Expression of carbonic anhydrase IX suggests poor outcome in rectal cancer

British Journal of Cancer

Volumn 100, Issue 6, 2009, Pages 874-880

  Korkeila, E ^a   Talvinen, K ^b   Jaakkola, P M ^a,b,c   Minn, H ^a,d   Syrjanen K ^a   Sundstrom J ^a,b   Pyrhonen S ^a  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c ÅBO AKADEMI UNIVERSITY   (Finland)

^d TURKU PET CENTRE   (Finland)

Author keywords

CA IX; Chemotherapy; Predictive factor; Prognosis; Radiotherapy; Rectal cancer

Indexed keywords

CARBONATE DEHYDRATASE IX;

AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER DIAGNOSIS; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; DISEASE FREE SURVIVAL; DISEASE SPECIFIC SURVIVAL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIMODALITY CANCER THERAPY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECTUM CANCER; WESTERN BLOTTING;

AGED; ANTIGENS, NEOPLASM; BIOPSY; CARBONIC ANHYDRASES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RECTAL NEOPLASMS;

EID: 62549099960     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604949     Document Type: Article

References (40)

1. Atkins M, Regan M, McDermott D, Mier J, Stanbridge E, Youmans A, Febbo P, Upton M, Lechpammer M, Signoretti S (2005) Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer. Clin Cancer Res 11: 3714-3721
2. Bache M, Reddemann R, Said H, Holzhausen H, Taubert H, Becker A, Kuhnt T, Hansgen G, Dunst J, Vordermark D (2006) Immunohistochemical detection of osteopontin in advanced head-and-neck cancer: prognostic role and correlation with oxygen electrode measurements, hypoxia-inducible-factor-1alpha-related markers, and hemoglobin levels. Int J Radiat Oncol Biol Phys 66: 1481-1487
3. Bendardaf R, Algars A, Elzagheid A, Korkeila E, Ristamäki R, Lamlum H, Collan Y, Syrjänen K, Pyrhönen S (2006) Comparison of CD44 expression in primary tumours and metastases of colorectal cancer. Oncol Rep 16: 741-746
4. Bendardaf R, Elzagheid A, Lamlum H, Algars A, Korkeila E, Ristamäki R, Collan Y, Syrjänen K, Pyrhönen S (2007) Thymidylate synthase expression in primary colorectal tumours is correlated with its expression in metastases. Scand J Gastroenterol 42: 471-476
5. Brennan D, Jirstrom K, Kronblad A, Millikan R, Landberg G, Duffy M, Ryden L, Gallagher W, O'Brien S (2006) CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance. Clin Cancer Res 12: 6421-6431
6. Brizel D, Scully S, Harrelson J, Layfield L, Bean J, Prosnitz L, Dewhirst M (1996) Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 56: 941-943
7. Bui M, Seligson D, Han K, Pantuck A, Dorey F, Huang Y, Horvath S, Leibovich B, Chopra S, Liao S, Stanbridge E, Lerman M, Palotie A, Figlin R, Belldegrun A (2003) Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. Clin Cancer Res 9: 802-811
8. Bui M, Visapaa H, Seligson D, Kim H, Han K, Huang Y, Horvath S, Stanbridge E, Palotie A, Figlin R, Belldegrun A (2004) Prognostic value of carbonic anhydrase IX and KI67 as predictors of survival for renal clear cell carcinoma. J Urol 171: 2461-2466
9. Chia S, Wykoff C, Watson P, Han C, Leek R, Pastorek J, Gatter K, Ratcliffe P, Harris A (2001) Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma. J Clin Oncol 19: 3660-3668
10. Dworak O, Keilholz L, Hoffmann A (1997) Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Dis 12: 19-23
11. Ferlay J, Parkin D, Bray F, Pisani P (2004) Globocan 2002. Cancer Incidence, Mortality and Prevalence Worldwide. IARC Cancer Base; No 5, version 2.0. IARC Press: Lyon
12. Generali D, Berruti A, Brizzi M, Campo L, Bonardi S, Wigfield S, Bersiga A, Allevi G, Milani M, Aguggini S, Gandolfi V, Dogliotti L, Bottini A, Harris A, Fox S (2006) Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer. Clin Cancer Res 12: 4562-4568
13. Giatromanolaki A, Koukourakis M, Sivridis E, Pastorek J, Wykoff C, Gatter K, Harris A (2001) Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res 61: 7992-7998
14. Harris A (2002) Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47
15. Hilvo M, Supuran C, Parkkila S (2007) Characterization and inhibition of the recently discovered carbonic anhydrase isoforms CA XIII, XIV and XV. Curr Top Med Chem 7: 893-899
16. Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56: 4509-4515
17. Hoskin P, Sibtain A, Daley F, Wilson G (2003) GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: relationship with vascularity and proliferation as predictors of outcome of ARCON. Br J Cancer 89: 1290-1297
18. Hussain S, Ganesan R, Reynolds G, Gross L, Stevens A, Pastorek J, Murray P, Perunovic B, Anwar M, Billingham L, James N, Spooner D, Poole C, Rea D, Palmer D (2007) Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer. Br J Cancer 96: 104-109
19. Ivanov S, Liao S, Ivanova A, Danilkovitch-Miagkova A, Tarasova N, Weirich G, Merrill M, Proescholdt M, Oldfield E, Lee J, Zavada J, Waheed A, Sly W, Lerman M, Stanbridge E (2001) Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Am J Pathol 158: 905-919
20. Järvelä S, Parkkila S, Bragge H, Kähkönen M, Parkkila A, Soini Y, Pastorekova S, Pastorek J, Haapasalo H (2008) Carbonic anhydrase IX in oligodendroglial brain tumors. BMC Cancer 8: 1, doi:10.1186/1471-2407-8-1
21. Kappler M, Taubert H, Holzhausen H, Reddemann R, Rot S, Becker A, Kuhnt T, Dellas K, Dunst J, Vordermark D, Hansgen G, Bache M (2008) Immunohistochemical detection of HIF-1alpha and CAIX in advanced head-and-neck cancer: prognostic role and correlation with tumor markers and tumor oxygenation parameters. Strahlenther Onkol 184: 491
22. Kim S, Rabbani Z, Dewhirst M, Vujaskovic Z, Vollmer R, Schreiber E, Oosterwijk E, Kelley M (2005) Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer. Lung Cancer 49: 325-335
23. Kivelä A, Saarnio J, Karttunen T, Kivelä J, Parkkila A, Pastorekova S, Pastorek J, Waheed A, Sly W, Parkkila T, Rajaniemi H (2001) Differential expression of cytoplasmic carbonic anhydrases, CA I and II, and membrane-associated isozymes, CA IX and XII, in normal mucosa of large intestine and in colorectal tumors. Dig Dis Sci 46: 2179-2186
24. Kon-no H, Ishii G, Nagai K, Yoshida J, Nishimura M, Nara M, Fujii T, Murata Y, Miyamoto H, Ochiai A (2006) Carbonic anhydrase IX expression is associated with tumor progression and a poor prognosis of lung adenocarcinoma. Lung Cancer 54: 409-418
25. Marijnen C, Nagtegaal I, Kranenbarg E, Hermans J, van de Velde C, Leer J, van Krieken J (2001) No downstaging after short-term preoperative radiotherapy in rectal cancer patients. J Clin Oncol 19: 1976-1984
26. Niemelä A, Hynninen P, Mecklin J, Kuopio T, Kokko A, Aaltonen L, Parkkila A, Pastorekova S, Pastorek J, Waheed A, Sly W, Orntoft T, Kruhoffer M, Haapasalo H, Parkkila S, Kivelä A (2007) Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer. Cancer Epidemiol Biomarkers Prev 16: 1760-1766
27. Opavsky R, Pastorekova S, Zelnik V, Gibadulinova A, Stanbridge E, Zavada J, Kettmann R, Pastorek J (1996) Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships. Genomics 33: 480-487
28. Pastorek J, Pastorekova S, Callebaut I, Mornon J, Zelnik V, Opavsky R, Zatovicova M, Liao S, Portetelle D, Stanbridge E (1994) Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loophelix DNA binding segment. Oncogene 9: 2877-2888
29. Pastorekova S, Kopacek J, Pastorek J (2007) Carbonic anhydrase inhibitors and the management of cancer. Curr Top Med Chem 7: 865-878
30. Patard J, Fergelot P, Karakiewicz P, Klatte T, Trinh Q, Rioux-Leclercq N, Said J, Belldegrun A, Pantuck A (2008) Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma. Int J Cancer 123: 395-400
31. Robertson N, Potter C, Harris A (2004) Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion. Cancer Res 64: 6160-6165
32. Rödel C, Martus P, Papadoupolos T, Fuzesi L, Klimpfinger M, Fietkau R, Liersch T, Hohenberger W, Raab R, Sauer R, Wittekind C (2005) Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol 23: 8688-8696
33. Ruo L, Tickoo S, Klimstra D, Minsky B, Saltz L, Mazumdar M, Paty P, Wong W, Larson S, Cohen A, Guillem J (2002) Long-term prognostic significance of extent of rectal cancer response to preoperative radiation and chemotherapy. Ann Surg 236: 75-81
34. Saarnio J, Parkkila S, Parkkila A, Haukipuro K, Pastorekova S, Pastorek J, Kairaluoma M, Karttunen T (1998) Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Am J Pathol 153: 279-285
35. Semenza G (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732
36. Simi L, Venturini G, Malentacchi F, Gelmini S, Andreani M, Janni A, Pastorekova S, Supuran C, Pazzagli M, Orlando C (2006) Quantitative analysis of carbonic anhydrase IX mRNA in human non-small cell lung cancer. Lung Cancer 52: 59-66
37. Swinson D, Jones J, Richardson D, Wykoff C, Turley H, Pastorek J, Taub N, Harris A, O'Byrne K (2003) Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. J Clin Oncol 21: 473-482
38. Talvinen K, Tuikkala J, Grönroos J, Huhtinen H, Kronqvist P, Aittokallio T, Nevalainen O, Hiekkanen H, Nevalainen T, Sundström J (2006) Biochemical and clinical approaches in evaluating the prognosis of colon cancer. Anticancer Res 26: 4745-4751
39. Trastour C, Benizri E, Ettore F, Ramaioli A, Chamorey E, Pouyssegur J, Berra E (2007) HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome. Int J Cancer 120: 1451-1458
40. Wykoff C, Beasley N, Watson P, Turner K, Pastorek J, Sibtain A, Wilson G, Turley H, Talks K, Maxwell P, Pugh C, Ratcliffe P, Harris A (2000) Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res 60: 7075-7083