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Volumn 101, Issue 4, 2009, Pages 645-657

Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours

Author keywords

CA IX; Carbonic anhydrase; Hypoxia; Phage display; Tumour targeting

Indexed keywords

CARBONATE DEHYDRATASE IX; ENZYME ANTIBODY; HUMAN MONOCLONAL ANTIBODY; HUMAN MONOCLONAL ANTIBODY A3; HUMAN MONOCLONAL ANTIBODY CC7; MONOCLONAL ANTIBODY L19; PIMONIDAZOLE; UNCLASSIFIED DRUG;

EID: 68749119336     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605200     Document Type: Article
Times cited : (89)

References (93)
  • 2
    • 27144449009 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of cancer
    • Adams GP, Weiner LM (2005) Monoclonal antibody therapy of cancer. Nat Biotechnol 23: 1147-1157
    • (2005) Nat Biotechnol , vol.23 , pp. 1147-1157
    • Adams, G.P.1    Weiner, L.M.2
  • 3
    • 67651091693 scopus 로고    scopus 로고
    • In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives
    • e-pub ahead of print 13 June, doi:1016/j.bmcl.2009.06.022
    • Ahlskog J, Dumelin CE, Trüssel S, Marlind J, Neri D (2009) In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives. Bioorg Med Chem Lett, e-pub ahead of print 13 June 2009; doi:1016/j.bmcl.2009.06.022
    • (2009) Bioorg Med Chem Lett
    • Ahlskog, J.1    Dumelin, C.E.2    Trüssel, S.3    Marlind, J.4    Neri, D.5
  • 4
    • 0035392959 scopus 로고    scopus 로고
    • Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density
    • Beasley NJ, Wykoff CC, Watson PH, Leek R, Turley H, Gatter K, Pastorek J, Cox GJ, Ratcliffe P, Harris AL (2001) Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density. Cancer Res 61: 5262-5267
    • (2001) Cancer Res , vol.61 , pp. 5262-5267
    • Beasley, N.J.1    Wykoff, C.C.2    Watson, P.H.3    Leek, R.4    Turley, H.5    Gatter, K.6    Pastorek, J.7    Cox, G.J.8    Ratcliffe, P.9    Harris, A.L.10
  • 6
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • Bertout JA, Patel SA, Simon MC (2008) The impact of O2 availability on human cancer. Nat Rev Cancer 8: 967-975
    • (2008) Nat Rev Cancer , vol.8 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 10
    • 33744811140 scopus 로고    scopus 로고
    • Tumor-targeting properties of novel antibodies specific to the large isoform of tenascin-C
    • Brack SS, Silacci M, Birchler M, Neri D (2006) Tumor-targeting properties of novel antibodies specific to the large isoform of tenascin-C. Clin Cancer Res 12: 3200-3208
    • (2006) Clin Cancer Res , vol.12 , pp. 3200-3208
    • Brack, S.S.1    Silacci, M.2    Birchler, M.3    Neri, D.4
  • 12
    • 1542399581 scopus 로고    scopus 로고
    • Optimization of radioimmunotherapy of renal cell carcinoma: Labeling of monoclonal antibody cG250 with 131I, 90Y, 177Lu, or 186Re
    • Brouwers AH, van Eerd JE, Frielink C, Oosterwijk E, Oyen WJ, Corstens FH, Boerman OC (2004) Optimization of radioimmunotherapy of renal cell carcinoma: labeling of monoclonal antibody cG250 with 131I, 90Y, 177Lu, or 186Re. J Nucl Med 45: 327-337
    • (2004) J Nucl Med , vol.45 , pp. 327-337
    • Brouwers, A.H.1    van Eerd, J.E.2    Frielink, C.3    Oosterwijk, E.4    Oyen, W.J.5    Corstens, F.H.6    Boerman, O.C.7
  • 13
    • 33646352962 scopus 로고    scopus 로고
    • Potent antibody therapeutics by design
    • Carter PJ (2006) Potent antibody therapeutics by design. Nat Rev Immunol 6: 343-357
    • (2006) Nat Rev Immunol , vol.6 , pp. 343-357
    • Carter, P.J.1
  • 14
    • 49449119098 scopus 로고    scopus 로고
    • Antibody-drug conjugates for cancer therapy
    • Carter PJ, Senter PD (2008) Antibody-drug conjugates for cancer therapy. Cancer J 14: 154-169
    • (2008) Cancer J , vol.14 , pp. 154-169
    • Carter, P.J.1    Senter, P.D.2
  • 15
    • 33751416666 scopus 로고    scopus 로고
    • A chemical proteomics approach for the identification of accessible antigens expressed in human kidney cancer
    • Castronovo V, Waltregny D, Kischel P, Roesli C, Elia G, Rybak JN, Neri D (2006) A chemical proteomics approach for the identification of accessible antigens expressed in human kidney cancer. Mol Cell Proteomics 5: 2083-2091
    • (2006) Mol Cell Proteomics , vol.5 , pp. 2083-2091
    • Castronovo, V.1    Waltregny, D.2    Kischel, P.3    Roesli, C.4    Elia, G.5    Rybak, J.N.6    Neri, D.7
  • 16
    • 22744446294 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors
    • Cecchi A, Hulikova A, Pastorek J, Pastoreková S, Scozzafava A, Winum JY, Montero JL, Supuran CT. (2005) Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors. J Med Chem 48: 4834-4841
    • (2005) J Med Chem , vol.48 , pp. 4834-4841
    • Cecchi, A.1    Hulikova, A.2    Pastorek, J.3    Pastoreková, S.4    Scozzafava, A.5    Winum, J.Y.6    Montero, J.L.7    Supuran, C.T.8
  • 17
    • 33745135802 scopus 로고    scopus 로고
    • Current development status of small-molecule vascular disrupting agents
    • Chaplin DJ, Horsman MR, Siemann DW (2006) Current development status of small-molecule vascular disrupting agents. Curr Opin Investig Drugs 7: 522-528
    • (2006) Curr Opin Investig Drugs , vol.7 , pp. 522-528
    • Chaplin, D.J.1    Horsman, M.R.2    Siemann, D.W.3
  • 18
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    • Chiche J, Ilc K, Laferriere J, Trottier E, Dayan F, Mazure NM, Brahimi-Horn MC, Pouyssegur J (2009) Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res 69: 358-368
    • (2009) Cancer Res , vol.69 , pp. 358-368
    • Chiche, J.1    Ilc, K.2    Laferriere, J.3    Trottier, E.4    Dayan, F.5    Mazure, N.M.6    Brahimi-Horn, M.C.7    Pouyssegur, J.8
  • 19
    • 0037270299 scopus 로고    scopus 로고
    • Immunotargeting of human cervical carcinoma xenograft expressing CA IX tumor-associated antigen by 125I-labeled M75 monoclonal antibody
    • Chrastina A, Pastorekova S, Pastorek J (2003a) Immunotargeting of human cervical carcinoma xenograft expressing CA IX tumor-associated antigen by 125I-labeled M75 monoclonal antibody. Neoplasma 50: 13-21
    • (2003) Neoplasma , vol.50 , pp. 13-21
    • Chrastina, A.1    Pastorekova, S.2    Pastorek, J.3
  • 20
    • 0038118505 scopus 로고    scopus 로고
    • Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma
    • Chrastina A, Zavada J, Parkkila S, Kaluz S, Kaluzova M, Rajcani J, Pastorek J, Pastorekova S (2003b) Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma. Int J Cancer 105: 873-881
    • (2003) Int J Cancer , vol.105 , pp. 873-881
    • Chrastina, A.1    Zavada, J.2    Parkkila, S.3    Kaluz, S.4    Kaluzova, M.5    Rajcani, J.6    Pastorek, J.7    Pastorekova, S.8
  • 22
    • 0035096320 scopus 로고    scopus 로고
    • Selective targeting of tumour neovasculature by a radiohalogenated human antibody fragment specific for the ED-B domain of fibronectin
    • Demartis S, Tarli L, Borsi L, Zardi L, Neri D (2001) Selective targeting of tumour neovasculature by a radiohalogenated human antibody fragment specific for the ED-B domain of fibronectin. Eur J Nucl Med 28: 534-539
    • (2001) Eur J Nucl Med , vol.28 , pp. 534-539
    • Demartis, S.1    Tarli, L.2    Borsi, L.3    Zardi, L.4    Neri, D.5
  • 25
    • 0025035899 scopus 로고
    • Establishment and characterization of human renal cancer and normal kidney cell lines
    • Ebert T, Bander NH, Finstad CL, Ramsawak RD, Old LJ (1990) Establishment and characterization of human renal cancer and normal kidney cell lines. Cancer Res 50: 5531-5536
    • (1990) Cancer Res , vol.50 , pp. 5531-5536
    • Ebert, T.1    Bander, N.H.2    Finstad, C.L.3    Ramsawak, R.D.4    Old, L.J.5
  • 28
    • 52049121634 scopus 로고    scopus 로고
    • Microdistribution of targeted, fluorescently labeled anti-carcinoembryonic antigen antibody in meta-static colorectal cancer: Implications for radioimmunotherapy
    • Fidarova EF, El-Emir E, Boxer GM, Qureshi U, Dearling JL, Robson MP, Begent RH, Trott KR, Pedley RB (2008) Microdistribution of targeted, fluorescently labeled anti-carcinoembryonic antigen antibody in meta-static colorectal cancer: implications for radioimmunotherapy. Clin Cancer Res 14: 2639-2646
    • (2008) Clin Cancer Res , vol.14 , pp. 2639-2646
    • Fidarova, E.F.1    El-Emir, E.2    Boxer, G.M.3    Qureshi, U.4    Dearling, J.L.5    Robson, M.P.6    Begent, R.H.7    Trott, K.R.8    Pedley, R.B.9
  • 32
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56: 4509-4515
    • (1996) Cancer Res , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 34
    • 0242298213 scopus 로고    scopus 로고
    • GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: Relationship with vascularity and proliferation as predictors of outcome of ARCON
    • Hoskin PJ, Sibtain A, Daley FM, Wilson GD (2003) GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: relationship with vascularity and proliferation as predictors of outcome of ARCON. Br J Cancer 89: 1290-1297
    • (2003) Br J Cancer , vol.89 , pp. 1290-1297
    • Hoskin, P.J.1    Sibtain, A.2    Daley, F.M.3    Wilson, G.D.4
  • 35
    • 0023219734 scopus 로고
    • Transport of molecules in the tumor interstitium: A review
    • Jain RK (1987) Transport of molecules in the tumor interstitium: a review. Cancer Res 47: 3039-3051
    • (1987) Cancer Res , vol.47 , pp. 3039-3051
    • Jain, R.K.1
  • 38
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel R, Folkman J (2002) Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2: 727-739
    • (2002) Nat Rev Cancer , vol.2 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 39
  • 40
    • 0026575333 scopus 로고
    • Experimental analysis by site-directed mutagenesis of somatic mutation effects on affinity and fine specificity in antibodies specific for lysozyme
    • Lavoie TB, Drohan WN, Smith-Gill SJ (1992) Experimental analysis by site-directed mutagenesis of somatic mutation effects on affinity and fine specificity in antibodies specific for lysozyme. J Immunol 148: 503-513
    • (1992) J Immunol , vol.148 , pp. 503-513
    • Lavoie, T.B.1    Drohan, W.N.2    Smith-Gill, S.J.3
  • 42
    • 34548018979 scopus 로고    scopus 로고
    • Visualization of hypoxia in microscopic tumors by immunofluorescent microscopy
    • Li XF, Carlin S, Urano M, Russell J, Ling CC, O'Donoghue JA (2007) Visualization of hypoxia in microscopic tumors by immunofluorescent microscopy. Cancer Res 67: 7646-7653
    • (2007) Cancer Res , vol.67 , pp. 7646-7653
    • Li, X.F.1    Carlin, S.2    Urano, M.3    Russell, J.4    Ling, C.C.5    O'Donoghue, J.A.6
  • 43
    • 0035418586 scopus 로고    scopus 로고
    • Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
    • Loncaster JA, Harris AL, Davidson SE, Logue JP, Hunter RD, Wycoff CC, Pastorek J, Ratcliffe PJ, Stratford IJ, West CM (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res 61: 6394-6399
    • (2001) Cancer Res , vol.61 , pp. 6394-6399
    • Loncaster, J.A.1    Harris, A.L.2    Davidson, S.E.3    Logue, J.P.4    Hunter, R.D.5    Wycoff, C.C.6    Pastorek, J.7    Ratcliffe, P.J.8    Stratford, I.J.9    West, C.M.10
  • 44
    • 38949215454 scopus 로고    scopus 로고
    • Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases
    • Low PS, Henne WA, Doorneweerd DD (2008) Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases. Acc Chem Res 41: 120-129
    • (2008) Acc Chem Res , vol.41 , pp. 120-129
    • Low, P.S.1    Henne, W.A.2    Doorneweerd, D.D.3
  • 46
    • 0027787968 scopus 로고
    • Immunologic and biochemical analysis of TNT-1 and TNT-2 monoclonal antibody binding to histones
    • Miller GK, Naeve GS, Gaffar SA, Epstein AL (1993) Immunologic and biochemical analysis of TNT-1 and TNT-2 monoclonal antibody binding to histones. Hybridoma 12: 689-698
    • (1993) Hybridoma , vol.12 , pp. 689-698
    • Miller, G.K.1    Naeve, G.S.2    Gaffar, S.A.3    Epstein, A.L.4
  • 47
    • 20344367537 scopus 로고    scopus 로고
    • Tumour vascular targeting
    • Neri D, Bicknell R (2005) Tumour vascular targeting. Nat Rev Cancer 5: 436-446
    • (2005) Nat Rev Cancer , vol.5 , pp. 436-446
    • Neri, D.1    Bicknell, R.2
  • 51
    • 0042787657 scopus 로고    scopus 로고
    • Progress in immunoconjugate cancer therapeutics
    • Payne G (2003) Progress in immunoconjugate cancer therapeutics. Cancer Cell 3: 207-212
    • (2003) Cancer Cell , vol.3 , pp. 207-212
    • Payne, G.1
  • 52
    • 0038476357 scopus 로고    scopus 로고
    • Immunogenicity of therapeutic monoclonal antibodies
    • Pendley C, Schantz A, Wagner C (2003) Immunogenicity of therapeutic monoclonal antibodies. Curr Opin Mol Ther 5: 172-179
    • (2003) Curr Opin Mol Ther , vol.5 , pp. 172-179
    • Pendley, C.1    Schantz, A.2    Wagner, C.3
  • 53
    • 0032555478 scopus 로고    scopus 로고
    • Design and use of a phage display library Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel
    • Pini A, Viti F, Santucci A, Carnemolla B, Zardi L, Neri P, Neri D (1998) Design and use of a phage display library Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel. J Biol Chem 273: 21769-21776
    • (1998) J Biol Chem , vol.273 , pp. 21769-21776
    • Pini, A.1    Viti, F.2    Santucci, A.3    Carnemolla, B.4    Zardi, L.5    Neri, P.6    Neri, D.7
  • 54
    • 0014062860 scopus 로고
    • Catalytic versatility of erythrocyte carbonic anhydrase III kinetic studies of the enzyme-catalyzed hydrolysis of p-Nitrophenyl acetate
    • Pocker Y, Stone JT (1967) Catalytic versatility of erythrocyte carbonic anhydrase III kinetic studies of the enzyme-catalyzed hydrolysis of p-Nitrophenyl acetate. Biochemistry 6: 668-678
    • (1967) Biochemistry , vol.6 , pp. 668-678
    • Pocker, Y.1    Stone, J.T.2
  • 55
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouyssegur J, Dayan F, Mazure NM (2006) Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441: 437-443
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 56
    • 33747616656 scopus 로고    scopus 로고
    • Engineering of therapeutic antibodies to minimize immunogenicity and optimize function
    • Presta LG (2006) Engineering of therapeutic antibodies to minimize immunogenicity and optimize function. Adv Drug Deliv Rev 58: 640-656
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 640-656
    • Presta, L.G.1
  • 57
    • 38349035880 scopus 로고    scopus 로고
    • VHL inactivation in renal cell carcinoma: Implications for diagnosis, prognosis and treatment
    • Rathmell WK, Chen S (2008) VHL inactivation in renal cell carcinoma: implications for diagnosis, prognosis and treatment. Expert Rev Anticancer Ther 8: 63-73
    • (2008) Expert Rev Anticancer Ther , vol.8 , pp. 63-73
    • Rathmell, W.K.1    Chen, S.2
  • 59
    • 63849261384 scopus 로고    scopus 로고
    • Sauer S, Erba PA, Petrini M, Menrad A, Giovannoni L, Grana C, Hirsch B, Zardi L, Paganelli G, Mariani G, Neri D, Durkop H, Menssen HD (2009) Expression of the oncofetal ED-B containing fibronectin isoform in hematologic tumors enables ED-B targeted 131I-L19SIP radioimmu-notherapy in Hodgkin's lymphoma patients. Blood 113: 2265-2274, e-pub 8 Jan 2009
    • Sauer S, Erba PA, Petrini M, Menrad A, Giovannoni L, Grana C, Hirsch B, Zardi L, Paganelli G, Mariani G, Neri D, Durkop H, Menssen HD (2009) Expression of the oncofetal ED-B containing fibronectin isoform in hematologic tumors enables ED-B targeted 131I-L19SIP radioimmu-notherapy in Hodgkin's lymphoma patients. Blood 113: 2265-2274, e-pub 8 Jan 2009
  • 60
    • 2942557164 scopus 로고    scopus 로고
    • Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study
    • Scheurer SB, Rybak JN, Rosli C, Neri D, Elia G (2004) Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: a transcriptomic and proteomic study. Proteomics 4: 1737-1760
    • (2004) Proteomics , vol.4 , pp. 1737-1760
    • Scheurer, S.B.1    Rybak, J.N.2    Rosli, C.3    Neri, D.4    Elia, G.5
  • 61
    • 35848962936 scopus 로고    scopus 로고
    • Antibody-based targeting of the tumor vasculature
    • Schliemann C, Neri D (2007) Antibody-based targeting of the tumor vasculature. Biochim Biophys Acta 1776: 175-192
    • (2007) Biochim Biophys Acta , vol.1776 , pp. 175-192
    • Schliemann, C.1    Neri, D.2
  • 62
    • 0032514402 scopus 로고    scopus 로고
    • Vascular targeting as a strategy for cancer therapy
    • Schnitzer JE (1998) Vascular targeting as a strategy for cancer therapy. N Engl J Med 339: 472-474
    • (1998) N Engl J Med , vol.339 , pp. 472-474
    • Schnitzer, J.E.1
  • 64
    • 20644469912 scopus 로고    scopus 로고
    • Design, construction, and characterization of a large synthetic human antibody phage display library
    • Silacci M, Brack S, Schirru G, Marlind J, Ettorre A, Merlo A, Viti F, Neri D (2005) Design, construction, and characterization of a large synthetic human antibody phage display library. Proteomics 5: 2340-2350
    • (2005) Proteomics , vol.5 , pp. 2340-2350
    • Silacci, M.1    Brack, S.2    Schirru, G.3    Marlind, J.4    Ettorre, A.5    Merlo, A.6    Viti, F.7    Neri, D.8
  • 66
    • 23844485492 scopus 로고    scopus 로고
    • Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors
    • Sobhanifar S, Aquino-Parsons C, Stanbridge EJ, Olive P (2005) Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors. Cancer Res 65: 7259-7266
    • (2005) Cancer Res , vol.65 , pp. 7259-7266
    • Sobhanifar, S.1    Aquino-Parsons, C.2    Stanbridge, E.J.3    Olive, P.4
  • 67
    • 0141828145 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    • Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley EJ, Krek W (2003) Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 425: 307-311
    • (2003) Nature , vol.425 , pp. 307-311
    • Staller, P.1    Sulitkova, J.2    Lisztwan, J.3    Moch, H.4    Oakeley, E.J.5    Krek, W.6
  • 69
    • 38849143765 scopus 로고    scopus 로고
    • Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators
    • Supuran CT (2008) Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov 7: 168-181
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 168-181
    • Supuran, C.T.1
  • 72
    • 33750082400 scopus 로고    scopus 로고
    • Targeting tumor-associated carbonic anhydrase IX in cancer therapy
    • Thiry A, Dogne JM, Masereel B, Supuran CT (2006) Targeting tumor-associated carbonic anhydrase IX in cancer therapy. Trends Pharmacol Sci 27: 566-573
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 566-573
    • Thiry, A.1    Dogne, J.M.2    Masereel, B.3    Supuran, C.T.4
  • 73
    • 0842311621 scopus 로고    scopus 로고
    • Vascular targeting agents as cancer therapeutics
    • Thorpe PE (2004) Vascular targeting agents as cancer therapeutics. Clin Cancer Res 10: 415-427
    • (2004) Clin Cancer Res , vol.10 , pp. 415-427
    • Thorpe, P.E.1
  • 75
    • 0026785856 scopus 로고
    • The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops
    • Tomlinson IM, Walter G, Marks JD, Llewelyn MB, Winter G (1992) The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J Mol Biol 227: 776-798
    • (1992) J Mol Biol , vol.227 , pp. 776-798
    • Tomlinson, I.M.1    Walter, G.2    Marks, J.D.3    Llewelyn, M.B.4    Winter, G.5
  • 76
    • 0025912699 scopus 로고
    • Localization of monoclonal antibody G250 and bispecific monoclonal antibody CD3/G250 in human renal-cell carcinoma xenografts: Relative effects of size and affinity
    • van Dijk J, Zegveld ST, Fleuren GJ, Warnaar SO (1991) Localization of monoclonal antibody G250 and bispecific monoclonal antibody CD3/G250 in human renal-cell carcinoma xenografts: relative effects of size and affinity. Int J Cancer 48: 738-743
    • (1991) Int J Cancer , vol.48 , pp. 738-743
    • van Dijk, J.1    Zegveld, S.T.2    Fleuren, G.J.3    Warnaar, S.O.4
  • 78
    • 3142587028 scopus 로고    scopus 로고
    • Tumor microenvironmental physiology and its implications for radiation oncology
    • Vaupel P (2004) Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 14: 198-206
    • (2004) Semin Radiat Oncol , vol.14 , pp. 198-206
    • Vaupel, P.1
  • 79
    • 42549099073 scopus 로고    scopus 로고
    • A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculature in vivo
    • Villa A, Trachsel E, Kaspar M, Schliemann C, Sommavilla R, Rybak JN, Rosli C, Borsi L, Neri D (2008) A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculature in vivo. Int J Cancer 122: 2405-2413
    • (2008) Int J Cancer , vol.122 , pp. 2405-2413
    • Villa, A.1    Trachsel, E.2    Kaspar, M.3    Schliemann, C.4    Sommavilla, R.5    Rybak, J.N.6    Rosli, C.7    Borsi, L.8    Neri, D.9
  • 80
    • 0033555628 scopus 로고    scopus 로고
    • Increased binding affinity and valence of recombinant antibody fragments lead to improved targeting of tumoral angiogenesis
    • Viti F, Tarli L, Giovannoni L, Zardi L, Neri D (1999) Increased binding affinity and valence of recombinant antibody fragments lead to improved targeting of tumoral angiogenesis. Cancer Res 59: 347-352
    • (1999) Cancer Res , vol.59 , pp. 347-352
    • Viti, F.1    Tarli, L.2    Giovannoni, L.3    Zardi, L.4    Neri, D.5
  • 82
    • 33746163862 scopus 로고    scopus 로고
    • Biopharmaceutical benchmarks 2006
    • Walsh G (2006) Biopharmaceutical benchmarks 2006. Nat Biotechnol 24: 769-776
    • (2006) Nat Biotechnol , vol.24 , pp. 769-776
    • Walsh, G.1
  • 84
    • 1542408478 scopus 로고    scopus 로고
    • Tumour hypoxia: Impact on biology, prognosis and treatment of solid malignant tumours
    • Weinmann M, Belka C, Plasswilm L (2004) Tumour hypoxia: impact on biology, prognosis and treatment of solid malignant tumours. Onkologie 27: 83-90
    • (2004) Onkologie , vol.27 , pp. 83-90
    • Weinmann, M.1    Belka, C.2    Plasswilm, L.3
  • 88
    • 52649113251 scopus 로고    scopus 로고
    • Antibodies for molecular imaging of cancer
    • Wu AM, Olafsen T (2008) Antibodies for molecular imaging of cancer. Cancer J 14: 191-197
    • (2008) Cancer J , vol.14 , pp. 191-197
    • Wu, A.M.1    Olafsen, T.2
  • 89
    • 27144550160 scopus 로고    scopus 로고
    • Arming antibodies: Prospects and challenges for immunoconjugates
    • Wu AM, Senter PD (2005) Arming antibodies: prospects and challenges for immunoconjugates. Nat Biotechnol 23: 1137-1146
    • (2005) Nat Biotechnol , vol.23 , pp. 1137-1146
    • Wu, A.M.1    Senter, P.D.2
  • 92
    • 0026684815 scopus 로고
    • Rapid tumor penetration of a single-chain Fv and comparison with other immuno-globulin forms
    • Yokota T, Milenic DE, Whitlow M, Schlom J (1992) Rapid tumor penetration of a single-chain Fv and comparison with other immuno-globulin forms. Cancer Res 52: 3402-3408
    • (1992) Cancer Res , vol.52 , pp. 3402-3408
    • Yokota, T.1    Milenic, D.E.2    Whitlow, M.3    Schlom, J.4


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