Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma

International Journal of Cancer

Volumn 105, Issue 6, 2003, Pages 873-881

  Chrastina, Adrián ^a   Závada, Jan ^b   Parkkila, Seppo ^c   Kaluz, Štefan ^a   Kaluzová, Milota ^a   Rajčáni, Július ^a   Pastorek, Jaromír ^a   Pastoreková, Silvia ^a  

^a INSTITUTE OF VIROLOGY   (Slovakia)

^b INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^c UNIVERSITY OF TAMPERE   (Finland)

Author keywords

Biodistribution; Carbonic anhydrase IX; Hypoxia; M75 monoclonal antibody; Pharmacokinetics; Tumor targeting

Indexed keywords

CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE IX; IODINE 125; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY M75; UNCLASSIFIED DRUG; CA9 PROTEIN, HUMAN; RADIOACTIVE IODINE; TUMOR ANTIGEN; TUMOR MARKER; TUMOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CELL HYPOXIA; COLORECTAL CARCINOMA; COMPARTMENT MODEL; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG UPTAKE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTERNALIZATION; MOUSE; NONHUMAN; NUDE MOUSE; PLASMA CLEARANCE; PRIORITY JOURNAL; TUMOR XENOGRAFT; ANIMAL; ANTIBODY SPECIFICITY; CARCINOMA; CELL CULTURE; CELL STRAIN HT29; COLORECTAL TUMOR; DRUG SCREENING; ENZYMOLOGY; IMMUNOLOGY; KINETICS; METABOLISM; PATHOLOGY; TISSUE DISTRIBUTION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS, NEOPLASM; AUTORADIOGRAPHY; CARBONIC ANHYDRASES; CARCINOMA; CELL HYPOXIA; COLORECTAL NEOPLASMS; HT29 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; IODINE RADIOISOTOPES; KINETICS; MICE; MICE, NUDE; NEOPLASM PROTEINS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0038118505     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11142     Document Type: Article

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