Microenvironmental and cellular consequences of altered blood flow in tumors. Br J Radiol 2003; 76: S11-22 (Pubitemid 39530312)
-
(2003)
British Journal of Radiology
, vol.76
, Issue.SPEC. ISS. 1
-
-
Raghunand, N.1
Gatenby, R.A.2
Gillies, R.J.3
-
52
-
-
4344699403
-
Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion
-
DOI 10.1158/0008-5472.CAN-03-2224
-
Robertson N, Potter C, Harris AL, Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion. Cancer Res 2004; 64: 6160-6165 (Pubitemid 39129417)
-
(2004)
Cancer Research
, vol.64
, Issue.17
, pp. 6160-6165
-
-
Robertson, N.1
Potter, C.2
Harris, A.L.3
-
53
-
-
34547793020
-
Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters
-
DOI 10.1152/ajpcell.00157.2007
-
Morgan PE, Pastoreková S, StuartTilley AK, Alper SL, Casey JR, Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters. Am J Physiol Cell Physiol 2007; 293: C738-48 (Pubitemid 47235179)
-
(2007)
American Journal of Physiology - Cell Physiology
, vol.293
, Issue.2
-
-
Morgan, P.E.1
Pastorekova, S.2
Stuart-Tilley, A.K.3
Alper, S.L.4
Casey, J.R.5
-
54
-
-
22744446294
-
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors
-
DOI 10.1021/jm0501073
-
Cecchi A, Hulikova A, Pastorek J et al. Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors. J Med Chem 2005; 48: 4834-4841 (Pubitemid 41033126)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.15
, pp. 4834-4841
-
-
Cecchi, A.1
Hulikova, A.2
Pastorek, J.3
Pastorekova, S.4
Scozzafava, A.5
Winum, J.-Y.6
Montero, J.-L.7
Supuran, C.T.8
-
55
-
-
26844517863
-
Carbonic anhydrase IX (CA IX) as a potential target for cancer therapy. Review article
-
Available at: Accessed March
-
Pastorekova S. Zavada J. Carbonic anhydrase IX (CA IX) as a potential target for cancer therapy. Review article. Available at: http://www. cancertherapy.org. Accessed March 2008. Cancer Ther 2004; 2: 245-262
-
(2008)
Cancer Ther 2004
, vol.2
, pp. 245-262
-
-
Pastorekova, S.1
Zavada, J.2
-
57
-
-
2542601328
-
Hypoxia inducible carbonic anhydrase IX, marker of tumor hypoxia, survival pathway and therapy target
-
Potter C, Harris AL. Hypoxia inducible carbonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target. Cell Cycle 2004; 3: 164-167 (Pubitemid 40268690)
-
(2004)
Cell Cycle
, vol.3
, Issue.2
, pp. 164-167
-
-
Potter, C.1
Harris, A.L.2
-
58
-
-
0141887319
-
Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients
-
DOI 10.1038/sj.bjc.6601264
-
Zavada J, Zavadova Z, Zatovicova M, Hyrsl L, Kawaciuk I. Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. Br J Cancer 2003; 89: 1067-1071 (Pubitemid 37239213)
-
(2003)
British Journal of Cancer
, vol.89
, Issue.6
, pp. 1067-1071
-
-
Zavada, J.1
Zavadova, Z.2
Zat'Ovicova, M.3
Hyrsl, L.4
Kawaciuk, I.5
-
59
-
-
0028947939
-
The use of monoclonal antibody G250 in the therapy of renal-cell carcinoma
-
Oosterwijk E, Debruyne FM, Schalken JA. The use of monoclonal antibody G250 in the therapy of renal-cell carcinoma. Semin Oncol 1995; 22: 34-41
-
(1995)
Semin Oncol
, vol.22
, pp. 34-41
-
-
Oosterwijk, E.1
Debruyne, F.M.2
Schalken, J.A.3
-
60
-
-
0142219359
-
Pathobiology, Prognosis, and Targeted Therapy for Renal Cell Carcinoma: Exploiting the Hypoxia-Induced Pathway
-
Pantuck AJ, Zeng G, Belldegrun AS, Figlin RA. Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: exploiting the hypoxia-induced pathway. Clin Cancer Res 2003; 9: 4641-4652 (Pubitemid 37323266)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.13
, pp. 4641-4652
-
-
Pantuck, A.J.1
Zeng, G.2
Belldegrun, A.S.3
Figlin, R.A.4
-
61
-
-
0034018870
-
Carbonic-anhydrase inhibitors and their therapeutic potential
-
Supuran CT, Scozzafava A. Carbonic anhydrase inhibitors and their therapeutic potential. Expert Opin Ther Patents 2000; 10:575-600 (Pubitemid 30251754)
-
(2000)
Expert Opinion on Therapeutic Patents
, vol.10
, Issue.5
, pp. 575-600
-
-
Supuran, C.T.1
Scozzafava, A.2
-
62
-
-
34249691363
-
Carbonic anhydrases as drug targets - An overview
-
DOI 10.2174/156802607780636690
-
Supuran CT. Carbonic anhydrases as drug targets - an overview. Curr Top Med Chem 2007; 7: 825-833 (Pubitemid 46825080)
-
(2007)
Current Topics in Medicinal Chemistry
, vol.7
, Issue.9
, pp. 825-833
-
-
Supuran, C.T.1
-
63
-
-
1842790839
-
Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. the first subnanomolar CA IX inhibitor discovered
-
DOI 10.1016/j.bmcl.2004.01.095, PII S0960894X04001829
-
Vullo D, Scozzafava A, Pastorekova S, Pastorek J, Supuran CT. Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered. Bioorg Med Chem Lett 2004; 14: 2351-2356 (Pubitemid 38481419)
-
(2004)
Bioorganic and Medicinal Chemistry Letters
, vol.14
, Issue.9
, pp. 2351-2356
-
-
Vullo, D.1
Scozzafava, A.2
Pastorekova, S.3
Pastorek, J.4
Supuran, C.T.5
-
64
-
-
34250322126
-
Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors
-
DOI 10.1016/j.radonc.2007.04.018, PII S0167814007001752, Highlights from the 10th International ESTRO-Wolfsberg Meeting on Molecular Radiation Biology/Oncology 2007
-
Dubois L, Douma K, Supuran CT et al. Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors. Radiother Oncol 2007; 83: 367-373 (Pubitemid 46915545)
-
(2007)
Radiotherapy and Oncology
, vol.83
, Issue.3
, pp. 367-373
-
-
Dubois, L.1
Douma, K.2
Supuran, C.T.3
Chiu, R.K.4
Van, Z.5
Pastorekova, S.6
Scozzafava, A.7
Wouters, B.G.8
Lambin, P.9
-
65
-
-
1842852597
-
Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells
-
Rafajova M, Zatovicova M, Kettmann R, Pastorek J, Pastorekova S. Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells. Int J Oncol 2004; 24: 995-1004
-
(2004)
Int J Oncol
, vol.24
, pp. 995-1004
-
-
Rafajova, M.1
Zatovicova, M.2
Kettmann, R.3
Pastorek, J.4
Pastorekova, S.5
-
66
-
-
0035106202
-
Carbonic anhydrase inhibitors: Sulfonamides as antitumor agents?
-
DOI 10.1016/S0968-0896(00)00288-1, PII S0968089600002881
-
Supuran CT, Briganti F, Tilli S, Chegwidden WR, Scozzafava A. Carbonic anhydrase inhibitors: sulfonamides as antitumor agents? Bioorg Med Chem Lett 2001 ; 9: 703-714 (Pubitemid 32208589)
-
(2001)
Bioorganic and Medicinal Chemistry
, vol.9
, Issue.3
, pp. 703-714
-
-
Supuran, C.T.1
Briganti, F.2
Tilli, S.3
Chegwidden, W.R.4
Scozzafava, A.5
-
67
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
DOI 10.1038/nature04871, PII NATURE04871
-
Pouysségur J, Dayan F, Mazure NM. Hypoxia signalling and approaches to enforce tumour regression. Nature 2006; 441: 437-443 (Pubitemid 44050138)
-
(2006)
Nature
, vol.441
, Issue.7092
, pp. 437-443
-
-
Pouyssegur, J.1
Dayan, F.2
Mazure, N.M.3
-
68
-
-
0027367258
-
A carbonic anhydrase inhibitor as a potential modulator of cancer therapies
-
Teicher BA, Liu SD, Liu JT, Holden SA, Herman TS. A carbonic anhydrase inhibitor as a potential modulator of cancer therapies. Anticancer Res 1993; 13: 1549-1556
-
(1993)
Anticancer Res
, vol.13
, pp. 1549-1556
-
-
Teicher, B.A.1
Liu, S.D.2
Liu, J.T.3
Holden, S.A.4
Herman, T.S.5
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