PH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

International Journal of Cancer

Volumn 127, Issue 1, 2010, Pages 207-219

  De Milito, Angelo ^a   Canese, Rossella ^a   Marino, Maria Lucia ^a   Borghi, Martina ^a   Iero, Manuela ^b   Villa, Antonello ^c   Venturi, Giulietta ^a   Lozupone, Francesco ^a   Iessi, Elisabetta ^a   Logozzi, Mariantonia ^a   Mina, Pamela Della ^b,c   Santinami, Mario ^b   Rodolfo, Monica ^b   Podo, Franca ^a   Rivoltini, Licia ^b   Fais, Stefano ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Human melanoma; Magnetic resonance spectroscopy; Proton pump inhibitors; SCID mice; Tumor acidity; Vacuolar ATPase

Indexed keywords

BENZYLOXYCARBONYL VALYLALANYLASPARTIC ACID FLUOROMETHYL KETONE; CASPASE; CASPASE INHIBITOR; ESOMEPRAZOLE; UNCLASSIFIED DRUG; OMEPRAZOLE; PROTON PUMP INHIBITOR;

ACIDIFICATION; ACIDITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CELL PH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENGRAFTMENT; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IN VITRO STUDY; MELANOMA CELL; MOUSE; MUTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SCID MOUSE; SURVIVAL RATE; TUMOR GROWTH; XENOTRANSPLANTATION; ANIMAL; APOPTOSIS; DRUG EFFECT; FLOW CYTOMETRY; MELANOMA; METABOLISM; MOUSE MUTANT; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PH; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; FLOW CYTOMETRY; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE IMAGING; MELANOMA; MICE; MICE, SCID; OMEPRAZOLE; PROTON PUMP INHIBITORS;

EID: 77953463274     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25009     Document Type: Article

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