SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 20, 2009, Pages 5825-5828

The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors

(6) Innocenti, Alessio a Pastorekova, Silvia b Pastorek, Jaromir b Scozzafava, Andrea a Simone, Giuseppina De c Supuran, Claudiu T a

a UNIVERSITY OF FLORENCE (Italy)

b INSTITUTE OF VIROLOGY (Slovakia)

c CNR (Italy)

Author keywords

Carbonic anhydrase; CO2 hydration; Hypoxia; Isozymes I, II, IX, XII, XIV; pH dependency; pKa; Solid tumor; Tumor acidification

Indexed keywords

CARBON DIOXIDE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; PROTEOGLYCAN;

ACIDITY; ARTICLE; CATALYSIS; ENZYME ACTIVITY; HYDRATION; HYPOXIA; PH MEASUREMENT; PROTEIN EXPRESSION; SOLID TUMOR;

ANTIGENS, NEOPLASM; CARBON DIOXIDE; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; NEOPLASMS; PROTEIN ISOFORMS; PROTEOGLYCANS; RECOMBINANT PROTEINS;

EID: 70349199011 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2009.08.088 Document Type: Article

Times cited : (66)

References (28)

1
- 38849143765
- Supuran C.T. Nat. Rev. Drug Disc. 7 (2008) 168
- (2008) Nat. Rev. Drug Disc. , vol.7 , pp. 168
- Supuran, C.T.¹

2
- 34248659399
- Supuran C.T., and Scozzafava A. Bioorg. Med. Chem. 15 (2007) 4336
- (2007) Bioorg. Med. Chem. , vol.15 , pp. 4336
- Supuran, C.T.¹ Scozzafava, A.²

3
- 84889476926
- X-ray Crystallography of CA Inhibitors and its Importance in Drug Design
- Supuran C.T., and Winum J.Y. (Eds), Wiley, Hoboken
- Alterio V., Di Fiore A., D'Ambrosio K., Supuran C.T., and De Simone G. X-ray Crystallography of CA Inhibitors and its Importance in Drug Design. In: Supuran C.T., and Winum J.Y. (Eds). Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications (2009), Wiley, Hoboken 73-138
- (2009) Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications , pp. 73-138
- Alterio, V.¹ Di Fiore, A.² D'Ambrosio, K.³ Supuran, C.T.⁴ De Simone, G.⁵

4
- 5144224910
- Development of Sulfonamide Carbonic Anhydrase Inhibitors
- Supuran C.T., Scozzafava A., and Conway J. (Eds), CRC Press, Boca Raton
- Supuran C.T., Scozzafava A., and Casini A. Development of Sulfonamide Carbonic Anhydrase Inhibitors. In: Supuran C.T., Scozzafava A., and Conway J. (Eds). Carbonic Anhydrase-Its Inhibitors and Activators (2004), CRC Press, Boca Raton 67-147
- (2004) Carbonic Anhydrase-Its Inhibitors and Activators , pp. 67-147
- Supuran, C.T.¹ Scozzafava, A.² Casini, A.³

5
- 84889385876
- Carbonic Anhydrases as Drug Targets-General Presentation
- Supuran C.T., and Winum J.Y. (Eds), Wiley, Hoboken
- Supuran C.T. Carbonic Anhydrases as Drug Targets-General Presentation. In: Supuran C.T., and Winum J.Y. (Eds). Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications (2009), Wiley, Hoboken 15-38
- (2009) Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications , pp. 15-38
- Supuran, C.T.¹

6
- 42149114451
- Supuran C.T. Curr. Pharm. Des. 14 (2008) 641
- (2008) Curr. Pharm. Des. , vol.14 , pp. 641
- Supuran, C.T.¹

7
- 41949096461
- Temperini C., Cecchi A., Scozzafava A., and Supuran C.T. Bioorg. Med. Chem. Lett. 18 (2008) 2567
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 2567
- Temperini, C.¹ Cecchi, A.² Scozzafava, A.³ Supuran, C.T.⁴

8
- 3442883664
- Pastorekova S., Parkkila S., Pastorek J., and Supuran C.T. J. Enzyme Inhib. Med. Chem. 19 (2004) 199
- (2004) J. Enzyme Inhib. Med. Chem. , vol.19 , pp. 199
- Pastorekova, S.¹ Parkkila, S.² Pastorek, J.³ Supuran, C.T.⁴

9
- 33750082400
- Thiry A., Dogné J.M., Masereel B., and Supuran C.T. Trends Pharmacol. Sci. 27 (2006) 566
- (2006) Trends Pharmacol. Sci. , vol.27 , pp. 566
- Thiry, A.¹ Dogné, J.M.² Masereel, B.³ Supuran, C.T.⁴

10
- 0032710065
- Clare B.W., and Supuran C.T. Eur. J. Med. Chem. 34 (1999) 463
- (1999) Eur. J. Med. Chem. , vol.34 , pp. 463
- Clare, B.W.¹ Supuran, C.T.²

11
- 42149143745
- Krishnamurthy V.M., Kaufman G.K., Urbach A.R., Gitlin I., Gudiksen K.L., Weibel D.B., and Whitesides G.M. Chem. Rev. 108 (2008) 946
- (2008) Chem. Rev. , vol.108 , pp. 946
- Krishnamurthy, V.M.¹ Kaufman, G.K.² Urbach, A.R.³ Gitlin, I.⁴ Gudiksen, K.L.⁵ Weibel, D.B.⁶ Whitesides, G.M.⁷

12
- 57149100954
- Stiti M., Cecchi A., Rami M., Abdaoui M., Barragan-Montero V., Scozzafava A., Guari Y., Winum J.Y., and Supuran C.T. J. Am. Chem. Soc. 130 (2008) 16130
- (2008) J. Am. Chem. Soc. , vol.130 , pp. 16130
- Stiti, M.¹ Cecchi, A.² Rami, M.³ Abdaoui, M.⁴ Barragan-Montero, V.⁵ Scozzafava, A.⁶ Guari, Y.⁷ Winum, J.Y.⁸ Supuran, C.T.⁹

13
- 33745644458
- Alterio V., Vitale R.M., Monti S.M., Pedone C., Scozzafava A., Cecchi A., De Simone G., and Supuran C.T. J. Am. Chem. Soc. 128 (2006) 8329
- (2006) J. Am. Chem. Soc. , vol.128 , pp. 8329
- Alterio, V.¹ Vitale, R.M.² Monti, S.M.³ Pedone, C.⁴ Scozzafava, A.⁵ Cecchi, A.⁶ De Simone, G.⁷ Supuran, C.T.⁸

14
- 34250322126
- Dubois L., Douma K., Supuran C.T., Chiu R.K., van Zandvoort M.A.M.J., Pastorekova S., Scozzafava A., Wouters B.G., and Lambin P. Radiother. Oncol. 83 (2007) 367
- (2007) Radiother. Oncol. , vol.83 , pp. 367
- Dubois, L.¹ Douma, K.² Supuran, C.T.³ Chiu, R.K.⁴ van Zandvoort, M.A.M.J.⁵ Pastorekova, S.⁶ Scozzafava, A.⁷ Wouters, B.G.⁸ Lambin, P.⁹

15
- 55549090009
- Hilvo M., Baranauskiene L., Salzano A.M., Scaloni A., Matulis D., Innocenti A., Scozzafava A., Monti S.M., Di Fiore A., De Simone G., Lindfors M., Janis J., Valjakka J., Pastorekova S., Pastorek J., Kulomaa M.S., Nordlund H.R., Supuran C.T., and Parkkila S. J. Biol. Chem. 283 (2008) 27799
- (2008) J. Biol. Chem. , vol.283 , pp. 27799
- Hilvo, M.¹ Baranauskiene, L.² Salzano, A.M.³ Scaloni, A.⁴ Matulis, D.⁵ Innocenti, A.⁶ Scozzafava, A.⁷ Monti, S.M.⁸ Di Fiore, A.⁹ De Simone, G.¹⁰ Lindfors, M.¹¹ Janis, J.¹² Valjakka, J.¹³ Pastorekova, S.¹⁴ Pastorek, J.¹⁵ Kulomaa, M.S.¹⁶ Nordlund, H.R.¹⁷ Supuran, C.T.¹⁸ Parkkila, S.¹⁹

16
- 8844249356
- Svastova E., Hulikova A., Rafajova M., Zat'ovicova M., Gibadulinova A., Casini A., Cecchi A., Scozzafava A., Supuran C.T., Pastorek J., and Pastorekova S. FEBS Lett. 577 (2004) 439
- (2004) FEBS Lett. , vol.577 , pp. 439
- Svastova, E.¹ Hulikova, A.² Rafajova, M.³ Zat'ovicova, M.⁴ Gibadulinova, A.⁵ Casini, A.⁶ Cecchi, A.⁷ Scozzafava, A.⁸ Supuran, C.T.⁹ Pastorek, J.¹⁰ Pastorekova, S.¹¹

17
- 22744446294
- Cecchi A., Hulikova A., Pastorek J., Pastorekova S., Scozzafava A., Winum J.Y., Montero J.L., and Supuran C.T. J. Med. Chem. 48 (2005) 4834
- (2005) J. Med. Chem. , vol.48 , pp. 4834
- Cecchi, A.¹ Hulikova, A.² Pastorek, J.³ Pastorekova, S.⁴ Scozzafava, A.⁵ Winum, J.Y.⁶ Montero, J.L.⁷ Supuran, C.T.⁸

18
- 70349224835
- in press
- Dubois, L.; Lieuwes, N.G.; Maresca, A.; Thiry, A.; Supuran, C.T.; Scozzafava, A.; Wouters, B.G.; Lambin, P. Radiother. Oncol., in press.
- Radiother. Oncol
- Dubois, L.¹ Lieuwes, N.G.² Maresca, A.³ Thiry, A.⁴ Supuran, C.T.⁵ Scozzafava, A.⁶ Wouters, B.G.⁷ Lambin, P.⁸

19
- 35248828654
- Brahimi-Horn M.C., and Pouysségur J. Essays Biochem. 43 (2007) 165
- (2007) Essays Biochem. , vol.43 , pp. 165
- Brahimi-Horn, M.C.¹ Pouysségur, J.²

20
- 68349129756
- in press
- Stock, C.; Schwab, A. Pflugers Arch., in press.
- Pflugers Arch
- Stock, C.¹ Schwab, A.²

21
- 58249094845
- Chiche J., Ilc K., Laferrière J., Trottier E., Dayan F., Mazure N.M., Brahimi-Horn M.C., and Pouysségur J. Cancer Res. 69 (2009) 358
- (2009) Cancer Res. , vol.69 , pp. 358
- Chiche, J.¹ Ilc, K.² Laferrière, J.³ Trottier, E.⁴ Dayan, F.⁵ Mazure, N.M.⁶ Brahimi-Horn, M.C.⁷ Pouysségur, J.⁸

22
- 66549090944
- Ebbesen P., Pettersen E.O., Gorr T.A., Jobst G., Williams K., Kienninger J., Wenger R.H., Pastorekova S., Dubois L., Lambin P., Wouters B.G., Supuran C.T., Poellinger L., Ratcliffe P., Kanopka A., Görlach A., Gasmann M., Harris A.L., Maxwell P., and Scozzafava A. J. Enzyme Inhib. Med. Chem. 24 (2009) 1
- (2009) J. Enzyme Inhib. Med. Chem. , vol.24 , pp. 1
- Ebbesen, P.¹ Pettersen, E.O.² Gorr, T.A.³ Jobst, G.⁴ Williams, K.⁵ Kienninger, J.⁶ Wenger, R.H.⁷ Pastorekova, S.⁸ Dubois, L.⁹ Lambin, P.¹⁰ Wouters, B.G.¹¹ Supuran, C.T.¹² Poellinger, L.¹³ Ratcliffe, P.¹⁴ Kanopka, A.¹⁵ Görlach, A.¹⁶ Gasmann, M.¹⁷ Harris, A.L.¹⁸ Maxwell, P.¹⁹ Scozzafava, A.²⁰ more..

23
- 50649105780
- Swietach P., Wigfield S., Cobden P., Supuran C.T., Harris A.L., and Vaughan-Jones R.D. J. Biol. Chem. 283 (2008) 20473
- (2008) J. Biol. Chem. , vol.283 , pp. 20473
- Swietach, P.¹ Wigfield, S.² Cobden, P.³ Supuran, C.T.⁴ Harris, A.L.⁵ Vaughan-Jones, R.D.⁶

24
- 67749145635
- Swietach P., Patiar D., Supuran C.T., Harris A.L., and Vaughan-Jones R.D. J. Biol. Chem. 284 (2009) 20299
- (2009) J. Biol. Chem. , vol.284 , pp. 20299
- Swietach, P.¹ Patiar, D.² Supuran, C.T.³ Harris, A.L.⁴ Vaughan-Jones, R.D.⁵

25
- 67651091693
- Ahlskog J.K.J., Dumelin C.E., Trüssel S., Marlind J., and Neri D. Bioorg. Med. Chem. Lett. 19 (2009) 4851
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 4851
- Ahlskog, J.K.J.¹ Dumelin, C.E.² Trüssel, S.³ Marlind, J.⁴ Neri, D.⁵

26
- 0142121458
- Svastová E., Zilka N., Zat'ovicová M., Gibadulinová A., Ciampor F., Pastorek J., and Pastoreková S. Exp. Cell Res. 290 (2003) 332
- (2003) Exp. Cell Res. , vol.290 , pp. 332
- Svastová, E.¹ Zilka, N.² Zat'ovicová, M.³ Gibadulinová, A.⁴ Ciampor, F.⁵ Pastorek, J.⁶ Pastoreková, S.⁷

27
- 0015239422
- Khalifah, R. G. J. Biol. Chem. 1971, 246, 2561. An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol Red (at a concentration of 0.2 mM) has been used as indicator, working at the absorbance maximum of 557 nm, with 10 mM Hepes (pH 7.4) as buffer, 0.1 M Na2SO4 or NaClO4 (for maintaining constant the ionic strength; these anions are not inhibitory in the used concentration),7,8 following the CA-catalyzed CO2 hydration reaction for a period of 5-10 s. Saturated CO2 solutions in water at 25 °C were used as substrate. Triplicate experiments were done for each enzyme, and the values reported throughout the paper are the mean of such results. For obtaining the pH dependency, the following buffer/indicator pairs were used: pH 6.0, Mes, methyl red, working at 433 nM; pH 6.2 and 6.5, Mes, chlorophenol red, working at 574 nM; pH 6.8
- 4,6,8

28
- 0028111173
- Pastorek J., Pastorekova S., Callebaut I., Mornon J.P., Zelnik V., Opavsky R., Zatovicova M., Liao S., Portetelle D., Stanbridge E.J., Zavada J., Burny A., and Kettmann R. Oncogene 9 (1994) 2877
- (1994) Oncogene , vol.9 , pp. 2877
- Pastorek, J.¹ Pastorekova, S.² Callebaut, I.³ Mornon, J.P.⁴ Zelnik, V.⁵ Opavsky, R.⁶ Zatovicova, M.⁷ Liao, S.⁸ Portetelle, D.⁹ Stanbridge, E.J.¹⁰ Zavada, J.¹¹ Burny, A.¹² Kettmann, R.¹³

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.