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Volumn 6, Issue 4, 2009, Pages 1041-1051

Extracellularly activated nanocarriers: A new paradigm of tumor targeted drug delivery

Author keywords

Activatable (activated) nanocarriers; Active targeting; Drug delivery; Nanocarriers; Passive targeting; Tumor targeting

Indexed keywords

ANTINEOPLASTIC AGENT; DENDRIMER; DOXORUBICIN; IMMUNOLIPOSOME; LIPOSOME; MATRIX METALLOPROTEINASE; NANOCARRIER; NANOPARTICLE; PACLITAXEL; POLY(DEXTRO,LEVO LACTIC CO GLYCOLIC ACID)POLY(ETHYLENE GLYCOL); POLY(EPSILONE CAPROLACTONE)POLY(ETHYL ETHYLENE PHOSPHATE); POLY(LACTIC ACID)POLY(ETHYLENE OXIDE); POLYMER; UNCLASSIFIED DRUG;

EID: 68249118615     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp900090z     Document Type: Review
Times cited : (422)

References (114)
  • 1
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura, Y.; Maeda, H. A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs. Cancer Res. 1986, 46, 6387-6392. (Pubitemid 17221789)
    • (1986) Cancer Research , vol.46 , Issue.12 I , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 2
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review
    • DOI 10.1016/S0168-3659(99)00248-5, PII S0168365999002485
    • Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J. Controlled Release 2000, 65 (1-2), 271. (Pubitemid 30122932)
    • (2000) Journal of Controlled Release , vol.65 , Issue.1-2 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3    Matsumura, Y.4    Hori, K.5
  • 4
    • 33746172167 scopus 로고    scopus 로고
    • Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models
    • Kirpotin, D. B.; Drummond, D. C.; Shao, Y.; Shalaby, M. R.; Hong, K. L.; Nielsen, U. B.; Marks, J. D.; Benz, C. C.; Park, J. W. Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res. 2006, 66 (13), 6732-6740.
    • (2006) Cancer Res. , vol.66 , Issue.13 , pp. 6732-6740
    • Kirpotin, D.B.1    Drummond, D.C.2    Shao, Y.3    Shalaby, M.R.4    Hong, K.L.5    Nielsen, U.B.6    Marks, J.D.7    Benz, C.C.8    Park, J.W.9
  • 5
    • 29244489232 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo
    • Mamot, C.; Drummond, D. C.; Noble, C. O.; Kallab, V.; Guo, Z. X.; Hong, K. L.; Kirpotin, D. B.; Park, J. W. Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo. Cancer Res. 2005, 65 (24), 11631-11638.
    • (2005) Cancer Res. , vol.65 , Issue.24 , pp. 11631-11638
    • Mamot, C.1    Drummond, D.C.2    Noble, C.O.3    Kallab, V.4    Guo, Z.X.5    Hong, K.L.6    Kirpotin, D.B.7    Park, J.W.8
  • 6
    • 34248588338 scopus 로고    scopus 로고
    • Difunctional Pluronic copolymer micelles for paclitaxel delivery: Synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines
    • Wang, Y. Z.; Yu, L.; Han, L. M.; Sha, X. Y.; Fang, X. L. Difunctional Pluronic copolymer micelles for paclitaxel delivery: Synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines. Int. J. Pharm. 2007, 337 (1-2), 63-73.
    • (2007) Int. J. Pharm. , vol.337 , Issue.1-2 , pp. 63-73
    • Wang, Y.Z.1    Yu, L.2    Han, L.M.3    Sha, X.Y.4    Fang, X.L.5
  • 7
    • 0141886984 scopus 로고    scopus 로고
    • VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: In vivo studies
    • DOI 10.1016/S0168-3659(03)00242-6
    • Dagar, S.; Krishnadas, A.; Rubinstein, I.; Blend, M. J.; Onyuksel, H. VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: in vivo studies. J. Controlled Release 2003, 91 (1-2), 123-133. (Pubitemid 37288883)
    • (2003) Journal of Controlled Release , vol.91 , Issue.1-2 , pp. 123-133
    • Dagar, S.1    Krishnadas, A.2    Rubinstein, I.3    Blend, M.J.4    Onyuksel, H.5
  • 8
    • 57249084773 scopus 로고    scopus 로고
    • Polymeric Micellar Delivery Systems in Oncology
    • Matsumura, Y. Polymeric Micellar Delivery Systems in Oncology. Jpn. J. Clin. Oncol. 2008, 38 (12), 793-802.
    • (2008) Jpn. J. Clin. Oncol. , vol.38 , Issue.12 , pp. 793-802
    • Matsumura, Y.1
  • 9
    • 51649108542 scopus 로고    scopus 로고
    • Disposition of Drugs in Block Copolymer Micelle Delivery Systems: From Discovery to Recovery
    • Hamidreza Montazeri, A.; Shahin, M.; Brocks, D. R.; Lavasanifar, A. Disposition of Drugs in Block Copolymer Micelle Delivery Systems: From Discovery to Recovery. Clin. Pharmacokinet. 2008, 47, 619-634.
    • (2008) Clin. Pharmacokinet. , vol.47 , pp. 619-634
    • Hamidreza Montazeri, A.1    Shahin, M.2    Brocks, D.R.3    Lavasanifar, A.4
  • 10
    • 23744471772 scopus 로고    scopus 로고
    • Drug targeting with nano-sized carrier systems
    • DOI 10.1007/s10047-005-0285-0
    • Yokoyama, M. Drug targeting with nano-sized carrier systems. J. Artif. Organs 2005, 8 (2), 77-84. (Pubitemid 41139586)
    • (2005) Journal of Artificial Organs , vol.8 , Issue.2 , pp. 77-84
    • Yokoyama, M.1
  • 12
  • 13
    • 1642362625 scopus 로고    scopus 로고
    • Drug Delivery Systems: Entering the Mainstream
    • DOI 10.1126/science.1095833
    • Allen, T. M.; Cullis, P. R. Drug Delivery Systems: Entering the Mainstream. Science 2004, 303 (5665), 1818-1822. (Pubitemid 38374867)
    • (2004) Science , vol.303 , Issue.5665 , pp. 1818-1822
    • Allen, T.M.1    Cullis, P.R.2
  • 14
    • 34249327294 scopus 로고    scopus 로고
    • Targeted pharmaceutical nanocarriers for cancer therapy and Imaging
    • Torchilin, V. P. Targeted pharmaceutical nanocarriers for cancer therapy and Imaging. AAPS J. 2007, 9 (2), E128-E147.
    • (2007) AAPS J. , vol.9 , Issue.2
    • Torchilin, V.P.1
  • 15
    • 37249093948 scopus 로고    scopus 로고
    • Biodegradable, polymeric nanoparticle delivery systems for cancer therapy
    • DOI 10.2217/17435889.2.5.669
    • Pridgen, E. M.; Langer, R.; Farokhzad, O. C. Biodegradable, polymeric nanoparticle delivery systems for cancer therapy. Nanomedicine 2007, 2 (5), 669-680. (Pubitemid 350268246)
    • (2007) Nanomedicine , vol.2 , Issue.5 , pp. 669-680
    • Pridgen, E.M.1    Langer, R.2    Farokhzad, O.C.3
  • 16
    • 34250819325 scopus 로고    scopus 로고
    • Poly(ethylene glycol)-modified Nanocarriers for Tumor-targeted and Intracellular Delivery
    • van Vlerken, L.; Vyas, T.; Amiji, M. Poly(ethylene glycol)-modified Nanocarriers for Tumor-targeted and Intracellular Delivery. Pharm. Res. 2007, 24 (8), 1405-1414.
    • (2007) Pharm. Res. , vol.24 , Issue.8 , pp. 1405-1414
    • Van Vlerken, L.1    Vyas, T.2    Amiji, M.3
  • 17
    • 33745703563 scopus 로고    scopus 로고
    • Polymer Therapeutics: Concepts and Applications
    • Haag, R.; Kratz, F. Polymer Therapeutics: Concepts and Applications. Angew. Chem., Int. Ed. 2006, 45 (8), 1198-1215.
    • (2006) Angew. Chem., Int. Ed. , vol.45 , Issue.8 , pp. 1198-1215
    • Haag, R.1    Kratz, F.2
  • 18
    • 36849067019 scopus 로고    scopus 로고
    • Nanocarriers as an emerging platform for cancer therapy
    • DOI 10.1038/nnano.2007.387, PII NNANO2007387
    • Peer, D.; Karp, J. M.; Hong, S.; Farokhzad, O. C.; Margalit, R.; Langer, R. Nanocarriers as an emerging platform for cancer therapy. Nat. Nano 2007, 2 (12), 751-760. (Pubitemid 350223348)
    • (2007) Nature Nanotechnology , vol.2 , Issue.12 , pp. 751-760
    • Peer, D.1    Karp, J.M.2    Hong, S.3    Farokhzad, O.C.4    Margalit, R.5    Langer, R.6
  • 19
    • 38449092058 scopus 로고    scopus 로고
    • Pharmaceutical applications of dendrimers: Promising nanocarriers for drug delivery
    • Cheng, Y. Y.; Wang, J. R.; Rao, T. L.; He, X. X.; Xu, T. W. Pharmaceutical applications of dendrimers: promising nanocarriers for drug delivery. Front. Biosci. 2008, 13, 1447-1471.
    • (2008) Front. Biosci. , vol.13 , pp. 1447-1471
    • Cheng, Y.Y.1    Wang, J.R.2    Rao, T.L.3    He, X.X.4    Xu, T.W.5
  • 20
    • 42749091133 scopus 로고    scopus 로고
    • Polymer-drug conjugates: Recent development in clinical oncology
    • Li, C.; Wallace, S. Polymer-drug conjugates: Recent development in clinical oncology. Adv. Drug Delivery Rev. 2008, 60 (8), 886-898.
    • (2008) Adv. Drug Delivery Rev. , vol.60 , Issue.8 , pp. 886-898
    • Li, C.1    Wallace, S.2
  • 21
    • 39649120532 scopus 로고    scopus 로고
    • A review of stimuli-responsive nanocarriers for drug and gene delivery
    • Ganta, S.; Devalapally, H.; Shahiwala, A.; Amiji, M. A review of stimuli-responsive nanocarriers for drug and gene delivery. J. Controlled Release 2008, 126 (3), 187-204.
    • (2008) J. Controlled Release , vol.126 , Issue.3 , pp. 187-204
    • Ganta, S.1    Devalapally, H.2    Shahiwala, A.3    Amiji, M.4
  • 22
    • 39449102666 scopus 로고    scopus 로고
    • Polymeric nanoparticles for cancer therapy
    • Parveen, S.; Sahoo, S. K. Polymeric nanoparticles for cancer therapy. J. Drug Targeting 2008, 16 (2), 108-123.
    • (2008) J. Drug Targeting , vol.16 , Issue.2 , pp. 108-123
    • Parveen, S.1    Sahoo, S.K.2
  • 24
    • 40949127319 scopus 로고    scopus 로고
    • Therapeutic nanoparticles for drug delivery in cancer
    • Cho, K. J.; Wang, X.; Nie, S. M.; Chen, Z.; Shin, D. M. Therapeutic nanoparticles for drug delivery in cancer. Clin. Cancer Res. 2008, 14 (5), 1310-1316.
    • (2008) Clin. Cancer Res. , vol.14 , Issue.5 , pp. 1310-1316
    • Cho, K.J.1    Wang, X.2    Nie, S.M.3    Chen, Z.4    Shin, D.M.5
  • 25
    • 64249144692 scopus 로고    scopus 로고
    • Targeted Cancer Immunotherapy Using Ligands of the Tumor Necrosis Factor Super-Family
    • Bremer, E.; de Bruyn, M.; Wajant, H.; Helfrich, W. Targeted Cancer Immunotherapy Using Ligands of the Tumor Necrosis Factor Super-Family. Curr. Drug Targets 2009, 10 (2), 94-103.
    • (2009) Curr. Drug Targets , vol.10 , Issue.2 , pp. 94-103
    • Bremer, E.1    De Bruyn, M.2    Wajant, H.3    Helfrich, W.4
  • 26
    • 55849099605 scopus 로고    scopus 로고
    • Active targeting schemes for nanoparticle systems in cancer therapeutics
    • Byrne, J. D.; Betancourt, T.; Brannon-Peppas, L. Active targeting schemes for nanoparticle systems in cancer therapeutics. Adv. Drug Delivery Rev. 2008, 60 (15), 1615-1626.
    • (2008) Adv. Drug Delivery Rev. , vol.60 , Issue.15 , pp. 1615-1626
    • Byrne, J.D.1    Betancourt, T.2    Brannon-Peppas, L.3
  • 27
    • 58149235638 scopus 로고    scopus 로고
    • Nanomedicine: New Challenges and Opportunities in Cancer Therapy
    • Hervella, P.; Lozano, V.; Garcia-Fuentes, M. Nanomedicine: New Challenges and Opportunities in Cancer Therapy. J. Biomed. Nanotechnol. 2008, 4 (3), 276-292.
    • (2008) J. Biomed. Nanotechnol. , vol.4 , Issue.3 , pp. 276-292
    • Hervella, P.1    Lozano, V.2    Garcia-Fuentes, M.3
  • 28
    • 61649093243 scopus 로고    scopus 로고
    • Tumor targeting using liposomal antineoplastic drugs
    • Huwyler, J.; Drewe, J.; Krahenbuhl, S. Tumor targeting using liposomal antineoplastic drugs. Int. J. Nanomed. 2008, 3 (1), 21-29.
    • (2008) Int. J. Nanomed. , vol.3 , Issue.1 , pp. 21-29
    • Huwyler, J.1    Drewe, J.2    Krahenbuhl, S.3
  • 29
    • 42749088011 scopus 로고    scopus 로고
    • Factors affecting toxicity and efficacy of polymeric nanomedicines
    • Igarashi, E. Factors affecting toxicity and efficacy of polymeric nanomedicines. Toxicol. Appl. Pharmacol. 2008, 229 (1), 121-134.
    • (2008) Toxicol. Appl. Pharmacol. , vol.229 , Issue.1 , pp. 121-134
    • Igarashi, E.1
  • 30
    • 53649089895 scopus 로고    scopus 로고
    • Multi-functional nanocarriers to overcome tumor drug resistance
    • Jabr-Milane, L. S.; van Vlerken, L. E.; Yadav, S.; Amiji, M. M. Multi-functional nanocarriers to overcome tumor drug resistance. Cancer Treat. Rev. 2008, 34 (7), 592-602.
    • (2008) Cancer Treat. Rev. , vol.34 , Issue.7 , pp. 592-602
    • Jabr-Milane, L.S.1    Van Vlerken, L.E.2    Yadav, S.3    Amiji, M.M.4
  • 31
    • 55949115619 scopus 로고    scopus 로고
    • Colloidal Drug Delivery Systems - Recent Advances with Polymeric Micelles
    • Mondon, K.; Gurny, R.; Moller, M. Colloidal Drug Delivery Systems - Recent Advances With Polymeric Micelles. Chimia 2008, 62 (10), 832-840.
    • (2008) Chimia , vol.62 , Issue.10 , pp. 832-840
    • Mondon, K.1    Gurny, R.2    Moller, M.3
  • 32
    • 0034993240 scopus 로고    scopus 로고
    • The enhanced permeability and retention (EPR) effect in tumor vasculature: The key role of tumor-selective macromolecular drug targeting
    • DOI 10.1016/S0065-2571(00)00013-3, PII S0065257100000133
    • Maeda, H. The enhanced permeability and retention (EPR) effect in tumor vasculature: The key role of tumor-selective macromolecular drug targeting. Adv. Enzyme Regul. 2001, 41, 189-207. (Pubitemid 32520323)
    • (2001) Advances in Enzyme Regulation , vol.41 , pp. 189-207
    • Maeda, H.1
  • 33
    • 34547653668 scopus 로고    scopus 로고
    • Enhanced permeability and retention of macromolecular drugs in solid tumors: A royal gate for targeted anticancer nanomedicines
    • DOI 10.1080/10611860701539584, PII 781027183
    • Greish, K. Enhanced permeability and retention of macromolecular drugs in solid tumors: a royal gate for targeted anticancer nanomedicines. J Drug Targeting 2007, 15 (7-8), 457-464 (Pubitemid 47209047)
    • (2007) Journal of Drug Targeting , vol.15 , Issue.7-8 , pp. 457-464
    • Greish, K.1
  • 34
    • 0029150245 scopus 로고
    • Vascular permeability in a human tumor xenograft: Molecular size dependence and cutoff size
    • Yuan, F.; Dellian, M.; Fukumura, D.; Leunig, M.; Berk, D. A.; Torchilin, V. P.; Jain, R. K. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res. 1995, 55 (17), 3752-3756.
    • (1995) Cancer Res. , vol.55 , Issue.17 , pp. 3752-3756
    • Yuan, F.1    Dellian, M.2    Fukumura, D.3    Leunig, M.4    Berk, D.A.5    Torchilin, V.P.6    Jain, R.K.7
  • 35
  • 36
    • 33748498232 scopus 로고    scopus 로고
    • Pros and cons of the liposome platform in cancer drug targeting
    • DOI 10.1080/08982100600848769, PII L240472212U58PQ4
    • Gabizon, A. A.; Shmeeda, H.; Zalipsky, S. Pros and cons of the liposome platform in cancer drug targeting. J. Liposome Res. 2006, 16 (3), 175-183. (Pubitemid 44358991)
    • (2006) Journal of Liposome Research , vol.16 , Issue.3 , pp. 175-183
    • Gabizon, A.A.1    Shmeeda, H.2    Zalipsky, S.3
  • 37
    • 34548859519 scopus 로고    scopus 로고
    • Tumor pH-responsive flower-like micelles of poly(L-lactic acid)-b-poly (ethylene glycol)-b-poly(L-histidine)
    • Lee, E. S.; Oh, K. T.; Kim, D.; Youn, Y. S.; Bae, Y. H. Tumor pH-responsive flower-like micelles of poly(L-lactic acid)-b-poly (ethylene glycol)-b-poly(L-histidine). J. Controlled Release 2007, 123 (1), 19-26.
    • (2007) J. Controlled Release , vol.123 , Issue.1 , pp. 19-26
    • Lee, E.S.1    Oh, K.T.2    Kim, D.3    Youn, Y.S.4    Bae, Y.H.5
  • 38
    • 0344420226 scopus 로고    scopus 로고
    • Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates
    • Caliceti, P.; Veronese, F. M. Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates. Adv. Drug Delivery Rev. 2003, 55 (10), 1261-1277.
    • (2003) Adv. Drug Delivery Rev. , vol.55 , Issue.10 , pp. 1261-1277
    • Caliceti, P.1    Veronese, F.M.2
  • 39
    • 51049092308 scopus 로고    scopus 로고
    • Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
    • Alexis, F.; Pridgen, E.; Molnar, L. K.; Farokhzad, O. C. Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles. Mol. Pharmaceutics 2008, 5 (4), 505-515.
    • (2008) Mol. Pharmaceutics , vol.5 , Issue.4 , pp. 505-515
    • Alexis, F.1    Pridgen, E.2    Molnar, L.K.3    Farokhzad, O.C.4
  • 40
    • 0027362463 scopus 로고
    • Charge selectivity of the glomerular filtration barrier in healthy and nephrotic humans
    • Guasch, A.; Deen, W. M.; Myers, B. D. Charge selectivity of the glomerular filtration barrier in healthy and nephrotic humans. J. Clin. Invest. 1993, 92 (5), 2274-2282. (Pubitemid 23333533)
    • (1993) Journal of Clinical Investigation , vol.92 , Issue.5 , pp. 2274-2282
    • Guasch, A.1    Deen, W.M.2    Myers, B.D.3
  • 41
    • 0016716868 scopus 로고
    • Role of molecular charge in glomerular permeability. Tracer studies with cationized ferritins
    • Rennke, H. G.; Cotran, R. S.; Venkatachalam, M. A. Role of molecular charge in glomerular permeability. Tracer studies with cationized ferritins. J. Cell Biol. 1975, 67 (3), 638-646.
    • (1975) J. Cell Biol. , vol.67 , Issue.3 , pp. 638-646
    • Rennke, H.G.1    Cotran, R.S.2    Venkatachalam, M.A.3
  • 42
    • 28844488494 scopus 로고    scopus 로고
    • Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
    • Owens, D. E.; Peppas, N. A. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int. J. Pharm. 2006, 307 (1), 93-102.
    • (2006) Int. J. Pharm. , vol.307 , Issue.1 , pp. 93-102
    • Owens, D.E.1    Peppas, N.A.2
  • 43
    • 58149099457 scopus 로고    scopus 로고
    • PEGylation of nanocarrier drug delivery systems: State of the art
    • Howard, M. D.; Jay, M.; Dziublal, T. D.; Lu, X. L. PEGylation of nanocarrier drug delivery systems: State of the art. J. Biomed. Nanotechnol. 2008, 4 (2), 133-148.
    • (2008) J. Biomed. Nanotechnol. , vol.4 , Issue.2 , pp. 133-148
    • Howard, M.D.1    Jay, M.2    Dziublal, T.D.3    Lu, X.L.4
  • 44
    • 0033782389 scopus 로고    scopus 로고
    • Evaluation of drug targeting strategies and liposomal trafficking
    • Oku, N.; Tokudome, Y.; Asai, T.; Tsukada, H. Evaluation of Drug Targeting Strategies and Liposomal Trafficking. Curr. Pharm. Des. 2000, 6, 1669-1691. (Pubitemid 30765418)
    • (2000) Current Pharmaceutical Design , vol.6 , Issue.16 , pp. 1669-1691
    • Oku, N.1    Tokudome, Y.2    Asai, T.3    Tsukada, H.4
  • 45
    • 0037681850 scopus 로고    scopus 로고
    • Pharmacokinetics of pegylated liposomal doxorubicin: Review of animal and human studies
    • DOI 10.2165/00003088-200342050-00002
    • Gabizon, A.; Shmeeda, H.; Barenholz, Y. Pharmacokinetics of pegylated liposomal doxorubicin - Review of animal and human studies. Clin. Pharmacokinet. 2003, 42 (5), 419-436. (Pubitemid 36649037)
    • (2003) Clinical Pharmacokinetics , vol.42 , Issue.5 , pp. 419-436
    • Gabizon, A.1    Shmeeda, H.2    Barenholz, Y.3
  • 46
    • 0035005359 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin: Metamorphosis of an old drug into a new form of chemotherapy
    • Gabizon, A. A. Pegylated liposomal doxorubicin: Metamorphosis of an old drug into a new form of chemotherapy. Cancer Invest. 2001, 19 (4), 424-436.
    • (2001) Cancer Invest. , vol.19 , Issue.4 , pp. 424-436
    • Gabizon, A.A.1
  • 47
    • 0032793990 scopus 로고    scopus 로고
    • Significant increase in antitumor potency of doxorubicin HCl by its encapsulation in pegylated liposomes
    • Colbern, G. T.; Hiller, A. J.; Musterer, R. S.; Pegg, E.; Henderson, I. C.; Working, P. K. Significant increase in antitumor potency of doxorubicin HCl by its encapsulation in pegylated liposomes. J. Liposome Res. 1999, 9 (4), 523-538.
    • (1999) J. Liposome Res. , vol.9 , Issue.4 , pp. 523-538
    • Colbern, G.T.1    Hiller, A.J.2    Musterer, R.S.3    Pegg, E.4    Henderson, I.C.5    Working, P.K.6
  • 48
    • 57049158125 scopus 로고    scopus 로고
    • Drug targeting and tumor heterogeneity
    • Bae, Y. H. Drug targeting and tumor heterogeneity. J. Controlled Release 2009, 133 (1), 2-3.
    • (2009) J. Controlled Release , vol.133 , Issue.1 , pp. 2-3
    • Bae, Y.H.1
  • 50
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure - An obstacle in cancer therapy
    • DOI 10.1038/nrc1456
    • Heldin, C.-H.; Rubin, K.; Pietras, K.; Ostman, A. High interstitial fluid pressure-an obstacle in cancer therapy. Nat. Rev. Cancer 2004, 4, 806-813. (Pubitemid 39331152)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.10 , pp. 806-813
    • Heldin, C.-H.1    Rubin, K.2    Pietras, K.3    Ostman, A.4
  • 51
    • 0030200835 scopus 로고    scopus 로고
    • Effect of Transvascular Fluid Exchange on Pressure-Flow Relationship in Tumors: A Proposed Mechanism for Tumor Blood Flow Heterogeneity
    • Netti, P. A.; Roberge, S.; Boucher, Y.; Baxter, L. T.; Jain, R. K. Effect of Transvascular Fluid Exchange on Pressure-Flow Relationship in Tumors: A Proposed Mechanism for Tumor Blood Flow Heterogeneity. Microvasc. Res. 1996, 52 (1), 27-46.
    • (1996) Microvasc. Res. , vol.52 , Issue.1 , pp. 27-46
    • Netti, P.A.1    Roberge, S.2    Boucher, Y.3    Baxter, L.T.4    Jain, R.K.5
  • 52
    • 2942632966 scopus 로고    scopus 로고
    • PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles
    • Mishra, S.; Webster, P.; Davis, M. E. PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles. Eur. J. Cell Biol. 2004, 83 (3), 97-111.
    • (2004) Eur. J. Cell Biol. , vol.83 , Issue.3 , pp. 97-111
    • Mishra, S.1    Webster, P.2    Davis, M.E.3
  • 54
    • 38049165716 scopus 로고    scopus 로고
    • Sheddable Coatings for Long-Circulating Nanoparticles
    • Romberg, B.; Hennink, W.; Storm, G. Sheddable Coatings for Long-Circulating Nanoparticles. Pharm. Res. 2008, 25 (1), 55-71.
    • (2008) Pharm. Res. , vol.25 , Issue.1 , pp. 55-71
    • Romberg, B.1    Hennink, W.2    Storm, G.3
  • 55
    • 0032713936 scopus 로고    scopus 로고
    • Direct comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: Is surface coating with polyethylene glycol beneficial
    • Hong, R. L.; Huang, C. J.; Tseng, Y. L.; Pang, V. F.; Chen, S. T.; Liu, J. J.; Chang, F. H. Direct comparison of liposomal doxorubicin with or without polyethylene glycol coating in C-26 tumor-bearing mice: Is surface coating with polyethylene glycol beneficial. Clin. Cancer Res. 1999, 5 (11), 3645-3652.
    • (1999) Clin. Cancer Res. , vol.5 , Issue.11 , pp. 3645-3652
    • Hong, R.L.1    Huang, C.J.2    Tseng, Y.L.3    Pang, V.F.4    Chen, S.T.5    Liu, J.J.6    Chang, F.H.7
  • 56
    • 0035910885 scopus 로고    scopus 로고
    • Screening effect of PEG on avidin binding to liposome surface receptors
    • DOI 10.1016/S0378-5173(00)00633-5, PII S0378517300006335
    • Kaasgaard, T.; Mouritsen, O. G.; Jørgensen, K. Screening effect of PEG on avidin binding to liposome surface receptors. Int. J. Pharm. 2001, 214 (1-2), 63-65. (Pubitemid 32244079)
    • (2001) International Journal of Pharmaceutics , vol.214 , Issue.1-2 , pp. 63-65
    • Kaasgaard, T.1    Mouritsen, O.G.2    Jorgensen, K.3
  • 57
    • 33845625261 scopus 로고    scopus 로고
    • Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid
    • DOI 10.1038/sj.gt.3302843, PII 3302843
    • Hatakeyama, H.; Akita, H.; Kogure, K.; Oishi, M.; Nagasaki, Y.; Kihira, Y.; Ueno, M.; Kobayashi, H.; Kikuchi, H.; Harashima, H. Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid. Gene Ther. 2007, 14 (1), 68-77. (Pubitemid 44942867)
    • (2007) Gene Therapy , vol.14 , Issue.1 , pp. 68-77
    • Hatakeyama, H.1    Akita, H.2    Kogure, K.3    Oishi, M.4    Nagasaki, Y.5    Kihira, Y.6    Ueno, M.7    Kobayashi, H.8    Kikuchi, H.9    Harashima, H.10
  • 58
    • 0037148656 scopus 로고    scopus 로고
    • Poly(ethylene oxide)-block-poly(L-amino acid) micelles for drug delivery
    • Lavasanifar, A.; Samuel, J.; Kwon, G. S. Poly(ethylene oxide)-block-poly(L-amino acid) micelles for drug delivery. Adv. Drug Delivery Rev. 2002, 54 (2), 169-190.
    • (2002) Adv. Drug Delivery Rev. , vol.54 , Issue.2 , pp. 169-190
    • Lavasanifar, A.1    Samuel, J.2    Kwon, G.S.3
  • 61
    • 1242271202 scopus 로고    scopus 로고
    • Herceptin-Geldanamycin Immunoconjugates: Pharmacokinetics, Biodistribution, and Enhanced Antitumor Activity
    • Mandler, R.; Kobayashi, H.; Hinson, E. R.; Brechbiel, M. W.; Waldmann, T. A. Herceptin-Geldanamycin Immunoconjugates: Pharmacokinetics, Biodistribution, and Enhanced Antitumor Activity. Cancer Res. 2004, 64 (4), 1460-1467.
    • (2004) Cancer Res. , vol.64 , Issue.4 , pp. 1460-1467
    • Mandler, R.1    Kobayashi, H.2    Hinson, E.R.3    Brechbiel, M.W.4    Waldmann, T.A.5
  • 62
    • 38949215454 scopus 로고    scopus 로고
    • Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases
    • Low, P. S.; Henne, W. A.; Doorneweerd, D. D. Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases. Acc. Chem. Res. 2007, 41 (1), 120-129.
    • (2007) Acc. Chem. Res. , vol.41 , Issue.1 , pp. 120-129
    • Low, P.S.1    Henne, W.A.2    Doorneweerd, D.D.3
  • 63
    • 62649125368 scopus 로고    scopus 로고
    • Tumor-Specific Anti-Nucleosome Antibody Improves Therapeutic Efficacy of Doxorubicin-Loaded Long-Circulating Liposomes against Primary and Metastatic Tumor in Mice
    • ElBayoumi, T. A.; Torchilin, V. P. Tumor-Specific Anti-Nucleosome Antibody Improves Therapeutic Efficacy of Doxorubicin-Loaded Long-Circulating Liposomes against Primary and Metastatic Tumor in Mice. Mol. Pharmaceutics 2009, 6 (1), 246-254.
    • (2009) Mol. Pharmaceutics , vol.6 , Issue.1 , pp. 246-254
    • Elbayoumi, T.A.1    Torchilin, V.P.2
  • 64
    • 34848918210 scopus 로고    scopus 로고
    • Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
    • Bartlett, D. W.; Su, H.; Hildebrandt, I. J.; Weber, W. A.; Davis, M. E. Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging. Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (39), 15549-15554.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , Issue.39 , pp. 15549-15554
    • Bartlett, D.W.1    Su, H.2    Hildebrandt, I.J.3    Weber, W.A.4    Davis, M.E.5
  • 65
    • 0346333236 scopus 로고    scopus 로고
    • In Vivo Fate of Folate-Targeted Polyethylene-Glycol Liposomes in Tumor-Bearing Mice
    • Gabizon, A.; Horowitz, A. T.; Goren, D.; Tzemach, D.; Shmeeda, H.; Zalipsky, S. In vivo fate of folate-targeted polyethyleneglycol liposomes in tumor-bearing mice. Clin. Cancer Res. 2003, 9 (17), 6551-6559. (Pubitemid 38031844)
    • (2003) Clinical Cancer Research , vol.9 , Issue.17 , pp. 6551-6559
    • Gabizon, A.1    Horowitz, A.T.2    Goren, D.3    Tzemach, D.4    Shmeeda, H.5    Zalipsky, S.6
  • 66
    • 25444471028 scopus 로고    scopus 로고
    • Intracellular delivery of doxorubicin with RGD-modified sterically stabilized liposomes for an improved antitumor efficacy: In vitro and in vivo
    • DOI 10.1002/jps.20397
    • Xiong, X. B.; Huang, Y.; Lu, W. L.; Zhang, X.; Zhang, H.; Nagai, T.; Zhang, Q. Intracellular delivery of doxorubicin with RGD-modified sterically stabilized liposomes for an improved antitumor efficacy: in vitro and in vivo. J. Pharm. Sci. 2005, 94 (8), 1782-1793. (Pubitemid 41360872)
    • (2005) Journal of Pharmaceutical Sciences , vol.94 , Issue.8 , pp. 1782-1793
    • Xiong, X.-B.1    Huang, Y.2    Lu, W.-L.3    Zhang, X.4    Zhang, H.5    Nagai, T.6    Zhang, Q.7
  • 67
    • 21244494846 scopus 로고    scopus 로고
    • Enhanced intracellular uptake of sterically stabilized liposomal doxorubicin in Vitro resulting in improved antitumor activity in Vivo
    • DOI 10.1007/s11095-005-4588-x
    • Xiong, X. B.; Huang, Y.; Lu, W. L.; Zhang, H.; Zhang, X.; Zhang, Q. Enhanced intracellular uptake of sterically stabilized liposomal Doxorubicin in vitro resulting in improved antitumor activity in vivo. Pharm. Res. 2005, 22 (6), 933-939. (Pubitemid 40898103)
    • (2005) Pharmaceutical Research , vol.22 , Issue.6 , pp. 933-939
    • Xiong, X.-B.1    Huang, Y.2    Lu, W.-L.3    Zhang, H.4    Zhang, X.5    Zhang, Q.6
  • 68
    • 63549094211 scopus 로고    scopus 로고
    • Tumor-Targeted Nanomedicines: Enhanced Antitumor Efficacy in vivo of Doxorubicin-Loaded, Long-Circulating Liposomes Modified with Cancer-Specific Monoclonal Antibody
    • ElBayoumi, T. A.; Torchilin, V. P. Tumor-Targeted Nanomedicines: Enhanced Antitumor Efficacy In vivo of Doxorubicin-Loaded, Long-Circulating Liposomes Modified with Cancer-Specific Monoclonal Antibody. Clin. Cancer Res. 2009, 15 (6), 1973-1980.
    • (2009) Clin. Cancer Res. , vol.15 , Issue.6 , pp. 1973-1980
    • ElBayoumi, T.A.1    Torchilin, V.P.2
  • 69
    • 43049105075 scopus 로고    scopus 로고
    • Arg-Gly-Asp (RGD) peptide conjugated poly(lactic acid)-poly(ethylene oxide) micelle for targeted drug delivery
    • Hu, Z. Y.; Luo, F.; Pan, Y. F.; Hou, C.; Ren, L. F.; Chen, J. J.; Wang, J. W.; Zhang, Y. D. Arg-Gly-Asp (RGD) peptide conjugated poly(lactic acid)-poly(ethylene oxide) micelle for targeted drug delivery. J. Biomed. Mater. Res. Part A 2008, 85A (3), 797-807.
    • (2008) J. Biomed. Mater. Res. Part A , vol.85 A , Issue.3 , pp. 797-807
    • Hu, Z.Y.1    Luo, F.2    Pan, Y.F.3    Hou, C.4    Ren, L.F.5    Chen, J.J.6    Wang, J.W.7    Zhang, Y.D.8
  • 70
    • 35848961893 scopus 로고    scopus 로고
    • Antitumor effect of paclitaxel-loaded PEGylated immunoliposomes against human breast cancer cells
    • Yang, T.; Choi, M. K.; Cui, F. D.; Lee, S. J.; Chung, S. J.; Shim, C. K.; Kim, D. D. Antitumor effect of paclitaxel-loaded PEGylated immunoliposomes against human breast cancer cells. Pharm. Res. 2007, 24 (12), 2402-2411.
    • (2007) Pharm. Res. , vol.24 , Issue.12 , pp. 2402-2411
    • Yang, T.1    Choi, M.K.2    Cui, F.D.3    Lee, S.J.4    Chung, S.J.5    Shim, C.K.6    Kim, D.D.7
  • 71
    • 1842638560 scopus 로고    scopus 로고
    • Folate receptor targeted biodegradable polymeric doxorubicin micelles
    • Yoo, H. S.; Park, T. G. Folate receptor targeted biodegradable polymeric doxorubicin micelles. J. Controlled Release 2004, 96 (2), 273-283.
    • (2004) J. Controlled Release , vol.96 , Issue.2 , pp. 273-283
    • Yoo, H.S.1    Park, T.G.2
  • 73
    • 33846210997 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics, tissue distribution, and antitumor activity of a folate-hapten conjugate-targeted immunotherapy in hapten-immunized mice
    • Lu, Y. J.; Xu, L. C.; Parker, N.; Westrick, E.; Reddy, J. A.; Vetzel, M.; Low, P. S.; Leamon, C. P. Preclinical pharmacokinetics, tissue distribution, and antitumor activity of a folate-hapten conjugate-targeted immunotherapy in hapten-immunized mice. Mol. Cancer Ther. 2006, 5 (12), 3258-3267.
    • (2006) Mol. Cancer Ther. , vol.5 , Issue.12 , pp. 3258-3267
    • Lu, Y.J.1    Xu, L.C.2    Parker, N.3    Westrick, E.4    Reddy, J.A.5    Vetzel, M.6    Low, P.S.7    Leamon, C.P.8
  • 74
    • 1942439013 scopus 로고    scopus 로고
    • Tumor cell targeting of liposome-entrapped drugs with phospholipid-anchored folic acid-PEG conjugates
    • DOI 10.1016/j.addr.2004.01.011, PII S0169409X04000201
    • Gabizon, A.; Shmeeda, H.; Horowitz, A. T.; Zalipsky, S. Tumor cell targeting of liposome-entrapped drugs with phospholipid-anchored folic acid-PEG conjugates. Adv. Drug Delivery Rev. 2004, 56 (8), 1177-1192. (Pubitemid 38496514)
    • (2004) Advanced Drug Delivery Reviews , vol.56 , Issue.8 , pp. 1177-1192
    • Gabizon, A.1    Shmeeda, H.2    Horowitz, A.T.3    Zalipsky, S.4
  • 75
    • 7444223607 scopus 로고    scopus 로고
    • Nanoparticle-aptamer bioconjugates: A new approach for targeting prostate cancer cells
    • DOI 10.1158/0008-5472.CAN-04-2550
    • Farokhzad, O. C.; Jon, S. Y.; Khadelmhosseini, A.; Tran, T. N. T.; LaVan, D. A.; Langer, R. Nanopartide-aptamer bioconjugates: A new approach for targeting prostate cancer cells. Cancer Res. 2004, 64 (21), 7668-7672. (Pubitemid 39446893)
    • (2004) Cancer Research , vol.64 , Issue.21 , pp. 7668-7672
    • Farokhzad, O.C.1    Jon, S.2    Khademhosseini, A.3    Tran, T.-N.T.4    Lavan, D.A.5    Langer, R.6
  • 78
    • 0029971428 scopus 로고    scopus 로고
    • Cellular pH gradient in tumor versus normal tissue: Potential exploitation for the treatment of cancer
    • Gerweck, L. E.; Seetharaman, K. Cellular pH gradient in tumor versus normal tissue: Potential exploitation for the treatment of cancer. Cancer Res. 1996, 56 (6), 1194-1198. (Pubitemid 26080953)
    • (1996) Cancer Research , vol.56 , Issue.6 , pp. 1194-1198
    • Gerweck, L.E.1    Seetharaman, K.2
  • 79
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad, M.; Werb, Z. New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer 2002, 2 (3), 161-174. (Pubitemid 37328786)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.3 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 80
    • 0030754527 scopus 로고    scopus 로고
    • Breast cancer cells have a high capacity to acidify extracellular milieu by a dual mechanism
    • DOI 10.1023/A:1018446104071
    • Montcourrier, P.; Silver, I.; Farnoud, R.; Bird, I.; Rochefort, H. Breast cancer cells have a high capacity to acidify extracellular milieu by a dual mechanism. Clin. Exp. Metastasis 1997, 15 (4), 382-392. (Pubitemid 27285811)
    • (1997) Clinical and Experimental Metastasis , vol.15 , Issue.4 , pp. 382-392
    • Montcourrier, P.1    Silver, I.2    Farnoud, R.3    Bird, I.4    Rochefort, H.5
  • 81
    • 0025304344 scopus 로고
    • +-ATPase regulates cytoplasmic pH in murine macrophages
    • Swallow, C. J.; Grinstein, S.; Rotstein, O. D. A vacuolar type H(+)-ATPase regulates cytoplasmic pH in murine macrophages. J. Biol. Chem. 1990, 265 (13), 7645-7654. (Pubitemid 20162517)
    • (1990) Journal of Biological Chemistry , vol.265 , Issue.13 , pp. 7645-7654
    • Swallow, C.J.1    Grinstein, S.2    Rotstein, O.D.3
  • 82
    • 61549102484 scopus 로고    scopus 로고
    • PEGylated and MMP-2 Specifically DePEGylated Quantum Dots: Comparative Evaluation of Cellular Uptake
    • Mok, H.; Bae, K. H.; Ahn, C.-H.; Park, T. G. PEGylated and MMP-2 Specifically DePEGylated Quantum Dots: Comparative Evaluation of Cellular Uptake. Langmuir 2009, 25 (3), 1645-1650.
    • (2009) Langmuir , vol.25 , Issue.3 , pp. 1645-1650
    • Mok, H.1    Bae, K.H.2    Ahn, C.-H.3    Park, T.G.4
  • 83
    • 52249097640 scopus 로고    scopus 로고
    • Dark Quenched Matrix Metalloproteinase Fluorogenic Probe for Imaging Osteoarthritis Development in Vivo
    • Lee, S.; Park, K.; Lee, S.-Y.; Ryu, J. H.; Park, J. W.; Ahn, H. J.; Kwon, I. C.; Youn, I.-C.; Kim, K.; Choi, K. Dark Quenched Matrix Metalloproteinase Fluorogenic Probe for Imaging Osteoarthritis Development in Vivo. Bioconjugate Chem. 2008, 19 (9), 1743-1747.
    • (2008) Bioconjugate Chem. , vol.19 , Issue.9 , pp. 1743-1747
    • Lee, S.1    Park, K.2    Lee, S.-Y.3    Ryu, J.H.4    Park, J.W.5    Ahn, H.J.6    Kwon, I.C.7    Youn, I.-C.8    Kim, K.9    Choi, K.10
  • 84
    • 61749094550 scopus 로고    scopus 로고
    • Optical imaging of matrix metalloproteinase-7 activity in vivo using a proteolytic nanobeacon
    • Scherer, R. L.; VanSaun, M. N.; McIntyre, J. O.; Matrisian, L. M. Optical imaging of matrix metalloproteinase-7 activity in vivo using a proteolytic nanobeacon. Mol. Imaging 2008, 7 (3), 118-131.
    • (2008) Mol. Imaging , vol.7 , Issue.3 , pp. 118-131
    • Scherer, R.L.1    VanSaun, M.N.2    McIntyre, J.O.3    Matrisian, L.M.4
  • 85
    • 4043179911 scopus 로고    scopus 로고
    • In vivo imaging of protease activity in arthritis: A novel approach for monitoring treatment response
    • DOI 10.1002/art.20379
    • Wunder, A.; Tung, C. H.; Muller-Ladner, U.; Weissleder, R.; Mahmood, U. In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response. Arthritis Rheum. 2004, 50 (8), 2459-2465. (Pubitemid 39062705)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.8 , pp. 2459-2465
    • Wunder, A.1    Tung, C.-H.2    Muller-Ladner, U.3    Weissleder, R.4    Mahmood, U.5
  • 86
    • 0032951071 scopus 로고    scopus 로고
    • In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
    • Weissleder, R.; Tung, C. H.; Mahmood, U.; Bogdanov, A., Jr. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat. Biotechnol. 1999, 17 (4), 375-378.
    • (1999) Nat. Biotechnol. , vol.17 , Issue.4 , pp. 375-378
    • Weissleder, R.1    Tung, C.H.2    Mahmood, U.3    Bogdanov Jr., A.4
  • 87
    • 56949105019 scopus 로고    scopus 로고
    • Recent progress in tumor pH targeting nanotechnology
    • Lee, E. S.; Gao, Z.; Bae, Y. H. Recent progress in tumor pH targeting nanotechnology. J. Controlled Release 2008, 132 (3), 164-170.
    • (2008) J. Controlled Release , vol.132 , Issue.3 , pp. 164-170
    • Lee, E.S.1    Gao, Z.2    Bae, Y.H.3
  • 88
    • 47349097049 scopus 로고    scopus 로고
    • Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance
    • Lee, E. S.; Gao, Z.; Kim, D.; Park, K.; Kwon, I. C.; Bae, Y. H. Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance. J. Controlled Release 2008, 129 (3), 228-236.
    • (2008) J. Controlled Release , vol.129 , Issue.3 , pp. 228-236
    • Lee, E.S.1    Gao, Z.2    Kim, D.3    Park, K.4    Kwon, I.C.5    Bae, Y.H.6
  • 89
    • 35248821266 scopus 로고    scopus 로고
    • Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly (beta-amino ester) block copolymer micelles for cancer therapy
    • Ko, J.; Park, K.; Kim, Y. S.; Kim, M. S.; Han, J. K.; Kim, K.; Park, R. W.; Kim, I. S.; Song, H. K.; Lee, D. S.; Kwon, I. C. Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly (beta-amino ester) block copolymer micelles for cancer therapy. J. Controlled Release 2007, 123 (2), 109-115.
    • (2007) J. Controlled Release , vol.123 , Issue.2 , pp. 109-115
    • Ko, J.1    Park, K.2    Kim, Y.S.3    Kim, M.S.4    Han, J.K.5    Kim, K.6    Park, R.W.7    Kim, I.S.8    Song, H.K.9    Lee, D.S.10    Kwon, I.C.11
  • 90
    • 42049121123 scopus 로고    scopus 로고
    • Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy
    • Min, K. H.; Park, K.; Kim, Y. S.; Bae, S. M.; Lee, S.; Jo, H. G.; Park, R. W.; Kim, I. S.; Jeong, S. Y.; Kim, K.; Kwon, I. C. Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy. J. Controlled Release 2008, 127 (3), 208-218.
    • (2008) J. Controlled Release , vol.127 , Issue.3 , pp. 208-218
    • Min, K.H.1    Park, K.2    Kim, Y.S.3    Bae, S.M.4    Lee, S.5    Jo, H.G.6    Park, R.W.7    Kim, I.S.8    Jeong, S.Y.9    Kim, K.10    Kwon, I.C.11
  • 92
    • 10044287286 scopus 로고    scopus 로고
    • An investigation on the physicochemical properties of chitosan/DNA polyelectrolyte complexes
    • DOI 10.1016/j.biomaterials.2004.07.038, PII S0142961204006908
    • Liu, W. G.; Sun, S. J.; Cao, Z. Q.; Xin, Z.; Yao, K. D.; Lu, W. W.; Luk, K. D. K. An investigation on the physicochemical properties of chitosan/DNA polyelectrolyte complexes. Biomaterials 2005, 26 (15), 2705-2711. (Pubitemid 39600723)
    • (2005) Biomaterials , vol.26 , Issue.15 , pp. 2705-2711
    • Liu, W.1    Sun, S.2    Cao, Z.3    Zhang, X.4    Yao, K.5    Lu, W.W.6    Luk, K.D.K.7
  • 93
  • 94
    • 33847671358 scopus 로고    scopus 로고
    • TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors
    • Sethuraman, V. A.; Bae, Y. H. TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors. J. Controlled Release 2007, 118 (2), 216-224.
    • (2007) J. Controlled Release , vol.118 , Issue.2 , pp. 216-224
    • Sethuraman, V.A.1    Bae, Y.H.2
  • 95
    • 40549135373 scopus 로고    scopus 로고
    • A Biodegradable pH-sensitive Micelle System for Targeting Acidic Solid Tumors
    • Sethuraman, V.; Lee, M.; Bae, Y. A Biodegradable pH-sensitive Micelle System for Targeting Acidic Solid Tumors. Pharm. Res. 2008, 25 (3), 657-666.
    • (2008) Pharm. Res. , vol.25 , Issue.3 , pp. 657-666
    • Sethuraman, V.1    Lee, M.2    Bae, Y.3
  • 96
    • 14644433029 scopus 로고    scopus 로고
    • Super pH-sensitive multifunctional polymeric micelle
    • Lee, E. S.; Na, K.; Bae, Y. H. Super pH-sensitive multifunctional polymeric micelle. Nano Lett. 2005, 5 (2), 325-329.
    • (2005) Nano Lett. , vol.5 , Issue.2 , pp. 325-329
    • Lee, E.S.1    Na, K.2    Bae, Y.H.3
  • 97
    • 3242762259 scopus 로고    scopus 로고
    • Synthesis and Characterization of Dextran-Peptide-Methotrexate Conjugates for Tumor Targeting via Mediation by Matrix Metalloproteinase II and Matrix Metalloproteinase IX
    • Chau, Y.; Tan, F. E.; Langer, R. Synthesis and Characterization of Dextran-Peptide-Methotrexate Conjugates for Tumor Targeting via Mediation by Matrix Metalloproteinase II and Matrix Metalloproteinase IX. Bioconjugate Chem. 2004, 15 (4), 931-941.
    • (2004) Bioconjugate Chem. , vol.15 , Issue.4 , pp. 931-941
    • Chau, Y.1    Tan, F.E.2    Langer, R.3
  • 98
    • 33645328042 scopus 로고    scopus 로고
    • Investigation of targeting mechanism of new dextran-peptide-methotrexate conjugates using biodistribution study in matrix-metalloproteinase- overexpressing tumor xenograft model
    • Chau, Y.; Dang, N. M.; Tan, F. E.; Langer, R. Investigation of targeting mechanism of new dextran-peptide-methotrexate conjugates using biodistribution study in matrix-metalloproteinase-overexpressing tumor xenograft model. J. Pharm. Sci. 2006, 95 (3), 542-551.
    • (2006) J. Pharm. Sci. , vol.95 , Issue.3 , pp. 542-551
    • Chau, Y.1    Dang, N.M.2    Tan, F.E.3    Langer, R.4
  • 99
    • 33644500132 scopus 로고    scopus 로고
    • Antitumor efficacy of a novel polymer-peptide-drug conjugate in human tumor xenograft models
    • DOI 10.1002/ijc.21495
    • Chau, Y.; Padera, R. F.; Dang, N. M.; Langer, R. Antitumor efficacy of a novel polymer-peptide-drug conjugate in human tumor xenograft models. Int. J. Cancer 2006, 118 (6), 1519-1526. (Pubitemid 43306541)
    • (2006) International Journal of Cancer , vol.118 , Issue.6 , pp. 1519-1526
    • Chau, Y.1    Padera, R.F.2    Dang, N.M.3    Langer, R.4
  • 100
    • 44649136172 scopus 로고    scopus 로고
    • Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo Forster resonance energy transfer imaging
    • Chen, H.; Kim, S.; He, W.; Wang, H.; Low, P. S.; Park, K.; Cheng, J. X. Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo Forster resonance energy transfer imaging. Langmuir 2008, 24 (10), 5213-5217.
    • (2008) Langmuir , vol.24 , Issue.10 , pp. 5213-5217
    • Chen, H.1    Kim, S.2    He, W.3    Wang, H.4    Low, P.S.5    Park, K.6    Cheng, J.X.7
  • 103
    • 48749113674 scopus 로고    scopus 로고
    • Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: Disulfide bonds boost intracellular release of the cargo
    • Breunig, M.; Hozsa, C.; Lungwitz, U.; Watanabe, K.; Umeda, I.; Kato, H.; Goepferich, A. Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: Disulfide bonds boost intracellular release of the cargo. J. Controlled Release 2008, 130, 57-63.
    • (2008) J. Controlled Release , vol.130 , pp. 57-63
    • Breunig, M.1    Hozsa, C.2    Lungwitz, U.3    Watanabe, K.4    Umeda, I.5    Kato, H.6    Goepferich, A.7
  • 104
    • 33846291770 scopus 로고    scopus 로고
    • Stabilized nanocarriers for plasmids based upon cross-linked poly(ethylene imine)
    • DOI 10.1021/bm060788z
    • Neu, M.; Sitterberg, J.; Bakowsky, U.; Kissel, T. Stabilized Nanocarriers for Plasmids Based Upon Cross-linked Poly(ethylene imine). Biomacromolecules 2006, 7 (12), 3428-3438. (Pubitemid 46111798)
    • (2006) Biomacromolecules , vol.7 , Issue.12 , pp. 3428-3438
    • Neu, M.1    Sitterberg, J.2    Bakowsky, U.3    Kissel, T.4
  • 105
    • 12344269847 scopus 로고    scopus 로고
    • Preparation and Biological Characterization of Polymeric Micelle Drug Carriers with Intracellular pH-Triggered Drug Release Property: Tumor Permeability, Controlled Subcellular Drug Distribution, and Enhanced in Vivo Antitumor Efficacy
    • Bae, Y.; Nishiyama, N.; Fukushima, S.; Koyama, H.; Yasuhiro, M.; Kataoka, K. Preparation and Biological Characterization of Polymeric Micelle Drug Carriers with Intracellular pH-Triggered Drug Release Property: Tumor Permeability, Controlled Subcellular Drug Distribution, and Enhanced in Vivo Antitumor Efficacy. Bioconjugate Chem. 2005, 16 (1), 122-130.
    • (2005) Bioconjugate Chem. , vol.16 , Issue.1 , pp. 122-130
    • Bae, Y.1    Nishiyama, N.2    Fukushima, S.3    Koyama, H.4    Yasuhiro, M.5    Kataoka, K.6
  • 106
    • 0033537026 scopus 로고    scopus 로고
    • Environment-Sensitive Stabilization of Core-Shell Structured Polyion Complex Micelle by Reversible Cross-Linking of the Core through Disulfide Bond
    • Kakizawa, Y.; Harada, A.; Kataoka, K. Environment-Sensitive Stabilization of Core-Shell Structured Polyion Complex Micelle by Reversible Cross-Linking of the Core through Disulfide Bond. J. Am. Chem. Soc. 1999, 121 (48), 11247-11248.
    • (1999) J. Am. Chem. Soc. , vol.121 , Issue.48 , pp. 11247-11248
    • Kakizawa, Y.1    Harada, A.2    Kataoka, K.3
  • 107
    • 7444236397 scopus 로고    scopus 로고
    • Tumor-targeted liposomes: Doxorubicin-loaded long-circulating liposomes modified with anti-cancer antibody
    • Lukyanov, A. N.; Elbayoumi, T. A.; Chakilam, A. R.; Torchilin, V. P. Tumor-targeted liposomes: doxorubicin-loaded long-circulating liposomes modified with anti-cancer antibody. J. Controlled Release 2004, 100 (1), 135-144.
    • (2004) J. Controlled Release , vol.100 , Issue.1 , pp. 135-144
    • Lukyanov, A.N.1    Elbayoumi, T.A.2    Chakilam, A.R.3    Torchilin, V.P.4
  • 108
    • 34948876843 scopus 로고    scopus 로고
    • Enhanced cytotoxicity of monoclonal anticancer antibody 2C5-modified doxorubicin-loaded PEGylated liposomes against various tumor cell lines
    • Elbayoumi, T. A.; Torchilin, V. P. Enhanced cytotoxicity of monoclonal anticancer antibody 2C5-modified doxorubicin-loaded PEGylated liposomes against various tumor cell lines. Eur. J. Pharm. Sci. 2007, 32 (3), 159-168.
    • (2007) Eur. J. Pharm. Sci. , vol.32 , Issue.3 , pp. 159-168
    • Elbayoumi, T.A.1    Torchilin, V.P.2
  • 110
    • 34249894977 scopus 로고    scopus 로고
    • Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody
    • DOI 10.1016/j.jconrel.2007.03.012, PII S0168365907001472
    • Kocbek, P.; Obermajer, N.; Cegnar, M.; Kos, J.; Kristl, J. Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody. J. Controlled Release 2007, 120 (1-2), 18-26. (Pubitemid 46874614)
    • (2007) Journal of Controlled Release , vol.120 , Issue.1-2 , pp. 18-26
    • Kocbek, P.1    Obermajer, N.2    Cegnar, M.3    Kos, J.4    Kristl, J.5
  • 111
    • 25844461769 scopus 로고    scopus 로고
    • Target-specific cellular uptake of PLGA nanoparticles coated with poly(L-lysine)-poly(ethylene glycol)-folate conjugate
    • Kim, S. H.; Jeong, J. H.; Chun, K. W.; Park, T. G. Target-specific cellular uptake of PLGA nanoparticles coated with poly(L-lysine)-poly(ethylene glycol)-folate conjugate. Langmuir 2005, 21 (19), 8852-8857.
    • (2005) Langmuir , vol.21 , Issue.19 , pp. 8852-8857
    • Kim, S.H.1    Jeong, J.H.2    Chun, K.W.3    Park, T.G.4
  • 113
    • 42749086352 scopus 로고    scopus 로고
    • Functionalized micelles from block copolymer of polyphosphoester and poly(epsilon-caprolactone) for receptor-mediated drug delivery
    • Wang, Y. C.; Liu, X. Q.; Sun, T. M.; Xiong, M. H.; Wang, J. Functionalized micelles from block copolymer of polyphosphoester and poly(epsilon-caprolactone) for receptor-mediated drug delivery. J. Controlled Release 2008, 128 (1), 32-40.
    • (2008) J. Controlled Release , vol.128 , Issue.1 , pp. 32-40
    • Wang, Y.C.1    Liu, X.Q.2    Sun, T.M.3    Xiong, M.H.4    Wang, J.5


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