메뉴 건너뛰기




Volumn 195, Issue 1, 2003, Pages 1-16

Prognostic significance of tumor oxygenation in humans

Author keywords

2 Nitroimidazole; CA9; EF5; HIF1; Hypoxia; PET imaging; Polarographic needle electrodes; Prognosis; Radiation resistance; SPECT imaging

Indexed keywords

2 (2 NITRO 1H IMIDAZOL 1 YL) N (2,2,3,3,3 PENTAFLUOROPROPYL)ACETAMIDE; BIOLOGICAL MARKER; CARBONATE DEHYDRATASE IX; COPPER 64; COPPER 67; FLUORINE 18; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IODINE 123; IODOAZOMYCIN ARABINOSIDE I 123; ISOENZYME; OSTEOPONTIN; OXO[3,3,9,9 TETRAMETHYL 1 (2 NITRO 1H IMIDAZOL 1 YL) 4,8 DIAZAUNDECANE 2,10 DIONEDIOXIMATO]TECHNETIUM TC 99M; OXYGEN; PIMONIDAZOLE; RADIOPHARMACEUTICAL AGENT; TECHNETIUM 99M; THROMBOSPONDIN; UNCLASSIFIED DRUG; UPENAZIME; VASCULOTROPIN;

EID: 0038293080     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(03)00012-0     Document Type: Review
Times cited : (236)

References (145)
  • 2
    • 0021273337 scopus 로고
    • Hypoxic fraction determinations in the BA1112 rat sarcoma: Variations within and among assay techniques
    • Moulder J.E., Martin D.F. Hypoxic fraction determinations in the BA1112 rat sarcoma: variations within and among assay techniques. Radiat. Res. 1984;99.
    • (1984) Radiat. Res. , pp. 99
    • Moulder, J.E.1    Martin, D.F.2
  • 4
    • 0022453572 scopus 로고
    • Late results of a trial of hyperbaric oxygen and radiotherapy in head and neck cancer: A rationale for hypoxic cell sensitizers
    • Henk J.M. Late results of a trial of hyperbaric oxygen and radiotherapy in head and neck cancer: a rationale for hypoxic cell sensitizers. Int. J. Radiat. Oncol. Biol. Phys. 12:1986;1339-1341.
    • (1986) Int. J. Radiat. Oncol. Biol. Phys. , vol.12 , pp. 1339-1341
    • Henk, J.M.1
  • 5
    • 0017404572 scopus 로고
    • Radiotherapy and hyperbaric oxygen in head and neck cancer: Interim report of the second clinical trial
    • Henk J.M., Smith C.W. Radiotherapy and hyperbaric oxygen in head and neck cancer: interim report of the second clinical trial. Lancet. 2:1977;104-105.
    • (1977) Lancet , vol.2 , pp. 104-105
    • Henk, J.M.1    Smith, C.W.2
  • 6
    • 0024384825 scopus 로고
    • Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of the larynx and pharynx: Report from the DAHANCA 2 study
    • Overgaard J., Hansen H., Sandersen A.P., Hjelm-Hansen M., Jorgensen K., Sandberg E., et al. Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of the larynx and pharynx: report from the DAHANCA 2 study. Int. J. Radiat. Oncol. Biol. Phys. 16:1989;1065-1068.
    • (1989) Int. J. Radiat. Oncol. Biol. Phys. , vol.16 , pp. 1065-1068
    • Overgaard, J.1    Hansen, H.2    Sandersen, A.P.3    Hjelm-Hansen, M.4    Jorgensen, K.5    Sandberg, E.6
  • 7
    • 0002786083 scopus 로고
    • Importance of tumor hypoxia in radiotherapy. A meta-analysis of controlled clinical trials
    • Overgaard J. Importance of tumor hypoxia in radiotherapy. A meta-analysis of controlled clinical trials. Radiother. Oncol. 24:1992;S64.
    • (1992) Radiother. Oncol. , vol.24 , pp. 64
    • Overgaard, J.1
  • 8
    • 0019415634 scopus 로고
    • Final report on the United States phase I clinical trial of the hypoxic cell radiosensitizer, misonidazole (RO-07-0582; NSC #261037)
    • Phillips T.L., Wasserman T.H., Johnson R.J., Levin V.A., VanRaalte G. Final report on the United States phase I clinical trial of the hypoxic cell radiosensitizer, misonidazole (RO-07-0582; NSC #261037). Cancer. 48:1981;1687-1704.
    • (1981) Cancer , vol.48 , pp. 1687-1704
    • Phillips, T.L.1    Wasserman, T.H.2    Johnson, R.J.3    Levin, V.A.4    VanRaalte, G.5
  • 11
    • 0024994008 scopus 로고
    • Vascular and interstitial barriers to delivery of therapeutic agents in tumors
    • Jain R.K. Vascular and interstitial barriers to delivery of therapeutic agents in tumors. Cancer Metastasis Rev. 9:1990;253-266.
    • (1990) Cancer Metastasis Rev. , vol.9 , pp. 253-266
    • Jain, R.K.1
  • 12
    • 0020622749 scopus 로고
    • Factors influencing intracellular uptake and radiosensitization by 2-nitroimidazoles in vitro
    • Brown D.M., Gonsalez-Mendez R., Brown J.M. Factors influencing intracellular uptake and radiosensitization by 2-nitroimidazoles in vitro. Radiat. Res. 93:1983;492-505.
    • (1983) Radiat. Res. , vol.93 , pp. 492-505
    • Brown, D.M.1    Gonsalez-Mendez, R.2    Brown, J.M.3
  • 13
    • 0034807497 scopus 로고    scopus 로고
    • The K(m) for radiosensitization of human tumor cells by oxygen is much greater than 3 mmHg and is further increased by elevated levels of cysteine
    • Horan A.D., Koch C.J. The K(m) for radiosensitization of human tumor cells by oxygen is much greater than 3 mmHg and is further increased by elevated levels of cysteine. Radiat. Res. 156:2001;388-398.
    • (2001) Radiat. Res. , vol.156 , pp. 388-398
    • Horan, A.D.1    Koch, C.J.2
  • 14
    • 0029739455 scopus 로고    scopus 로고
    • Cysteine concentrations in rodent tumors: Unexpectedly high values may cause therapy resistance
    • Koch C.J., Evans S.M. Cysteine concentrations in rodent tumors: unexpectedly high values may cause therapy resistance. Int. J. Cancer. 67:1996;661-667.
    • (1996) Int. J. Cancer , vol.67 , pp. 661-667
    • Koch, C.J.1    Evans, S.M.2
  • 15
    • 0028290306 scopus 로고
    • Enhanced radiation-sensitivity by preincubation with nitroimidazoles: Effect of glutathione depletion
    • Koch C.J., Skov K.A. Enhanced radiation-sensitivity by preincubation with nitroimidazoles: effect of glutathione depletion. Int. J. Radiat. Oncol., Biol., Phys. 29:1994;345-349.
    • (1994) Int. J. Radiat. Oncol., Biol., Phys. , vol.29 , pp. 345-349
    • Koch, C.J.1    Skov, K.A.2
  • 16
    • 0018895221 scopus 로고
    • Interaction of misonidazole and oxygen in the radiosensitization of mammalian cells
    • Ling C., Michaels H., Epp E., Peterson E. Interaction of misonidazole and oxygen in the radiosensitization of mammalian cells. Int. J. Radiat. Oncol. Biol. Phys. 6:1980;583-589.
    • (1980) Int. J. Radiat. Oncol. Biol. Phys. , vol.6 , pp. 583-589
    • Ling, C.1    Michaels, H.2    Epp, E.3    Peterson, E.4
  • 17
    • 0036022343 scopus 로고    scopus 로고
    • Range of oxygenation in SiHa tumor xenografts
    • Olive P. Range of oxygenation in SiHa tumor xenografts. Radiat. Res. 158:2002;159-166.
    • (2002) Radiat. Res. , vol.158 , pp. 159-166
    • Olive, P.1
  • 18
    • 0030926491 scopus 로고    scopus 로고
    • Cells at intermediate oxygen levels can be more important than the 'hypoxic fraction' in determining tumor response to fractionated radiation therapy
    • Wouters B.G., Brown J.M. Cells at intermediate oxygen levels can be more important than the 'hypoxic fraction' in determining tumor response to fractionated radiation therapy. Radiat. Res. 147:1997;541-550.
    • (1997) Radiat. Res. , vol.147 , pp. 541-550
    • Wouters, B.G.1    Brown, J.M.2
  • 19
    • 0030032917 scopus 로고    scopus 로고
    • Detection of individual hypoxic cells in multicellular spheroids by flow cytometry using the 2-nitroimidazole. EF5, and monoclonal antibodies
    • Woods M.L., Koch C.J., Lord E.M. Detection of individual hypoxic cells in multicellular spheroids by flow cytometry using the 2-nitroimidazole. EF5, and monoclonal antibodies. Int. J. Radiat. Oncol., Biol., Phys. 34:1996;93-101.
    • (1996) Int. J. Radiat. Oncol., Biol., Phys. , vol.34 , pp. 93-101
    • Woods, M.L.1    Koch, C.J.2    Lord, E.M.3
  • 20
    • 0030423710 scopus 로고    scopus 로고
    • Biodistribution of the nitroimidazole EF5 (2-[2-nitro-1H-imidazol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl) acetamide) in mice bearing subcutaneous EMT6 tumors
    • Laughlin K.M., Evans S.M., Jenkins W.T., Tracy M., Chan C.Y., Lord E.M., et al. Biodistribution of the nitroimidazole EF5 (2-[2-nitro-1H-imidazol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl) acetamide) in mice bearing subcutaneous EMT6 tumors. J. Pharmacol. Exp. Therap. 277:1996;1049-1057.
    • (1996) J. Pharmacol. Exp. Therap. , vol.277 , pp. 1049-1057
    • Laughlin, K.M.1    Evans, S.M.2    Jenkins, W.T.3    Tracy, M.4    Chan, C.Y.5    Lord, E.M.6
  • 21
    • 0030032543 scopus 로고    scopus 로고
    • 2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9L s.c. tumors
    • Evans S.M., Jenkins W.T., Joiner B., Lord E.M., Koch C.J. 2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9L s.c. tumors. Cancer Res. 56:1996;405-411.
    • (1996) Cancer Res. , vol.56 , pp. 405-411
    • Evans, S.M.1    Jenkins, W.T.2    Joiner, B.3    Lord, E.M.4    Koch, C.J.5
  • 22
    • 0036645420 scopus 로고    scopus 로고
    • Radiosensitization of hypoxic tumor cells by dodecafluoropentane: A gas-phase perfluorochemical emulsion
    • Koch C.J., Oprysko P.R., Shuman A.L., Jenkins W.T., Brandt G., Evans S.M. Radiosensitization of hypoxic tumor cells by dodecafluoropentane: a gas-phase perfluorochemical emulsion. Cancer Res. 62:2002;3626-3629.
    • (2002) Cancer Res. , vol.62 , pp. 3626-3629
    • Koch, C.J.1    Oprysko, P.R.2    Shuman, A.L.3    Jenkins, W.T.4    Brandt, G.5    Evans, S.M.6
  • 23
    • 0034798178 scopus 로고    scopus 로고
    • Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis and proliferation
    • Evans S., Hahn S., Magarelli D., Koch C. Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis and proliferation. Am. J. Clin. Oncol. 24:2001;467-472.
    • (2001) Am. J. Clin. Oncol. , vol.24 , pp. 467-472
    • Evans, S.1    Hahn, S.2    Magarelli, D.3    Koch, C.4
  • 24
    • 0009662654 scopus 로고    scopus 로고
    • Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and the 2-nitroimidazole EF5
    • Packer, Editor, Academic Press: San Diego, California
    • C. Koch, Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and the 2-nitroimidazole EF5, in Antioxidants and Redox Signaling, Packer, Editor. 2001, Academic Press: San Diego, California.
    • (2001) Antioxidants and Redox Signaling
    • Koch, C.1
  • 25
    • 0032700201 scopus 로고    scopus 로고
    • Implications of prognostic markers in brain tumors
    • Grzybicki D.M., Moore S.A. Implications of prognostic markers in brain tumors. Clin. Lab. Med. 19:1999;833-847.
    • (1999) Clin. Lab. Med. , vol.19 , pp. 833-847
    • Grzybicki, D.M.1    Moore, S.A.2
  • 26
    • 0027141149 scopus 로고
    • Oxygen in human tumors: Correlations between methods of measurement and response to therapy. Summary of a workshop held November 19-20, 1992, at the National Cancer Institute, Bethesda, Maryland
    • Stone H.B., Brown J.M., Phillips T.L., Sutherland R.M. Oxygen in human tumors: correlations between methods of measurement and response to therapy. Summary of a workshop held November 19-20, 1992, at the National Cancer Institute, Bethesda, Maryland. Radiat. Res. 136:1993;422-434.
    • (1993) Radiat. Res. , vol.136 , pp. 422-434
    • Stone, H.B.1    Brown, J.M.2    Phillips, T.L.3    Sutherland, R.M.4
  • 27
    • 0028632781 scopus 로고
    • Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors
    • Overgaard J. Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors. Oncol. Res. 6:1994;509-518.
    • (1994) Oncol. Res. , vol.6 , pp. 509-518
    • Overgaard, J.1
  • 29
    • 0033222410 scopus 로고    scopus 로고
    • Damage measured by the comet assay in head and neck cancer patients treated with tirapazamine
    • Dorie M.J., Kovacs M.S., Gabalski E.C., Adam M., Le Q.T., Bloch D.A., et al. Damage measured by the comet assay in head and neck cancer patients treated with tirapazamine. Neoplasia (New York). 1:1999;461-467.
    • (1999) Neoplasia (New York) , vol.1 , pp. 461-467
    • Dorie, M.J.1    Kovacs, M.S.2    Gabalski, E.C.3    Adam, M.4    Le, Q.T.5    Bloch, D.A.6
  • 30
    • 0034117277 scopus 로고    scopus 로고
    • Single-arm, open-label phase II study of intravenously administered tirapazamine and radiation therapy for glioblastoma multiforme
    • Del Rowe J., Scott C., Werner-Wasik M., Bahary J.P., Curran W.J., Urtasun R.C., et al. Single-arm, open-label phase II study of intravenously administered tirapazamine and radiation therapy for glioblastoma multiforme. J. Clin. Oncol. 18:2000;1254-1259.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1254-1259
    • Del Rowe, J.1    Scott, C.2    Werner-Wasik, M.3    Bahary, J.P.4    Curran, W.J.5    Urtasun, R.C.6
  • 31
    • 0027376264 scopus 로고
    • Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts
    • Lord E.M., Harwell L., Koch C.J. Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts. Cancer Res. 53:1993;5271-5276.
    • (1993) Cancer Res. , vol.53 , pp. 5271-5276
    • Lord, E.M.1    Harwell, L.2    Koch, C.J.3
  • 36
    • 0036682009 scopus 로고    scopus 로고
    • Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 stabilization
    • Kaluz S., Kaluzová M., Chrastina A., Olive P.L., Pastoreková S., Pastorek J., et al. Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 stabilization. Cancer Res. 62:2002;4469-4477.
    • (2002) Cancer Res. , vol.62 , pp. 4469-4477
    • Kaluz, S.1    Kaluzová, M.2    Chrastina, A.3    Olive, P.L.4    Pastoreková, S.5    Pastorek, J.6
  • 37
    • 0031029634 scopus 로고    scopus 로고
    • Correlation of high lactate levels in head and neck tumors with incidence of metastasis
    • Walenta S., Salameh A., Lyng H., Evensen J.F., Mitze M., Rofstad E.K., et al. Correlation of high lactate levels in head and neck tumors with incidence of metastasis. Am. J. Pathol. 150:1997;409-415.
    • (1997) Am. J. Pathol. , vol.150 , pp. 409-415
    • Walenta, S.1    Salameh, A.2    Lyng, H.3    Evensen, J.F.4    Mitze, M.5    Rofstad, E.K.6
  • 38
    • 0020526966 scopus 로고
    • Necrosis as a prognostic criterion in malignant supratentorial, astrocyticgliomas
    • Nelson J.S., Tsukada Y., Schoenfeld D., Fulling K., Lamarche J., Peress N. Necrosis as a prognostic criterion in malignant supratentorial, astrocyticgliomas. Cancer. 52:1983;550-554.
    • (1983) Cancer , vol.52 , pp. 550-554
    • Nelson, J.S.1    Tsukada, Y.2    Schoenfeld, D.3    Fulling, K.4    Lamarche, J.5    Peress, N.6
  • 39
    • 0021329546 scopus 로고
    • The grading of soft tissue sarcomas. Results of a clinicohistopathologic correlation in a series of 163 cases
    • Costa J., Wesley R.A., Glatstein E., Rosenberg S.A. The grading of soft tissue sarcomas. Results of a clinicohistopathologic correlation in a series of 163 cases. Cancer. 53:1984;530-541.
    • (1984) Cancer , vol.53 , pp. 530-541
    • Costa, J.1    Wesley, R.A.2    Glatstein, E.3    Rosenberg, S.A.4
  • 42
    • 0021701786 scopus 로고
    • Heterogeneous oxygenation of rectal carcinomas in humans. A critical parameter for pre-operative irradiation
    • Wendling P., Manz R., Thews G., Vaupel P. Heterogeneous oxygenation of rectal carcinomas in humans. A critical parameter for pre-operative irradiation. Adv. Exp. Med. Biol. 180:1984;293-300.
    • (1984) Adv. Exp. Med. Biol. , vol.180 , pp. 293-300
    • Wendling, P.1    Manz, R.2    Thews, G.3    Vaupel, P.4
  • 43
    • 8544273661 scopus 로고    scopus 로고
    • Interlaboratory variation in oxygen tension measurement by Eppendorf 'Histograph' and comparison with hypoxic marker
    • Nozue M., Lee I., Yuan F., Teicher B.A., Brizel D.M., Dewhirst M.W., et al. Interlaboratory variation in oxygen tension measurement by Eppendorf 'Histograph' and comparison with hypoxic marker. J. Surg. Oncol. 66:1997;30-38.
    • (1997) J. Surg. Oncol. , vol.66 , pp. 30-38
    • Nozue, M.1    Lee, I.2    Yuan, F.3    Teicher, B.A.4    Brizel, D.M.5    Dewhirst, M.W.6
  • 44
    • 0033997568 scopus 로고    scopus 로고
    • Hypoxia and necrosis in rat 9L glioma and Morris 7777 hepatoma tumors: Comparative measurements using EF5 binding and the Eppendorf needle electrode
    • Jenkins W.T., Evans S.M., Koch C.J. Hypoxia and necrosis in rat 9L glioma and Morris 7777 hepatoma tumors: comparative measurements using EF5 binding and the Eppendorf needle electrode. Int. J. Radiat. Oncol., Biol., Phys. 46:2000;1005-1017.
    • (2000) Int. J. Radiat. Oncol., Biol., Phys. , vol.46 , pp. 1005-1017
    • Jenkins, W.T.1    Evans, S.M.2    Koch, C.J.3
  • 53
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel M., Schlenger K., Aral B., Mitze M., Schaffer U., Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56:1996;4509-4515.
    • (1996) Cancer Res. , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 55
    • 0030022252 scopus 로고    scopus 로고
    • Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
    • Brizel D.M., Scully S.P., Harrelson J.M., Layfield L.J., Bean J.M., Prosnitz L.R., et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res. 56:1996;941-943.
    • (1996) Cancer Res. , vol.56 , pp. 941-943
    • Brizel, D.M.1    Scully, S.P.2    Harrelson, J.M.3    Layfield, L.J.4    Bean, J.M.5    Prosnitz, L.R.6
  • 58
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours [see comments]. Hypoxia-mediated selection of cells with diminished
    • Graeber T.G., Osmanian C., Jacks T., Housman D.E., Koch C.J., Lowe S.W., et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours [see comments]. Hypoxia-mediated selection of cells with diminished. Nature. 379:1996;88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6
  • 59
    • 0010170555 scopus 로고
    • Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells
    • Young S.D., Marshall R.S., Hill R.P. Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc. Natl. Acad. Sci. USA. 85:1988;9533-9537.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 9533-9537
    • Young, S.D.1    Marshall, R.S.2    Hill, R.P.3
  • 61
    • 0018635742 scopus 로고
    • Hypoxic sensitizers - Implications for radiation therapy
    • Chapman J.D. Hypoxic sensitizers - implications for radiation therapy. New Engl. J. Med. 301:1979;1429-1432.
    • (1979) New Engl. J. Med. , vol.301 , pp. 1429-1432
    • Chapman, J.D.1
  • 62
    • 0017089008 scopus 로고
    • Hypoxia-dependent reduction of 1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol by Chinese hamster ovary cells and KHT tumor cells in vitro and in vivo
    • Varghese A.J., Gulyas S., Mohindra J.K. Hypoxia-dependent reduction of 1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol by Chinese hamster ovary cells and KHT tumor cells in vitro and in vivo. Cancer Res. 36:1976;3761-3765.
    • (1976) Cancer Res. , vol.36 , pp. 3761-3765
    • Varghese, A.J.1    Gulyas, S.2    Mohindra, J.K.3
  • 63
    • 0025650261 scopus 로고
    • Importance of thiols in the reductive binding of 2-nitroimidazoles to macromolecules
    • Raleigh J.A., Koch C.J. Importance of thiols in the reductive binding of 2-nitroimidazoles to macromolecules. Biochem. Pharmacol. 40:1990;2457-2464.
    • (1990) Biochem. Pharmacol. , vol.40 , pp. 2457-2464
    • Raleigh, J.A.1    Koch, C.J.2
  • 64
    • 0021382389 scopus 로고
    • Culturing technique allowing rapid gas-liquid equilibration (6 sec) with no toxicity to mammalian cells
    • Koch C.J., thin-film A. culturing technique allowing rapid gas-liquid equilibration (6 sec) with no toxicity to mammalian cells. Radiat. Res. 97:1984;434-442.
    • (1984) Radiat. Res. , vol.97 , pp. 434-442
    • Koch, C.J.1    Thin-film, A.2
  • 65
    • 0018116095 scopus 로고
    • Differences in the toxicity and metabolism of the 2-nitroimidazole misonidazole (Ro-07-0582) in HeLa and Chinese hamster ovary cells
    • Taylor Y.C., Rauth A.M. Differences in the toxicity and metabolism of the 2-nitroimidazole misonidazole (Ro-07-0582) in HeLa and Chinese hamster ovary cells. Cancer Res. 38:1978;2745-2752.
    • (1978) Cancer Res. , vol.38 , pp. 2745-2752
    • Taylor, Y.C.1    Rauth, A.M.2
  • 68
    • 0020004479 scopus 로고
    • 14C-misonidazole to hypoxic cells in V79 spheroids
    • 14C-misonidazole to hypoxic cells in V79 spheroids. Br. J. Cancer. 45:1982;694-699.
    • (1982) Br. J. Cancer , vol.45 , pp. 694-699
    • Franko, A.J.1    Chapman, J.D.2
  • 69
    • 0027050090 scopus 로고
    • Nitroimidazole adducts as markers for tissue hypoxia: Mechanistic studies in aerobic normal tissues and tumour cells
    • Parliament M.B., Wiebe L.I., Franko A.J. Nitroimidazole adducts as markers for tissue hypoxia: mechanistic studies in aerobic normal tissues and tumour cells. Br. J. Cancer. 66:1992;1103-1108.
    • (1992) Br. J. Cancer , vol.66 , pp. 1103-1108
    • Parliament, M.B.1    Wiebe, L.I.2    Franko, A.J.3
  • 70
    • 0000009127 scopus 로고
    • Radiation-induced events and their time scale in mammalian cells
    • Chapman J.D., Gillespie C.J. Radiation-induced events and their time scale in mammalian cells. Adv. Radiat. Biol. 9:1981;143-198.
    • (1981) Adv. Radiat. Biol. , vol.9 , pp. 143-198
    • Chapman, J.D.1    Gillespie, C.J.2
  • 73
    • 0034879404 scopus 로고    scopus 로고
    • Pharmacokinetics of EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] in human patients: Implications for hypoxia measurements in vivo by 2-nitroimidazoles
    • Koch C.J., Hahn S.M., Rockwell K. Jr., Covey J.M., McKenna W.G., Evans S.M. Pharmacokinetics of EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] in human patients: implications for hypoxia measurements in vivo by 2-nitroimidazoles. Cancer Chemother. Pharmacol. 48:2001;177-187.
    • (2001) Cancer Chemother. Pharmacol. , vol.48 , pp. 177-187
    • Koch, C.J.1    Hahn, S.M.2    Rockwell K., Jr.3    Covey, J.M.4    McKenna, W.G.5    Evans, S.M.6
  • 77
    • 0029935943 scopus 로고    scopus 로고
    • Marking hypoxic cells for complement and cytotoxic T lymphocyte-mediated lysis: Using pimonidazole
    • Chou S.C., Flood P.M., Raleigh J.A. Marking hypoxic cells for complement and cytotoxic T lymphocyte-mediated lysis: using pimonidazole. Br. J. Cancer Suppl. 27:1996;S213-S216.
    • (1996) Br. J. Cancer Suppl. , vol.27
    • Chou, S.C.1    Flood, P.M.2    Raleigh, J.A.3
  • 79
    • 0029012868 scopus 로고
    • Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids
    • Gross M.W., Karbach U., Groebe K., Franko A.J., Mueller-Klieser W. Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids. Int. J. Cancer. 61:1995;567-573.
    • (1995) Int. J. Cancer , vol.61 , pp. 567-573
    • Gross, M.W.1    Karbach, U.2    Groebe, K.3    Franko, A.J.4    Mueller-Klieser, W.5
  • 81
    • 0036896722 scopus 로고    scopus 로고
    • Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer
    • Kaanders J., Wijffels K., Marres H., Ljungkvist A., Pop L., Hoogen F., et al. Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer. Cancer Res. 62:2002;7066-7074.
    • (2002) Cancer Res. , vol.62 , pp. 7066-7074
    • Kaanders, J.1    Wijffels, K.2    Marres, H.3    Ljungkvist, A.4    Pop, L.5    Hoogen, F.6
  • 82
    • 0027294649 scopus 로고
    • Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials [see comments]
    • Curran W.J. Jr., Scott C.B., Horton J., Nelson J.S., Weinstein A.S., Fischbach A.J., et al. Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials [see comments]. J. Natl. Cancer Inst. 85:1993;704-710.
    • (1993) J. Natl. Cancer Inst. , vol.85 , pp. 704-710
    • Curran W.J., Jr.1    Scott, C.B.2    Horton, J.3    Nelson, J.S.4    Weinstein, A.S.5    Fischbach, A.J.6
  • 83
    • 0022559184 scopus 로고
    • Renal metabolism during normoxia, hypoxia, and ischemic injury
    • Jones D.P. Renal metabolism during normoxia, hypoxia, and ischemic injury. Annu. Rev. Physiol. 48:1986;33-50.
    • (1986) Annu. Rev. Physiol. , vol.48 , pp. 33-50
    • Jones, D.P.1
  • 84
    • 0035093491 scopus 로고    scopus 로고
    • Coregulation of glucose uptake and vascular endothelial growth factor (VEGF) in two small-cell lung cancer (SCLC) sublines in vivo and in vitro
    • Pedersen M.W., Holm S., Lund E.L., Hojgaard L., Kristjansen P.E. Coregulation of glucose uptake and vascular endothelial growth factor (VEGF) in two small-cell lung cancer (SCLC) sublines in vivo and in vitro. Neoplasia (New York). 3:2001;80-87.
    • (2001) Neoplasia (New York) , vol.3 , pp. 80-87
    • Pedersen, M.W.1    Holm, S.2    Lund, E.L.3    Hojgaard, L.4    Kristjansen, P.E.5
  • 85
    • 0033693293 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha(hypoxia response element(VEGF cascade differentially regulates vascular response and growth rate in tumors
    • Tsuzuki Y., Fukumura D., Oosthuyse B., Koike C., Carmeliet P., Jain R.K. Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha(hypoxia response element(VEGF cascade differentially regulates vascular response and growth rate in tumors. Cancer Res. 60:2000;6248-6252.
    • (2000) Cancer Res. , vol.60 , pp. 6248-6252
    • Tsuzuki, Y.1    Fukumura, D.2    Oosthuyse, B.3    Koike, C.4    Carmeliet, P.5    Jain, R.K.6
  • 86
    • 0035871337 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor transcription by endothelial PAS domain protein 1 (EPAS1) and possible involvement of EPAS1 in the angiogenesis of renal cell carcinoma
    • Xia G., Kageyama Y., Hayashi T., Kawakami S., Yoshida M., Kihara K. Regulation of vascular endothelial growth factor transcription by endothelial PAS domain protein 1 (EPAS1) and possible involvement of EPAS1 in the angiogenesis of renal cell carcinoma. Cancer. 91:2001;1429-1436.
    • (2001) Cancer , vol.91 , pp. 1429-1436
    • Xia, G.1    Kageyama, Y.2    Hayashi, T.3    Kawakami, S.4    Yoshida, M.5    Kihara, K.6
  • 87
    • 0035328635 scopus 로고    scopus 로고
    • Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis
    • Tendler D.S., Bao C., Wang T., Huang E.L., Ratovitski E.A., Pardoll D.A., Lowenstein C.J. Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis. Cancer Res. 61:2001;3682-3688.
    • (2001) Cancer Res. , vol.61 , pp. 3682-3688
    • Tendler, D.S.1    Bao, C.2    Wang, T.3    Huang, E.L.4    Ratovitski, E.A.5    Pardoll, D.A.6    Lowenstein, C.J.7
  • 88
    • 0034665113 scopus 로고    scopus 로고
    • Nitric oxide affects the production of reactive oxygen species in hepatoma cells: Implications for the process of oxygen sensing
    • Genius J., Fandrey J. Nitric oxide affects the production of reactive oxygen species in hepatoma cells: implications for the process of oxygen sensing. Free Radic. Biol. Med. 29:2000;515-521.
    • (2000) Free Radic. Biol. Med. , vol.29 , pp. 515-521
    • Genius, J.1    Fandrey, J.2
  • 89
    • 0034456537 scopus 로고    scopus 로고
    • Regulation of insulin-like growth factor-binding protein-1 by nitric oxide under hypoxic conditions
    • Sugawara J., Suh D.S., Faessen G.H., Suen L.F., Shibata T., Kaper F., et al. Regulation of insulin-like growth factor-binding protein-1 by nitric oxide under hypoxic conditions. J. Clin. Endocrinol. Metab. 85:2000;2714-2721.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 2714-2721
    • Sugawara, J.1    Suh, D.S.2    Faessen, G.H.3    Suen, L.F.4    Shibata, T.5    Kaper, F.6
  • 90
    • 0035835819 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene
    • Kondo K., Kaelin W.G. Jr. The von Hippel-Lindau tumor suppressor gene. Exp. Cell Res. 264:2001;117-125.
    • (2001) Exp. Cell Res. , vol.264 , pp. 117-125
    • Kondo, K.1    Kaelin W.G., Jr.2
  • 91
    • 0035105565 scopus 로고    scopus 로고
    • Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast
    • Wykoff C.C., Beasley N., Watson P.H., Campo L., Chia S.K., English R., et al. Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast. Am. J. Pathol. 158:2001;1011-1019.
    • (2001) Am. J. Pathol. , vol.158 , pp. 1011-1019
    • Wykoff, C.C.1    Beasley, N.2    Watson, P.H.3    Campo, L.4    Chia, S.K.5    English, R.6
  • 92
    • 0035392959 scopus 로고    scopus 로고
    • Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density
    • Beasley N.J., Wykoff C.C., Watson P.H., Leek R., Turley H., Gatter K., et al. Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density. Cancer Res. 61:2001;5262-5267.
    • (2001) Cancer Res. , vol.61 , pp. 5262-5267
    • Beasley, N.J.1    Wykoff, C.C.2    Watson, P.H.3    Leek, R.4    Turley, H.5    Gatter, K.6
  • 93
    • 0035881075 scopus 로고    scopus 로고
    • Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma
    • Chia S.K., Wykoff C.C., Watson P.H., Han C., Leek R.D., Pastorek J., et al. Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma. J. Clin. Oncol. 19:2001;3660-3668.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3660-3668
    • Chia, S.K.1    Wykoff, C.C.2    Watson, P.H.3    Han, C.4    Leek, R.D.5    Pastorek, J.6
  • 95
    • 0033924882 scopus 로고    scopus 로고
    • Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor
    • Laderoute K.R., Alarcon R.M., Brody M.D., Calaoagan J.M., Chen E.Y., Knapp A.M., et al. Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor. Clin. Cancer Res. 6:2000;2941-2950.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2941-2950
    • Laderoute, K.R.1    Alarcon, R.M.2    Brody, M.D.3    Calaoagan, J.M.4    Chen, E.Y.5    Knapp, A.M.6
  • 96
    • 0034981380 scopus 로고    scopus 로고
    • Hypoxia stimulates osteopontin expression and proliferation of cultured vascular smooth muscle cells: Potentiation by high glucose
    • Sodhi C.P., Phadke S.A., Batlle D., Sahai A. Hypoxia stimulates osteopontin expression and proliferation of cultured vascular smooth muscle cells: potentiation by high glucose. Diabetes. 50:2001;1482-1490.
    • (2001) Diabetes , vol.50 , pp. 1482-1490
    • Sodhi, C.P.1    Phadke, S.A.2    Batlle, D.3    Sahai, A.4
  • 97
    • 0034213146 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1alpha in brain tumors: Association with angiogenesis, invasion, and progression
    • Zagzag D., Zhong H., Scalzitti J.M., Laughner E., Simons J.W., Semenza G.L. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer. 88:2000;2606-2618.
    • (2000) Cancer , vol.88 , pp. 2606-2618
    • Zagzag, D.1    Zhong, H.2    Scalzitti, J.M.3    Laughner, E.4    Simons, J.W.5    Semenza, G.L.6
  • 98
    • 0035300410 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
    • Aebersold D.M., Burri P., Beer K.T., Laissue J., Djonov V., Greiner R.H., et al. Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res. 61:2001;2911-2916.
    • (2001) Cancer Res. , vol.61 , pp. 2911-2916
    • Aebersold, D.M.1    Burri, P.2    Beer, K.T.3    Laissue, J.4    Djonov, V.5    Greiner, R.H.6
  • 99
    • 0028864565 scopus 로고
    • Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker
    • Waleh N.S., Brody M.D., Knapp M.A., Mendonca H.L., Lord E.M., Koch C.J., et al. Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker. Cancer Res. 55:1995;6222-6226.
    • (1995) Cancer Res. , vol.55 , pp. 6222-6226
    • Waleh, N.S.1    Brody, M.D.2    Knapp, M.A.3    Mendonca, H.L.4    Lord, E.M.5    Koch, C.J.6
  • 100
    • 0032857478 scopus 로고    scopus 로고
    • Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis
    • Rosmorduc O., Wendum D., Corpechot C., Galy B., Sebbagh N., Raleigh J., et al. Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis. Am. J. Pathol. 155:1999;1065-1073.
    • (1999) Am. J. Pathol. , vol.155 , pp. 1065-1073
    • Rosmorduc, O.1    Wendum, D.2    Corpechot, C.3    Galy, B.4    Sebbagh, N.5    Raleigh, J.6
  • 101
    • 0032170012 scopus 로고    scopus 로고
    • Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker
    • Raleigh J.A., Calkins-Adams D.P., Rinker L.H., Ballenger C.A., Weissler M.C., Fowler W.C. Jr., et al. Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker. Cancer Res. 58:1998;3765-3768.
    • (1998) Cancer Res. , vol.58 , pp. 3765-3768
    • Raleigh, J.A.1    Calkins-Adams, D.P.2    Rinker, L.H.3    Ballenger, C.A.4    Weissler, M.C.5    Fowler W.C., Jr.6
  • 102
    • 0033953487 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression is independent of hypoxia in human malignant glioma spheroids and tumours
    • Parliament M.B., Allalunis-Turner M.J., Franko A.J., Olive P.L., Mandyam R., Santos C., et al. Vascular endothelial growth factor expression is independent of hypoxia in human malignant glioma spheroids and tumours. Br. J. Cancer. 82:2000;635-641.
    • (2000) Br. J. Cancer , vol.82 , pp. 635-641
    • Parliament, M.B.1    Allalunis-Turner, M.J.2    Franko, A.J.3    Olive, P.L.4    Mandyam, R.5    Santos, C.6
  • 103
    • 0033038190 scopus 로고    scopus 로고
    • A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular endothelial growth factor (VEGF) mRNA in cervical cancer cell lines
    • Chiarotto J.A., Hill R.P. A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular endothelial growth factor (VEGF) mRNA in cervical cancer cell lines. Br. J. Cancer. 80:1999;1518-1524.
    • (1999) Br. J. Cancer , vol.80 , pp. 1518-1524
    • Chiarotto, J.A.1    Hill, R.P.2
  • 104
    • 0032514685 scopus 로고    scopus 로고
    • Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
    • Ivanov S.V., Kuzmin I., Wei M.H., Pack S., Geil L., Johnson B.E., et al. Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. Proc. Natl. Acad. Sci. USA. 95:1998;12596-12601.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 12596-12601
    • Ivanov, S.V.1    Kuzmin, I.2    Wei, M.H.3    Pack, S.4    Geil, L.5    Johnson, B.E.6
  • 106
    • 0035418586 scopus 로고    scopus 로고
    • Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
    • Loncaster J.A., Harris A.L., Davidson S.E., Logue J.P., Hunter R.D., Wycoff C.C., et al. Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 61:2001;6394-6399.
    • (2001) Cancer Res. , vol.61 , pp. 6394-6399
    • Loncaster, J.A.1    Harris, A.L.2    Davidson, S.E.3    Logue, J.P.4    Hunter, R.D.5    Wycoff, C.C.6
  • 108
    • 0034753330 scopus 로고    scopus 로고
    • Imaging hypoxia in tumors
    • Ballinger J.R. Imaging hypoxia in tumors. Semin. Nuclear Med. 31:2001;321-329.
    • (2001) Semin. Nuclear Med. , vol.31 , pp. 321-329
    • Ballinger, J.R.1
  • 109
    • 0035863303 scopus 로고    scopus 로고
    • Phase I trial of concurrent tirapazamine, cisplatin, and radiotherapy in patients with advanced head and neck cancer
    • Rischin D., Peters L., Hicks R., Hughes P., Fisher R., Hart R., et al. Phase I trial of concurrent tirapazamine, cisplatin, and radiotherapy in patients with advanced head and neck cancer. J. Clin. Oncol. 19:2001;535-542.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 535-542
    • Rischin, D.1    Peters, L.2    Hicks, R.3    Hughes, P.4    Fisher, R.5    Hart, R.6
  • 111
    • 0029800972 scopus 로고    scopus 로고
    • Fluorine-18 fluoromisonidazole tumour to muscle retention ratio for the detection of hypoxia in nasopharyngeal carcinoma
    • Yeh S.H., Liu R.S., Wu L.C., Yang D.J., Yen S.H., Chang C.W., et al. Fluorine-18 fluoromisonidazole tumour to muscle retention ratio for the detection of hypoxia in nasopharyngeal carcinoma. Eur. J. Nucl. Med. 23:1996;1378-1383.
    • (1996) Eur. J. Nucl. Med. , vol.23 , pp. 1378-1383
    • Yeh, S.H.1    Liu, R.S.2    Wu, L.C.3    Yang, D.J.4    Yen, S.H.5    Chang, C.W.6
  • 112
    • 0026475672 scopus 로고
    • Hypoxia in human gliomas: Demonstration by PET with fluorine-18-fluoromisonidazole
    • Valk P.E., Mathis C.A., Prados M.D., Gilbert J.C., Budinger T.F. Hypoxia in human gliomas: demonstration by PET with fluorine-18-fluoromisonidazole. J. Nuclear Med. 33:1992;2133-2137.
    • (1992) J. Nuclear Med. , vol.33 , pp. 2133-2137
    • Valk, P.E.1    Mathis, C.A.2    Prados, M.D.3    Gilbert, J.C.4    Budinger, T.F.5
  • 117
    • 0028215490 scopus 로고
    • Direct measurement of the PO2 distribution in human malignant brain tumours
    • Cruickshank G.S., Rampling R.P., Cowans W. Direct measurement of the PO2 distribution in human malignant brain tumours. Adv. Exp. Med. Biol. 345:1994;465-470.
    • (1994) Adv. Exp. Med. Biol. , vol.345 , pp. 465-470
    • Cruickshank, G.S.1    Rampling, R.P.2    Cowans, W.3
  • 118
    • 0032726709 scopus 로고    scopus 로고
    • Polarographic measurements of oxygen tension in human glioma and surrounding peritumoural brain tissue
    • Collingridge D.R., Piepmeier J.M., Rockwell S., Knisely J.P. Polarographic measurements of oxygen tension in human glioma and surrounding peritumoural brain tissue. Radiother. Oncol. 53:1999;127-131.
    • (1999) Radiother. Oncol. , vol.53 , pp. 127-131
    • Collingridge, D.R.1    Piepmeier, J.M.2    Rockwell, S.3    Knisely, J.P.4
  • 119
    • 0035122603 scopus 로고    scopus 로고
    • Marking hypoxia in rat prostate carcinomas with beta-D-and 125I azomycin galactopyranoside
    • Iyer R.V., Haynes P.T., Schneider R.F., Movsas B., Chapman J.D. Marking hypoxia in rat prostate carcinomas with beta-D-and 125I azomycin galactopyranoside. J. Nuclear Med. 42:2001;337-344.
    • (2001) J. Nuclear Med. , vol.42 , pp. 337-344
    • Iyer, R.V.1    Haynes, P.T.2    Schneider, R.F.3    Movsas, B.4    Chapman, J.D.5
  • 120
    • 0030811565 scopus 로고    scopus 로고
    • Copper-62-ATSM: A new hypoxia imaging agent with high membrane permeability and low redox potential
    • Fujibayashi Y., Taniuchi H., Yonekura Y., Ohtani H., Konishi J., Yokoyama A. Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential. J. Nuclear Med. 38:1997;1155-1160.
    • (1997) J. Nuclear Med. , vol.38 , pp. 1155-1160
    • Fujibayashi, Y.1    Taniuchi, H.2    Yonekura, Y.3    Ohtani, H.4    Konishi, J.5    Yokoyama, A.6
  • 121
    • 0035043960 scopus 로고    scopus 로고
    • Tumor uptake of copper-diacetyl-bis(N(4)-methylthiosemicarbazone): Effect of changes in tissue oxygenation
    • Lewis J.S., Sharp T.L., Laforest R., Fujibayashi Y., Welch M.J. Tumor uptake of copper-diacetyl-bis(N(4)-methylthiosemicarbazone): effect of changes in tissue oxygenation. J. Nuclear Med. 42:2001;655-661.
    • (2001) J. Nuclear Med. , vol.42 , pp. 655-661
    • Lewis, J.S.1    Sharp, T.L.2    Laforest, R.3    Fujibayashi, Y.4    Welch, M.J.5
  • 122
    • 0002112458 scopus 로고    scopus 로고
    • Evaluation of tumor hypoxia with Cu-ATSM and PET (abstr.)
    • Dehdashti F., Mintum M., Lewis J., et al. Evaluation of tumor hypoxia with Cu-ATSM and PET (abstr.). J. Nuclear Med. 41:2000;34.
    • (2000) J. Nuclear Med. , vol.41 , pp. 34
    • Dehdashti, F.1    Mintum, M.2    Lewis, J.3
  • 124
    • 0031716020 scopus 로고    scopus 로고
    • Oxygenation predicts radiation response and survival in patients with cervix cancer [published erratum appears in Radiother. Oncol. 1999 Mar;50(3):371]
    • Fyles A.W., Milosevic M., Wong R., Kavanagh M.C., Pintilie M., Sun A., et al. Oxygenation predicts radiation response and survival in patients with cervix cancer [published erratum appears in Radiother. Oncol. 1999 Mar;50(3):371]. Radiother. Oncol. 48:1998;149-156.
    • (1998) Radiother. Oncol. , vol.48 , pp. 149-156
    • Fyles, A.W.1    Milosevic, M.2    Wong, R.3    Kavanagh, M.C.4    Pintilie, M.5    Sun, A.6
  • 126
    • 0031688165 scopus 로고    scopus 로고
    • Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix
    • Sundfor K., Lyng H., Rofstad E.K. Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix. Br. J. Cancer. 78:1998;822-827.
    • (1998) Br. J. Cancer , vol.78 , pp. 822-827
    • Sundfor, K.1    Lyng, H.2    Rofstad, E.K.3
  • 127
    • 0034002284 scopus 로고    scopus 로고
    • Treatment outcome in advanced squamous cell carcinoma of the uterine cervix: Relationships to pretreatment tumor oxygenation and vascularization
    • Sundfor K., Lyng H., Trope C.G., Rofstad E.K. Treatment outcome in advanced squamous cell carcinoma of the uterine cervix: relationships to pretreatment tumor oxygenation and vascularization. Radiother. Oncol. 54:2000;101-107.
    • (2000) Radiother. Oncol. , vol.54 , pp. 101-107
    • Sundfor, K.1    Lyng, H.2    Trope, C.G.3    Rofstad, E.K.4
  • 128
    • 0033922706 scopus 로고    scopus 로고
    • Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis
    • Rofstad E.K., Sundfor K., Lyng H., Trope C.G. Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis. Br. J. Cancer. 83:2000;354-359.
    • (2000) Br. J. Cancer , vol.83 , pp. 354-359
    • Rofstad, E.K.1    Sundfor, K.2    Lyng, H.3    Trope, C.G.4
  • 129
    • 0032585864 scopus 로고    scopus 로고
    • Intratumoral pO2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix
    • Knocke T.H., Weitmann H.D., Feldmann H.J., Selzer E., Potter R. Intratumoral pO2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix. Radiother. Oncol. 53:1999;99-104.
    • (1999) Radiother. Oncol. , vol.53 , pp. 99-104
    • Knocke, T.H.1    Weitmann, H.D.2    Feldmann, H.J.3    Selzer, E.4    Potter, R.5
  • 130
    • 0029955072 scopus 로고    scopus 로고
    • Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
    • Nordsmark M., Overgaard M., Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother. Oncol. 41:1996;31-39.
    • (1996) Radiother. Oncol. , vol.41 , pp. 31-39
    • Nordsmark, M.1    Overgaard, M.2    Overgaard, J.3
  • 132
    • 0032708195 scopus 로고    scopus 로고
    • Oxygenation of head and neck cancer: Changes during radiotherapy and impact on treatment outcome
    • Brizel D.M., Dodge R.K., Clough R.W., Dewhirst M.W. Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother. Oncol. 53:1999;113-117.
    • (1999) Radiother. Oncol. , vol.53 , pp. 113-117
    • Brizel, D.M.1    Dodge, R.K.2    Clough, R.W.3    Dewhirst, M.W.4
  • 134
    • 0034307238 scopus 로고    scopus 로고
    • Repeatability and prognostic impact of the pretreatment pO(2) histography in patients with advanced head and neck cancer
    • Rudat V., Vanselow B., Wollensack P., Bettscheider C., Osman-Ahmet S., Eble M.J., et al. Repeatability and prognostic impact of the pretreatment pO(2) histography in patients with advanced head and neck cancer. Radiother. Oncol. 57:2000;31-37.
    • (2000) Radiother. Oncol. , vol.57 , pp. 31-37
    • Rudat, V.1    Vanselow, B.2    Wollensack, P.3    Bettscheider, C.4    Osman-Ahmet, S.5    Eble, M.J.6
  • 135
    • 0034819345 scopus 로고    scopus 로고
    • Predictive value of the tumor oxygenation by means of pO2 histography in patients with advanced head and neck cancer
    • Rudat V., Stadler P., Becker A., Vanselow B., Dietz A., Wannenmacher M., et al. Predictive value of the tumor oxygenation by means of pO2 histography in patients with advanced head and neck cancer. Strahlenther. Onkol. 177:2001;462-468.
    • (2001) Strahlenther. Onkol. , vol.177 , pp. 462-468
    • Rudat, V.1    Stadler, P.2    Becker, A.3    Vanselow, B.4    Dietz, A.5    Wannenmacher, M.6
  • 136
    • 0034020976 scopus 로고    scopus 로고
    • Head and neck cancer: The importance of oxygen
    • Terris D.J. Head and neck cancer: the importance of oxygen. Laryngoscope. 110:2000;697-707.
    • (2000) Laryngoscope , vol.110 , pp. 697-707
    • Terris, D.J.1
  • 137
    • 0035917618 scopus 로고    scopus 로고
    • Hypoxia in human soft tissue sarcomas: Adverse impact on survival and no association with p53 mutations
    • Nordsmark M., Alsner J., Keller J., Nielsen O.S., Jensen O.M., Horsman M.R., et al. Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations. Br. J. Cancer. 84:2001;1070-1075.
    • (2001) Br. J. Cancer , vol.84 , pp. 1070-1075
    • Nordsmark, M.1    Alsner, J.2    Keller, J.3    Nielsen, O.S.4    Jensen, O.M.5    Horsman, M.R.6
  • 139
    • 0022632870 scopus 로고
    • A clinical phase I toxicity study of Ro 03-8799: Plasma, urine, tumour and normal brain pharmacokinetics
    • Roberts J.T., Bleehen N.M., Walton M.I., Workman P., A clinical phase I toxicity study of Ro 03-8799: plasma, urine, tumour and normal brain pharmacokinetics. Br. J. Radiol. 59:1986;107-116.
    • (1986) Br. J. Radiol. , vol.59 , pp. 107-116
    • Roberts, J.T.1    Bleehen, N.M.2    Walton, M.I.3    Workman, P.4
  • 140
    • 0023681482 scopus 로고
    • Hypoxic cell radiosensitizers in the treatment of high grade gliomas: A new direction using combined Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole)
    • Newman H.F., Bleehen N.M., Ward R., Workman P. Hypoxic cell radiosensitizers in the treatment of high grade gliomas: a new direction using combined Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole). Int. J. Radiat. Oncol., Biol., Phys. 15:1988;677-684.
    • (1988) Int. J. Radiat. Oncol., Biol., Phys. , vol.15 , pp. 677-684
    • Newman, H.F.1    Bleehen, N.M.2    Ward, R.3    Workman, P.4
  • 141
    • 0035698467 scopus 로고    scopus 로고
    • Measuring hypoxia in solid tumours - Is there a gold standard?
    • Olive P.L., Banath J.P., Aquino-Parsons C. Measuring hypoxia in solid tumours - is there a gold standard? Acta Oncol. 40:2001;917-923.
    • (2001) Acta Oncol. , vol.40 , pp. 917-923
    • Olive, P.L.1    Banath, J.P.2    Aquino-Parsons, C.3
  • 142
    • 0035702911 scopus 로고    scopus 로고
    • Hypoxia and perfusion measurements in human tumors - Initial experience with pimonidazole and IUdR
    • Begg A.C., Janssen H., Sprong D., Hofland I., Blommestijn G., Raleigh J.A., et al. Hypoxia and perfusion measurements in human tumors - initial experience with pimonidazole and IUdR. Acta Oncol. 40:2001;924-928.
    • (2001) Acta Oncol. , vol.40 , pp. 924-928
    • Begg, A.C.1    Janssen, H.2    Sprong, D.3    Hofland, I.4    Blommestijn, G.5    Raleigh, J.A.6
  • 143
  • 145
    • 0030871773 scopus 로고    scopus 로고
    • Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: Relationship to tumor hypoxia
    • Siim B.G., Menke D.R., Dorie M.J., Brown J.M. Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia. Cancer Res. 57:1997;2922-2928.
    • (1997) Cancer Res. , vol.57 , pp. 2922-2928
    • Siim, B.G.1    Menke, D.R.2    Dorie, M.J.3    Brown, J.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.