Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths

Journal of Biological Chemistry

Volumn 283, Issue 29, 2008, Pages 20473-20483

  Swietach, Pawel ^a   Wigfield, Simon ^b   Cobden, Philip ^a   Supuran, Claudiu T ^c   Harris, Adrian L ^b   Vaughan Jones, Richard D ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; CARBON MONOXIDE; CELL MEMBRANES; COORDINATION REACTIONS; ENZYME ACTIVITY; ENZYMES; ONCOLOGY; THREE DIMENSIONAL; TUMORS;

CARBONIC ANHYDRASE; CELLS LACKING; CLINICAL TREATMENTS; EXTERNAL SURFACES; EXTRACELLULAR SPACES; FUNCTIONAL ROLES; NOVEL STRATEGIES; PHARMACOLOGICAL INHIBITIONS; SURVIVAL AND GROWTHS; TIME- DELAYS;

ENZYME INHIBITION;

CARBON DIOXIDE; CARBONATE DEHYDRATASE IX; ENZYME; CA9 PROTEIN, HUMAN; CARBONATE DEHYDRATASE; PROTON; TUMOR ANTIGEN;

ACIDITY; ARTICLE; BLADDER CARCINOMA; CANCER CELL; CANCER SURVIVAL; CARBON DIOXIDE CONCENTRATING MECHANISM; CELL CULTURE; CELL GROWTH; CELL ISOLATION; CELL PH; CHEMICAL REACTION; DIFFUSION; ENZYME INHIBITION; ENZYME REGULATION; EXTRACELLULAR SPACE; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; MULTICELLULAR SPHEROID; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SPATIAL AUTOCORRELATION ANALYSIS; THREE DIMENSIONAL IMAGING; TUMOR GROWTH; WILD TYPE; APOPTOSIS; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEOPLASM; PH; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

ANTIGENS, NEOPLASM; APOPTOSIS; CARBON DIOXIDE; CARBONIC ANHYDRASES; CELL LINE, TUMOR; CELL MEMBRANE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; PROTONS;

EID: 50649105780     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801330200     Document Type: Article

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