Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 38, 2009, Pages 16233-16238

  Alterio, Vincenzo ^a   Hilvo, Mika ^b,c   Di Fiore, Anna ^a   Supuran, Claudiu T ^d   Pan, Peiwen ^b   Parkkila, Seppo ^b   Scaloni, Andrea ^e   Pastorek, Jaromir ^f   Pastorekova, Silvia ^f   Pedone, Carlo ^a   Scozzafava, Andrea ^d   Monti, Simona Maria ^a   De Simone, Giuseppina ^a  

^a CNR   (Italy)

^b UNIVERSITY OF TAMPERE   (Finland)

^c VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^d UNIVERSITY OF FLORENCE   (Italy)

^e CNR   (Italy)

^f INSTITUTE OF VIROLOGY   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; CARBON DIOXIDE; CARBONATE DEHYDRATASE IX; DIMER;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CRYSTAL STRUCTURE; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STABILITY; ENZYME STRUCTURE; HYDRATION; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANTIGENS, NEOPLASM; BICARBONATES; CARBON DIOXIDE; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DISULFIDES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASMS; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTONS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 70349490906     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908301106     Document Type: Article

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